Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000130702 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000015647 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Durkin ME, Loechel F, Mattei MG, Gilpin BJ, Albrechtsen R, Wewer UM (Jul 1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". FEBS Letters. 411 (2–3): 296–300. doi:10.1016/S0014-5793(97)00686-8. PMID 9271224. S2CID 45286880.
^Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (Jan 2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776. S2CID 10715366.
^Kikkawa Y, Moulson CL, Virtanen I, Miner JH (Nov 2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". The Journal of Biological Chemistry. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.
Further readingedit
Utani A, Nomizu M, Yamada Y (Jan 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". The Journal of Biological Chemistry. 272 (5): 2814–20. doi:10.1074/jbc.272.5.2814. PMID 9006922.
Rousselle P, Keene DR, Ruggiero F, Champliaud MF, Rest M, Burgeson RE (Aug 1997). "Laminin 5 binds the NC-1 domain of type VII collagen". The Journal of Cell Biology. 138 (3): 719–28. doi:10.1083/jcb.138.3.719. PMC2141627. PMID 9245798.
Tiger CF, Champliaud MF, Pedrosa-Domellof F, Thornell LE, Ekblom P, Gullberg D (Nov 1997). "Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies". The Journal of Biological Chemistry. 272 (45): 28590–5. doi:10.1074/jbc.272.45.28590. PMID 9353324.
Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Archivum Immunologiae et Therapiae Experimentalis. 45 (2–3): 255–9. PMID 9597096.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Shimizu H, Hosokawa H, Ninomiya H, Miner JH, Masaki T (Apr 1999). "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan". The Journal of Biological Chemistry. 274 (17): 11995–2000. doi:10.1074/jbc.274.17.11995. hdl:2433/180895. PMID 10207021.
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS (Jan 2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface". The Journal of Biological Chemistry. 275 (1): 451–60. doi:10.1074/jbc.275.1.451. PMID 10617638.
Köhler D, Kruse M, Stöcker W, Sterchi EE (Jan 2000). "Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro". FEBS Letters. 465 (1): 2–7. doi:10.1016/S0014-5793(99)01712-3. PMID 10620696. S2CID 22895580.
Kikkawa Y, Sanzen N, Fujiwara H, Sonnenberg A, Sekiguchi K (Mar 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal of Cell Science. 113 ( Pt 5) (5): 869–76. doi:10.1242/jcs.113.5.869. PMID 10671376.
Champliaud MF, Virtanen I, Tiger CF, Korhonen M, Burgeson R, Gullberg D (Sep 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta". Experimental Cell Research. 259 (2): 326–35. doi:10.1006/excr.2000.4980. PMID 10964500.
Libby RT, Champliaud MF, Claudepierre T, Xu Y, Gibbons EP, Koch M, Burgeson RE, Hunter DD, Brunken WJ (Sep 2000). "Laminin expression in adult and developing retinae: evidence of two novel CNS laminins". The Journal of Neuroscience. 20 (17): 6517–28. doi:10.1523/JNEUROSCI.20-17-06517.2000. PMC2924637. PMID 10964957.
Pierce RA, Griffin GL, Miner JH, Senior RM (Dec 2000). "Expression patterns of laminin alpha1 and alpha5 in human lung during development". American Journal of Respiratory Cell and Molecular Biology. 23 (6): 742–7. doi:10.1165/ajrcmb.23.6.4202. PMID 11104726.
Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (Jan 2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776. S2CID 10715366.
Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV (Feb 2001). "Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations". The American Journal of Pathology. 158 (2): 723–34. doi:10.1016/S0002-9440(10)64015-1. PMC1850323. PMID 11159210.
McArthur CP, Wang Y, Heruth D, Gustafson S (Jun 2001). "Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53". Archives of Oral Biology. 46 (6): 545–55. doi:10.1016/S0003-9969(01)00014-0. PMID 11311202.
Gagnoux-Palacios L, Allegra M, Spirito F, Pommeret O, Romero C, Ortonne JP, Meneguzzi G (May 2001). "The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion". The Journal of Cell Biology. 153 (4): 835–50. doi:10.1083/jcb.153.4.835. PMC2192378. PMID 11352943.
Nagase T, Kikuno R, Ohara O (Aug 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
Doi M, Thyboll J, Kortesmaa J, Jansson K, Iivanainen A, Parvardeh M, Timpl R, Hedin U, Swedenborg J, Tryggvason K (Apr 2002). "Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells". The Journal of Biological Chemistry. 277 (15): 12741–8. doi:10.1074/jbc.M111228200. PMID 11821406.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
laminin, alpha, laminin, subunit, alpha, protein, that, humans, encoded, lama5, gene, lama5available, structurespdbortholog, search, pdbe, rcsblist, codes2y38identifiersaliaseslama5, laminin, subunit, alpha, 5external, idsomim, 601033, 105382, homologene, 4060. Laminin subunit alpha 5 is a protein that in humans is encoded by the LAMA5 gene 5 6 LAMA5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2Y38IdentifiersAliasesLAMA5 Laminin alpha 5 laminin subunit alpha 5External IDsOMIM 601033 MGI 105382 HomoloGene 4060 GeneCards LAMA5Gene location Human Chr Chromosome 20 human 1 Band20q13 33Start62 307 955 bp 1 End62 367 312 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 H4 2 102 7 cMStart179 818 166 bp 2 End179 867 652 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tuberight lungright coronary arterypopliteal arterygastric mucosaupper lobe of left lungskin of abdomenright lobe of thyroid glandleft lobe of thyroid glandleft uterine tubeTop expressed inascending aortamedullary collecting ductleft lung lobemolaraortic valveblastocystislet of Langerhanslipyolk sacglomerulusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionstructural molecule activity integrin binding signaling receptor binding extracellular matrix structural constituentCellular componentextracellular matrix laminin 5 complex extracellular region basement membrane laminin 10 complex laminin 11 complex extracellular exosome nucleus extracellular space synaptic cleft neuromuscular junction collagen containing extracellular matrixBiological processhair follicle development cell differentiation regulation of embryonic development regulation of cell migration cell recognition embryo development lung development muscle organ development extracellular matrix organization morphogenesis of a polarized epithelium odontogenesis of dentin containing tooth focal adhesion assembly branching involved in ureteric bud morphogenesis regulation of cell adhesion cell adhesion regulation of cell population proliferation cytoskeleton organization angiogenesis neural crest cell migration animal organ morphogenesis integrin mediated signaling pathway endothelial cell differentiation substrate adhesion dependent cell spreading morphogenesis of embryonic epithelium cell population proliferation cell migration branching morphogenesis of an epithelial tube branching involved in salivary gland morphogenesis cilium assembly protein localization to plasma membrane cytokine mediated signaling pathway tissue development cell cell adhesionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez391116776EnsemblENSG00000130702ENSMUSG00000015647UniProtO15230Q61001RefSeq mRNA NM 005560NM 001081171RefSeq protein NP 005551NP 001074640Location UCSC Chr 20 62 31 62 37 MbChr 2 179 82 179 87 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editComponents of the extracellular matrix exert myriad effects on tissues throughout the body In particular the laminins a family of heterotrimeric extracellular glycoproteins affect tissue development and integrity in such diverse organs as the kidney lung skin and nervous system It is thought that laminins mediate the attachment migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components Laminins function as heterotrimeric complexes of alpha beta and gamma chains with each chain type representing a different subfamily of proteins The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes Two transcript variants encoding different isoforms have been found for this gene but the full length nature of one of them has not been determined 6 Interactions editLaminin alpha 5 has been shown to interact with BCAM 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000130702 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000015647 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Durkin ME Loechel F Mattei MG Gilpin BJ Albrechtsen R Wewer UM Jul 1997 Tissue specific expression of the human laminin alpha5 chain and mapping of the gene to human chromosome 20q13 2 13 3 and to distal mouse chromosome 2 near the locus for the ragged Ra mutation FEBS Letters 411 2 3 296 300 doi 10 1016 S0014 5793 97 00686 8 PMID 9271224 S2CID 45286880 a b Entrez Gene LAMA5 laminin alpha 5 Parsons SF Lee G Spring FA Willig TN Peters LL Gimm JA Tanner MJ Mohandas N Anstee DJ Chasis JA Jan 2001 Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain containing human laminin with high affinity Blood 97 1 312 20 doi 10 1182 blood V97 1 312 PMID 11133776 S2CID 10715366 Kikkawa Y Moulson CL Virtanen I Miner JH Nov 2002 Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo The Journal of Biological Chemistry 277 47 44864 9 doi 10 1074 jbc M208731200 PMID 12244066 Further reading editUtani A Nomizu M Yamada Y Jan 1997 Fibulin 2 binds to the short arms of laminin 5 and laminin 1 via conserved amino acid sequences The Journal of Biological Chemistry 272 5 2814 20 doi 10 1074 jbc 272 5 2814 PMID 9006922 Rousselle P Keene DR Ruggiero F Champliaud MF Rest M Burgeson RE Aug 1997 Laminin 5 binds the NC 1 domain of type VII collagen The Journal of Cell Biology 138 3 719 28 doi 10 1083 jcb 138 3 719 PMC 2141627 PMID 9245798 Tiger CF Champliaud MF Pedrosa Domellof F Thornell LE Ekblom P Gullberg D Nov 1997 Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies The Journal of Biological Chemistry 272 45 28590 5 doi 10 1074 jbc 272 45 28590 PMID 9353324 Mrowiec T Melchar C Gorski A 1998 HIV protein mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium Archivum Immunologiae et Therapiae Experimentalis 45 2 3 255 9 PMID 9597096 Nagase T Ishikawa K Miyajima N Tanaka A Kotani H Nomura N Ohara O Feb 1998 Prediction of the coding sequences of unidentified human genes IX The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro DNA Research 5 1 31 9 doi 10 1093 dnares 5 1 31 PMID 9628581 Shimizu H Hosokawa H Ninomiya H Miner JH Masaki T Apr 1999 Adhesion of cultured bovine aortic endothelial cells to laminin 1 mediated by dystroglycan The Journal of Biological Chemistry 274 17 11995 2000 doi 10 1074 jbc 274 17 11995 hdl 2433 180895 PMID 10207021 Son YJ Scranton TW Sunderland WJ Baek SJ Miner JH Sanes JR Carlson SS Jan 2000 The synaptic vesicle protein SV2 is complexed with an alpha5 containing laminin on the nerve terminal surface The Journal of Biological Chemistry 275 1 451 60 doi 10 1074 jbc 275 1 451 PMID 10617638 Kohler D Kruse M Stocker W Sterchi EE Jan 2000 Heterologously overexpressed affinity purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro FEBS Letters 465 1 2 7 doi 10 1016 S0014 5793 99 01712 3 PMID 10620696 S2CID 22895580 Kikkawa Y Sanzen N Fujiwara H Sonnenberg A Sekiguchi K Mar 2000 Integrin binding specificity of laminin 10 11 laminin 10 11 are recognized by alpha 3 beta 1 alpha 6 beta 1 and alpha 6 beta 4 integrins Journal of Cell Science 113 Pt 5 5 869 76 doi 10 1242 jcs 113 5 869 PMID 10671376 Champliaud MF Virtanen I Tiger CF Korhonen M Burgeson R Gullberg D Sep 2000 Posttranslational modifications and beta gamma chain associations of human laminin alpha1 and laminin alpha5 chains purification of laminin 3 from placenta Experimental Cell Research 259 2 326 35 doi 10 1006 excr 2000 4980 PMID 10964500 Libby RT Champliaud MF Claudepierre T Xu Y Gibbons EP Koch M Burgeson RE Hunter DD Brunken WJ Sep 2000 Laminin expression in adult and developing retinae evidence of two novel CNS laminins The Journal of Neuroscience 20 17 6517 28 doi 10 1523 JNEUROSCI 20 17 06517 2000 PMC 2924637 PMID 10964957 Pierce RA Griffin GL Miner JH Senior RM Dec 2000 Expression patterns of laminin alpha1 and alpha5 in human lung during development American Journal of Respiratory Cell and Molecular Biology 23 6 742 7 doi 10 1165 ajrcmb 23 6 4202 PMID 11104726 Parsons SF Lee G Spring FA Willig TN Peters LL Gimm JA Tanner MJ Mohandas N Anstee DJ Chasis JA Jan 2001 Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain containing human laminin with high affinity Blood 97 1 312 20 doi 10 1182 blood V97 1 312 PMID 11133776 S2CID 10715366 Saghizadeh M Brown DJ Castellon R Chwa M Huang GH Ljubimova JY Rosenberg S Spirin KS Stolitenko RB Adachi W Kinoshita S Murphy G Windsor LJ Kenney MC Ljubimov AV Feb 2001 Overexpression of matrix metalloproteinase 10 and matrix metalloproteinase 3 in human diabetic corneas a possible mechanism of basement membrane and integrin alterations The American Journal of Pathology 158 2 723 34 doi 10 1016 S0002 9440 10 64015 1 PMC 1850323 PMID 11159210 McArthur CP Wang Y Heruth D Gustafson S Jun 2001 Amplification of extracellular matrix and oncogenes in tat transfected human salivary gland cell lines with expression of laminin fibronectin collagens I III IV c myc and p53 Archives of Oral Biology 46 6 545 55 doi 10 1016 S0003 9969 01 00014 0 PMID 11311202 Gagnoux Palacios L Allegra M Spirito F Pommeret O Romero C Ortonne JP Meneguzzi G May 2001 The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion The Journal of Cell Biology 153 4 835 50 doi 10 1083 jcb 153 4 835 PMC 2192378 PMID 11352943 Nagase T Kikuno R Ohara O Aug 2001 Prediction of the coding sequences of unidentified human genes XXI The complete sequences of 60 new cDNA clones from brain which code for large proteins DNA Research 8 4 179 87 doi 10 1093 dnares 8 4 179 PMID 11572484 Doi M Thyboll J Kortesmaa J Jansson K Iivanainen A Parvardeh M Timpl R Hedin U Swedenborg J Tryggvason K Apr 2002 Recombinant human laminin 10 alpha5beta1gamma1 Production purification and migration promoting activity on vascular endothelial cells The Journal of Biological Chemistry 277 15 12741 8 doi 10 1074 jbc M111228200 PMID 11821406 nbsp This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Laminin alpha 5 amp oldid 1184106014, wikipedia, wiki, book, books, library,
