Intimal hyperplasia is the thickening of the tunica intima of a blood vessel as a complication of a reconstruction procedure or endarterectomy.[1] Intimal hyperplasia is the universal response of a vessel to injury. It is a restenosis and this is an important reason of late bypass graft failure, particularly in vein and synthetic vascular grafts.[2]
A possible treatment to avoid this could be hydrogen sulfide. Hydrogen sulfide (H2S) works as a vasculoprotective gasotransmitter in the human body but is also tested to reduced intimal hyperplasia. There are different kinds of H2S donors: NaHS (the reference in scientific literature despite the fact it is too toxic to use it in human patients) and STS (already used in patient to treat cyanide poisoning).
^Kaban, Leonard B. (1 January 2004). "CHAPTER 20 - Acquired Abnormalities of the Temporomandibular Joint". Pediatric Oral and Maxillofacial Surgery. W.B. Saunders. pp. 340–376. ISBN978-0-7216-9691-1. Retrieved 20 October 2021.
^Haruguchi, Hiroaki; Teraoka, Satoshi (2003). "Intimal hyperplasia and hemodynamic factors in arterial bypass and arteriovenous grafts: a review". Journal of Artificial Organs. 6 (4): 227–235. doi:10.1007/s10047-003-0232-x. ISSN 1434-7229. PMID 14691664. S2CID 24921182.
Déglise S, Bechelli C, Allagnat F. Vascular smooth muscle cells in intimal hyperplasia, an update. Front Physiol. 2023 Jan 4;13:1081881. doi: 10.3389/fphys.2022.1081881. PMID 36685215; PMCID: PMC9845604.[2]
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intimal, hyperplasia, thickening, tunica, intima, blood, vessel, complication, reconstruction, procedure, endarterectomy, universal, response, vessel, injury, restenosis, this, important, reason, late, bypass, graft, failure, particularly, vein, synthetic, vas. Intimal hyperplasia is the thickening of the tunica intima of a blood vessel as a complication of a reconstruction procedure or endarterectomy 1 Intimal hyperplasia is the universal response of a vessel to injury It is a restenosis and this is an important reason of late bypass graft failure particularly in vein and synthetic vascular grafts 2 Contents 1 Cause 2 Possible treatment 3 See also 4 References 5 External linksCause editIntimal hyperplasia is due to a dysfunction of endothelial cells which results in a reprogramming of the vascular smooth muscle cells VSMCs As a result VSMCs proliferate and change their phenotype 1 Possible treatment editA possible treatment to avoid this could be hydrogen sulfide Hydrogen sulfide H2S works as a vasculoprotective gasotransmitter in the human body but is also tested to reduced intimal hyperplasia There are different kinds of H2S donors NaHS the reference in scientific literature despite the fact it is too toxic to use it in human patients and STS already used in patient to treat cyanide poisoning See also editHyperplasia Medical graftingReferences edit Kaban Leonard B 1 January 2004 CHAPTER 20 Acquired Abnormalities of the Temporomandibular Joint Pediatric Oral and Maxillofacial Surgery W B Saunders pp 340 376 ISBN 978 0 7216 9691 1 Retrieved 20 October 2021 Haruguchi Hiroaki Teraoka Satoshi 2003 Intimal hyperplasia and hemodynamic factors in arterial bypass and arteriovenous grafts a review Journal of Artificial Organs 6 4 227 235 doi 10 1007 s10047 003 0232 x ISSN 1434 7229 PMID 14691664 S2CID 24921182 Deglise S Bechelli C Allagnat F Vascular smooth muscle cells in intimal hyperplasia an update Front Physiol 2023 Jan 4 13 1081881 doi 10 3389 fphys 2022 1081881 PMID 36685215 PMCID PMC9845604 2 External links edit Intimal hyperplasia the obstacle in bypass grafts This article about a medical condition affecting the circulatory system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Intimal hyperplasia amp oldid 1208935328, wikipedia, wiki, book, books, library,
