Pines research investigates cyclin, the cell cycle and mitosis.[2] He pioneered the use of fluorescent tags to analyse the dynamic behaviour and stability of these regulators in living cells.[6]
Pines discoveries have revealed that mitotic regulators are targeted to specific substructures at specific times, and that mitosis is exquisitely coordinated by the destruction of key regulators at different times in cell division. Pines work has provided insights into how chromosome behaviour in mitosis controls both the time and the rate at which essential mitotic regulators are destroyed, and these discoveries have wider implications for how cancers develop.[6]
He has made key discoveries in the cell cycle field, many of which have opened up new avenues of research. He cloned the original 'cyclin' as a PhD student with Tim Hunt and demonstrated that it had mitosis-promoting activity. This discovery was essential to the subsequent cloning of Xenopus cyclins and kept the Hunt lab at the forefront of cyclin research. Subsequently he cloned and characterised the first human cyclins with Tony Hunter. This was crucial to recognising that cyclins are conserved critical regulators of cell division. He provided the first evidence that there is a family of cyclin-dependent kinases by identifying the second Cdk, Cdk2, and identified the first link between cyclins and oncoproteins by showing that cyclin A bound to adenovirus E1A, thus linking cyclins to the E2F/Retinoblastoma pathway. These discoveries sparked intensive efforts by many laboratories. In leading his own group he has shown the importance of analysing both the spatial and temporal control of the cell cycle, pioneering fluorescence time-lapse microscopy to study the cell cycle. After discovering that mitotic cyclins localise to different sub-cellular compartments he showed how they dynamically specify their localisation. Recently, he discovered that the mitotic kinase, cyclin B1-Cdk1 is activated on centrosomes, and thereby prompted considerable interest in the role of the centrosome in initiating mitosis. He has developed a novel live-cell assay for proteolysis and uncovered new mechanisms by which cells control mitosis. His analyses have shown how ubiquitin-mediated proteolysis coordinates chromosome congression with cytokinesis and mitotic exit by degrading specific proteins at specific times.[5]
^Draviam, Viji Mythily (2002). Studies on human B- type cyclins. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 894595569. EThOS uk.bl.ethos.620365.
^ abAnon (2017). "Pines, Prof. Jonathon Noë Joseph". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U287310. (Subscription or UK public library membership required.)
^ abcAnon (2016). . London: acmedsci.ac.uk. Archived from the original on 10 May 2016.
^ abcdAnon (2016). . London: Royal Society. Archived from the original on 29 April 2016. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --. Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
^ ab. Cambridge: University of Cambridge. Archived from the original on 9 March 2016.
^Pines, Jonathon Noe Joseph (1987). Cyclin: a major maternal message in sea urchin eggs. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 499166627. EThOS uk.bl.ethos.233321.
^Pines, Jonathon; Hunt, Tim (1987). "Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs". The EMBO Journal. 6 (10): 2987–2995. doi:10.1002/j.1460-2075.1987.tb02604.x. PMC553735. PMID 2826125.
^ ab. Cambridge: University of Cambridge. Archived from the original on 15 May 2015.
^Pines, Jonathon; Hunter, Tony (1990). "Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B". Nature. 346 (6286): 760–763. Bibcode:1990Natur.346..760P. doi:10.1038/346760a0. PMID 2143810. S2CID 4333058.
^Hunter, Tony; Pines, Jonathon (1994). "Cyclins and cancer II: Cyclin D and CDK inhibitors come of age". Cell. 79 (4): 573–582. doi:10.1016/0092-8674(94)90543-6. PMID 7954824. S2CID 24867886.
^Professor Jonathon Pines on his election to the Royal Society on YouTube Institute of Cancer Research, London
^Professor Jonathon Pines elected as a Fellow of the Royal Society on YouTube Institute of Cancer Research, London
November 01, 2023
jonathon, pines, jonathon, noë, joseph, pines, fmedsci, born, october, 1961, head, cancer, biology, division, institute, cancer, research, london, formerly, senior, group, leader, gurdon, institute, university, cambridge, fmedscipines, 2016bornjonathon, noë, j. Jonathon Noe Joseph Pines FRS FMedSci 5 6 born 11 October 1961 4 is Head of the Cancer Biology Division at the Institute of Cancer Research in London He was formerly a senior group leader at the Gurdon Institute at the University of Cambridge 5 7 Jonathon PinesFRS FMedSciPines in 2016BornJonathon Noe Joseph Pines 1961 10 11 11 October 1961 age 62 4 Alma materUniversity of Cambridge BA PhD AwardsEMBO Member 2001 1 Scientific careerFieldsCyclin Mitosis Cell cycle 2 InstitutionsGurdon Institute Institute of Cancer Research Salk Institute for Biological StudiesThesisCyclin a major maternal message in sea urchin eggs 1987 Doctoral advisorTim HuntOther academic advisorsAnthony R HunterDoctoral studentsViji Draviam 3 Websiteicr wbr ac wbr uk wbr our research wbr researchers and teams wbr professor jonathon pines Contents 1 Education 2 Research and career 2 1 Awards and honours 3 ReferencesEducation editPines was educated at the University of Cambridge where he was awarded a PhD in 1987 for research on cyclin in sea urchin eggs 8 supervised by Tim Hunt 9 10 Research and career editFollowing his PhD Pines was a postdoctoral researcher supervised by Anthony R Hunter at the Salk Institute in La Jolla California 10 11 12 13 before moving to the Gurdon Institute at the University of Cambridge then the Institute of Cancer Research in 2015 7 Pines research investigates cyclin the cell cycle and mitosis 2 He pioneered the use of fluorescent tags to analyse the dynamic behaviour and stability of these regulators in living cells 6 Pines discoveries have revealed that mitotic regulators are targeted to specific substructures at specific times and that mitosis is exquisitely coordinated by the destruction of key regulators at different times in cell division Pines work has provided insights into how chromosome behaviour in mitosis controls both the time and the rate at which essential mitotic regulators are destroyed and these discoveries have wider implications for how cancers develop 6 Since 2020 Pines has been Editor in Chief of the Royal Society journal Open Biology Awards and honours edit Pines was elected a member of the European Molecular Biology Organisation EMBO in 2001 1 and a Fellow of the Academy of Medical Sciences FMedSci in 2005 His citation on election reads He has made key discoveries in the cell cycle field many of which have opened up new avenues of research He cloned the original cyclin as a PhD student with Tim Hunt and demonstrated that it had mitosis promoting activity This discovery was essential to the subsequent cloning of Xenopus cyclins and kept the Hunt lab at the forefront of cyclin research Subsequently he cloned and characterised the first human cyclins with Tony Hunter This was crucial to recognising that cyclins are conserved critical regulators of cell division He provided the first evidence that there is a family of cyclin dependent kinases by identifying the second Cdk Cdk2 and identified the first link between cyclins and oncoproteins by showing that cyclin A bound to adenovirus E1A thus linking cyclins to the E2F Retinoblastoma pathway These discoveries sparked intensive efforts by many laboratories In leading his own group he has shown the importance of analysing both the spatial and temporal control of the cell cycle pioneering fluorescence time lapse microscopy to study the cell cycle After discovering that mitotic cyclins localise to different sub cellular compartments he showed how they dynamically specify their localisation Recently he discovered that the mitotic kinase cyclin B1 Cdk1 is activated on centrosomes and thereby prompted considerable interest in the role of the centrosome in initiating mitosis He has developed a novel live cell assay for proteolysis and uncovered new mechanisms by which cells control mitosis His analyses have shown how ubiquitin mediated proteolysis coordinates chromosome congression with cytokinesis and mitotic exit by degrading specific proteins at specific times 5 Pines was elected a Fellow of the Royal Society FRS in 2016 6 14 15 References edit a b EMBO member Jonathon Pines Heidelberg EMBO a b Jonathon Pines publications indexed by Google Scholar Draviam Viji Mythily 2002 Studies on human B type cyclins cam ac uk PhD thesis University of Cambridge OCLC 894595569 EThOS uk bl ethos 620365 a b Anon 2017 Pines Prof Jonathon Noe Joseph Who s Who online Oxford University Press ed Oxford A amp C Black doi 10 1093 ww 9780199540884 013 U287310 Subscription or UK public library membership required a b c Anon 2016 Dr Jonathon Pines FMedSci London acmedsci ac uk Archived from the original on 10 May 2016 a b c d Anon 2016 Dr Jonathon Pines FRS London Royal Society Archived from the original on 29 April 2016 One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies Archived from the original on 25 September 2015 Retrieved 9 March 2016 a href Template Cite web html title Template Cite web cite web a CS1 maint bot original URL status unknown link a b Jonathon Pines PhD FMedSci Cancer Research UK Director of Research in Cell Division Member of the Zoology Department Cambridge University of Cambridge Archived from the original on 9 March 2016 Pines Jonathon Noe Joseph 1987 Cyclin a major maternal message in sea urchin eggs cam ac uk PhD thesis University of Cambridge OCLC 499166627 EThOS uk bl ethos 233321 Pines Jonathon Hunt Tim 1987 Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs The EMBO Journal 6 10 2987 2995 doi 10 1002 j 1460 2075 1987 tb02604 x PMC 553735 PMID 2826125 a b Dr Jonathon Pines Department of Zoology Cambridge University of Cambridge Archived from the original on 15 May 2015 Pines Jonathon Hunter Tony 1990 Human cyclin A is adenovirus E1A associated protein p60 and behaves differently from cyclin B Nature 346 6286 760 763 Bibcode 1990Natur 346 760P doi 10 1038 346760a0 PMID 2143810 S2CID 4333058 Hunter Tony Pines Jonathon 1991 Cyclins and cancer Cell 66 6 1071 1074 doi 10 1016 0092 8674 91 90028 W PMID 1833062 S2CID 29568380 Hunter Tony Pines Jonathon 1994 Cyclins and cancer II Cyclin D and CDK inhibitors come of age Cell 79 4 573 582 doi 10 1016 0092 8674 94 90543 6 PMID 7954824 S2CID 24867886 Professor Jonathon Pines on his election to the Royal Society on YouTube Institute of Cancer Research London Professor Jonathon Pines elected as a Fellow of the Royal Society on YouTube Institute of Cancer Research London Retrieved from https en wikipedia org w index php title Jonathon Pines amp oldid 1170375724, wikipedia, wiki, book, books, library,
