Iotrolan (trade name Isovist) is an iodine-containing radiocontrast agent, a substance used to improve the visibility of body structures on images obtained by X-ray techniques.[1]
Hysterosalpingography is contraindicated during pregnancy and during acute inflammation in the pelvic region.[2]
Adverse effectsedit
The most common side effects are nausea and vomiting. Redness and a hot feeling of the skin is relatively common when the medication is injected into a vein. When injected into the cerebrospinal fluid, headache is among the most common adverse effects, and sometimes confusion or hallucinations can occur. Allergy-like reactions such as fever, hypotension (low blood pressure) and shock have also been observed.[2]
Interactionsedit
Drug interactions are similar to other iodine-containing contrast agents. Iodine-131, a radioactive isotope used for thyroid imaging (scintigraphy) and therapy of thyroid cancers, can be less effective when used within two to six weeks after application of iotrolan because of residual iodine in the body. Iotrolan can slow down the excretion of the diabetes drug metformin, potentially resulting in lactic acidosis.[2]
Chemically, the substance is a dimer of a triiodinated isophthalic acid derivative. The iodine atoms readily absorb X-rays, improving the contrast in X-ray images of the body. It is non-ionic but water soluble.[2]
Referencesedit
^Sviridov NK (1994). "[The new nonionic contrast preparation for myelography iotrolan]". Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko (in Russian) (2): 35–6. PMID 8209595.
^. Archived from the original on 2019-08-25. Retrieved 2011-09-16.
April 10, 2024
iotrolan, trade, name, isovist, iodine, containing, radiocontrast, agent, substance, used, improve, visibility, body, structures, images, obtained, techniques, clinical, datatrade, namesisovistahfs, drugs, cominternational, drug, namespregnancycategorycontrain. Iotrolan trade name Isovist is an iodine containing radiocontrast agent a substance used to improve the visibility of body structures on images obtained by X ray techniques 1 IotrolanClinical dataTrade namesIsovistAHFS Drugs comInternational Drug NamesPregnancycategoryContraindicatedATC codeV08AB06 WHO Legal statusLegal statusIn general Prescription only Pharmacokinetic dataProtein bindingNegligibleExcretion99 via kidneysIdentifiersIUPAC name 2 4 6 triiodo 5 N methyl 2 methyl 2 4 6 triiodo 3 5 bis 1 3 4 trihydroxybutan 2 yl carbamoyl phenyl carbamoyl acetamido 1 N 3 N bis 1 3 4 trihydroxybutan 2 yl benzene 1 3 dicarboxamideCAS Number79770 24 4 YPubChem CID3738ChemSpider3607UNII16FL47B687KEGGD01714 YChEMBLChEMBL1200555 NCompTox Dashboard EPA DTXSID0023165Chemical and physical dataFormulaC 37H 48I 6N 6O 18Molar mass1626 242 g mol 13D model JSmol Interactive imageSMILES CN c1c c c c c1I C O NC CO C CO O I C O NC CO C CO O I C O CC O N C c2c c c c c2I C O NC CO C CO O I C O NC CO C CO O IInChI InChI 1S C37H48I6N6O18 c1 48 32 28 40 22 34 64 44 12 4 50 16 58 8 54 26 38 23 29 32 41 35 65 45 13 5 51 17 59 9 55 20 62 3 21 63 49 2 33 30 42 24 36 66 46 14 6 52 18 60 10 56 27 39 25 31 33 43 37 67 47 15 7 53 19 61 11 57 h12 19 50 61H 3 11H2 1 2H3 H 44 64 H 45 65 H 46 66 H 47 67 Key XUHXFSYUBXNTHU UHFFFAOYSA N N Y what is this verify As of 2021 update it is unknown whether it is still marketed anywhere in the world Contents 1 Medical uses 2 Contraindications 3 Adverse effects 4 Interactions 5 Chemistry and mechanism of action 6 ReferencesMedical uses editIt is particularly used to image spaces surrounding the central nervous system such as the ventricles after injection into the cerebrospinal fluid and also for angiography imaging of blood vessels urography imaging of the urinary tract and hysterosalpingography imaging of uterus and fallopian tubes 2 3 It can also be used to image joint spaces and in endoscopic retrograde cholangiopancreatography ERCP citation needed Contraindications editHysterosalpingography is contraindicated during pregnancy and during acute inflammation in the pelvic region 2 Adverse effects editThe most common side effects are nausea and vomiting Redness and a hot feeling of the skin is relatively common when the medication is injected into a vein When injected into the cerebrospinal fluid headache is among the most common adverse effects and sometimes confusion or hallucinations can occur Allergy like reactions such as fever hypotension low blood pressure and shock have also been observed 2 Interactions editDrug interactions are similar to other iodine containing contrast agents Iodine 131 a radioactive isotope used for thyroid imaging scintigraphy and therapy of thyroid cancers can be less effective when used within two to six weeks after application of iotrolan because of residual iodine in the body Iotrolan can slow down the excretion of the diabetes drug metformin potentially resulting in lactic acidosis 2 Chemistry and mechanism of action editFurther information Iodinated contrast Chemically the substance is a dimer of a triiodinated isophthalic acid derivative The iodine atoms readily absorb X rays improving the contrast in X ray images of the body It is non ionic but water soluble 2 References edit Sviridov NK 1994 The new nonionic contrast preparation for myelography iotrolan Zhurnal Voprosy Neirokhirurgii Imeni N N Burdenko in Russian 2 35 6 PMID 8209595 a b c d e Haberfeld H ed 2020 Austria Codex in German Vienna Osterreichischer Apothekerverlag Isovist 240 mg J ml Stechampulle Isovist 280 mg J ml parenterale Rontgenkontrastmittellosung Package insert Archived from the original on 2019 08 25 Retrieved 2011 09 16 Retrieved from https en wikipedia org w index php title Iotrolan amp oldid 1203342980, wikipedia, wiki, book, books, library,
