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Wikipedia

LDB1

April 18, 2024

LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.[5][6][7]

LDB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLDB1, CLIM2, NLI, CLIM-2, LDB-1, LIM domain binding 1
External IDsOMIM: 603451 MGI: 894762 HomoloGene: 2891 GeneCards: LDB1
Orthologs
SpeciesHumanMouse
Entrez

8861

16825

Ensembl

ENSG00000198728

ENSMUSG00000025223

UniProt

Q86U70

P70662

RefSeq (mRNA)

NM_001113407
NM_003893
NM_001321612

NM_001113408
NM_010697
NM_001360336

RefSeq (protein)

NP_001106878
NP_001308541
NP_003884

NP_001106879
NP_034827
NP_001347265

Location (UCSC)Chr 10: 102.11 – 102.12 MbChr 19: 46.02 – 46.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

LDB1 has been shown to interact with LMO4,[8][9] TCF3,[10] TAL1[10] and CBFA2T3.[10]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198728 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025223 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1". Genomics. 48 (1): 87–92. doi:10.1006/geno.1997.5163. PMID 9503020.
  6. ^ Semina EV, Altherr MR, Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849. S2CID 28813194.
  7. ^ "Entrez Gene: LDB1 LIM domain binding 1".
  8. ^ Sutherland KD, Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972. S2CID 20908722.
  9. ^ Deane JE, Mackay Joel P, Kwan Ann H Y, Sum Eleanor Y M, Visvader Jane E, Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888.
  10. ^ a b c Goardon N, Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. ISSN 0261-4189. PMC 1383517. PMID 16407974.

Further reading edit

  • Osada H, Grutz GG, Axelson H, et al. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 (Suppl 3): 307–12. PMID 9209374.
  • Wadman IA, Osada H, Grütz GG, et al. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins". EMBO J. 16 (11): 3145–57. doi:10.1093/emboj/16.11.3145. PMC 1169933. PMID 9214632.
  • Jurata LW, Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI". Mol. Cell. Biol. 17 (10): 5688–98. doi:10.1128/MCB.17.10.5688. PMC 232417. PMID 9315627.
  • Visvader JE, Mao X, Fujiwara Y, et al. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13707–12. Bibcode:1997PNAS...9413707V. doi:10.1073/pnas.94.25.13707. PMC 28370. PMID 9391090.
  • Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.
  • Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. Bibcode:1998PNAS...9511257K. doi:10.1073/pnas.95.19.11257. PMC 21629. PMID 9736723.
  • Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene. 17 (24): 3199–202. doi:10.1038/sj.onc.1202353. PMID 9872335. S2CID 9835264.
  • Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi:10.1007/s100380050120. PMID 10083735.
  • Drechsler M, Schumacher V, Friedrich S, et al. (2000). "Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1". Cytogenet. Cell Genet. 87 (1–2): 119–24. doi:10.1159/000015377. PMID 10640831. S2CID 23735189.
  • Dreyer SD, Morello R, German MS, et al. (2000). "LMX1B transactivation and expression in nail-patella syndrome". Hum. Mol. Genet. 9 (7): 1067–74. doi:10.1093/hmg/9.7.1067. PMID 10767331.
  • Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.
  • Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. Bibcode:2002Natur.416...99O. doi:10.1038/416099a. PMID 11882901. S2CID 4426785.
  • Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. doi:10.1023/A:1016363414644. PMID 12153047. S2CID 30891765.
  • Chen L, Segal D, Hukriede NA, et al. (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–5. Bibcode:2002PNAS...9914320C. doi:10.1073/pnas.212532399. PMC 137882. PMID 12381786.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo". Development. 130 (9): 1915–25. doi:10.1242/dev.00389. PMID 12642495. S2CID 6211268.
  • Deane JE, Mackay JP, Kwan AH, et al. (2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. PMC 156068. PMID 12727888.
  • Marini M, Bongers EM, Cusano R, et al. (2004). "Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome". Int. J. Mol. Med. 12 (1): 79–82. doi:10.3892/ijmm.12.1.79. PMID 12792813.
 

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

April 18, 2024
ldb1, domain, binding, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2xjy, 2xjz, 2ypaidentifiersaliases, clim2, clim, domain, binding, 1external, idsomim, 603451, 894762, homologene, 2891, genecar. LIM domain binding protein 1 is a protein that in humans is encoded by the LDB1 gene 5 6 7 LDB1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2XJY 2XJZ 2YPAIdentifiersAliasesLDB1 CLIM2 NLI CLIM 2 LDB 1 LIM domain binding 1External IDsOMIM 603451 MGI 894762 HomoloGene 2891 GeneCards LDB1Gene location Human Chr Chromosome 10 human 1 Band10q24 32Start102 106 489 bp 1 End102 120 368 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 C3 19 38 75 cMStart46 020 009 bp 2 End46 033 653 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubeganglionic eminencegastric mucosaskin of abdomencanal of the cervixsural nervestromal cell of endometriumanterior pituitaryleft uterine tuberight lobe of thyroid glandTop expressed inlipthymusyolk sacsuperior frontal gyruscorneal stromaneural tubemaxillary prominenceganglionic eminencecerebellar cortexlensMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein homodimerization activity transcription corepressor activity LIM domain binding chromatin binding protein self association protein binding cis regulatory region sequence specific DNA binding enzyme binding transcription coregulator activityCellular componenttranscription regulator complex nucleus cell leading edge nucleoplasm beta catenin TCF complex protein containing complexBiological processhair follicle development transcription dependent tethering of RNA polymerase II gene DNA at nuclear periphery epithelial structure maintenance regulation of transcription DNA templated positive regulation of hemoglobin biosynthetic process somatic stem cell population maintenance regulation of transcription by RNA polymerase II gastrulation with mouth forming second cerebellar Purkinje cell differentiation regulation of DNA templated transcription elongation head development histone H3 K4 acetylation Wnt signaling pathway transcription by RNA polymerase II transcription DNA templated cerebellum development negative regulation of erythrocyte differentiation multicellular organism development neuron differentiation anterior posterior axis specification cellular component assembly negative regulation of transcription DNA templated positive regulation of transcription by RNA polymerase II positive regulation of cell adhesion regulation of focal adhesion assembly regulation of cell migration regulation of kinase activity regulation of hematopoietic stem cell differentiation negative regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez886116825EnsemblENSG00000198728ENSMUSG00000025223UniProtQ86U70P70662RefSeq mRNA NM 001113407NM 003893NM 001321612NM 001113408NM 010697NM 001360336RefSeq protein NP 001106878NP 001308541NP 003884NP 001106879NP 034827NP 001347265Location UCSC Chr 10 102 11 102 12 MbChr 19 46 02 46 03 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editLDB1 has been shown to interact with LMO4 8 9 TCF3 10 TAL1 10 and CBFA2T3 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000198728 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025223 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yamashita T Agulnick AD Copeland NG Gilbert DJ Jenkins NA Westphal H Apr 1998 Genomic structure and chromosomal localization of the mouse LIM domain binding protein 1 gene Ldb1 Genomics 48 1 87 92 doi 10 1006 geno 1997 5163 PMID 9503020 Semina EV Altherr MR Murray JC Dec 1998 Cloning and chromosomal localization of two novel human genes encoding LIM domain binding factors CLIM1 and CLIM2 LDB1 NLI Mamm Genome 9 11 921 4 doi 10 1007 s003359900899 PMID 9799849 S2CID 28813194 Entrez Gene LDB1 LIM domain binding 1 Sutherland KD Visvader Jane E Choong David Y H Sum Eleanor Y M Lindeman Geoffrey J Campbell Ian G Oct 2003 Mutational analysis of the LMO4 gene encoding a BRCA1 interacting protein in breast carcinomas Int J Cancer 107 1 155 8 doi 10 1002 ijc 11343 ISSN 0020 7136 PMID 12925972 S2CID 20908722 Deane JE Mackay Joel P Kwan Ann H Y Sum Eleanor Y M Visvader Jane E Matthews Jacqueline M May 2003 Structural basis for the recognition of ldb1 by the N terminal LIM domains of LMO2 and LMO4 EMBO J 22 9 2224 33 doi 10 1093 emboj cdg196 ISSN 0261 4189 PMC 156068 PMID 12727888 a b c Goardon N Lambert Julie A Rodriguez Patrick Nissaire Philippe Herblot Sabine Thibault Pierre Dumenil Dominique Strouboulis John Romeo Paul Henri Hoang Trang Jan 2006 ETO2 coordinates cellular proliferation and differentiation during erythropoiesis EMBO J 25 2 357 66 doi 10 1038 sj emboj 7600934 ISSN 0261 4189 PMC 1383517 PMID 16407974 Further reading editOsada H Grutz GG Axelson H et al 1997 LIM only protein Lmo2 forms a protein complex with erythroid transcription factor GATA 1 Leukemia 11 Suppl 3 307 12 PMID 9209374 Wadman IA Osada H Grutz GG et al 1997 The LIM only protein Lmo2 is a bridging molecule assembling an erythroid DNA binding complex which includes the TAL1 E47 GATA 1 and Ldb1 NLI proteins EMBO J 16 11 3145 57 doi 10 1093 emboj 16 11 3145 PMC 1169933 PMID 9214632 Jurata LW Gill GN 1997 Functional analysis of the nuclear LIM domain interactor NLI Mol Cell Biol 17 10 5688 98 doi 10 1128 MCB 17 10 5688 PMC 232417 PMID 9315627 Visvader JE Mao X Fujiwara Y et al 1998 The LIM domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation Proc Natl Acad Sci U S A 94 25 13707 12 Bibcode 1997PNAS 9413707V doi 10 1073 pnas 94 25 13707 PMC 28370 PMID 9391090 Jurata LW Pfaff SL Gill GN 1998 The nuclear LIM domain interactor NLI mediates homo and heterodimerization of LIM domain transcription factors J Biol Chem 273 6 3152 7 doi 10 1074 jbc 273 6 3152 PMID 9452425 Kenny DA Jurata LW Saga Y Gill GN 1998 Identification and characterization of LMO4 an LMO gene with a novel pattern of expression during embryogenesis Proc Natl Acad Sci U S A 95 19 11257 62 Bibcode 1998PNAS 9511257K doi 10 1073 pnas 95 19 11257 PMC 21629 PMID 9736723 Valge Archer V Forster A Rabbitts TH 1999 The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t 11 14 p15 q11 Oncogene 17 24 3199 202 doi 10 1038 sj onc 1202353 PMID 9872335 S2CID 9835264 Ueki N Seki N Yano K et al 1999 Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins CLIM1 and CLIM2 J Hum Genet 44 2 112 5 doi 10 1007 s100380050120 PMID 10083735 Drechsler M Schumacher V Friedrich S et al 2000 Genomic structure alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1 Cytogenet Cell Genet 87 1 2 119 24 doi 10 1159 000015377 PMID 10640831 S2CID 23735189 Dreyer SD Morello R German MS et al 2000 LMX1B transactivation and expression in nail patella syndrome Hum Mol Genet 9 7 1067 74 doi 10 1093 hmg 9 7 1067 PMID 10767331 Sum EY Peng B Yu X et al 2002 The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity J Biol Chem 277 10 7849 56 doi 10 1074 jbc M110603200 PMID 11751867 Ostendorff HP Peirano RI Peters MA et al 2002 Ubiquitination dependent cofactor exchange on LIM homeodomain transcription factors Nature 416 6876 99 103 Bibcode 2002Natur 416 99O doi 10 1038 416099a PMID 11882901 S2CID 4426785 Deane JE Visvader JE Mackay JP Matthew JM 2003 1H 15N and 13C assignments of FLIN4 an intramolecular LMO4 ldb1 complex J Biomol NMR 23 2 165 6 doi 10 1023 A 1016363414644 PMID 12153047 S2CID 30891765 Chen L Segal D Hukriede NA et al 2002 Ssdp proteins interact with the LIM domain binding protein Ldb1 to regulate development Proc Natl Acad Sci U S A 99 22 14320 5 Bibcode 2002PNAS 9914320C doi 10 1073 pnas 212532399 PMC 137882 PMID 12381786 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 van Meyel DJ Thomas JB Agulnick AD 2003 Ssdp proteins bind to LIM interacting co factors and regulate the activity of LIM homeodomain protein complexes in vivo Development 130 9 1915 25 doi 10 1242 dev 00389 PMID 12642495 S2CID 6211268 Deane JE Mackay JP Kwan AH et al 2003 Structural basis for the recognition of ldb1 by the N terminal LIM domains of LMO2 and LMO4 EMBO J 22 9 2224 33 doi 10 1093 emboj cdg196 PMC 156068 PMID 12727888 Marini M Bongers EM Cusano R et al 2004 Confirmation of CLIM2 LMX1B interaction by yeast two hybrid screening and analysis of its involvement in nail patella syndrome Int J Mol Med 12 1 79 82 doi 10 3892 ijmm 12 1 79 PMID 12792813 nbsp This article on a gene on human chromosome 10 is a stub You can help Wikipedia by expanding 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