This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.
left, right, determination, factor, protein, that, humans, encoded, lefty1, gene, lefty1identifiersaliaseslefty1, leftb, leftyb, left, right, determination, factor, 1external, idsomim, 603037, 107405, homologene, 49231, genecards, lefty1gene, location, human, . Left right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene 5 LEFTY1IdentifiersAliasesLEFTY1 LEFTB LEFTYB left right determination factor 1External IDsOMIM 603037 MGI 107405 HomoloGene 49231 GeneCards LEFTY1Gene location Human Chr Chromosome 1 human 1 Band1q42 12Start225 886 282 bp 1 End225 911 382 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 H4Start180 762 587 bp 2 End180 765 965 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbody of pancreasrectumendometriumappendixmonocytecerebellar hemispherenucleus accumbensBrodmann area 9prefrontal cortexputamenTop expressed inneural plateRegion I of hippocampus properlipankle jointislet of Langerhansepithelium of stomachPaneth cellleft colonskin of abdomenparotid glandMore reference expression dataBioGPSn aGene ontologyMolecular functiontransforming growth factor beta receptor binding cytokine activity growth factor activityCellular componentextracellular region extracellular spaceBiological processregulation of apoptotic process multicellular organism development positive regulation of pathway restricted SMAD protein phosphorylation heart morphogenesis determination of left right symmetry negative regulation of transcription by RNA polymerase II transforming growth factor beta receptor signaling pathway regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway regulation of signaling receptor activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1063713590EnsemblENSG00000243709ENSMUSG00000038793UniProtO75610Q64280RefSeq mRNA NM 020997NM 010094RefSeq protein NP 066277NP 034224Location UCSC Chr 1 225 89 225 91 MbChr 1 180 76 180 77 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further readingFunction editThis gene encodes a member of the TGF beta family of proteins A similar secreted protein in mouse plays a role in left right asymmetry determination of organ systems during development Alternative processing of this protein can yield three different products This gene is closely linked to both a related family member and a related pseudogene See also editLefty Lefty 1References edit a b c GRCh38 Ensembl release 89 ENSG00000243709 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038793 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Left right determination factor 1 Retrieved 2016 08 03 Further reading editBesser D 2004 Expression of nodal lefty a and lefty B in undifferentiated human embryonic stem cells requires activation of Smad2 3 J Biol Chem 279 43 45076 84 doi 10 1074 jbc M404979200 PMID 15308665 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Left right determination factor 1 amp oldid 1081540892, wikipedia, wiki, book, books, library,
