The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000187772 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000063804 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
lin28b, gene, homolog, protein, that, humans, encoded, lin28b, gene, lin28bavailable, structurespdbortholog, search, pdbe, rcsblist, codes4a4iidentifiersaliaseslin28b, csdd2, homolog, bexternal, idsomim, 611044, 3584032, homologene, 47607, genecards, lin28bgen. Lin 28 homolog B is a protein that in humans is encoded by the LIN28B gene 5 LIN28BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4A4IIdentifiersAliasesLIN28B CSDD2 lin 28 homolog BExternal IDsOMIM 611044 MGI 3584032 HomoloGene 47607 GeneCards LIN28BGene location Human Chr Chromosome 6 human 1 Band6q16 3 q21Start104 936 616 bp 1 End105 083 332 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 B2Start45 252 716 bp 2 End45 362 491 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inplacentasecondary oocytespermBrodmann area 23testicleprefrontal cortexganglionic eminenceBrodmann area 9hypothalamussuperior frontal gyrusTop expressed insecondary oocytespermatocytemorulayolk sacsuperior frontal gyrusneural tubespermatidmirrorblastocystcerebellar cortexMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding zinc ion binding protein binding metal ion binding RNA binding nucleic acid bindingCellular componentcytoplasm nucleus nucleolus cytosolBiological processpre miRNA processing miRNA catabolic process gene silencing regulation of transcription DNA templated RNA 3 end processingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez389421380669EnsemblENSG00000187772ENSMUSG00000063804UniProtQ6ZN17Q45KJ6RefSeq mRNA NM 001004317NM 001031772NM 001033152RefSeq protein NP 001004317NP 001026942Location UCSC Chr 6 104 94 105 08 MbChr 10 45 25 45 36 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction EditThe protein encoded by this gene belongs to the lin 28 family which is characterized by the presence of a cold shock domain and a pair of CCHC zinc finger domains This gene is highly expressed in testis fetal liver placenta and in primary human tumors and cancer cell lines It is negatively regulated by microRNAs that target sites in the 3 UTR and overexpression of this gene in primary tumors is linked to the repression of let 7 family of microRNAs and derepression of let 7 targets which facilitates cellular transformation References Edit a b c GRCh38 Ensembl release 89 ENSG00000187772 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000063804 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Lin 28 homolog B Retrieved 2016 03 06 Further reading EditThis article incorporates text from the United States National Library of Medicine which is in the public domain This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LIN28B gene amp oldid 1142674059, wikipedia, wiki, book, books, library,
