JTE-907 is a drug used in scientific research that acts as a selective CB2inverse agonist.[1][2] It has antiinflammatory effects in animal studies,[3] thought to be mediated by an interaction between the CB2 receptor and IgE.[4]
^Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T (February 2001). "In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor". The Journal of Pharmacology and Experimental Therapeutics. 296 (2): 420–5. PMID 11160626.
^Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T (March 2006). "Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists". Journal of Medicinal Chemistry. 49 (6): 2022–7. doi:10.1021/jm050879z. PMID 16539390.
^Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H (September 2005). "Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice". European Journal of Pharmacology. 520 (1–3): 164–71. doi:10.1016/j.ejphar.2005.08.013. PMID 16153638.
^Ueda Y, Miyagawa N, Wakitani K (January 2007). "Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice". Life Sciences. 80 (5): 414–9. doi:10.1016/j.lfs.2006.09.026. PMID 17055000.
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drug, used, scientific, research, that, acts, selective, inverse, agonist, antiinflammatory, effects, animal, studies, thought, mediated, interaction, between, receptor, legal, statuslegal, statusca, schedule, iiidentifiersiupac, name, benzo, dioxol, ylmethyl,. JTE 907 is a drug used in scientific research that acts as a selective CB2 inverse agonist 1 2 It has antiinflammatory effects in animal studies 3 thought to be mediated by an interaction between the CB2 receptor and IgE 4 JTE 907Legal statusLegal statusCA Schedule IIIdentifiersIUPAC name N benzo 1 3 dioxol 5 ylmethyl 7 methoxy 2 oxo 8 pentyloxy 1 2 dihydroquinoline 3 carboxamideCAS Number282089 49 0 YPubChem CID9867770ChemSpider8043461UNIIDAV3Q7SNOLCompTox Dashboard EPA DTXSID001010010ECHA InfoCard100 209 196Chemical and physical dataFormulaC 24H 26N 2O 6Molar mass438 480 g mol 13D model JSmol Interactive imageSMILES c4c3OCOc3ccc4CNC O c cc2ccc1OC c O nH c2c1OCCCCCInChI InChI 1S C24H26N2O6 c1 3 4 5 10 30 22 19 29 2 9 7 16 12 17 24 28 26 21 16 22 23 27 25 13 15 6 8 18 20 11 15 32 14 31 18 h6 9 11 12H 3 5 10 13 14H2 1 2H3 H 25 27 H 26 28 Key GRAJFFFXJYFVOC UHFFFAOYSA N verify See also editJTE 7 31References edit Iwamura H Suzuki H Ueda Y Kaya T Inaba T February 2001 In vitro and in vivo pharmacological characterization of JTE 907 a novel selective ligand for cannabinoid CB2 receptor The Journal of Pharmacology and Experimental Therapeutics 296 2 420 5 PMID 11160626 Raitio KH Savinainen JR Vepsalainen J Laitinen JT Poso A Jarvinen T Nevalainen T March 2006 Synthesis and SAR studies of 2 oxoquinoline derivatives as CB2 receptor inverse agonists Journal of Medicinal Chemistry 49 6 2022 7 doi 10 1021 jm050879z PMID 16539390 Ueda Y Miyagawa N Matsui T Kaya T Iwamura H September 2005 Involvement of cannabinoid CB 2 receptor mediated response and efficacy of cannabinoid CB 2 receptor inverse agonist JTE 907 in cutaneous inflammation in mice European Journal of Pharmacology 520 1 3 164 71 doi 10 1016 j ejphar 2005 08 013 PMID 16153638 Ueda Y Miyagawa N Wakitani K January 2007 Involvement of cannabinoid CB2 receptors in the IgE mediated triphasic cutaneous reaction in mice Life Sciences 80 5 414 9 doi 10 1016 j lfs 2006 09 026 PMID 17055000 nbsp This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title JTE 907 amp oldid 1215442085, wikipedia, wiki, book, books, library,
