Laudexium[1] is no longer used in clinical practice, though it was introduced clinically in the early 1950s.[citation needed] It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine.[2] As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases.
The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.[3]
Referencesedit
^Taylor EP (1952). "Synthetic neuromuscular blocking agents. Part II. Bis(quaternary ammonium salts) derived from laudanosine". J Chem Soc: 142–145. doi:10.1039/JR9520000142.
^Hunter AR (February 1955). "The action of laudexium in man and experimental animals" (PDF). British Journal of Anaesthesia. 27 (2): 73–9. doi:10.1093/bja/27.2.73. PMID 13230365.
^Collier HO, Macauley B (September 1952). "The pharmacological properties of "laudolissin" a long-acting curarizing agent". British Journal of Pharmacology and Chemotherapy. 7 (3): 398–408. doi:10.1111/j.1476-5381.1952.tb00707.x. PMC1509112. PMID 12978243.
External linksedit
Neuromuscular+blocking+agents at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
April 12, 2024
laudexium, metilsulfate, neuromuscular, blocking, drug, skeletal, muscle, relaxant, category, depolarizing, neuromuscular, blocking, drugs, used, adjunctively, surgical, anesthesia, facilitate, endotracheal, intubation, provide, skeletal, muscle, relaxation, d. Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non depolarizing neuromuscular blocking drugs used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation Laudexium metilsulfateClinical dataOther namesLaudolissinRoutes ofadministrationIVLegal statusLegal statusdiscontinued from clinical usePharmacokinetic dataBioavailability100 IV IdentifiersIUPAC name 1 3 4 Dimethoxyphenyl methyl 2 10 1 3 4 dimethoxyphenyl methyl 6 7 dimethoxy 2 methyl 3 4 dihydro 1H isoquinolin 2 ium 2 yl decyl 6 7 dimethoxy 2 methyl 3 4 dihydro 1H isoquinolin 2 ium methyl sulfateCAS Number3253 60 9 YPubChem CID18618ChemSpider17584 NUNIID067KDG4NUChemical and physical dataFormulaC 54H 80N 2O 16S 2Molar mass1077 35 g mol 13D model JSmol Interactive imageSMILES C N 1 CCC2 CC C C C2C1CC3 CC C C C3 OC OC OC OC CCCCCCCCCC N 4 CCC5 CC C C C5C4CC6 CC C C C6 OC OC OC OC C COS O O O COS O O O InChI InChI 1S C52H74N2O8 2CH4O4S c1 53 27 23 39 33 49 59 7 51 61 9 35 41 39 43 53 29 37 19 21 45 55 3 47 31 37 57 5 25 17 15 13 11 12 14 16 18 26 54 2 28 24 40 34 50 60 8 52 62 10 36 42 40 44 54 30 38 20 22 46 56 4 48 32 38 58 6 2 1 5 6 2 3 4 h19 22 31 36 43 44H 11 18 23 30H2 1 10H3 2 1H3 H 2 3 4 q 2 p 2 NKey LADQAYSLFLCKOD UHFFFAOYSA L N N Y what is this verify Laudexium 1 is no longer used in clinical practice though it was introduced clinically in the early 1950s citation needed It has about half the potency a slower onset of action and a duration of action much longer than that of d tubocurarine 2 As with all clinically established as well as experimental agents with a non depolarizing mechanism of action its pharmacological action can be antagonized by anticholinesterases The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post operative re curarization 3 References edit Taylor EP 1952 Synthetic neuromuscular blocking agents Part II Bis quaternary ammonium salts derived from laudanosine J Chem Soc 142 145 doi 10 1039 JR9520000142 Hunter AR February 1955 The action of laudexium in man and experimental animals PDF British Journal of Anaesthesia 27 2 73 9 doi 10 1093 bja 27 2 73 PMID 13230365 Collier HO Macauley B September 1952 The pharmacological properties of laudolissin a long acting curarizing agent British Journal of Pharmacology and Chemotherapy 7 3 398 408 doi 10 1111 j 1476 5381 1952 tb00707 x PMC 1509112 PMID 12978243 External links editNeuromuscular blocking agents at the U S National Library of Medicine Medical Subject Headings MeSH Retrieved from https en wikipedia org w index php title Laudexium metilsulfate amp oldid 1135223513, wikipedia, wiki, book, books, library,
