LIM domain-binding protein family
In molecular biology, the LIM domain-binding protein family is a family of proteins which binds to the LIM domain of LIM (LIN-11, Isl-1 and MEC-3) homeodomain proteins which are transcriptional regulators of development.
Examples edit
Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with ISL1 in early motor neuron differentiation and has a suggested role in the ISL1 dependent development of motor neurons.[1] It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development.[2] The Drosophila melanogaster protein Chip is required for segmentation and activity of a remote wing margin enhancer.[3] Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development.[3] It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.[3]
References edit
- ^ Jurata LW, Kenny DA, Gill GN (October 1996). "Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11693–8. Bibcode:1996PNAS...9311693J. doi:10.1073/pnas.93.21.11693. PMC 38120. PMID 8876198.
- ^ Bach I, Carriere C, Ostendorff HP, Andersen B, Rosenfeld MG (June 1997). "A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins". Genes Dev. 11 (11): 1370–80. doi:10.1101/gad.11.11.1370. PMID 9192866.
- ^ a b c Morcillo P, Rosen C, Baylies MK, Dorsett D (October 1997). "Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila". Genes Dev. 11 (20): 2729–40. doi:10.1101/gad.11.20.2729. PMC 316608. PMID 9334334.