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John Raymond Hobbs

January 01, 1970

John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 – 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health.[1]

John Raymond Hobbs
Professor John Hobbs
Born17 April 1929
Aldershot, Hampshire, England
Died13 July 2008(2008-07-13) (aged 79)
Uxbridge, London, England
EducationMiddlesex Hospital, London
OccupationProfessor of Chemical Immunology
SpousePatricia Hobbs
Parent(s)Frederick Walter Haydn Hobbs, Anna Helena Hobbs.

Early life edit

John Hobbs was born in Aldershot. He was the third son of four male children of a soldier's family. His family moved around considerably due to his father's career in the British Army. The family eventually settled in his father's home town of Plymouth in the county of Devon. During the Second World War, John, along with his three brothers Frederick, William and Dennis, were evacuated from blitz-torn Plymouth to Penzance. He left school at 16 and worked as a pathology laboratory assistant and did his National Service in Egypt with the British Army Medical Corps. After National Service, John used the money he had saved from his army sergeant's pay to put himself into Plymouth and Devonport Technical College where he achieved an External Inter.BSc within 9 months, gaining a state scholarship to study medicine, where he chose the Middlesex Hospital in London and won 7 prizes. From 1968–1996 Hobbs received 4 national prizes, 15 international awards and 4 honorary fellowships

Medicine edit

 
Bone marrow harvest

He specialised in Pathology and in 1963 was appointed consultant at Hammersmith Hospital, London. In 1970 he was appointed as Professor of Chemical Pathology at Westminster Medical School. In the early 1970s Professor Hobbs's Westminster team were doing ground breaking work. In 1970 the world's first successful intended stem cell transplant for a previously fatal human disease.[2] In 1971 the first British Bone Marrow Transplant using bone marrow from a matching sibling.[3] In the following year a transplant was successful using the bone marrow from father to son.[4] In April 1973 Hobbs and his team were able to achieve the world's first bone marrow transplant using a matched but unrelated volunteer donor.[5][6] With the success of this procedure steps were taken by professor Hobbs's team to set up the world's first unrelated bone marrow donor register. The tissue typing specialist of the team, David James, was instrumental in the setting up and the administration of this ground breaking register which was later named after Anthony Nolan.[7] It established the future use of unrelated donors to patients, so far for over 10,000 people. This initiative was the blue print which would be copied around the world. The Westminster team completed 285 transplants before it and its specialist unit's sudden, unexpected, enforced closure, effectively in autumn of 1992. Tragically, this left a waiting list of children with virtually nowhere else in Britain to go for treatment of their genetic diseases and inborn errors. However, Hobbs had founded the COrrection of GEnetic diseases by Transplantation or COGENT movement, with a charitable trust which attracted £13 million 1971–2007. The remaining balance, with the assistance of the late Professor Anthony Oakhill, was used to create a new unit at the Royal Hospital for Sick Children in the city of Bristol, and so allowing work to be continued. It is now headed by Colin Steward.[8] As for the children who were treated by Hobbs's bone marrow team at the Westminster hospital, most of these children now enjoy full lives as adults.

Passing on his Knowledge edit

Hobbs became an enthusiastic and accomplished teacher and accepted invitations to lecture (over 30 endowed) in 58 different countries (in over half of Europe's medical schools, 25 in the US and over 30 of the Commonwealth universities)He was given the status of visiting professor on over 25 occasions and he contributed to many international meetings and committees. He was re-invited many times and Presidential status was awarded to him in 5 different scientific meetings. He acted as an advisor to Health Ministers in Russia, Poland, Uruguay, Hong Kong, China and Peru.[citation needed]

Throughout 30 years as a recognised teacher Hobbs encouraged his juniors. 134 university higher degrees were achieved by trainees for work completed within the departments he headed; 48 full university chairs have been awarded to such staff; 70 have become members or fellows of the royal College of Pathologists (including 18 non-medical); 12 scientific staff were helped to medical degrees; together with 42 students contemporary with his daughters.[citation needed]

Achievements edit

  • In Protein biochemistry – proved females treated for iron deficiency achieved the male normal range for haemoglobin blood levels;[9] the preexisting 'normal' ranges for females were no longer acceptable.
  • From monitoring the Myeloma Trials, the first to describe the natural history of myelomatosis[10][11] and helped in 1971 to set up the Protein Reference Units which save the national health service £3 million each year. Hobbs retired as PRU chairman in 1994.
  • Established the first non-invasive screening test of the newborn to detect those affected by cystic fibrosis 1968[12]
  • As Chairman of the Expert Panel on Proteins of the International Federation of Clinical Chemists (1971–1979) created International standards for many serum proteins.[13]
  • Developed successful uses of human tumour markers[14]
  • In Clinical Immunology,
  • Standardised methods and reagents (some for WHO) to provide normal ranges from 12 weeks gestation to old age for caucasian populations
  • Immunoglobolin levels.[15]
  • Responses to candida albicans.[16]
  • Complement activation.[17]
  • Mixed lymphocyte reaction[18] T-cell receptors.[19][20]
  • Phagocyte function.[21]
  • First to fully describe IgA deficiency.[22]
  • IgM deficiency[23] selective deficiency to staphylococci.[24]
  • Early to recognise a circulating subset of T-cells co-optable through Fc-receptors to become killer cells.[25]
  • Defined secondary deficiencies of B-cells>[26] and T-cells[27] and their possible treatments[28][29] predictable by cytofluorometry[30]
  • In Bone Marrow Transplantation he had been taught at Registrar level, by the late Joseph Humble at Westminster Hospital in 1959–61 and was a volunteer donor of 500 ml of his own bone marrow (under anaesthesia) to be used for research purposes. When he returned in 1970 as head of chemical Pathology and Immunology he created the Westminster Children's Bone Marrow Team and lead it until 1992 in its pioneering work to treat 133 children with otherwise fatal genetic diseases.[31][32][33][34][35][36][37][38][39][40] The team became so skilled that, of their last 56 transplants from matched family donors, all survived for over 100 days (a criterion for safety of the procedure). From matched unrelated donors 91% survived over 100 days. By 1992 these results were probably among the best in the world. The improvements in bone marrow transplantation introduced by Westminster have been published[41][42][43]
  • In Current Contents 1972, Hobbs was one of 11 British medical doctors included in a list of 'The World's top 1,000 scientists'.

Family edit

John Raymond Hobbs was third eldest of four brothers. He was also the father of three daughters and eight grandchildren.

Publications (some of 630) edit

7. Hobbs J.R., Bayliss, R.I.S., MacLagan, N.F. The routine use of 132-I in the diagnosis of thyroid disease (1963) Lancet, i, 8–13. (M.D. Thesis, London)

Hobbs, J. R. Displacement bone marrow transplantation and immunoprophylaxis for genetic diseases.Adv. Intern. Med. 33 (1987) 81–118

126 Valdimarrson, J.H., Higgs, J.M., Wells, R.S., Yamamura, M, Hobbs, J.R., Holt, P.J. Immune abnormalities associated with chronic mucocutaneous candidiasis, (1973) Cell Immunol. 6, 348–61

144 Ezeoke, A., Ferguson, N, Fakhri, O, Hekkens, W and Hobbs, J.R. Antibodies in the sera of celiac patients which can co-opt K-cells to attack gluten-labelled targets (1974) in W Hekkens, A.S. Pena (eds) Coeliac Disease, Stenfert Kroese/Leiden, pp 176–188

174 Hobbs, J.R., Barrett, A, de Souza, I., Morgan, L., Raggatt, P., Salih, H., Selection of anti-hormonal therapy of some cancers (1975) in D Minzuni et al. (eds) Host Defense Against Cancer and Its Potentiation, Univ of Tokyo Press, Tokyo/Univ. Park Press/Baltimore, pp 451–6

204 Hobbs J.R., Encouragement from research on the cancer of the individual patient (1977) in R.W. Raven, Outlook on Cancer, Plenum/London, pp 147–162

319 Hobbs J.R., AIDS (1984) letter B.J. Hosp. Med. 32:51

448 Hobbs J.R., The use of volunteer unrelated donors in J R Hobbs (ed) Correction of certain genetic diseases by transplantation, 1989, COGENT/London 1989: 147–158

484 Henderson D.C., Sheldon J., Riches P.G., Hobbs J.R. Cytokine induction of neopterin production, Clin Exp Immunol 1991; 83: 479–482

497 Wang Q., Rowbottom A., Riches P.G., Dadian G., Hobbs J.R. Combined detection of phenotype and Y chromosome by immunoenzymelabelling and in situ hybridisation on peripheral lymphocytes, J Immunol Methods 1991; 139: 251–5

547 Hobbs J.R., Wang Q., Henderson D.C., Downie C., Obaro S., Busulphan-cyclophosphamide induction used twice with 9/12 successes in the second bone-marrow transplant, COGENT 1992; 2: 127–135

630 Hobbs J.R., Further aspects of human immunoglobulin A deficiency, Ann Clin Biochem 2007; 44: 496–7

References edit

  1. ^ . The Daily Telegraph. 16 July 2008. Archived from the original on 13 May 2014. Retrieved 26 April 2012.
  2. ^ Hobbs J.R.., Letter to British Medical journal., 7 December 1998: Bone marrow stem cell transplants (from alternative donors) and Leukaemia.
  3. ^ Yamamura, M., Newton, R.C.F.., James, D.C.O., Humble, J.G.., Butler, L.F.., Hobbs, J.R. Uncomplicated HL-A matched sibling bone marrow graft from combined immune deficiency.1972 British Medical Journal. 2, 265–269
  4. ^ Hobbs, J.R.., Humble, J.G.., Anderson, I.M.., James, D.C.O., The elective treatment of graft-versus-host disease following a bone marrow graft from a father to a so with severe combined immunodeficiency. 1976 Postgraduate Medical Journal 52, (suppl.5) 90–94
  5. ^ Foroozanfar, H., Hobbs, J.R., Hugh-Jones, K., Humble, J.G., James, D.C.O., Selwyn, S., Watson, J.G., Yamamura, M. Bone marrow transplant from an unrelated donor for chronic granulomatous disease, 1977 Lancet I, 210–213
  6. ^ Hugh-Jones, K., Selwyn, S., Riches, P. Who pioneered the use of alternative donors (and stem cells from peripheral blood) in bone marrow transplantation? Arch. Dis. Child., 1991, 66: 102
  7. ^ . Archived from the original on 13 May 2008. Retrieved 20 May 2008. Anthony Nolan Trust
  8. ^ [1][permanent dead link] Colin Steward, Bristol
  9. ^ Hobbs, J.R. Iron deficiency after partial gastrectomy, I Aetiology, II Treatment (1961) Gut, 2, 141–149
  10. ^ Hobbs, J.R., Paraproteins, benign or malignant? 1967 British Medical Journal., 4, 699–704 (citation classic 1986)
  11. ^ Hobbs J.R., Immunocytoma o' mice an' men (1971) British Medical journal. 2, 67–72
  12. ^ Hobbs, J.R. First meconium in the detection of fibrocystic disease of the pancreas, (1968) Protides of the Biol Fluids, 16, 517–524
  13. ^ Hobbs, J.R., Harboe, N., Alper, C., Johansson, B.G. The human serum standard IFCC 74/1. 1979 Clin. Chim. Acta 98, 179F-186F.
  14. ^ Hobbs, J.R., Melino, G, Riches, P. Successful uses of tumour markers in man. In 'Protides of the Biological Fluids' 31. ed. H. Peeters. (1984) Pergamon/Oxford, pp. 255–262
  15. ^ Hobbs, J.R. Immunoglobulins in clinical chemistry, Chapter in Advances in Clinical Chemistry, Vol. 14, Eds. O. Bodansky, A.L. Latner, Academic Press, N.Y. pp. 219–317
  16. ^ Foroozanfar, N., Yamamura, M. and Hobbs, J.R. Standardization of lymphocyte transformation to candida immunogen, (1974) Clin.Exp.Immunol. 16, 301–310
  17. ^ Versey, J.M.B., Slater, L., Hobbs, J.R. Activation of complement in relation to disease, (1975) J.Clin.Path. 28, Suppl. 6. 38–44
  18. ^ Yamamura, M., Nikbin, B., Hobbs, J.R. Standardisation of the mixed lymphocyte reaction (1976) Journal of Immunological Methods 10, 367–8
  19. ^ Hobbs, J.R., Malka, S., Byrom, N.A. Density and inducibility of T-cell receptors in relation to the age of the lymphocyte donor and the conditions of culture. Protides Biol. Fluids 25, 605–610
  20. ^ Robinson, M., O’Donohue, J., Dadian, G., Wankowicz, A., Barltrop, B., Hobbs, J.R., An analysis of the normal ranges of lymphocyte subpopulations in children aged 5–13 years, Eur.J.Pediatr. 1996; 155: 535–539
  21. ^ Hobbs, J.R., Foroozanfar, N., Grohmann, Preci, H., Yegin, O. Deficienza fagocitarie(1984) La Clinica Terapeutica. 110: 367–373
  22. ^ Hobbs, J.R., Immune imbalance in dysgammaglobulinaemia, Type IV (now IgA deficiency) Lancet i1968 110–114
  23. ^ Hobbs, J.R. IgM Deficiency (1975) Birth Defects: Original Article Series IX, 1, 112–6. Publ. Sinauer/Sunderland, Mass., U.S.A.
  24. ^ Monteil, M., Hobbs, J.R., Citron, K. Selective immunodeficiency affecting staphylococcal response, (1987) Lancet, ii, 880–883
  25. ^ Fakhri, O., Hobbs, J.R. Target cell death without added complement after cooperation of 7S-antibodies with non-immune lymphocytes. (1972) Nature New Biology 235, 177–178
  26. ^ Hobbs, J.R. Secondary antibody deficiency,1968 Proc.R.Soc.Med. 61, 883–887
  27. ^ Hobbs, J.R. Deficiencias de linfocitos T, (1980) Rev.Bras.Alerg.Imunop., 2, 243–248
  28. ^ Riches, P.G., Hobbs, J.R. Mechanisms in secondary hypogammaglobulinaemia, (1979) J.Clin.Path, 32, Suppl. (Roy Coll Path) 13, 15–22
  29. ^ Byrom, N.A., Hobbs, J.R., eds Thymic factor therapy, (1985) Serono Symposia Publications, Vol. 16: 457pp. Raven Press NY.
  30. ^ Hobbs, J.R. Cytofluorometry to predict effects of biological response modifiers in Poulik D. et al. eds. 'Protides of the biological fluids' 1989; 36: 3–17
  31. ^ Hobbs, J. R., Barrett, A. J., Chambers, J. D., James, D. C. O., Hugh-Jones, K., Byrom, N., Henry, K. and Lucas, C. F. Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone marrow transplantation. Lancet 2 1981 709–712
  32. ^ Hobbs, J. R. Bone marrow transplantation for inborn errors.Lancet 2 1981 735–739
  33. ^ Hobbs, J. R. The scope of allogeneic bone marrow transplantation. In Losowsky, M. and Bolton, R. (eds.), Advanced Medicine Leeds, Pitman, Bath, 1983, pp. 378–391
  34. ^ Hobbs, J. R. Correction of 34 genetic diseases by displacement bone marrow transplantation.Plasma Ther. Transpl. Tech. 61985 221–246
  35. ^ Hobbs, J. R. and Hugh-Jones, K. Immunodeficiencies better treated by transplantation.Tokai J. Exp. Clin. Med. 10 1985 85–97
  36. ^ Hobbs, J.R., Williamson, S., Chambers, J.D., James, D.C.O., Joshi, R., Shaw, P. and Hugh-Jones, K. Use of donors sharing one genetic haplogype for bone marrow transplantation. Tokai J. Exp. Clin. Med. 10 1985 207–214
  37. ^ Hobbs, J. R., Hugh-Jones, K., Shaw, P., Lindsay, I. and Hancock, M., Beneficial effect of pretransplant splenectomy on displacement bone marrow transplantation for Gaucher's syndrome. Lancet 1 (1987) 1111–1115
  38. ^ Hobbs, J.R., Displacement bone marrow transplantation and immunoprophylaxis for genetic diseases, Adv. Inter. Med. 33 1987 81–118
  39. ^ Hobbs, J.R. (ed.) The correction of certain genetic diseases by transplantation, 1989, COGENT Press, Westminster, 1989, pp. 147–159
  40. ^ J. R. Hobbs, M. Monteil, D. R. McCluskey, E. Jurges and M. El Tumi, Chronic granulomatous disease 100% corrected by displacement bone marrow transplantation from a volunteer unrelated donor, 1992 Europ.J.Paed.151: 806–810
  41. ^ Hobbs, J.R., The achievements of the Westminster children’s bone marrow team for some genetic diseases. In Steward C.G. Hobbs, J.R. eds. Correction of genetic diseases by transplantation III, London COGENT, 1995:1–15
  42. ^ Hobbs, J.R., Immunology and replacement treatments of some genetic diseases. In Ringden, O., Hobbs, J.R., Steward C.G., eds. Correction of Genetic Diseases by Transplantation IV 1997, NOBEL symposium, COGENT press/ London 1997: 101–110
  43. ^ Hobbs, J.R., The Westminster contribution to the correction of thalassaemia major and other inborn anaemias. In Steward C.G., Hobbs, J.R. eds. Correction of genetic diseases by transplantation III, London COGENT, 1995: 80–89

References Compiled and amended with the help of J R Hobbs.

See also edit

January 01, 1970
john, raymond, hobbs, mrcs, frcp, frcpath, frcpaed, april, 1929, july, 2008, professor, forefront, techniques, clinical, immunology, protein, biochemistry, bone, marrow, transplantation, specifically, child, health, professor, john, hobbsborn17, april, 1929ald. John Raymond Hobbs MRCS FRCP FRCPath FRCPaed 17 April 1929 13 July 2008 was a professor who was at the forefront of the techniques of clinical immunology protein biochemistry and bone marrow transplantation specifically in child health 1 John Raymond HobbsProfessor John HobbsBorn17 April 1929Aldershot Hampshire EnglandDied13 July 2008 2008 07 13 aged 79 Uxbridge London EnglandEducationMiddlesex Hospital LondonOccupationProfessor of Chemical ImmunologySpousePatricia HobbsParent s Frederick Walter Haydn Hobbs Anna Helena Hobbs Contents 1 Early life 2 Medicine 3 Passing on his Knowledge 4 Achievements 5 Family 6 Publications some of 630 7 References 8 See alsoEarly life editJohn Hobbs was born in Aldershot He was the third son of four male children of a soldier s family His family moved around considerably due to his father s career in the British Army The family eventually settled in his father s home town of Plymouth in the county of Devon During the Second World War John along with his three brothers Frederick William and Dennis were evacuated from blitz torn Plymouth to Penzance He left school at 16 and worked as a pathology laboratory assistant and did his National Service in Egypt with the British Army Medical Corps After National Service John used the money he had saved from his army sergeant s pay to put himself into Plymouth and Devonport Technical College where he achieved an External Inter BSc within 9 months gaining a state scholarship to study medicine where he chose the Middlesex Hospital in London and won 7 prizes From 1968 1996 Hobbs received 4 national prizes 15 international awards and 4 honorary fellowshipsMedicine edit nbsp Bone marrow harvest He specialised in Pathology and in 1963 was appointed consultant at Hammersmith Hospital London In 1970 he was appointed as Professor of Chemical Pathology at Westminster Medical School In the early 1970s Professor Hobbs s Westminster team were doing ground breaking work In 1970 the world s first successful intended stem cell transplant for a previously fatal human disease 2 In 1971 the first British Bone Marrow Transplant using bone marrow from a matching sibling 3 In the following year a transplant was successful using the bone marrow from father to son 4 In April 1973 Hobbs and his team were able to achieve the world s first bone marrow transplant using a matched but unrelated volunteer donor 5 6 With the success of this procedure steps were taken by professor Hobbs s team to set up the world s first unrelated bone marrow donor register The tissue typing specialist of the team David James was instrumental in the setting up and the administration of this ground breaking register which was later named after Anthony Nolan 7 It established the future use of unrelated donors to patients so far for over 10 000 people This initiative was the blue print which would be copied around the world The Westminster team completed 285 transplants before it and its specialist unit s sudden unexpected enforced closure effectively in autumn of 1992 Tragically this left a waiting list of children with virtually nowhere else in Britain to go for treatment of their genetic diseases and inborn errors However Hobbs had founded the COrrection of GEnetic diseases by Transplantation or COGENT movement with a charitable trust which attracted 13 million 1971 2007 The remaining balance with the assistance of the late Professor Anthony Oakhill was used to create a new unit at the Royal Hospital for Sick Children in the city of Bristol and so allowing work to be continued It is now headed by Colin Steward 8 As for the children who were treated by Hobbs s bone marrow team at the Westminster hospital most of these children now enjoy full lives as adults Passing on his Knowledge editHobbs became an enthusiastic and accomplished teacher and accepted invitations to lecture over 30 endowed in 58 different countries in over half of Europe s medical schools 25 in the US and over 30 of the Commonwealth universities He was given the status of visiting professor on over 25 occasions and he contributed to many international meetings and committees He was re invited many times and Presidential status was awarded to him in 5 different scientific meetings He acted as an advisor to Health Ministers in Russia Poland Uruguay Hong Kong China and Peru citation needed Throughout 30 years as a recognised teacher Hobbs encouraged his juniors 134 university higher degrees were achieved by trainees for work completed within the departments he headed 48 full university chairs have been awarded to such staff 70 have become members or fellows of the royal College of Pathologists including 18 non medical 12 scientific staff were helped to medical degrees together with 42 students contemporary with his daughters citation needed Achievements editIn Protein biochemistry proved females treated for iron deficiency achieved the male normal range for haemoglobin blood levels 9 the preexisting normal ranges for females were no longer acceptable From monitoring the Myeloma Trials the first to describe the natural history of myelomatosis 10 11 and helped in 1971 to set up the Protein Reference Units which save the national health service 3 million each year Hobbs retired as PRU chairman in 1994 Established the first non invasive screening test of the newborn to detect those affected by cystic fibrosis 1968 12 As Chairman of the Expert Panel on Proteins of the International Federation of Clinical Chemists 1971 1979 created International standards for many serum proteins 13 Developed successful uses of human tumour markers 14 In Clinical Immunology Standardised methods and reagents some for WHO to provide normal ranges from 12 weeks gestation to old age for caucasian populations Immunoglobolin levels 15 Responses to candida albicans 16 Complement activation 17 Mixed lymphocyte reaction 18 T cell receptors 19 20 Phagocyte function 21 First to fully describe IgA deficiency 22 IgM deficiency 23 selective deficiency to staphylococci 24 Early to recognise a circulating subset of T cells co optable through Fc receptors to become killer cells 25 Defined secondary deficiencies of B cells gt 26 and T cells 27 and their possible treatments 28 29 predictable by cytofluorometry 30 In Bone Marrow Transplantation he had been taught at Registrar level by the late Joseph Humble at Westminster Hospital in 1959 61 and was a volunteer donor of 500 ml of his own bone marrow under anaesthesia to be used for research purposes When he returned in 1970 as head of chemical Pathology and Immunology he created the Westminster Children s Bone Marrow Team and lead it until 1992 in its pioneering work to treat 133 children with otherwise fatal genetic diseases 31 32 33 34 35 36 37 38 39 40 The team became so skilled that of their last 56 transplants from matched family donors all survived for over 100 days a criterion for safety of the procedure From matched unrelated donors 91 survived over 100 days By 1992 these results were probably among the best in the world The improvements in bone marrow transplantation introduced by Westminster have been published 41 42 43 In Current Contents 1972 Hobbs was one of 11 British medical doctors included in a list of The World s top 1 000 scientists Family editJohn Raymond Hobbs was third eldest of four brothers He was also the father of three daughters and eight grandchildren Publications some of 630 edit7 Hobbs J R Bayliss R I S MacLagan N F The routine use of 132 I in the diagnosis of thyroid disease 1963 Lancet i 8 13 M D Thesis London Hobbs J R Displacement bone marrow transplantation and immunoprophylaxis for genetic diseases Adv Intern Med 33 1987 81 118126 Valdimarrson J H Higgs J M Wells R S Yamamura M Hobbs J R Holt P J Immune abnormalities associated with chronic mucocutaneous candidiasis 1973 Cell Immunol 6 348 61144 Ezeoke A Ferguson N Fakhri O Hekkens W and Hobbs J R Antibodies in the sera of celiac patients which can co opt K cells to attack gluten labelled targets 1974 in W Hekkens A S Pena eds Coeliac Disease Stenfert Kroese Leiden pp 176 188174 Hobbs J R Barrett A de Souza I Morgan L Raggatt P Salih H Selection of anti hormonal therapy of some cancers 1975 in D Minzuni et al eds Host Defense Against Cancer and Its Potentiation Univ of Tokyo Press Tokyo Univ Park Press Baltimore pp 451 6204 Hobbs J R Encouragement from research on the cancer of the individual patient 1977 in R W Raven Outlook on Cancer Plenum London pp 147 162319 Hobbs J R AIDS 1984 letter B J Hosp Med 32 51448 Hobbs J R The use of volunteer unrelated donors in J R Hobbs ed Correction of certain genetic diseases by transplantation 1989 COGENT London 1989 147 158484 Henderson D C Sheldon J Riches P G Hobbs J R Cytokine induction of neopterin production Clin Exp Immunol 1991 83 479 482497 Wang Q Rowbottom A Riches P G Dadian G Hobbs J R Combined detection of phenotype and Y chromosome by immunoenzymelabelling and in situ hybridisation on peripheral lymphocytes J Immunol Methods 1991 139 251 5547 Hobbs J R Wang Q Henderson D C Downie C Obaro S Busulphan cyclophosphamide induction used twice with 9 12 successes in the second bone marrow transplant COGENT 1992 2 127 135630 Hobbs J R Further aspects of human immunoglobulin A deficiency Ann Clin Biochem 2007 44 496 7References edit HOBBS Deaths Announcements The Daily Telegraph 16 July 2008 Archived from the original on 13 May 2014 Retrieved 26 April 2012 Hobbs J R Letter to British Medical journal 7 December 1998 Bone marrow stem cell transplants from alternative donors and Leukaemia Yamamura M Newton R C F James D C O Humble J G Butler L F Hobbs J R Uncomplicated HL A matched sibling bone marrow graft from combined immune deficiency 1972 British Medical Journal 2 265 269 Hobbs J R Humble J G Anderson I M James D C O The elective treatment of graft versus host disease following a bone marrow graft from a father to a so with severe combined immunodeficiency 1976 Postgraduate Medical Journal 52 suppl 5 90 94 Foroozanfar H Hobbs J R Hugh Jones K Humble J G James D C O Selwyn S Watson J G Yamamura M Bone marrow transplant from an unrelated donor for chronic granulomatous disease 1977 Lancet I 210 213 Hugh Jones K Selwyn S Riches P Who pioneered the use of alternative donors and stem cells from peripheral blood in bone marrow transplantation Arch Dis Child 1991 66 102 Anthony Nolan Trust Archived from the original on 13 May 2008 Retrieved 20 May 2008 Anthony Nolan Trust 1 permanent dead link Colin Steward Bristol Hobbs J R Iron deficiency after partial gastrectomy I Aetiology II Treatment 1961 Gut 2 141 149 Hobbs J R Paraproteins benign or malignant 1967 British Medical Journal 4 699 704 citation classic 1986 Hobbs J R Immunocytoma o mice an men 1971 British Medical journal 2 67 72 Hobbs J R First meconium in the detection of fibrocystic disease of the pancreas 1968 Protides of the Biol Fluids 16 517 524 Hobbs J R Harboe N Alper C Johansson B G The human serum standard IFCC 74 1 1979 Clin Chim Acta 98 179F 186F Hobbs J R Melino G Riches P Successful uses of tumour markers in man In Protides of the Biological Fluids 31 ed H Peeters 1984 Pergamon Oxford pp 255 262 Hobbs J R Immunoglobulins in clinical chemistry Chapter in Advances in Clinical Chemistry Vol 14 Eds O Bodansky A L Latner Academic Press N Y pp 219 317 Foroozanfar N Yamamura M and Hobbs J R Standardization of lymphocyte transformation to candida immunogen 1974 Clin Exp Immunol 16 301 310 Versey J M B Slater L Hobbs J R Activation of complement in relation to disease 1975 J Clin Path 28 Suppl 6 38 44 Yamamura M Nikbin B Hobbs J R Standardisation of the mixed lymphocyte reaction 1976 Journal of Immunological Methods 10 367 8 Hobbs J R Malka S Byrom N A Density and inducibility of T cell receptors in relation to the age of the lymphocyte donor and the conditions of culture Protides Biol Fluids 25 605 610 Robinson M O Donohue J Dadian G Wankowicz A Barltrop B Hobbs J R An analysis of the normal ranges of lymphocyte subpopulations in children aged 5 13 years Eur J Pediatr 1996 155 535 539 Hobbs J R Foroozanfar N Grohmann Preci H Yegin O Deficienza fagocitarie 1984 La Clinica Terapeutica 110 367 373 Hobbs J R Immune imbalance in dysgammaglobulinaemia Type IV now IgA deficiency Lancet i1968 110 114 Hobbs J R IgM Deficiency 1975 Birth Defects Original Article Series IX 1 112 6 Publ Sinauer Sunderland Mass U S A Monteil M Hobbs J R Citron K Selective immunodeficiency affecting staphylococcal response 1987 Lancet ii 880 883 Fakhri O Hobbs J R Target cell death without added complement after cooperation of 7S antibodies with non immune lymphocytes 1972 Nature New Biology 235 177 178 Hobbs J R Secondary antibody deficiency 1968 Proc R Soc Med 61 883 887 Hobbs J R Deficiencias de linfocitos T 1980 Rev Bras Alerg Imunop 2 243 248 Riches P G Hobbs J R Mechanisms in secondary hypogammaglobulinaemia 1979 J Clin Path 32 Suppl Roy Coll Path 13 15 22 Byrom N A Hobbs J R eds Thymic factor therapy 1985 Serono Symposia Publications Vol 16 457pp Raven Press NY Hobbs J R Cytofluorometry to predict effects of biological response modifiers in Poulik D et al eds Protides of the biological fluids 1989 36 3 17 Hobbs J R Barrett A J Chambers J D James D C O Hugh Jones K Byrom N Henry K and Lucas C F Reversal of clinical features of Hurler s disease and biochemical improvement after treatment by bone marrow transplantation Lancet 2 1981 709 712 Hobbs J R Bone marrow transplantation for inborn errors Lancet 2 1981 735 739 Hobbs J R The scope of allogeneic bone marrow transplantation In Losowsky M and Bolton R eds Advanced Medicine Leeds Pitman Bath 1983 pp 378 391 Hobbs J R Correction of 34 genetic diseases by displacement bone marrow transplantation Plasma Ther Transpl Tech 61985 221 246 Hobbs J R and Hugh Jones K Immunodeficiencies better treated by transplantation Tokai J Exp Clin Med 10 1985 85 97 Hobbs J R Williamson S Chambers J D James D C O Joshi R Shaw P and Hugh Jones K Use of donors sharing one genetic haplogype for bone marrow transplantation Tokai J Exp Clin Med 10 1985 207 214 Hobbs J R Hugh Jones K Shaw P Lindsay I and Hancock M Beneficial effect of pretransplant splenectomy on displacement bone marrow transplantation for Gaucher s syndrome Lancet 1 1987 1111 1115 Hobbs J R Displacement bone marrow transplantation and immunoprophylaxis for genetic diseases Adv Inter Med 33 1987 81 118 Hobbs J R ed The correction of certain genetic diseases by transplantation 1989 COGENT Press Westminster 1989 pp 147 159 J R Hobbs M Monteil D R McCluskey E Jurges and M El Tumi Chronic granulomatous disease 100 corrected by displacement bone marrow transplantation from a volunteer unrelated donor 1992 Europ J Paed 151 806 810 Hobbs J R The achievements of the Westminster children s bone marrow team for some genetic diseases In Steward C G Hobbs J R eds Correction of genetic diseases by transplantation III London COGENT 1995 1 15 Hobbs J R Immunology and replacement treatments of some genetic diseases In Ringden O Hobbs J R Steward C G eds Correction of Genetic Diseases by Transplantation IV 1997 NOBEL symposium COGENT press London 1997 101 110 Hobbs J R The Westminster contribution to the correction of thalassaemia major and other inborn anaemias In Steward C G Hobbs J R eds Correction of genetic diseases by transplantation III London COGENT 1995 80 89 References Compiled and amended with the help of J R Hobbs See also editHis brother Canadian artist William G Hobbs Retrieved from https en wikipedia org w index php title John Raymond Hobbs amp oldid 1108114844, wikipedia, wiki, book, books, library,

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