This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
^Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC26754. PMID 10051612.
^Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51). UNITED STATES: 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.
Further readingedit
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. PMID 10593900.
Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–399. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity". Differentiation. 63 (3): 151–157. doi:10.1046/j.1432-0436.1998.6330151.x. PMID 9697309.
This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.
lhx2, homeobox, protein, lhx2, protein, that, humans, encoded, gene, identifiersaliases, hlhx2, homeobox, 2external, idsomim, 603759, 96785, homologene, 55848, genecards, gene, location, human, chromosome, human, band9q33, 3start124, end124, gene, location, mo. LIM homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene 5 6 7 LHX2IdentifiersAliasesLHX2 LH2 hLhx2 LIM homeobox 2External IDsOMIM 603759 MGI 96785 HomoloGene 55848 GeneCards LHX2Gene location Human Chr Chromosome 9 human 1 Band9q33 3Start124 001 670 bp 1 End124 033 301 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 BStart38 229 293 bp 2 End38 259 745 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inhair follicleganglionic eminencespermretinal pigment epitheliumendothelial cellentorhinal cortexmiddle temporal gyrusBrodmann area 23amygdalapostcentral gyrusTop expressed inolfactory epitheliumganglionic eminencelipseptum transversumbarrel cortexhandhippocampus properhepatic diverticulummedial ganglionic eminenceprefrontal cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmetal ion binding sequence specific DNA binding chromatin binding DNA binding RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription activator activity RNA polymerase II specific DNA binding transcription factor activity RNA polymerase II specific transcription factor binding RNA polymerase II transcription regulatory region sequence specific DNA bindingCellular componentnucleus intracellular anatomical structureBiological processnegative regulation of transcription regulatory region DNA binding mesoderm development telencephalon development neural tube closure retina development in camera type eye cerebral cortex development transcription DNA templated axon guidance axon extension hair follicle development maintenance of epithelial cell apical basal polarity neurogenesis brain development olfactory bulb development nervous system development dorsal ventral pattern formation positive regulation of transcription DNA templated regulation of transcription DNA templated positive regulation of transcription by RNA polymerase II neuron differentiation anatomical structure formation involved in morphogenesis telencephalon regionalization transcription by RNA polymerase II negative regulation of gene expression epigenetic negative regulation of neurogenesis positive regulation of neural precursor cell proliferationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez935516870EnsemblENSG00000106689ENSMUSG00000000247UniProtP50458Q9Z0S2RefSeq mRNA NM 004789NM 001290646NM 010710RefSeq protein NP 004780NP 001277575NP 034840Location UCSC Chr 9 124 124 03 MbChr 2 38 23 38 26 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a protein belonging to a large protein family members of which carry the LIM domain a unique cysteine rich zinc binding domain The encoded protein may function as a transcriptional regulator The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein suggesting conservation of function during evolution 7 Interactions editLHX2 has been shown to interact with CITED2 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000106689 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000000247 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wu HK Heng HH Siderovski DP Dong WF Okuno Y Shi XM Tsui LC Minden MD July 1996 Identification of a human LIM Hox gene hLH 2 aberrantly expressed in chronic myelogenous leukaemia and located on 9q33 34 1 Oncogene 12 6 1205 1212 PMID 8649822 Rincon Limas DE Lu CH Canal I Calleja M Rodriguez Esteban C Izpisua Belmonte JC Botas J April 1999 Conservation of the expression and function of apterous orthologs in Drosophila and mammals Proc Natl Acad Sci U S A 96 5 2165 2170 Bibcode 1999PNAS 96 2165R doi 10 1073 pnas 96 5 2165 PMC 26754 PMID 10051612 a b Entrez Gene LHX2 LIM homeobox 2 Glenn D J Maurer R A December 1999 MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha subunit gene expression J Biol Chem 274 51 UNITED STATES 36159 36167 doi 10 1074 jbc 274 51 36159 ISSN 0021 9258 PMID 10593900 Further reading editGerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 2127 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 45 doi 10 1038 ng1285 PMID 14702039 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Glenn DJ Maurer RA 2000 MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha subunit gene expression J Biol Chem 274 51 36159 36167 doi 10 1074 jbc 274 51 36159 PMID 10593900 Bach I Rodriguez Esteban C Carriere C et al 1999 RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex Nat Genet 22 4 394 399 doi 10 1038 11970 PMID 10431247 S2CID 22326394 Bendall AJ Rincon Limas DE Botas J Abate Shen C 1998 Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity Differentiation 63 3 151 157 doi 10 1046 j 1432 0436 1998 6330151 x PMID 9697309 nbsp This article on a gene on human chromosome 9 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title LHX2 amp oldid 1150069137, wikipedia, wiki, book, books, library,
