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Large neutral amino acids transporter small subunit 1

December 15, 2023

Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene.[5][6]

SLC7A5
Identifiers
AliasesSLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1, solute carrier family 7 member 5
External IDsOMIM: 600182 MGI: 1298205 HomoloGene: 55759 GeneCards: SLC7A5
Orthologs
SpeciesHumanMouse
Entrez

8140

20539

Ensembl

ENSG00000103257

ENSMUSG00000040010

UniProt

Q01650

Q9Z127

RefSeq (mRNA)

NM_003486

NM_011404

RefSeq (protein)

NP_003477

NP_035534

Location (UCSC)Chr 16: 87.83 – 87.87 MbChr 8: 122.61 – 122.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103257 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040010 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
  6. ^ "UniProt". www.uniprot.org.

Further reading edit

  • Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma". Lung Cancer. 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID 19171406.
  • Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID 10568788. S2CID 25962115.
  • Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors". Int. J. Cancer. 119 (3): 484–92. doi:10.1002/ijc.21866. PMID 16496379. S2CID 41965333.
  • Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells". Brain Tumor Pathol. 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID 18095110. S2CID 22818900.
  • Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1". Cancer Sci. 99 (5): 1000–7. doi:10.1111/j.1349-7006.2008.00770.x. PMID 18294274. S2CID 205233796.
  • Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID 18262359. S2CID 25493412.
  • Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 Suppl 1: 11P–16P. doi:10.1254/fpj.114.supplement_11. PMID 10629848.
  • Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID 17622555. S2CID 2540836.
  • Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas". J Surg Oncol. 99 (7): 433–8. doi:10.1002/jso.21277. PMID 19347882. S2CID 5381963.
  • Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism". Neurogenetics. 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMC 2753863. PMID 19184136.
  • Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma". Mod. Pathol. 22 (8): 1032–43. doi:10.1038/modpathol.2009.60. PMID 19430419.
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID 18440724.
  • Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells". Neurosurgery. 62 (2): 493–503, discussion 503–4. doi:10.1227/01.neu.0000316018.51292.19. PMID 18382329.
  • Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. S2CID 25402443.
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer". Br. J. Cancer. 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMC 2259171. PMID 18253116.
  • Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms". Cancer Sci. 99 (12): 2380–6. doi:10.1111/j.1349-7006.2008.00969.x. PMID 19018776. S2CID 24560556.
  • Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer". Histopathology. 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID 19635099. S2CID 5787861.
  • Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells". Oncol. Rep. 20 (4): 885–9. doi:10.3892/or_00000087. PMID 18813831.
  • Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID 19121087. S2CID 32050759.


 

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

December 15, 2023
large, neutral, amino, acids, transporter, small, subunit, also, known, light, chain, cd98, light, chain, protein, that, humans, encoded, slc7a5, gene, slc7a5identifiersaliasesslc7a5, 4f2lc, cd98, d16s469e, lat1, mpe16, hlat1, solute, carrier, family, member, . Large neutral amino acids transporter small subunit 1 also known as 4F2 light chain or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene 5 6 SLC7A5IdentifiersAliasesSLC7A5 4F2LC CD98 D16S469E E16 LAT1 MPE16 hLAT1 solute carrier family 7 member 5External IDsOMIM 600182 MGI 1298205 HomoloGene 55759 GeneCards SLC7A5Gene location Human Chr Chromosome 16 human 1 Band16q24 2Start87 830 023 bp 1 End87 869 507 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 E1 8Start122 607 889 bp 2 End122 634 433 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inretinal pigment epitheliuminferior olivary nucleusbody of tonguecorpus epididymisventral tegmental areasuperior vestibular nucleussubthalamic nucleushypothalamusinferior ganglion of vagus nerveponsTop expressed inlacrimal glandlensseminal vesiculaspermatocytecalvariaoptic nerveparotid glandseminiferous tubulebloodhair follicleMore reference expression dataBioGPSn aGene ontologyMolecular functionpeptide antigen binding L amino acid transmembrane transporter activity amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity antiporter activity protein binding transmembrane transporter activityCellular componentintegral component of membrane membrane intracellular membrane bounded organelle plasma membrane apical plasma membrane extracellular exosome integral component of plasma membrane cytoplasm cytosolBiological processamino acid transmembrane transport cell differentiation cellular amino acid metabolic process nervous system development multicellular organism development L amino acid transport neutral amino acid transport leukocyte migration amino acid transport L alpha amino acid transmembrane transport transport transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez814020539EnsemblENSG00000103257ENSMUSG00000040010UniProtQ01650Q9Z127RefSeq mRNA NM 003486NM 011404RefSeq protein NP 003477NP 035534Location UCSC Chr 16 87 83 87 87 MbChr 8 122 61 122 63 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseSee also editHeterodimeric amino acid transporterReferences edit a b c GRCh38 Ensembl release 89 ENSG00000103257 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000040010 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene solute carrier family 7 cationic amino acid transporter UniProt www uniprot org Further reading editKaira K Oriuchi N Imai H et al 2009 Prognostic significance of L type amino acid transporter 1 LAT1 and 4F2 heavy chain CD98 expression in stage I pulmonary adenocarcinoma Lung Cancer 66 1 120 6 doi 10 1016 j lungcan 2008 12 015 PMID 19171406 Verrey F Jack DL Paulsen IT et al 1999 New glycoprotein associated amino acid transporters J Membr Biol 172 3 181 92 doi 10 1007 s002329900595 PMID 10568788 S2CID 25962115 Nawashiro H Otani N Shinomiya N et al 2006 L type amino acid transporter 1 as a potential molecular target in human astrocytic tumors Int J Cancer 119 3 484 92 doi 10 1002 ijc 21866 PMID 16496379 S2CID 41965333 Nawashiro H Otani N Uozumi Y et al 2005 High expression of L type amino acid transporter 1 in infiltrating glioma cells Brain Tumor Pathol 22 2 89 91 doi 10 1007 s10014 005 0188 z PMID 18095110 S2CID 22818900 Ohno Y Suda K Masuko K et al 2008 Production and characterization of highly tumor specific rat monoclonal antibodies recognizing the extracellular domain of human L type amino acid transporter 1 Cancer Sci 99 5 1000 7 doi 10 1111 j 1349 7006 2008 00770 x PMID 18294274 S2CID 205233796 Vumma R Wiesel FA Flyckt L et al 2008 Functional characterization of tyrosine transport in fibroblast cells from healthy controls Neurosci Lett 434 1 56 60 doi 10 1016 j neulet 2008 01 028 PMID 18262359 S2CID 25493412 Endou H Kanai Y 1999 Amino acid transporter molecule as a drug target Nippon Yakurigaku Zasshi 114 Suppl 1 11P 16P doi 10 1254 fpj 114 supplement 11 PMID 10629848 Nakanishi K Ogata S Matsuo H et al 2007 Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract Virchows Arch 451 3 681 90 doi 10 1007 s00428 007 0457 9 PMID 17622555 S2CID 2540836 Kaira K Oriuchi N Imai H et al 2009 L type amino acid transporter 1 LAT1 is frequently expressed in thymic carcinomas but is absent in thymomas J Surg Oncol 99 7 433 8 doi 10 1002 jso 21277 PMID 19347882 S2CID 5381963 Anderson BM Schnetz Boutaud NC Bartlett J et al 2009 Examination of association of genes in the serotonin system to autism Neurogenetics 10 3 209 16 doi 10 1007 s10048 009 0171 7 PMC 2753863 PMID 19184136 Ring BZ Seitz RS Beck RA et al 2009 A novel five antibody immunohistochemical test for subclassification of lung carcinoma Mod Pathol 22 8 1032 43 doi 10 1038 modpathol 2009 60 PMID 19430419 Kaira K Oriuchi N Imai H et al 2008 Expression of L type amino acid transporter 1 LAT1 in neuroendocrine tumors of the lung Pathol Res Pract 204 8 553 61 doi 10 1016 j prp 2008 02 003 PMID 18440724 Kobayashi K Ohnishi A Promsuk J et al 2008 Enhanced tumor growth elicited by L type amino acid transporter 1 in human malignant glioma cells Neurosurgery 62 2 493 503 discussion 503 4 doi 10 1227 01 neu 0000316018 51292 19 PMID 18382329 Kuhne A Kaiser R Schirmer M et al 2007 Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan Pharmacogenet Genomics 17 7 505 17 doi 10 1097 FPC 0b013e3280ea77cd PMID 17558306 S2CID 25402443 Kaira K Oriuchi N Imai H et al 2008 Prognostic significance of L type amino acid transporter 1 expression in resectable stage I III nonsmall cell lung cancer Br J Cancer 98 4 742 8 doi 10 1038 sj bjc 6604235 PMC 2259171 PMID 18253116 Broer S 2008 Amino acid transport across mammalian intestinal and renal epithelia Physiol Rev 88 1 249 86 doi 10 1152 physrev 00018 2006 PMID 18195088 Kaira K Oriuchi N Imai H et al 2008 l type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms Cancer Sci 99 12 2380 6 doi 10 1111 j 1349 7006 2008 00969 x PMID 19018776 S2CID 24560556 Imai H Kaira K Oriuchi N et al 2009 L type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non small cell lung cancer Histopathology 54 7 804 13 doi 10 1111 j 1365 2559 2009 03300 x PMID 19635099 S2CID 5787861 Shennan DB Thomson J 2008 Inhibition of system L LAT1 CD98hc reduces the growth of cultured human breast cancer cells Oncol Rep 20 4 885 9 doi 10 3892 or 00000087 PMID 18813831 Sakata T Ferdous G Tsuruta T et al 2009 L type amino acid transporter 1 as a novel biomarker for high grade malignancy in prostate cancer Pathol Int 59 1 7 18 doi 10 1111 j 1440 1827 2008 02319 x PMID 19121087 S2CID 32050759 nbsp This article on a gene on human chromosome 16 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Large neutral amino acids transporter small subunit 1 amp oldid 1170147201, wikipedia, wiki, book, books, library,

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