Kosan Biosciences

Kosan Biosciences, Inc. (stock symbol: KOSN), was a pharmaceutical company which dealt with cancer therapeutics medications. The company was working on advancing two new classes of anticancer agents through clinical development: heat shock protein 90 (Hsp90) inhibitors and epothilones.

Kosan Biosciences, Inc.

Founded	1995
Headquarters	Hayward, California
Key people	Helen S. Kim (President & CEO)
Number of employees	90
Parent	Bristol Myers Squibb

Their technology platform was based on manipulation of the genetic instructions of microbes for making natural product polyketides. Rearranging the modular units in natural polyketide synthases, combining modules from different enzymes, and incorporating novel synthetic chemical starter units enabled them to produce a wide variety of novel polyketides that would be difficult to obtain via organic synthesis alone.^[1]

Founded in 1995, Kosan was headquartered in Hayward, California and had approximately 90 employees. Kosan was funded in part as a venture capital start-up with funds from Sofinnova Ventures of California.

On June 26, 2008, Kosan Biosciences was acquired by Bristol-Myers Squibb for $190M.^[2]

Discodermolide

Discodermolide is a recently discovered polyketide natural product found to be a potent inhibitor of tumor cell growth. Kosan had been working in conjunction with the on a preclinical drug development program.

Management

Helen S. Kim was the President & CEO of Kosan Biosciences in 2008 until it was sold to BMS.^[3][4] One member of the Board of Directors, Dr. Jean Deleage, was one of the founders and managing partners of Burr, Egan, Deleage & Co., a private venture capital firm which invested in information technology, communications, and healthcare/biotechnology companies.

References

1. Menzella, H. G.; Carney, J. R.; Santi, D. V. (2007-02-01). "Rational Design and Assembly of Synthetic Trimodular Polyketide Synthases". Chemistry and Biology. 14 (2): 143–151. doi:10.1016/j.chembiol.2006.12.002. PMID 17317568.
2. "BMS buys Kosan for $190M". Fierce Biotech. Retrieved 14 June 2022.
3. "Kosan Biosciences appoints Helen Kim". Biospace. Retrieved 14 June 2022.
4. "Helen Kim". IconOVir. Retrieved 14 June 2022.

External links

• Bristol-Myers Squibb acquires Kosan (26 June 2008)^{[permanent dead link]}
• Chemical & Engineering News, (1 March 2004), "Scaled Up Synthesis of Discodermolide
• KOSAN BIOSCIENCES INC SEC FILINGS