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Wikipedia

Lamin B1

October 19, 2023

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.[5][6][7]

LMNB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLMNB1, ADLD, LMN, LMN2, LMNB, lamin B1, MCPH26
External IDsOMIM: 150340 MGI: 96795 HomoloGene: 55912 GeneCards: LMNB1
Orthologs
SpeciesHumanMouse
Entrez

4001

16906

Ensembl

ENSG00000113368

ENSMUSG00000024590

UniProt

P20700

P14733

RefSeq (mRNA)

NM_001198557
NM_005573

NM_010721

RefSeq (protein)

NP_001185486
NP_005564

NP_034851

Location (UCSC)Chr 5: 126.78 – 126.84 MbChr 18: 56.84 – 56.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.[7] Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.

Interactions Edit

LMNB1 has been shown to interact with Thymopoietin.[8][9] When double-strand breaks are induced in DNA by ionizing radiation, lamin B1 promotes repair of the breaks, as well as cell survival, by maintaining the level of the RAD51 protein that is employed in homologous recombinational repair.[10]

Pathology Edit

Mutations affecting the LMNB1 gene cause autosomal dominant adult-onset demyelinating leukodystrophy.

See also Edit

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113368 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024590 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lin F, Worman HJ (Nov 1995). "Structural organization of the human gene (LMNB1) encoding nuclear lamin B1". Genomics. 27 (2): 230–6. doi:10.1006/geno.1995.1036. PMID 7557986.
  6. ^ Wydner KL, McNeil JA, Lin F, Worman HJ, Lawrence JB (Feb 1997). "Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization". Genomics. 32 (3): 474–8. doi:10.1006/geno.1996.0146. PMID 8838815.
  7. ^ a b "Entrez Gene: LMNB1 lamin B1".
  8. ^ Furukawa, K; Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". Eur. J. Biochem. GERMANY. 251 (3): 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. ISSN 0014-2956. PMID 9490046.
  9. ^ Foisner, R; Gerace L (Jul 1993). "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation". Cell. UNITED STATES. 73 (7): 1267–79. doi:10.1016/0092-8674(93)90355-T. ISSN 0092-8674. PMID 8324822.
  10. ^ Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage. FASEB J. 2015 Jun;29(6):2514-25. doi: 10.1096/fj.14-265546. Epub 2015 Mar 2. PMID: 25733566

Further reading Edit

  • Gruenbaum Y, Wilson KL, Harel A, et al. (2000). "Review: nuclear lamins--structural proteins with fundamental functions". J. Struct. Biol. 129 (2–3): 313–23. doi:10.1006/jsbi.2000.4216. PMID 10806082.
  • Worman HJ, Courvalin JC (2000). "The inner nuclear membrane". J. Membr. Biol. 177 (1): 1–11. doi:10.1007/s002320001096. PMID 10960149. S2CID 20121844.
  • Djabali K, Portier MM, Gros F, et al. (1991). "Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments". Cell. 64 (1): 109–21. doi:10.1016/0092-8674(91)90213-I. PMID 1986862. S2CID 6246606.
  • Foisner R, Traub P, Wiche G (1991). "Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3812–6. Bibcode:1991PNAS...88.3812F. doi:10.1073/pnas.88.9.3812. PMC 51543. PMID 2023931.
  • Pollard KM, Chan EK, Grant BJ, et al. (1990). "In vitro posttranslational modification of lamin B cloned from a human T-cell line". Mol. Cell. Biol. 10 (5): 2164–75. doi:10.1128/mcb.10.5.2164. PMC 360564. PMID 2325650.
  • Müller WE, Okamoto T, Reuter P, et al. (1990). "Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix". J. Biol. Chem. 265 (7): 3803–8. doi:10.1016/S0021-9258(19)39665-6. PMID 2406262.
  • Müller WE, Wenger R, Reuter P, et al. (1989). "Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells". Biochim. Biophys. Acta. 1008 (2): 208–12. doi:10.1016/0167-4781(80)90011-1. PMID 2544227.
  • Eldridge R, Anayiotos CP, Schlesinger S, et al. (1984). "Hereditary adult-onset leukodystrophy simulating chronic progressive multiple sclerosis". N. Engl. J. Med. 311 (15): 948–53. doi:10.1056/NEJM198410113111504. PMID 6472420.
  • Ye Q, Worman HJ (1995). "Protein-protein interactions between human nuclear lamins expressed in yeast". Exp. Cell Res. 219 (1): 292–8. doi:10.1006/excr.1995.1230. PMID 7628545.
  • Goss VL, Hocevar BA, Thompson LJ, et al. (1994). "Identification of nuclear beta II protein kinase C as a mitotic lamin kinase". J. Biol. Chem. 269 (29): 19074–80. doi:10.1016/S0021-9258(17)32276-7. PMID 8034666.
  • Broers JL, Machiels BM, Kuijpers HJ, et al. (1997). "A- and B-type lamins are differentially expressed in normal human tissues". Histochem. Cell Biol. 107 (6): 505–17. doi:10.1007/s004180050138. PMID 9243284. S2CID 24088247.
  • Maison C, Pyrpasopoulou A, Theodoropoulos PA, Georgatos SD (1997). "The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles". EMBO J. 16 (16): 4839–50. doi:10.1093/emboj/16.16.4839. PMC 1170119. PMID 9305626.
  • Lin F, Worman HJ (1997). "Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes". Exp. Cell Res. 236 (2): 378–84. doi:10.1006/excr.1997.3735. PMID 9367621.
  • Vodicka MA, Koepp DM, Silver PA, Emerman M (1998). "HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection". Genes Dev. 12 (2): 175–85. doi:10.1101/gad.12.2.175. PMC 316441. PMID 9436978.
  • Furukawa K, Kondo T (1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". Eur. J. Biochem. 251 (3): 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046.
  • Kowluru A (2000). "Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell". Biochem. Biophys. Res. Commun. 268 (2): 249–54. doi:10.1006/bbrc.2000.2107. PMID 10679189.


 

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

October 19, 2023
lamin, lamin, protein, that, humans, encoded, lmnb1, gene, lmnb1available, structurespdbortholog, search, pdbe, rcsblist, codes2kpw, 3jt0, 3tyy, 3umnidentifiersaliaseslmnb1, adld, lmn2, lmnb, lamin, mcph26external, idsomim, 150340, 96795, homologene, 55912, ge. Lamin B1 is a protein that in humans is encoded by the LMNB1 gene 5 6 7 LMNB1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2KPW 3JT0 3TYY 3UMNIdentifiersAliasesLMNB1 ADLD LMN LMN2 LMNB lamin B1 MCPH26External IDsOMIM 150340 MGI 96795 HomoloGene 55912 GeneCards LMNB1Gene location Human Chr Chromosome 5 human 1 Band5q23 2Start126 776 623 bp 1 End126 837 020 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 D3 18 30 84 cMStart56 840 885 bp 2 End56 886 496 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencemonocyterectumappendixbone marrowbloodbone marrow cellslymph nodethymussecondary oocyteTop expressed inabdominal wallthymusyolk sacganglionic eminencemedial ganglionic eminencesomitecumulus celldermishandmolarMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionphospholipase binding structural molecule activity protein binding double stranded DNA binding sequence specific double stranded DNA bindingCellular componentnuclear matrix nuclear inner membrane nuclear membrane membrane intermediate filament lamin filament nucleoplasm nucleus nuclear envelopeBiological processinterleukin 12 mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez400116906EnsemblENSG00000113368ENSMUSG00000024590UniProtP20700P14733RefSeq mRNA NM 001198557NM 005573NM 010721RefSeq protein NP 001185486NP 005564NP 034851Location UCSC Chr 5 126 78 126 84 MbChr 18 56 84 56 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe nuclear lamina consists of a two dimensional matrix of proteins located next to the inner nuclear membrane The lamin family of proteins make up the matrix and are highly conserved in evolution During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression Vertebrate lamins consist of two types A and B This gene encodes one of the two B type proteins B1 7 Lamin B along with heterochromatin is anchored to the inner surface of the nuclear membrane by the lamin B receptor Contents 1 Interactions 2 Pathology 3 See also 4 References 5 Further readingInteractions EditLMNB1 has been shown to interact with Thymopoietin 8 9 When double strand breaks are induced in DNA by ionizing radiation lamin B1 promotes repair of the breaks as well as cell survival by maintaining the level of the RAD51 protein that is employed in homologous recombinational repair 10 Pathology EditMutations affecting the LMNB1 gene cause autosomal dominant adult onset demyelinating leukodystrophy See also EditLamin B2References Edit a b c GRCh38 Ensembl release 89 ENSG00000113368 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024590 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lin F Worman HJ Nov 1995 Structural organization of the human gene LMNB1 encoding nuclear lamin B1 Genomics 27 2 230 6 doi 10 1006 geno 1995 1036 PMID 7557986 Wydner KL McNeil JA Lin F Worman HJ Lawrence JB Feb 1997 Chromosomal assignment of human nuclear envelope protein genes LMNA LMNB1 and LBR by fluorescence in situ hybridization Genomics 32 3 474 8 doi 10 1006 geno 1996 0146 PMID 8838815 a b Entrez Gene LMNB1 lamin B1 Furukawa K Kondo T Feb 1998 Identification of the lamina associated polypeptide 2 binding domain of B type lamin Eur J Biochem GERMANY 251 3 729 33 doi 10 1046 j 1432 1327 1998 2510729 x ISSN 0014 2956 PMID 9490046 Foisner R Gerace L Jul 1993 Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes and binding is modulated by mitotic phosphorylation Cell UNITED STATES 73 7 1267 79 doi 10 1016 0092 8674 93 90355 T ISSN 0092 8674 PMID 8324822 Liu NA Sun J Kono K Horikoshi Y Ikura T Tong X Haraguchi T Tashiro S Regulation of homologous recombinational repair by lamin B1 in radiation induced DNA damage FASEB J 2015 Jun 29 6 2514 25 doi 10 1096 fj 14 265546 Epub 2015 Mar 2 PMID 25733566Further reading EditGruenbaum Y Wilson KL Harel A et al 2000 Review nuclear lamins structural proteins with fundamental functions J Struct Biol 129 2 3 313 23 doi 10 1006 jsbi 2000 4216 PMID 10806082 Worman HJ Courvalin JC 2000 The inner nuclear membrane J Membr Biol 177 1 1 11 doi 10 1007 s002320001096 PMID 10960149 S2CID 20121844 Djabali K Portier MM Gros F et al 1991 Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments Cell 64 1 109 21 doi 10 1016 0092 8674 91 90213 I PMID 1986862 S2CID 6246606 Foisner R Traub P Wiche G 1991 Protein kinase A and protein kinase C regulated interaction of plectin with lamin B and vimentin Proc Natl Acad Sci U S A 88 9 3812 6 Bibcode 1991PNAS 88 3812F doi 10 1073 pnas 88 9 3812 PMC 51543 PMID 2023931 Pollard KM Chan EK Grant BJ et al 1990 In vitro posttranslational modification of lamin B cloned from a human T cell line Mol Cell Biol 10 5 2164 75 doi 10 1128 mcb 10 5 2164 PMC 360564 PMID 2325650 Muller WE Okamoto T Reuter P et al 1990 Functional characterization of Tat protein from human immunodeficiency virus Evidence that Tat links viral RNAs to nuclear matrix J Biol Chem 265 7 3803 8 doi 10 1016 S0021 9258 19 39665 6 PMID 2406262 Muller WE Wenger R Reuter P et al 1989 Association of Tat protein and viral mRNA with nuclear matrix from HIV 1 infected H9 cells Biochim Biophys Acta 1008 2 208 12 doi 10 1016 0167 4781 80 90011 1 PMID 2544227 Eldridge R Anayiotos CP Schlesinger S et al 1984 Hereditary adult onset leukodystrophy simulating chronic progressive multiple sclerosis N Engl J Med 311 15 948 53 doi 10 1056 NEJM198410113111504 PMID 6472420 Ye Q Worman HJ 1995 Protein protein interactions between human nuclear lamins expressed in yeast Exp Cell Res 219 1 292 8 doi 10 1006 excr 1995 1230 PMID 7628545 Goss VL Hocevar BA Thompson LJ et al 1994 Identification of nuclear beta II protein kinase C as a mitotic lamin kinase J Biol Chem 269 29 19074 80 doi 10 1016 S0021 9258 17 32276 7 PMID 8034666 Broers JL Machiels BM Kuijpers HJ et al 1997 A and B type lamins are differentially expressed in normal human tissues Histochem Cell Biol 107 6 505 17 doi 10 1007 s004180050138 PMID 9243284 S2CID 24088247 Maison C Pyrpasopoulou A Theodoropoulos PA Georgatos SD 1997 The inner nuclear membrane protein LAP1 forms a native complex with B type lamins and partitions with spindle associated mitotic vesicles EMBO J 16 16 4839 50 doi 10 1093 emboj 16 16 4839 PMC 1170119 PMID 9305626 Lin F Worman HJ 1997 Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A C and B1 genes Exp Cell Res 236 2 378 84 doi 10 1006 excr 1997 3735 PMID 9367621 Vodicka MA Koepp DM Silver PA Emerman M 1998 HIV 1 Vpr interacts with the nuclear transport pathway to promote macrophage infection Genes Dev 12 2 175 85 doi 10 1101 gad 12 2 175 PMC 316441 PMID 9436978 Furukawa K Kondo T 1998 Identification of the lamina associated polypeptide 2 binding domain of B type lamin Eur J Biochem 251 3 729 33 doi 10 1046 j 1432 1327 1998 2510729 x PMID 9490046 Kowluru A 2000 Evidence for the carboxyl methylation of nuclear lamin B in the pancreatic beta cell Biochem Biophys Res Commun 268 2 249 54 doi 10 1006 bbrc 2000 2107 PMID 10679189 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Lamin B1 amp oldid 1170982845, wikipedia, wiki, book, books, library,

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