The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000110031 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024696 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lipsky BP, Beals CR, Staunton DE (Jun 1998). "Leupaxin is a novel LIM domain protein that forms a complex with PYK2". J Biol Chem. 273 (19): 11709–13. doi:10.1074/jbc.273.19.11709. PMID 9565592.
Sahu SN, Nunez S, Bai G, Gupta A (2007). "Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells". Am. J. Physiol., Cell Physiol. 292 (6): C2288–96. doi:10.1152/ajpcell.00503.2006. PMID 17329398.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Watanabe N, Amano N, Ishizuka H, Mashima K (2005). "Leupaxin binds to PEST domain tyrosine phosphatase PEP". Mol. Cell. Biochem. 269 (1–2): 13–7. doi:10.1007/s11010-005-2149-6. PMID 15786712. S2CID 21854825.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gupta A, Lee BS, Khadeer MA, et al. (2003). "Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast". J. Bone Miner. Res. 18 (4): 669–85. doi:10.1359/jbmr.2003.18.4.669. PMID 12674328. S2CID 24743841.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Liu S, Thomas SM, Woodside DG, et al. (2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–81. doi:10.1038/45264. PMID 10604475. S2CID 2770368.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
lpxn, leupaxin, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1x3h, 4xef, 4xek, 4xevidentifiersaliases, ldpl, leupaxinexternal, idsomim, 605390, 2147677, homologene, 3536, genecards, gene, location, human,. Leupaxin is a protein that in humans is encoded by the LPXN gene 5 6 LPXNAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1X3H 4XEF 4XEK 4XEVIdentifiersAliasesLPXN LDPL leupaxinExternal IDsOMIM 605390 MGI 2147677 HomoloGene 3536 GeneCards LPXNGene location Human Chr Chromosome 11 human 1 Band11q12 1Start58 526 871 bp 1 End58 578 220 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 19 AStart12 773 557 bp 2 End12 811 171 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocyteappendixlymph nodebloodthymusspleenthymusrectumbone marrow cellsgallbladderTop expressed inspermatocytespleenthymusseminiferous tubulebloodspermatidsubcutaneous adipose tissueurethrafemale urethradermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding transcription coregulator activity metal ion bindingCellular componentcytoplasm perinuclear region of cytoplasm podosome cell junction plasma membrane cell projection nucleus focal adhesion membrane cytosol nuclear speckBiological processnegative regulation of B cell receptor signaling pathway negative regulation of cell adhesion cell adhesion regulation of cell adhesion mediated by integrin regulation of transcription DNA templated transcription DNA templated signal transduction protein containing complex assembly regulation of nucleic acid templated transcriptionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez9404107321EnsemblENSG00000110031ENSMUSG00000024696UniProtO60711Q99N69RefSeq mRNA NM 001143995NM 001307951NM 004811NM 134152NM 001361971RefSeq protein NP 001137467NP 001294880NP 004802NP 598913NP 001348900Location UCSC Chr 11 58 53 58 58 MbChr 19 12 77 12 81 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein paxillin It may function in cell type specific signaling by associating with PYK2 a member of focal adhesion kinase family As a substrate for a tyrosine kinase in lymphoid cells this protein may also function in and be regulated by tyrosine kinase activity 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000110031 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024696 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lipsky BP Beals CR Staunton DE Jun 1998 Leupaxin is a novel LIM domain protein that forms a complex with PYK2 J Biol Chem 273 19 11709 13 doi 10 1074 jbc 273 19 11709 PMID 9565592 a b Entrez Gene LPXN leupaxin Further reading editChew V Lam KP 2007 Leupaxin negatively regulates B cell receptor signaling J Biol Chem 282 37 27181 91 doi 10 1074 jbc M704625200 PMID 17640867 Sahu SN Nunez S Bai G Gupta A 2007 Interaction of Pyk2 and PTP PEST with leupaxin in prostate cancer cells Am J Physiol Cell Physiol 292 6 C2288 96 doi 10 1152 ajpcell 00503 2006 PMID 17329398 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Tao WA Wollscheid B O Brien R et al 2005 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry Nat Methods 2 8 591 8 doi 10 1038 nmeth776 PMID 16094384 S2CID 20475874 Watanabe N Amano N Ishizuka H Mashima K 2005 Leupaxin binds to PEST domain tyrosine phosphatase PEP Mol Cell Biochem 269 1 2 13 7 doi 10 1007 s11010 005 2149 6 PMID 15786712 S2CID 21854825 Rush J Moritz A Lee KA et al 2005 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat Biotechnol 23 1 94 101 doi 10 1038 nbt1046 PMID 15592455 S2CID 7200157 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Brill LM Salomon AR Ficarro SB et al 2004 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry Anal Chem 76 10 2763 72 doi 10 1021 ac035352d PMID 15144186 Gupta A Lee BS Khadeer MA et al 2003 Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast J Bone Miner Res 18 4 669 85 doi 10 1359 jbmr 2003 18 4 669 PMID 12674328 S2CID 24743841 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Liu S Thomas SM Woodside DG et al 2000 Binding of paxillin to alpha4 integrins modifies integrin dependent biological responses Nature 402 6762 676 81 doi 10 1038 45264 PMID 10604475 S2CID 2770368 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LPXN amp oldid 1170019630, wikipedia, wiki, book, books, library,
