JWH-175 is a drug from the naphthylmethylindole family which acts as a cannabinoidreceptoragonist. It was invented by the scientist John W. Huffman and colleagues at Clemson University. JWH-175 is closely related to the widely used cannabinoid designer drugJWH-018, but with the ketone bridge replaced by a simpler methylene bridge. It is several times weaker than JWH-018, having a binding affinity at the CB1 receptor of 22 nM, though some derivatives substituted at the 4-position of the naphthyl ring have potency more closely approaching that of the equivalent naphthoylindoles.[1] This makes JWH-175 considerably less potent than most synthetic cannabinoid drugs used in synthetic cannabis blends, and it is unclear if JWH-175 has ever been used for this purpose. However it has still been explicitly banned in several jurisdictions including Russia and some Australian states, in order to stop its potential use as an ingredient in such products. In the United States, all CB1 receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-175 are Schedule I Controlled Substances.[2]
drug, from, naphthylmethylindole, family, which, acts, cannabinoid, receptor, agonist, invented, scientist, john, huffman, colleagues, clemson, university, closely, related, widely, used, cannabinoid, designer, drug, with, ketone, bridge, replaced, simpler, me. JWH 175 is a drug from the naphthylmethylindole family which acts as a cannabinoid receptor agonist It was invented by the scientist John W Huffman and colleagues at Clemson University JWH 175 is closely related to the widely used cannabinoid designer drug JWH 018 but with the ketone bridge replaced by a simpler methylene bridge It is several times weaker than JWH 018 having a binding affinity at the CB1 receptor of 22 nM though some derivatives substituted at the 4 position of the naphthyl ring have potency more closely approaching that of the equivalent naphthoylindoles 1 This makes JWH 175 considerably less potent than most synthetic cannabinoid drugs used in synthetic cannabis blends and it is unclear if JWH 175 has ever been used for this purpose However it has still been explicitly banned in several jurisdictions including Russia and some Australian states in order to stop its potential use as an ingredient in such products In the United States all CB1 receptor agonists of the 3 1 naphthylmethane indole class such as JWH 175 are Schedule I Controlled Substances 2 JWH 175Legal statusLegal statusAU Illegal UK Illegal US Schedule I Illegal in RussiaIdentifiersIUPAC name 1 Pentylindol 3 yl naphthalen 1 ylmethaneCAS Number619294 35 8 YPubChem CID56603534ChemSpider29341789 NUNII3S82KAS832CompTox Dashboard EPA DTXSID90717796Chemical and physical dataFormulaC 24H 25NMolar mass327 471 g mol 13D model JSmol Interactive imageSMILES c3cccc2c3cccc2Cc cn4CCCCC c1ccccc14InChI InChI 1S C24H25N c1 2 3 8 16 25 18 21 23 14 6 7 15 24 23 25 17 20 12 9 11 19 10 4 5 13 22 19 20 h4 7 9 15 18H 2 3 8 16 17H2 1H3 NKey TYBRSILIYTUTSQ UHFFFAOYSA N N N Y what is this See also EditJWH 176 JWH 184 JWH 185References Edit Huffman JW Padgett LW 2005 Recent developments in the medicinal chemistry of cannabimimetic indoles pyrroles and indenes Current Medicinal Chemistry 12 12 1395 411 doi 10 2174 0929867054020864 PMID 15974991 21 U S C 812 Schedules of controlled substances This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title JWH 175 amp oldid 1120771315, wikipedia, wiki, book, books, library,
