This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is (S)-lactate:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include lactate oxidative decarboxylase, lactate oxidase, lactic oxygenase, lactate oxygenase, lactic oxidase, L-lactate monooxygenase, lactate monooxygenase, and L-lactate-2-monooxygenase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FMN.
Structural studiesedit
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DU2.
Referencesedit
Hayaishi O, Sutton WB (1957). "Enzymatic oxygen fixation into acetate concomitant with the enzymatic decarboxylation of L-lactate". J. Am. Chem. Soc. 79 (17): 4809–4810. doi:10.1021/ja01574a060.
Sutton WB (May 1957). "Mechanism of action and crystallization of lactic oxidative decarboxylase from Mycobacterium phlei". The Journal of Biological Chemistry. 226 (1): 395–405. PMID 13428772.
lactate, monooxygenase, confused, with, lactate, oxidase, enzymology, lactate, monooxygenase, enzyme, that, catalyzes, chemical, reactionlactate, monooxygenaseidentifiersec, 4cas, 9028, 2databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkeg. Not to be confused with L lactate oxidase In enzymology a lactate 2 monooxygenase EC 1 13 12 4 is an enzyme that catalyzes the chemical reactionlactate 2 monooxygenaseIdentifiersEC no 1 13 12 4CAS no 9028 72 2DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins S lactate O2 displaystyle rightleftharpoons acetate CO2 H2O Thus the two substrates of this enzyme are S lactate and O2 whereas its 3 products are acetate CO2 and H2O This enzyme belongs to the family of oxidoreductases specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate oxygenases The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen internal monooxygenases o internal mixed function oxidases The systematic name of this enzyme class is S lactate oxygen 2 oxidoreductase decarboxylating Other names in common use include lactate oxidative decarboxylase lactate oxidase lactic oxygenase lactate oxygenase lactic oxidase L lactate monooxygenase lactate monooxygenase and L lactate 2 monooxygenase This enzyme participates in pyruvate metabolism It employs one cofactor FMN Structural studies editAs of late 2007 only one structure has been solved for this class of enzymes with the PDB accession code 2DU2 References editHayaishi O Sutton WB 1957 Enzymatic oxygen fixation into acetate concomitant with the enzymatic decarboxylation of L lactate J Am Chem Soc 79 17 4809 4810 doi 10 1021 ja01574a060 Sutton WB May 1957 Mechanism of action and crystallization of lactic oxidative decarboxylase from Mycobacterium phlei The Journal of Biological Chemistry 226 1 395 405 PMID 13428772 Portal nbsp Biology This EC 1 13 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Lactate 2 monooxygenase amp oldid 1172351718, wikipedia, wiki, book, books, library,
