^ abcGRCh38: Ensembl release 89: ENSG00000116990 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028654 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.
^Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC401025. PMID 2548855.
^Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–1217. Bibcode:1991Sci...251.1211B. doi:10.1126/science.2006410. PMID 2006410.
^FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.
Further readingedit
Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1–2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341.
Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. doi:10.1002/j.1460-2075.1989.tb03573.x. PMC401025. PMID 2548855.
Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. doi:10.1128/mcb.8.1.186. PMC363100. PMID 2827002.
De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. doi:10.1128/mcb.8.10.4381. PMC365511. PMID 3054516.
DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–1326. doi:10.1101/gad.1.10.1311. PMID 3322939.
Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–10221. Bibcode:1995PNAS...9210217A. doi:10.1073/pnas.92.22.10217. PMC40767. PMID 7479755.
FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.
Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. doi:10.1111/j.1349-7006.2002.tb01193.x. PMC5926866. PMID 11802801.
Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. doi:10.3892/or.9.2.345. PMID 11836605.
Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. doi:10.3892/or.9.3.551. PMID 11956626.
Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–222. doi:10.1111/j.1582-4934.2002.tb00188.x. PMC6740283. PMID 12169206.
Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. doi:10.1016/S0002-9440(10)64294-0. PMC1851191. PMID 12707044.
Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–1763. doi:10.1158/1078-0432.CCR-0779-3. PMID 15014029.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF). Lung Cancer. 55 (3): 271–277. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016. PMID 17145094.
mycl, proto, oncogene, protein, protein, that, humans, encoded, gene, identifiersaliases, lmyc, bhlhe38, avian, myelocytomatosis, viral, oncogene, lung, carcinoma, derived, homolog, proto, oncogene, bhlh, transcription, factorexternal, idsomim, 164850, 96799, . L myc 1 proto oncogene protein is a protein that in humans is encoded by the MYCL1 gene 5 6 MYCLIdentifiersAliasesMYCL LMYC MYCL1 bHLHe38 L Myc v myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog MYCL proto oncogene bHLH transcription factorExternal IDsOMIM 164850 MGI 96799 HomoloGene 3921 GeneCards MYCLGene location Human Chr Chromosome 1 human 1 Band1p34 2Start39 895 426 bp 1 End39 902 256 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 D2 2 4 57 36 cMStart122 889 445 bp 2 End122 896 278 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocyteepithelium of esophagusskin of abdomenbody of pancreasmucosa of urinary bladdergumsganglionic eminencecavity of mouthbronchial epithelial cellrectumTop expressed incorneal stromahair follicleganglionic eminencelipmedial ganglionic eminenceneural tubemaxillary prominenceesophagussomitecumulus cellMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity protein dimerization activity DNA binding DNA binding transcription factor activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription activator activity RNA polymerase II specificCellular componentnucleusBiological processregulation of transcription DNA templated regulation of inner ear auditory receptor cell differentiation regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez461016918EnsemblENSG00000116990ENSMUSG00000028654UniProtP12524P10166RefSeq mRNA NM 005376NM 001033081NM 001033082NM 008506NM 001303121RefSeq protein NP 001028253NP 001028254NP 005367NP 001290050NP 032532Location UCSC Chr 1 39 9 39 9 MbChr 4 122 89 122 9 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseMYCL1 is a bHLH basic helix loop helix transcription factor implicated in lung cancer 7 Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editMYCL1 has been shown to interact with MAX 8 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000116990 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028654 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Speleman F Van Camp G Van Roy N Jan 1997 Reassignment of MYCL1 to human chromosome 1p34 3 by fluorescence in situ hybridization Cytogenet Cell Genet 72 2 3 189 190 doi 10 1159 000134185 PMID 8978772 Entrez Gene MYCL1 v myc myelocytomatosis viral oncogene homolog 1 lung carcinoma derived avian Ikegaki N Minna J Kennett RH 1989 The human L myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines detection by monoclonal antibodies specific to two myc homology box sequences EMBO J 8 6 1793 9 doi 10 1002 j 1460 2075 1989 tb03573 x PMC 401025 PMID 2548855 Blackwood EM Eisenman RN Mar 1991 Max a helix loop helix zipper protein that forms a sequence specific DNA binding complex with Myc Science 251 4998 1211 1217 Bibcode 1991Sci 251 1211B doi 10 1126 science 2006410 PMID 2006410 FitzGerald MJ Arsura M Bellas RE Yang W Wu M Chin L Mann KK DePinho RA Sonenshein GE Apr 1999 Differential effects of the widely expressed dMax splice variant of Max on E box vs initiator element mediated regulation by c Myc Oncogene 18 15 2489 2498 doi 10 1038 sj onc 1202611 PMID 10229200 Further reading editLuscher B 2001 Function and regulation of the transcription factors of the Myc Max Mad network Gene 277 1 2 1 14 doi 10 1016 S0378 1119 01 00697 7 PMID 11602341 Ikegaki N Minna J Kennett RH 1989 The human L myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines detection by monoclonal antibodies specific to two myc homology box sequences EMBO J 8 6 1793 9 doi 10 1002 j 1460 2075 1989 tb03573 x PMC 401025 PMID 2548855 Kaye F Battey J Nau M Brooks B Seifter E De Greve J Birrer M Sausville E Minna J 1988 Structure and expression of the human L myc gene reveal a complex pattern of alternative mRNA processing Mol Cell Biol 8 1 186 95 doi 10 1128 mcb 8 1 186 PMC 363100 PMID 2827002 De Greve J Battey J Fedorko J Birrer M Evan G Kaye F Sausville E Minna J 1988 The human L myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs Mol Cell Biol 8 10 4381 8 doi 10 1128 mcb 8 10 4381 PMC 365511 PMID 3054516 DePinho RA Hatton KS Tesfaye A Yancopoulos GD Alt FW 1988 The human myc gene family structure and activity of L myc and an L myc pseudogene Genes Dev 1 10 1311 1326 doi 10 1101 gad 1 10 1311 PMID 3322939 Atchley WR Fitch WM 1995 Myc and Max molecular evolution of a family of proto oncogene products and their dimerization partner Proc Natl Acad Sci U S A 92 22 10217 10221 Bibcode 1995PNAS 9210217A doi 10 1073 pnas 92 22 10217 PMC 40767 PMID 7479755 FitzGerald MJ Arsura M Bellas RE Yang W Wu M Chin L Mann KK DePinho RA Sonenshein GE 1999 Differential effects of the widely expressed dMax splice variant of Max on E box vs initiator element mediated regulation by c Myc Oncogene 18 15 2489 2498 doi 10 1038 sj onc 1202611 PMID 10229200 Kumimoto H Hamajima N Nishimoto Y Matsuo K Shinoda M Hatooka S Ishizaki K 2002 L myc genotype is associated with different susceptibility to lung cancer in smokers Jpn J Cancer Res 93 1 1 5 doi 10 1111 j 1349 7006 2002 tb01193 x PMC 5926866 PMID 11802801 Suzuki H Yamashiro K 2002 L myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma Oncol Rep 9 2 345 7 doi 10 3892 or 9 2 345 PMID 11836605 Primdahl H von der Maase H Christensen M Wolf H Orntoft TF 2002 Allelic deletions of Rb and L myc in urine sediments from patients with bladder tumors or carcinoma in situ Oncol Rep 9 3 551 5 doi 10 3892 or 9 3 551 PMID 11956626 Demopoulos K Arvanitis DA Vassilakis DA Siafakas NM Spandidos DA 2003 MYCL1 FHIT SPARC p16 INK4 and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis J Cell Mol Med 6 2 215 222 doi 10 1111 j 1582 4934 2002 tb00188 x PMC 6740283 PMID 12169206 Wu R Lin L Beer DG Ellenson LH Lamb BJ Rouillard JM Kuick R Hanash S Schwartz DR Fearon ER Cho KR 2003 Amplification and overexpression of the L MYC proto oncogene in ovarian carcinomas Am J Pathol 162 5 1603 10 doi 10 1016 S0002 9440 10 64294 0 PMC 1851191 PMID 12707044 Kambara T Sharp GB Nagasaka T Takeda M Sasamoto H Nakagawa H Isozaki H MacPhee DG Jass JR Tanaka N Matsubara N 2004 Allelic loss of a common microsatellite marker MYCL1 a useful prognostic factor of poor outcomes in colorectal cancer Clin Cancer Res 10 5 1758 1763 doi 10 1158 1078 0432 CCR 0779 3 PMID 15014029 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 1178 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Spinola M Falvella FS Galvan A Pignatiello C Leoni VP Pastorino U Paroni R Chen S Skaug V Haugen A Dragani TA 2007 Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients survival PDF Lung Cancer 55 3 271 277 doi 10 1016 j lungcan 2006 10 023 hdl 2434 25016 PMID 17145094 External links editMYCL1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MYCL amp oldid 1081652754, wikipedia, wiki, book, books, library,
