This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[6]
^Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC262669. PMID 14612398.
Further readingedit
Ghaleb AM, Nandan MO, Chanchevalap S, Dalton WB, Hisamuddin IM, Yang VW (Feb 2005). "Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation". Cell Research. 15 (2): 92–6. doi:10.1038/sj.cr.7290271. PMC1317089. PMID 15740636.
Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I (Aug 2005). "Significance of the transcription factor KLF5 in cardiovascular remodeling". Journal of Thrombosis and Haemostasis. 3 (8): 1569–76. doi:10.1111/j.1538-7836.2005.01366.x. PMID 16102021.
McConnell BB, Ghaleb AM, Nandan MO, Yang VW (Jun 2007). "The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology". BioEssays. 29 (6): 549–57. doi:10.1002/bies.20581. PMC2211634. PMID 17508399.
Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (Feb 1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". Journal of Biochemistry. 121 (2): 389–96. doi:10.1093/oxfordjournals.jbchem.a021600. PMID 9089417.
Conkright MD, Wani MA, Anderson KP, Lingrel JB (Mar 1999). "A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells". Nucleic Acids Research. 27 (5): 1263–70. doi:10.1093/nar/27.5.1263. PMC148310. PMID 9973612.
Shi H, Zhang Z, Wang X, Liu S, Teng CT (Dec 1999). "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter". Nucleic Acids Research. 27 (24): 4807–15. doi:10.1093/nar/27.24.4807. PMC148782. PMID 10572182.
Hoshino Y, Kurabayashi M, Kanda T, Hasegawa A, Sakamoto H, Okamoto E, Kowase K, Watanabe N, Manabe I, Suzuki T, Nakano A, Takase S, Wilcox JN, Nagai R (Nov 2000). "Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis". Circulation. 102 (20): 2528–34. doi:10.1161/01.cir.102.20.2528. PMID 11076828.
Sun R, Chen X, Yang VW (Mar 2001). "Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation". The Journal of Biological Chemistry. 276 (10): 6897–900. doi:10.1074/jbc.C000870200. PMC2268089. PMID 11152667.
Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW (Jul 2002). "Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene". Nucleic Acids Research. 30 (13): 2736–41. doi:10.1093/nar/gkf400. PMC117055. PMID 12087155.
Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (Aug 2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nature Medicine. 8 (8): 856–63. doi:10.1038/nm738. PMID 12101409. S2CID 34181151.
Sur I, Undén AB, Toftgård R (Jun 2002). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". European Journal of Cell Biology. 81 (6): 323–34. doi:10.1078/0171-9335-00257. PMID 12113473.
Chen C, Bhalala HV, Qiao H, Dong JT (Sep 2002). "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer". Oncogene. 21 (43): 6567–72. doi:10.1038/sj.onc.1205817. PMID 12242654.
Yang XO, Doty RT, Hicks JS, Willerford DM (Jun 2003). "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs". Blood. 101 (11): 4492–9. doi:10.1182/blood-2002-08-2579. PMID 12576331.
Chen C, Bhalala HV, Vessella RL, Dong JT (May 2003). "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer". The Prostate. 55 (2): 81–8. doi:10.1002/pros.10205. PMID 12661032. S2CID 21150851.
Zhang Z, Teng CT (Apr 2003). "Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function". Nucleic Acids Research. 31 (8): 2196–208. doi:10.1093/nar/gkg310. PMC153738. PMID 12682370.
Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T (Aug 2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochemical and Biophysical Research Communications. 308 (2): 251–6. doi:10.1016/S0006-291X(03)01356-1. PMID 12901861.
Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins T, Nagai R (Jan 2004). "Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB". The Journal of Biological Chemistry. 279 (1): 70–6. doi:10.1074/jbc.M306621200. PMID 14573617.
Sato T, Kanda T, Iida T, Takahashi T, Kishi S, Hoshino Y (2004). "Immunohistochemical study of surgically excised choroidal neovascular membranes". The Journal of International Medical Research. 31 (5): 402–6. doi:10.1177/147323000303100507. PMID 14587307. S2CID 33670045.
klf5, krueppel, like, factor, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2ebtidentifiersaliases, bteb2, cklf, iklf, kruppel, like, factor, intestinal, kruppel, like, factor, 5external, idsomim, 602903, . Krueppel like factor 5 is a protein that in humans is encoded by the KLF5 gene 5 6 KLF5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2EBTIdentifiersAliasesKLF5 BTEB2 CKLF IKLF Kruppel like factor 5 intestinal Kruppel like factor 5External IDsOMIM 602903 MGI 1338056 HomoloGene 37520 GeneCards KLF5Gene location Human Chr Chromosome 13 human 1 Band13q22 1Start73 054 976 bp 1 End73 077 541 bp 1 Gene location Mouse Chr Chromosome 14 mouse 2 Band14 14 E2 2Start99 536 127 bp 2 End99 552 472 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inhuman penisamniotic fluidnippleskin of abdomencavity of mouthrectumpalpebral conjunctivaurethrajejunal mucosabody of tongueTop expressed inleft coloncrypt of lieberkuhn of small intestinemucosa of urinary bladderconjunctival fornixileumPaneth cellbelly cordleft lung lobegastric mucosacorneal stromaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding DNA binding transcription factor activity DNA binding transcription activator activity RNA polymerase II specific metal ion binding RNA polymerase II cis regulatory region sequence specific DNA binding protein binding nucleic acid binding sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific transcription factor binding MRF bindingCellular componentGolgi apparatus intracellular membrane bounded organelle nucleoplasm nucleus transcription regulator complexBiological processregulation of microvillus assembly microvillus assembly regulation of transcription DNA templated intestinal epithelial cell development regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription DNA templated positive regulation of transcription DNA templated angiogenesis skeletal muscle cell differentiation positive regulation of fat cell differentiation positive regulation of transcription by RNA polymerase II cellular response to organic cyclic compound positive regulation of cell population proliferation cellular response to peptide cellular response to leukemia inhibitory factor cell cell signaling via exosome positive regulation of pri miRNA transcription by RNA polymerase II regulation of gene expression skeletal muscle satellite cell differentiation satellite cell activation involved in skeletal muscle regeneration myotube differentiation involved in skeletal muscle regeneration skeletal muscle tissue regeneration positive regulation of transcription by transcription factor localizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez68812224EnsemblENSG00000102554ENSMUSG00000005148UniProtQ13887Q9Z0Z7RefSeq mRNA NM 001730NM 001286818NM 009769RefSeq protein NP 001273747NP 001721NP 033899Location UCSC Chr 13 73 05 73 08 MbChr 14 99 54 99 55 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction editThis gene encodes a member of the Kruppel like factor subfamily of zinc finger proteins Since the protein localizes to the nucleus and binds the epidermal growth factor response element it is thought to be a transcription factor 6 Interactions editKLF5 has been shown to interact with Protein SET 7 See also editKruppel like factorsReferences edit a b c GRCh38 Ensembl release 89 ENSG00000102554 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000005148 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sogawa K Imataka H Yamasaki Y Kusume H Abe H Fujii Kuriyama Y Apr 1993 cDNA cloning and transcriptional properties of a novel GC box binding protein BTEB2 Nucleic Acids Research 21 7 1527 32 doi 10 1093 nar 21 7 1527 PMC 309358 PMID 8479902 a b Entrez Gene KLF5 Kruppel like factor 5 intestinal Miyamoto S Suzuki T Muto S Aizawa K Kimura A Mizuno Y Nagino T Imai Y Adachi N Horikoshi M Nagai R Dec 2003 Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA binding domain Molecular and Cellular Biology 23 23 8528 41 doi 10 1128 MCB 23 23 8528 8541 2003 PMC 262669 PMID 14612398 Further reading editGhaleb AM Nandan MO Chanchevalap S Dalton WB Hisamuddin IM Yang VW Feb 2005 Kruppel like factors 4 and 5 the yin and yang regulators of cellular proliferation Cell Research 15 2 92 6 doi 10 1038 sj cr 7290271 PMC 1317089 PMID 15740636 Nagai R Suzuki T Aizawa K Shindo T Manabe I Aug 2005 Significance of the transcription factor KLF5 in cardiovascular remodeling Journal of Thrombosis and Haemostasis 3 8 1569 76 doi 10 1111 j 1538 7836 2005 01366 x PMID 16102021 McConnell BB Ghaleb AM Nandan MO Yang VW Jun 2007 The diverse functions of Kruppel like factors 4 and 5 in epithelial biology and pathobiology BioEssays 29 6 549 57 doi 10 1002 bies 20581 PMC 2211634 PMID 17508399 Kojima S Kobayashi A Gotoh O Ohkuma Y Fujii Kuriyama Y Sogawa K Feb 1997 Transcriptional activation domain of human BTEB2 a GC box binding factor Journal of Biochemistry 121 2 389 96 doi 10 1093 oxfordjournals jbchem a021600 PMID 9089417 Conkright MD Wani MA Anderson KP Lingrel JB Mar 1999 A gene encoding an intestinal enriched member of the Kruppel like factor family expressed in intestinal epithelial cells Nucleic Acids Research 27 5 1263 70 doi 10 1093 nar 27 5 1263 PMC 148310 PMID 9973612 Shi H Zhang Z Wang X Liu S Teng CT Dec 1999 Isolation and characterization of a gene encoding human Kruppel like factor 5 IKLF binding to the CAAT GT box of the mouse lactoferrin gene promoter Nucleic Acids Research 27 24 4807 15 doi 10 1093 nar 27 24 4807 PMC 148782 PMID 10572182 Hoshino Y Kurabayashi M Kanda T Hasegawa A Sakamoto H Okamoto E Kowase K Watanabe N Manabe I Suzuki T Nakano A Takase S Wilcox JN Nagai R Nov 2000 Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis Circulation 102 20 2528 34 doi 10 1161 01 cir 102 20 2528 PMID 11076828 Sun R Chen X Yang VW Mar 2001 Intestinal enriched Kruppel like factor Kruppel like factor 5 is a positive regulator of cellular proliferation The Journal of Biological Chemistry 276 10 6897 900 doi 10 1074 jbc C000870200 PMC 2268089 PMID 11152667 Dang DT Zhao W Mahatan CS Geiman DE Yang VW Jul 2002 Opposing effects of Kruppel like factor 4 gut enriched Kruppel like factor and Kruppel like factor 5 intestinal enriched Kruppel like factor on the promoter of the Kruppel like factor 4 gene Nucleic Acids Research 30 13 2736 41 doi 10 1093 nar gkf400 PMC 117055 PMID 12087155 Shindo T Manabe I Fukushima Y Tobe K Aizawa K Miyamoto S Kawai Kowase K Moriyama N Imai Y Kawakami H Nishimatsu H Ishikawa T Suzuki T Morita H Maemura K Sata M Hirata Y Komukai M Kagechika H Kadowaki T Kurabayashi M Nagai R Aug 2002 Kruppel like zinc finger transcription factor KLF5 BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling Nature Medicine 8 8 856 63 doi 10 1038 nm738 PMID 12101409 S2CID 34181151 Sur I Unden AB Toftgard R Jun 2002 Human Kruppel like factor5 KLF5 synergy with NF kappaB Rel factors and expression in human skin and hair follicles European Journal of Cell Biology 81 6 323 34 doi 10 1078 0171 9335 00257 PMID 12113473 Chen C Bhalala HV Qiao H Dong JT Sep 2002 A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer Oncogene 21 43 6567 72 doi 10 1038 sj onc 1205817 PMID 12242654 Yang XO Doty RT Hicks JS Willerford DM Jun 2003 Regulation of T cell receptor D beta 1 promoter by KLF5 through reiterated GC rich motifs Blood 101 11 4492 9 doi 10 1182 blood 2002 08 2579 PMID 12576331 Chen C Bhalala HV Vessella RL Dong JT May 2003 KLF5 is frequently deleted and down regulated but rarely mutated in prostate cancer The Prostate 55 2 81 8 doi 10 1002 pros 10205 PMID 12661032 S2CID 21150851 Zhang Z Teng CT Apr 2003 Phosphorylation of Kruppel like factor 5 KLF5 IKLF at the CBP interaction region enhances its transactivation function Nucleic Acids Research 31 8 2196 208 doi 10 1093 nar gkg310 PMC 153738 PMID 12682370 Ohnishi S Ohnami S Laub F Aoki K Suzuki K Kanai Y Haga K Asaka M Ramirez F Yoshida T Aug 2003 Downregulation and growth inhibitory effect of epithelial type Kruppel like transcription factor KLF4 but not KLF5 in bladder cancer Biochemical and Biophysical Research Communications 308 2 251 6 doi 10 1016 S0006 291X 03 01356 1 PMID 12901861 Aizawa K Suzuki T Kada N Ishihara A Kawai Kowase K Matsumura T Sasaki K Munemasa Y Manabe I Kurabayashi M Collins T Nagai R Jan 2004 Regulation of platelet derived growth factor A chain by Kruppel like factor 5 new pathway of cooperative activation with nuclear factor kappaB The Journal of Biological Chemistry 279 1 70 6 doi 10 1074 jbc M306621200 PMID 14573617 Sato T Kanda T Iida T Takahashi T Kishi S Hoshino Y 2004 Immunohistochemical study of surgically excised choroidal neovascular membranes The Journal of International Medical Research 31 5 402 6 doi 10 1177 147323000303100507 PMID 14587307 S2CID 33670045 External links editKLF5 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 13 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title KLF5 amp oldid 1187194977, wikipedia, wiki, book, books, library,
