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Leslie B. Vosshall

April 11, 2024

Leslie Birgit Vosshall (born July 5, 1965) is an American neurobiologist and currently a Howard Hughes Medical Institute (HHMI) investigator and the Robin Chemers Neustein Professor of Neurogenetics and Behavior at The Rockefeller University. In 2022 she was appointed Chief Scientific Officer and vice president of HHMI. She is also the director of the Kavli Neural Systems Institute at The Rockefeller University.[1] Vosshall, a member of the National Academy of Sciences, is known for her contributions to the field of olfaction, particularly for the discovery and subsequent characterization of the insect olfactory receptor family, and the genetic basis of chemosensory behavior in mosquitoes.[2] She has also extended her research into the study of human olfaction, revealing parts of human genetic olfactory architecture, and finding variations in odorant receptors that determine individuals’ abilities to detect odors. [3]

Leslie B. Vosshall
Leslie Vosshall in 2010
Born (1965-07-05) July 5, 1965 (age 58)
Lausanne, Switzerland
NationalityAmerican
Alma materColumbia College of Columbia University
Known forinsect olfaction
Scientific career
FieldsNeuroscience
InstitutionsThe Rockefeller University
Doctoral advisorMichael W. Young
Other academic advisorsRichard Axel

Early life edit

Leslie Vosshall was born in Lausanne, Switzerland where she spent most of her early childhood. Vosshall moved to New Jersey when she was 8 years old. She spent summers from age 17 to 19 working in the laboratory of her uncle, Philip Dunham, with Gerald Weissmann at the Marine Biological Laboratory (MBL) in Woods Hole. Vosshall said this experience was "an incredible introduction to the practice of science."[4]

Education edit

Vosshall received her B.A. in biochemistry[5] from Columbia University in 1987 and her Ph.D. from Rockefeller University in 1993. She returned to Columbia for a postdoctoral fellowship in the laboratory of future Nobel laureate Richard Axel from 1993-1997. She then worked in the position of Associate Research Scientist in Dr. Axel's laboratory from 1997-2000. Vosshall was offered the position of Assistant Professor at The Rockefeller University in 2000, and was promoted to Associate Professor in 2006.[1] In April 2010, she was granted tenure and is currently the Robin Chemers Neustein Professor and Head of the Laboratory of Neurogenetics and Behavior.[6] She served as associate director of the Kavli Neural Systems Institute from 2015-2016 and was promoted to director in 2016.[1]

Research edit

Vosshall’s laboratory studies three organisms: fruit flies, mosquitoes and humans, to understand the genetic and molecular underpinnings, as well as behavioral mechanisms, involved in olfaction and feeding behavior.[7] In addition, to find the genes that make the mosquito species Aedes aegypti prefer humans, Vosshall compares genes that drive host-seeking and blood-seeking behaviors in several different mosquito subspecies.[8] Vosshall’s and her associates’ research on Aedes aegypti, the mosquito responsible for transmitting yellow fever,[8] dengue, and Zika,[9] found that it has a particular odor-detecting gene (AaegOr4) that is highly attuned to sulcatone, a compound predominant in human odor.[8][10] Research from Vosshall’s lab demonstrated that a chemical transferred from the male of the species during sex plays a key role in shaping the female’s sexual proclivities.[11][12] In addition, Vosshall and her associates discovered ORCO, a mosquito co-receptor responsible for preference for humans over non-human animals and sensitivity to insect-repellent DEET.[13][14]

Awards and honors edit

Key papers edit

  • Vosshall LB, Amrein H, Morozov PS, Rzhetsky A, Axel R (March 1999). "A spatial map of olfactory receptor expression in the Drosophila antenna". Cell. 96 (5): 725–36. doi:10.1016/S0092-8674(00)80582-6. PMID 10089887. S2CID 9216020.
  • Vosshall LB, Wong AM, Axel R (July 2000). "An olfactory sensory map in the fly brain". Cell. 102 (2): 147–59. doi:10.1016/S0092-8674(00)00021-0. PMID 10943836. S2CID 17573876.
  • DeGennaro M, McBride CS, Seeholzer L, Nakagawa T, Dennis EJ, Goldman C, Jasinskiene N, James AA, Vosshall LB (29 May 2013). "orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET". Nature. 498 (7455): 487–491. Bibcode:2013Natur.498..487D. doi:10.1038/nature12206. PMC 3696029. PMID 23719379.
  • Larsson MC, Domingos AI, Jones WD, Chiappe ME, Amrein H, Vosshall LB (September 2 2004). "Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila Olfaction". Neuron. 43 (5): 703–714. doi:10.1016/j.neuron.2004.08.019. ISSN 0896-6273

Other selected publications edit

  • McBride, C.S. et al. Evolution of mosquito preference for humans linked to an odorant receptor. Nature 515, 222–227 (2014).[10]
  • Bushdid, C. et al. Humans can discriminate more than 1 trillion olfactory stimuli. Science 343, 1370–1372 (2014).[22]
  • McMeniman, C.J. et al. Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans. Cell 156,1060-1071 (2014).[23]

References edit

  1. ^ a b c d e "The Rockefeller University » Scientists & Research". www.rockefeller.edu. Retrieved 2017-03-10.
  2. ^ Prashant, Nair (29 June 2020). "QnAs with Leslie B. Vosshall". Proceedings of the National Academy of Sciences. 117 (28): 16100–16103. doi:10.1073/pnas.2011073117. PMC 7368263. PMID 32601194.
  3. ^ "Making the Paper: Leslie Vosshall and Hiroaki Matsunami". Nature. 449: xiii. 26 September 2007. Retrieved 15 July 2022.
  4. ^ Vosshall, Leslie B. (2012). "Leslie B. Vosshall". Current Biology. 22 (18): R782–R783. doi:10.1016/j.cub.2012.07.016. PMID 23193546.
  5. ^ "Leslie B. Vosshall". Our Scientists. Retrieved 2019-09-07.
  6. ^ Bonner, Joseph (2010-05-17). "The Rockefeller University: Leslie Vosshall promoted to professor". Retrieved 2017-10-24.
  7. ^ "Leslie B. Vosshall". Current Biology. 22 (28): PR782–R783. 25 September 2012. Retrieved 15 July 2022.
  8. ^ a b c "Researchers Find Gene that Makes Mosquitoes Prefer Humans over Animals". Entomology Today. Entomological Society of America. 13 November 2014. Retrieved 15 July 2022.
  9. ^ Lambert, Jonathon (25 April 2019). "How Do Mosquitoes Taste DEET? Hint: It's Not Their Mouthparts". Kuow.org. NPR. Retrieved 15 July 2022.
  10. ^ a b McBride, Carolyn S.; Baier, Felix; Omondi, Aman B.; Spitzer, Sarabeth A.; Lutomiah, Joel; Sang, Rosemary; Ignell, Rickard; Vosshall, Leslie B. (2014-11-13). "Evolution of mosquito preference for humans linked to an odorant receptor". Nature. 515 (7526): 222–227. Bibcode:2014Natur.515..222M. doi:10.1038/nature13964. ISSN 0028-0836. PMC 4286346. PMID 25391959.
  11. ^ Fenz-Rockefeller, Katherine (9 January 2018). "Mosquito sex swap leaves females 'loyal'". Futurity. Retrieved 19 July 2022.
  12. ^ "Mosquito sex protein could stem disease spread". Sky News. 13 December 2017. Retrieved 15 July 2022.
  13. ^ Lambert, Jonathon (25 April 2019). "How Do Mosquitoes Taste DEET? Hint: It's Not Their Mouthparts". Kuow.org. NPR. Retrieved 15 July 2022.
  14. ^ DeGennaro, Matthew; McBride, Carolyn S.; Seeholzer, Laura; Nakagawa, Takao; Dennis, Emily J.; Goldman, Chloe; Jasinskiene, Nijole; James, Anthony A.; Vosshall, Leslie B. (2013-06-27). "orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET". Nature. 498 (7455): 487–491. Bibcode:2013Natur.498..487D. doi:10.1038/nature12206. ISSN 1476-4687. PMC 3696029. PMID 23719379.
  15. ^ "Leslie B. Vosshall". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
  16. ^ Burke, Adrienne (November 2007). "The New York Academy of Sciences - Blavatnik Awards for Young Scientists". Retrieved 2010-06-04.
  17. ^ Bonner, Joseph (2008-06-02). "The Rockefeller University: Two Rockefeller faculty become new HHMI investigators". Retrieved 2017-10-24.
  18. ^ "Howard Hughes Medical Institute - HHMI News: HHMI Selects 56 of the Nation's Top Scientists". 2008-05-27. Retrieved 2010-06-04.
  19. ^ "New York University - NYU School of Medicine Presents Three Biomedical Researchers 2010 Dart/NYU Biotechnology Awards for Role of Pure Science". 2010-03-22. Retrieved 2010-06-04.
  20. ^ "Leslie Vosshall and Jean-Laurent Casanova elected to the National Academy of Sciences". Retrieved 2017-10-24.
  21. ^ "National Academy of Medicine Elects 100 New Members". Oct 18, 2021. Retrieved 2021-10-20.
  22. ^ Bushdid, C.; Magnasco, M. O.; Vosshall, L. B.; Keller, A. (2014-03-21). "Humans Can Discriminate More than 1 Trillion Olfactory Stimuli". Science. 343 (6177): 1370–1372. Bibcode:2014Sci...343.1370B. doi:10.1126/science.1249168. ISSN 0036-8075. PMC 4483192. PMID 24653035.
  23. ^ McMeniman, Conor J.; Corfas, Román A.; Matthews, Benjamin J.; Ritchie, Scott A.; Vosshall, Leslie B. (2014-02-27). "Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans". Cell. 156 (5): 1060–1071. doi:10.1016/j.cell.2013.12.044. ISSN 0092-8674. PMC 4007582. PMID 24581501.

External links edit

  • Rockefeller news search results for Leslie Vosshall
  • HHMI: Leslie B. Vosshall, Ph.D. (biography)
  • Rockefeller: Vosshall Lab Web Page

April 11, 2024
leslie, vosshall, leslie, birgit, vosshall, born, july, 1965, american, neurobiologist, currently, howard, hughes, medical, institute, hhmi, investigator, robin, chemers, neustein, professor, neurogenetics, behavior, rockefeller, university, 2022, appointed, c. Leslie Birgit Vosshall born July 5 1965 is an American neurobiologist and currently a Howard Hughes Medical Institute HHMI investigator and the Robin Chemers Neustein Professor of Neurogenetics and Behavior at The Rockefeller University In 2022 she was appointed Chief Scientific Officer and vice president of HHMI She is also the director of the Kavli Neural Systems Institute at The Rockefeller University 1 Vosshall a member of the National Academy of Sciences is known for her contributions to the field of olfaction particularly for the discovery and subsequent characterization of the insect olfactory receptor family and the genetic basis of chemosensory behavior in mosquitoes 2 She has also extended her research into the study of human olfaction revealing parts of human genetic olfactory architecture and finding variations in odorant receptors that determine individuals abilities to detect odors 3 Leslie B VosshallLeslie Vosshall in 2010Born 1965 07 05 July 5 1965 age 58 Lausanne SwitzerlandNationalityAmericanAlma materColumbia College of Columbia UniversityKnown forinsect olfactionScientific careerFieldsNeuroscienceInstitutionsThe Rockefeller UniversityDoctoral advisorMichael W YoungOther academic advisorsRichard Axel Contents 1 Early life 2 Education 3 Research 4 Awards and honors 5 Key papers 6 Other selected publications 7 References 8 External linksEarly life editLeslie Vosshall was born in Lausanne Switzerland where she spent most of her early childhood Vosshall moved to New Jersey when she was 8 years old She spent summers from age 17 to 19 working in the laboratory of her uncle Philip Dunham with Gerald Weissmann at the Marine Biological Laboratory MBL in Woods Hole Vosshall said this experience was an incredible introduction to the practice of science 4 Education editVosshall received her B A in biochemistry 5 from Columbia University in 1987 and her Ph D from Rockefeller University in 1993 She returned to Columbia for a postdoctoral fellowship in the laboratory of future Nobel laureate Richard Axel from 1993 1997 She then worked in the position of Associate Research Scientist in Dr Axel s laboratory from 1997 2000 Vosshall was offered the position of Assistant Professor at The Rockefeller University in 2000 and was promoted to Associate Professor in 2006 1 In April 2010 she was granted tenure and is currently the Robin Chemers Neustein Professor and Head of the Laboratory of Neurogenetics and Behavior 6 She served as associate director of the Kavli Neural Systems Institute from 2015 2016 and was promoted to director in 2016 1 Research editVosshall s laboratory studies three organisms fruit flies mosquitoes and humans to understand the genetic and molecular underpinnings as well as behavioral mechanisms involved in olfaction and feeding behavior 7 In addition to find the genes that make the mosquito species Aedes aegypti prefer humans Vosshall compares genes that drive host seeking and blood seeking behaviors in several different mosquito subspecies 8 Vosshall s and her associates research on Aedes aegypti the mosquito responsible for transmitting yellow fever 8 dengue and Zika 9 found that it has a particular odor detecting gene AaegOr4 that is highly attuned to sulcatone a compound predominant in human odor 8 10 Research from Vosshall s lab demonstrated that a chemical transferred from the male of the species during sex plays a key role in shaping the female s sexual proclivities 11 12 In addition Vosshall and her associates discovered ORCO a mosquito co receptor responsible for preference for humans over non human animals and sensitivity to insect repellent DEET 13 14 Awards and honors editBeckman Young Investigator Award 2001 15 McKnight Neuroscience Scholar Award 2001 National Science Foundation Early Career Development Award 2001 John Merck Fund Scholar 2002 Presidential Early Career Award for Scientists and Engineers 2002 New York City Mayor s Award for Excellence in Science and Technology 2005 Irma T Hirschl Monique Weill Caulier Trust Research Award 2005 1 Blavatnik Award for Young Scientists 2007 16 Howard Hughes Medical Institute investigator 2008 17 18 Lawrence C Katz Prize Duke University 2009 1 Dart NYU Biotechnology Achievement Award 2010 19 Gill Young Investigator Award 2011 Member National Academy of Sciences 2015 20 Pradel Research Award 2020 Member National Academy of Medicine 2021 21 Key papers editVosshall LB Amrein H Morozov PS Rzhetsky A Axel R March 1999 A spatial map of olfactory receptor expression in the Drosophila antenna Cell 96 5 725 36 doi 10 1016 S0092 8674 00 80582 6 PMID 10089887 S2CID 9216020 Vosshall LB Wong AM Axel R July 2000 An olfactory sensory map in the fly brain Cell 102 2 147 59 doi 10 1016 S0092 8674 00 00021 0 PMID 10943836 S2CID 17573876 DeGennaro M McBride CS Seeholzer L Nakagawa T Dennis EJ Goldman C Jasinskiene N James AA Vosshall LB 29 May 2013 orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET Nature 498 7455 487 491 Bibcode 2013Natur 498 487D doi 10 1038 nature12206 PMC 3696029 PMID 23719379 Larsson MC Domingos AI Jones WD Chiappe ME Amrein H Vosshall LB September 2 2004 Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila Olfaction Neuron 43 5 703 714 doi 10 1016 j neuron 2004 08 019 ISSN 0896 6273Other selected publications editMcBride C S et al Evolution of mosquito preference for humans linked to an odorant receptor Nature 515 222 227 2014 10 Bushdid C et al Humans can discriminate more than 1 trillion olfactory stimuli Science 343 1370 1372 2014 22 McMeniman C J et al Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans Cell 156 1060 1071 2014 23 References edit a b c d e The Rockefeller University Scientists amp Research www rockefeller edu Retrieved 2017 03 10 Prashant Nair 29 June 2020 QnAs with Leslie B Vosshall Proceedings of the National Academy of Sciences 117 28 16100 16103 doi 10 1073 pnas 2011073117 PMC 7368263 PMID 32601194 Making the Paper Leslie Vosshall and Hiroaki Matsunami Nature 449 xiii 26 September 2007 Retrieved 15 July 2022 Vosshall Leslie B 2012 Leslie B Vosshall Current Biology 22 18 R782 R783 doi 10 1016 j cub 2012 07 016 PMID 23193546 Leslie B Vosshall Our Scientists Retrieved 2019 09 07 Bonner Joseph 2010 05 17 The Rockefeller University Leslie Vosshall promoted to professor Retrieved 2017 10 24 Leslie B Vosshall Current Biology 22 28 PR782 R783 25 September 2012 Retrieved 15 July 2022 a b c Researchers Find Gene that Makes Mosquitoes Prefer Humans over Animals Entomology Today Entomological Society of America 13 November 2014 Retrieved 15 July 2022 Lambert Jonathon 25 April 2019 How Do Mosquitoes Taste DEET Hint It s Not Their Mouthparts Kuow org NPR Retrieved 15 July 2022 a b McBride Carolyn S Baier Felix Omondi Aman B Spitzer Sarabeth A Lutomiah Joel Sang Rosemary Ignell Rickard Vosshall Leslie B 2014 11 13 Evolution of mosquito preference for humans linked to an odorant receptor Nature 515 7526 222 227 Bibcode 2014Natur 515 222M doi 10 1038 nature13964 ISSN 0028 0836 PMC 4286346 PMID 25391959 Fenz Rockefeller Katherine 9 January 2018 Mosquito sex swap leaves females loyal Futurity Retrieved 19 July 2022 Mosquito sex protein could stem disease spread Sky News 13 December 2017 Retrieved 15 July 2022 Lambert Jonathon 25 April 2019 How Do Mosquitoes Taste DEET Hint It s Not Their Mouthparts Kuow org NPR Retrieved 15 July 2022 DeGennaro Matthew McBride Carolyn S Seeholzer Laura Nakagawa Takao Dennis Emily J Goldman Chloe Jasinskiene Nijole James Anthony A Vosshall Leslie B 2013 06 27 orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET Nature 498 7455 487 491 Bibcode 2013Natur 498 487D doi 10 1038 nature12206 ISSN 1476 4687 PMC 3696029 PMID 23719379 Leslie B Vosshall Arnold and Mabel Beckman Foundation Retrieved 1 August 2018 Burke Adrienne November 2007 The New York Academy of Sciences Blavatnik Awards for Young Scientists Retrieved 2010 06 04 Bonner Joseph 2008 06 02 The Rockefeller University Two Rockefeller faculty become new HHMI investigators Retrieved 2017 10 24 Howard Hughes Medical Institute HHMI News HHMI Selects 56 of the Nation s Top Scientists 2008 05 27 Retrieved 2010 06 04 New York University NYU School of Medicine Presents Three Biomedical Researchers 2010 Dart NYU Biotechnology Awards for Role of Pure Science 2010 03 22 Retrieved 2010 06 04 Leslie Vosshall and Jean Laurent Casanova elected to the National Academy of Sciences Retrieved 2017 10 24 National Academy of Medicine Elects 100 New Members Oct 18 2021 Retrieved 2021 10 20 Bushdid C Magnasco M O Vosshall L B Keller A 2014 03 21 Humans Can Discriminate More than 1 Trillion Olfactory Stimuli Science 343 6177 1370 1372 Bibcode 2014Sci 343 1370B doi 10 1126 science 1249168 ISSN 0036 8075 PMC 4483192 PMID 24653035 McMeniman Conor J Corfas Roman A Matthews Benjamin J Ritchie Scott A Vosshall Leslie B 2014 02 27 Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans Cell 156 5 1060 1071 doi 10 1016 j cell 2013 12 044 ISSN 0092 8674 PMC 4007582 PMID 24581501 External links editRockefeller news search results for Leslie Vosshall HHMI Leslie B Vosshall Ph D biography Rockefeller Vosshall Lab Web Page Retrieved from https en wikipedia org w index php title Leslie B Vosshall amp oldid 1181409260, wikipedia, wiki, book, books, library,

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