Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000162728 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038026 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG (Oct 1995). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics. 29 (3): 808–9. doi:10.1006/geno.1995.9928. PMID 8575783.
^Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
^Jelacic TM, Kennedy ME, Wickman K, Clapham DE (Nov 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.
^Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (Nov 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
Further readingEdit
Jelacic TM, Sims SM, Clapham DE (May 1999). "Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3". The Journal of Membrane Biology. 169 (2): 123–9. doi:10.1007/s002329900524. PMID 10341034. S2CID 13538678.
Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH (Dec 1999). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cellular Signalling. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.
Vaughn J, Wolford JK, Prochazka M, Permana PA (Aug 2000). "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)". Biochemical and Biophysical Research Communications. 274 (2): 302–9. doi:10.1006/bbrc.2000.3136. PMID 10913335.
Jelacic TM, Kennedy ME, Wickman K, Clapham DE (Nov 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.
Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (Nov 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer. 5: 104. doi:10.1186/1471-2407-5-104. PMC1208863. PMID 16109170.
kcnj9, protein, activated, inward, rectifier, potassium, channel, protein, that, humans, encoded, gene, identifiersaliases, girk3, kir3, potassium, voltage, gated, channel, subfamily, member, potassium, inwardly, rectifying, channel, subfamily, member, 9extern. G protein activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene 5 6 7 KCNJ9IdentifiersAliasesKCNJ9 GIRK3 KIR3 3 potassium voltage gated channel subfamily J member 9 potassium inwardly rectifying channel subfamily J member 9External IDsOMIM 600932 MGI 108007 HomoloGene 37989 GeneCards KCNJ9Gene location Human Chr Chromosome 1 human 1 Band1q23 2Start160 081 538 bp 1 End160 090 563 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H3 1 79 66 cMStart172 148 068 bp 2 End172 156 885 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmiddle temporal gyrusBrodmann area 23dorsolateral prefrontal cortexsuperior frontal gyrusprefrontal cortexpostcentral gyrusentorhinal cortexcingulate gyrusBrodmann area 9endothelial cellTop expressed incerebellar vermismedial dorsal nucleuslateral geniculate nucleusmedial geniculate nucleuscingulate gyrusprimary motor cortexentorhinal cortexsuperior frontal gyrusmammillary bodysuperior colliculusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding inward rectifier potassium channel activity voltage gated ion channel activity G protein activated inward rectifier potassium channel activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membrane parallel fiber to Purkinje cell synapse integral component of presynaptic membraneBiological processpotassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membraneSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez376516524EnsemblENSG00000162728ENSMUSG00000038026UniProtQ92806P48543RefSeq mRNA NM 004983NM 008429NM 001360808RefSeq protein NP 004974NP 032455NP 001347737Location UCSC Chr 1 160 08 160 09 MbChr 1 172 15 172 16 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction EditPotassium channels are present in most mammalian cells where they participate in a wide range of physiologic responses The protein encoded by this gene is an integral membrane protein and inward rectifier type potassium channel The encoded protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell is controlled by G proteins It associates with another G protein activated potassium channel to form a heteromultimeric pore forming complex 7 Interactions EditKCNJ9 has been shown to interact with KCNJ6 8 9 See also EditG protein coupled inwardly rectifying potassium channel Inward rectifier potassium ion channelReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000162728 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038026 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lesage F Fink M Barhanin J Lazdunski M Mattei MG Oct 1995 Assignment of human G protein coupled inward rectifier K channel homolog GIRK3 gene to chromosome 1q21 q23 Genomics 29 3 808 9 doi 10 1006 geno 1995 9928 PMID 8575783 Kubo Y Adelman JP Clapham DE Jan LY Karschin A Kurachi Y Lazdunski M Nichols CG Seino S Vandenberg CA Dec 2005 International Union of Pharmacology LIV Nomenclature and molecular relationships of inwardly rectifying potassium channels Pharmacological Reviews 57 4 509 26 doi 10 1124 pr 57 4 11 PMID 16382105 S2CID 11588492 a b Entrez Gene KCNJ9 potassium inwardly rectifying channel subfamily J member 9 Jelacic TM Kennedy ME Wickman K Clapham DE Nov 2000 Functional and biochemical evidence for G protein gated inwardly rectifying K GIRK channels composed of GIRK2 and GIRK3 The Journal of Biological Chemistry 275 46 36211 6 doi 10 1074 jbc M007087200 PMID 10956667 Lavine N Ethier N Oak JN Pei L Liu F Trieu P Rebois RV Bouvier M Hebert TE Van Tol HH Nov 2002 G protein coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase The Journal of Biological Chemistry 277 48 46010 9 doi 10 1074 jbc M205035200 PMID 12297500 Further reading EditJelacic TM Sims SM Clapham DE May 1999 Functional expression and characterization of G protein gated inwardly rectifying K channels containing GIRK3 The Journal of Membrane Biology 169 2 123 9 doi 10 1007 s002329900524 PMID 10341034 S2CID 13538678 Schoots O Wilson JM Ethier N Bigras E Hebert TE Van Tol HH Dec 1999 Co expression of human Kir3 subunits can yield channels with different functional properties Cellular Signalling 11 12 871 83 doi 10 1016 S0898 6568 99 00059 5 PMID 10659995 Vaughn J Wolford JK Prochazka M Permana PA Aug 2000 Genomic structure and expression of human KCNJ9 Kir3 3 GIRK3 Biochemical and Biophysical Research Communications 274 2 302 9 doi 10 1006 bbrc 2000 3136 PMID 10913335 Jelacic TM Kennedy ME Wickman K Clapham DE Nov 2000 Functional and biochemical evidence for G protein gated inwardly rectifying K GIRK channels composed of GIRK2 and GIRK3 The Journal of Biological Chemistry 275 46 36211 6 doi 10 1074 jbc M007087200 PMID 10956667 Lavine N Ethier N Oak JN Pei L Liu F Trieu P Rebois RV Bouvier M Hebert TE Van Tol HH Nov 2002 G protein coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase The Journal of Biological Chemistry 277 48 46010 9 doi 10 1074 jbc M205035200 PMID 12297500 Plummer HK Dhar MS Cekanova M Schuller HM 2006 Expression of G protein inwardly rectifying potassium channels GIRKs in lung cancer cell lines BMC Cancer 5 104 doi 10 1186 1471 2407 5 104 PMC 1208863 PMID 16109170 External links EditKCNJ9 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain This membrane protein related 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