The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[6]
References
^ abcGRCh38: Ensembl release 89: ENSG00000151657 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037262 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R (Nov 1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. doi:10.1093/nar/19.19.5117. PMC328864. PMID 1923796.
^ ab"Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)".
Further reading
Biard DS, Saintigny Y, Maratrat M, et al. (1997). "Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin" (PDF). Arch. Dermatol. Res. 289 (8): 448–56. doi:10.1007/s004030050220. PMID 9266022. S2CID 25828778.
Kannouche P, Angulo JF (1999). "Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells". J. Cell Sci. 112 (19): 3215–24. doi:10.1242/jcs.112.19.3215. PMID 10504327.
Blattner C, Kannouche P, Litfin M, et al. (2000). "UV-Induced stabilization of c-fos and other short-lived mRNAs". Mol. Cell. Biol. 20 (10): 3616–25. doi:10.1128/MCB.20.10.3616-3625.2000. PMC85654. PMID 10779351.
Kannouche P, Mauffrey P, Pinon-Lataillade G, et al. (2000). "Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans". Carcinogenesis. 21 (9): 1701–10. doi:10.1093/carcin/21.9.1701. PMID 10964102.
Biard DS, Miccoli L, Despras E, et al. (2002). "Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells". J. Biol. Chem. 277 (21): 19156–65. doi:10.1074/jbc.M200321200. PMID 11880372.
Miccoli L, Biard DS, Créminon C, Angulo JF (2002). "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication". Cancer Res. 62 (19): 5425–35. PMID 12359749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Masson C, Menaa F, Pinon-Lataillade G, et al. (2003). "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 616–21. Bibcode:2003PNAS..100..616M. doi:10.1073/pnas.0236176100. PMC141045. PMID 12525703.
Despras E, Miccoli L, Créminon C, et al. (2003). "Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells". Radiat. Res. 159 (6): 748–58. Bibcode:2003RadR..159..748D. doi:10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2. ISSN 0033-7587. PMID 12751957. S2CID 10841640.
Biard DS, Miccoli L, Despras E, et al. (2004). "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes". Mol. Cancer Res. 1 (7): 519–31. PMID 12754299.
Miccoli L, Biard DS, Frouin I, et al. (2003). "Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner". Nucleic Acids Res. 31 (14): 4162–75. doi:10.1093/nar/gkg459. PMC165974. PMID 12853634.
Miccoli L, Frouin I, Novac O, et al. (2005). "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins". Mol. Cell. Biol. 25 (9): 3814–30. doi:10.1128/MCB.25.9.3814-3830.2005. PMC1084281. PMID 15831485.
le Maire A, Schiltz M, Braud S, et al. (2006). "Crystallization and halide phasing of the C-terminal domain of human KIN17". Acta Crystallographica Section F. 62 (Pt 3): 245–8. doi:10.1107/S174430910600409X. PMC2197188. PMID 16511313.
le Maire A, Schiltz M, Stura EA, et al. (2007). "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics" (PDF). J. Mol. Biol. 364 (4): 764–76. doi:10.1016/j.jmb.2006.09.033. PMID 17045609.
External links
Overview of all the structural information available in the PDB for UniProt: O60870 (DNA/RNA-binding protein KIN17) at the PDBe-KB.
This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.
gene, binding, protein, kin17, protein, that, humans, encoded, gene, kinavailable, structurespdbortholog, search, pdbe, rcsblist, codes2ckk, 2v1nidentifiersaliaseskin, btcd, kin17, rts2, kin17, binding, proteinexternal, idsomim, 601720, 96676, homologene, 8196. DNA RNA binding protein KIN17 is a protein that in humans is encoded by the KIN gene 5 6 KINAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2CKK 2V1NIdentifiersAliasesKIN BTCD KIN17 Rts2 Kin17 DNA and RNA binding proteinExternal IDsOMIM 601720 MGI 96676 HomoloGene 8196 GeneCards KINGene location Human Chr Chromosome 10 human 1 Band10p14Start7 750 962 bp 1 End7 787 993 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 A1Start10 085 404 bp 2 End10 097 617 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocyteAchilles tendonganglionic eminenceleft lobe of thyroid glandpopliteal arterybody of pancreasleft uterine tubeascending aortaleft coronary arteryendothelial cellTop expressed inankle jointyolk sacganglionic eminencethymussupraoptic nucleusmorulaascending aortamaxillary prominencesecondary oocyteprimitive streakMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding double stranded DNA binding metal ion binding RNA binding protein bindingCellular componentcytoplasm nuclear matrix intracellular membrane bounded organelle nucleus nucleoplasm protein containing complexBiological processDNA replication mRNA processing DNA recombination viral process DNA repair cellular response to DNA damage stimulusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2294416588EnsemblENSG00000151657ENSMUSG00000037262UniProtO60870Q8K339RefSeq mRNA NM 012311NM 025280RefSeq protein NP 036443NP 079556Location UCSC Chr 10 7 75 7 79 MbChr 2 10 09 10 1 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle Short wave ultraviolet light provokes the relocalization of the protein suggesting its participation in the cellular response to DNA damage Originally selected based on protein binding with RecA antibodies the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein a characteristic shared by this human ortholog 6 References Edit a b c GRCh38 Ensembl release 89 ENSG00000151657 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000037262 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Angulo JF Rouer E Mazin A Mattei MG Tissier A Horellou P Benarous R Devoret R Nov 1991 Identification and expression of the cDNA of KIN17 a zinc finger gene located on mouse chromosome 2 encoding a new DNA binding protein Nucleic Acids Res 19 19 5117 23 doi 10 1093 nar 19 19 5117 PMC 328864 PMID 1923796 a b Entrez Gene KIN KIN antigenic determinant of recA protein homolog mouse Further reading EditBiard DS Saintigny Y Maratrat M et al 1997 Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin PDF Arch Dermatol Res 289 8 448 56 doi 10 1007 s004030050220 PMID 9266022 S2CID 25828778 Kannouche P Angulo JF 1999 Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells J Cell Sci 112 19 3215 24 doi 10 1242 jcs 112 19 3215 PMID 10504327 Blattner C Kannouche P Litfin M et al 2000 UV Induced stabilization of c fos and other short lived mRNAs Mol Cell Biol 20 10 3616 25 doi 10 1128 MCB 20 10 3616 3625 2000 PMC 85654 PMID 10779351 Kannouche P Mauffrey P Pinon Lataillade G et al 2000 Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans Carcinogenesis 21 9 1701 10 doi 10 1093 carcin 21 9 1701 PMID 10964102 Biard DS Miccoli L Despras E et al 2002 Ionizing radiation triggers chromatin bound kin17 complex formation in human cells J Biol Chem 277 21 19156 65 doi 10 1074 jbc M200321200 PMID 11880372 Miccoli L Biard DS Creminon C Angulo JF 2002 Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication Cancer Res 62 19 5425 35 PMID 12359749 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Masson C Menaa F Pinon Lataillade G et al 2003 Global genome repair is required to activate KIN17 a UVC responsive gene involved in DNA replication Proc Natl Acad Sci U S A 100 2 616 21 Bibcode 2003PNAS 100 616M doi 10 1073 pnas 0236176100 PMC 141045 PMID 12525703 Despras E Miccoli L Creminon C et al 2003 Depletion of KIN17 a human DNA replication protein increases the radiosensitivity of RKO cells Radiat Res 159 6 748 58 Bibcode 2003RadR 159 748D doi 10 1667 0033 7587 2003 159 0748 DOKAHD 2 0 CO 2 ISSN 0033 7587 PMID 12751957 S2CID 10841640 Biard DS Miccoli L Despras E et al 2004 Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes Mol Cancer Res 1 7 519 31 PMID 12754299 Miccoli L Biard DS Frouin I et al 2003 Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage and cell cycle regulated manner Nucleic Acids Res 31 14 4162 75 doi 10 1093 nar gkg459 PMC 165974 PMID 12853634 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Miccoli L Frouin I Novac O et al 2005 The human stress activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins Mol Cell Biol 25 9 3814 30 doi 10 1128 MCB 25 9 3814 3830 2005 PMC 1084281 PMID 15831485 le Maire A Schiltz M Braud S et al 2006 Crystallization and halide phasing of the C terminal domain of human KIN17 Acta Crystallographica Section F 62 Pt 3 245 8 doi 10 1107 S174430910600409X PMC 2197188 PMID 16511313 le Maire A Schiltz M Stura EA et al 2007 A tandem of SH3 like domains participates in RNA binding in KIN17 a human protein activated in response to genotoxics PDF J Mol Biol 364 4 764 76 doi 10 1016 j jmb 2006 09 033 PMID 17045609 External links EditOverview of all the structural information available in the PDB for UniProt O60870 DNA RNA binding protein KIN17 at the PDBe KB This article on a gene on human chromosome 10 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title KIN gene amp oldid 1116598842, wikipedia, wiki, book, books, library,
