Keratin 15 is a type I cytokeratin. It is well-expressed in the basal layer of complex epithelia. However, acral keratinocytes express little to no keratin 15.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000171346 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000054146 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenetics and Cell Genetics. 54 (3–4): 148–150. doi:10.1159/000132979. PMID 1702379.
^Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC2064177. PMID 16831889.
^Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16): e159762. doi:10.1172/jci.insight.159762. PMC9462509. PMID 35900871.
Further readingedit
Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M (April 2004). "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription". Molecular and Cellular Biology. 24 (8): 3168–3179. doi:10.1128/MCB.24.8.3168-3179.2004. PMC381600. PMID 15060141.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ (December 2009). "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin". Aging Cell. 8 (6): 738–751. doi:10.1111/j.1474-9726.2009.00526.x. hdl:2027.42/78718. PMID 20050020. S2CID 8832389.
Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, et al. (March 1999). "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes". The Journal of Investigative Dermatology. 112 (3): 362–369. doi:10.1046/j.1523-1747.1999.00535.x. PMID 10084315.
Blumenberg M, Savtchenko ES (1986). "Linkage of human keratin genes". Cytogenetics and Cell Genetics. 42 (1–2): 65–71. doi:10.1159/000132253. PMID 2424675.
Marchuk D, McCrohon S, Fuchs E (March 1985). "Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene". Proceedings of the National Academy of Sciences of the United States of America. 82 (6): 1609–1613. Bibcode:1985PNAS...82.1609M. doi:10.1073/pnas.82.6.1609. PMC397321. PMID 2580298.
Bader BL, Jahn L, Franke WW (December 1988). "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene". European Journal of Cell Biology. 47 (2): 300–319. PMID 2468493.
Choi CW, Park HS, Kim YK, Lee SH, Cho KH (August 2008). "Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma". The Journal of Dermatology. 35 (8): 499–502. doi:10.1111/j.1346-8138.2008.00510.x. PMID 18789069. S2CID 36019385.
Romano V, Bosco P, Rocchi M, Costa G, Leube RE, Franke WW, Romeo G (1988). "Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes". Cytogenetics and Cell Genetics. 48 (3): 148–151. doi:10.1159/000132612. PMID 2466616.
Leube RE, Bader BL, Bosch FX, Zimbelmann R, Achtstaetter T, Franke WW (April 1988). "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15". The Journal of Cell Biology. 106 (4): 1249–1261. doi:10.1083/jcb.106.4.1249. PMC2114990. PMID 2452170.
Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–252. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. S2CID 35796315.
Celis JE, Gromova I, Cabezón T, Gromov P, Shen T, Timmermans-Wielenga V, et al. (December 2007). "Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease". Molecular Oncology. 1 (3): 321–349. doi:10.1016/j.molonc.2007.09.004. PMC5543867. PMID 19383306.
Werner S, Munz B (January 2000). "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo". Experimental Cell Research. 254 (1): 80–90. doi:10.1006/excr.1999.4726. PMID 10623468.
Whittock NV, Eady RA, McGrath JA (January 2000). "Genomic organization and amplification of the human keratin 15 and keratin 19 genes". Biochemical and Biophysical Research Communications. 267 (1): 462–465. doi:10.1006/bbrc.1999.1966. PMID 10623642.
Al-Refu K, Goodfield M (May 2009). "Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus". Autoimmunity Reviews. 8 (6): 474–477. doi:10.1016/j.autrev.2008.12.015. PMID 19162247.
This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.
keratin, protein, that, humans, encoded, krt15, gene, also, been, referred, cytokeratin, k1co, krtb, krt15identifiersaliaseskrt15, ck15, k1co, keratin, 15external, idsomim, 148030, 96689, homologene, 1712, genecards, krt15gene, location, human, chromosome, hum. Keratin 15 is a protein that in humans is encoded by the KRT15 gene 5 6 It has also been referred to as cytokeratin 15 K1CO and KRTB KRT15IdentifiersAliasesKRT15 CK15 K15 K1CO keratin 15External IDsOMIM 148030 MGI 96689 HomoloGene 1712 GeneCards KRT15Gene location Human Chr Chromosome 17 human 1 Band17q21 2Start41 513 745 bp 1 End41 522 529 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 D 11 63 41 cMStart100 022 584 bp 2 End100 026 754 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomengumscervix epitheliumvulvanippleoral cavityhair folliclelactiferous ducthuman penisbody of tongueTop expressed inconjunctival fornixskin of abdomenlipesophaguscorneaskin of backbelly cordtracheaciliary bodycondyleMore reference expression dataBioGPSn aGene ontologyMolecular functionscaffold protein binding structural constituent of cytoskeleton protein binding structural molecule activityCellular componentextracellular exosome intermediate filament nucleus cytosolBiological processepidermis development cytoskeleton organization keratinization cornificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez386616665EnsemblENSG00000171346ENSMUSG00000054146UniProtP19012Q61414RefSeq mRNA NM 002275NM 008469RefSeq protein NP 002266NP 032495Location UCSC Chr 17 41 51 41 52 MbChr 11 100 02 100 03 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseKeratin 15 is a type I cytokeratin It is well expressed in the basal layer of complex epithelia However acral keratinocytes express little to no keratin 15 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000171346 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000054146 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Barletta C Batticane N Ragusa RM Leube R Peschle C Romano V 1990 Subchromosomal localization of two human cytokeratin genes KRT4 and KRT15 by in situ hybridization Cytogenetics and Cell Genetics 54 3 4 148 150 doi 10 1159 000132979 PMID 1702379 Schweizer J Bowden PE Coulombe PA Langbein L Lane EB Magin TM et al July 2006 New consensus nomenclature for mammalian keratins The Journal of Cell Biology 174 2 169 174 doi 10 1083 jcb 200603161 PMC 2064177 PMID 16831889 Merleev AA Le ST Alexanian C Toussi A Xie Y Marusina AI et al August 2022 Biogeographic and disease specific alterations in epidermal lipid composition and single cell analysis of acral keratinocytes JCI Insight 7 16 e159762 doi 10 1172 jci insight 159762 PMC 9462509 PMID 35900871 Further reading editRadoja N Stojadinovic O Waseem A Tomic Canic M Milisavljevic V Teebor S Blumenberg M April 2004 Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription Molecular and Cellular Biology 24 8 3168 3179 doi 10 1128 MCB 24 8 3168 3179 2004 PMC 381600 PMID 15060141 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N et al October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 1178 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Rittie L Stoll SW Kang S Voorhees JJ Fisher GJ December 2009 Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin Aging Cell 8 6 738 751 doi 10 1111 j 1474 9726 2009 00526 x hdl 2027 42 78718 PMID 20050020 S2CID 8832389 Waseem A Dogan B Tidman N Alam Y Purkis P Jackson S et al March 1999 Keratin 15 expression in stratified epithelia downregulation in activated keratinocytes The Journal of Investigative Dermatology 112 3 362 369 doi 10 1046 j 1523 1747 1999 00535 x PMID 10084315 Blumenberg M Savtchenko ES 1986 Linkage of human keratin genes Cytogenetics and Cell Genetics 42 1 2 65 71 doi 10 1159 000132253 PMID 2424675 Marchuk D McCrohon S Fuchs E March 1985 Complete sequence of a gene encoding a human type I keratin sequences homologous to enhancer elements in the regulatory region of the gene Proceedings of the National Academy of Sciences of the United States of America 82 6 1609 1613 Bibcode 1985PNAS 82 1609M doi 10 1073 pnas 82 6 1609 PMC 397321 PMID 2580298 Bader BL Jahn L Franke WW December 1988 Low level expression of cytokeratins 8 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom with an analysis of the chromosomal locus containing the cytokeratin 19 gene European Journal of Cell Biology 47 2 300 319 PMID 2468493 Choi CW Park HS Kim YK Lee SH Cho KH August 2008 Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma The Journal of Dermatology 35 8 499 502 doi 10 1111 j 1346 8138 2008 00510 x PMID 18789069 S2CID 36019385 Romano V Bosco P Rocchi M Costa G Leube RE Franke WW Romeo G 1988 Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes Cytogenetics and Cell Genetics 48 3 148 151 doi 10 1159 000132612 PMID 2466616 Leube RE Bader BL Bosch FX Zimbelmann R Achtstaetter T Franke WW April 1988 Molecular characterization and expression of the stratification related cytokeratins 4 and 15 The Journal of Cell Biology 106 4 1249 1261 doi 10 1083 jcb 106 4 1249 PMC 2114990 PMID 2452170 Hanukoglu I Fuchs E November 1982 The cDNA sequence of a human epidermal keratin divergence of sequence but conservation of structure among intermediate filament proteins Cell 31 1 243 252 doi 10 1016 0092 8674 82 90424 X PMID 6186381 S2CID 35796315 Celis JE Gromova I Cabezon T Gromov P Shen T Timmermans Wielenga V et al December 2007 Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15 relationship between CK15 progenitor amplified cells and pre malignant lesions and invasive disease Molecular Oncology 1 3 321 349 doi 10 1016 j molonc 2007 09 004 PMC 5543867 PMID 19383306 Werner S Munz B January 2000 Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo Experimental Cell Research 254 1 80 90 doi 10 1006 excr 1999 4726 PMID 10623468 Whittock NV Eady RA McGrath JA January 2000 Genomic organization and amplification of the human keratin 15 and keratin 19 genes Biochemical and Biophysical Research Communications 267 1 462 465 doi 10 1006 bbrc 1999 1966 PMID 10623642 Al Refu K Goodfield M May 2009 Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus Autoimmunity Reviews 8 6 474 477 doi 10 1016 j autrev 2008 12 015 PMID 19162247 nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Keratin 15 amp oldid 1183903197, wikipedia, wiki, book, books, library,
