fbpx
Wikipedia

RBP3

April 11, 2024

Retinol-binding protein 3, interstitial (RBP3), also known as interphotoreceptor retinoid-binding protein (IRBP), is a protein that in humans is encoded by the RBP3 gene.[5] RBP3 orthologs[6] have been identified in most eutherians except tenrecs and armadillos. A horizontal gene transfer from bacteria has been proposed to explain the evolution of the eye in chordates.[7]

RBP3
Identifiers
AliasesRBP3, D10S64, D10S65, D10S66, IRBP, RBPI, RP66, retinol binding protein 3
External IDsOMIM: 180290 MGI: 97878 HomoloGene: 9261 GeneCards: RBP3
Orthologs
SpeciesHumanMouse
Entrez

5949

19661

Ensembl

ENSG00000265203

ENSMUSG00000041534

UniProt

P10745

P49194

RefSeq (mRNA)

NM_002900

NM_015745

RefSeq (protein)

NP_002891

NP_056560

Location (UCSC)Chr 10: 47.35 – 47.36 MbChr 14: 33.68 – 33.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The inter-photoreceptor retinoid-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium (RPE) and the photoreceptor cells. It is thought to transport retinoids between the RPE and the photoreceptors, a critical role in the visual process.[8][9]

Gene edit

The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da.

Structure edit

The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.[5]

Application edit

The rbp3 gene is commonly used in animals as a nuclear DNA phylogenetic marker.[6] The exon 1 has first been used in a pioneer study to provide evidence for monophyly of Chiroptera.[10] Then, it has been used to infer the phylogeny of placental mammal orders,[11][12] and of the major clades of Rodentia,[13] Macroscelidea,[14] and Primates.[15] RBP3 is also useful at lower taxonomic levels, e.g., in muroid rodents[16] and Malagasy primates,[17] at the phylogeography level in Geomys and Apodemus rodents,[18][19] and even for carnivora species identification purposes.[20]

Note that the RBP3 intron 1 has also been used to investigate the platyrrhine primates phylogenetics.[21]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000265203 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041534 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RBP3 retinol binding protein 3, interstitial".
  6. ^ a b "OrthoMaM phylogenetic marker: RBP3 gene, exon 1".[permanent dead link]
  7. ^ Kalluraya CA, Weitzel AJ, Tsu BV, Daugherty MD (2023-04-18). "Bacterial origin of a key innovation in the evolution of the vertebrate eye". Proceedings of the National Academy of Sciences. 120 (16): e2214815120. Bibcode:2023PNAS..12014815K. doi:10.1073/pnas.2214815120. ISSN 0027-8424. PMC 10120077. PMID 37036996.
  8. ^ Pennisi E (10 Apr 2023). "An ancient gene stolen from bacteria set the stage for human sight". Science. doi:10.1126/science.adi2029. Retrieved 11 Apr 2023.
  9. ^ Kusakabe TG, Takimoto N, Jin M, Tsuda M (Oct 2009). "Evolution and the origin of the visual retinoid cycle in vertebrates". Philosophical Transactions B. 364 (1531): 2897–2910. doi:10.1098/rstb.2009.0043. PMC 2781855. PMID 19720652.
  10. ^ Stanhope MJ, Czelusniak J, Si JS, Nickerson J, Goodman M (Jun 1992). "A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein, with convincing evidence for bat monophyly". Molecular Phylogenetics and Evolution. 1 (2): 148–60. doi:10.1016/1055-7903(92)90026-D. PMID 1342928.
  11. ^ Stanhope MJ, Smith MR, Waddell VG, Porter CA, Shivji MS, Goodman M (Aug 1996). "Mammalian evolution and the interphotoreceptor retinoid binding protein (IRBP) gene: convincing evidence for several superordinal clades". Journal of Molecular Evolution. 43 (2): 83–92. Bibcode:1996JMolE..43...83S. doi:10.1007/BF02337352. PMID 8660440. S2CID 25865281.
  12. ^ Madsen O, Scally M, Douady CJ, Kao DJ, DeBry RW, Adkins R, Amrine HM, Stanhope MJ, de Jong WW, Springer MS (Feb 2001). "Parallel adaptive radiations in two major clades of placental mammals". Nature. 409 (6820): 610–4. doi:10.1038/35054544. PMID 11214318. S2CID 4398233.
  13. ^ Huchon D, Madsen O, Sibbald MJ, Ament K, Stanhope MJ, Catzeflis F, de Jong WW, Douzery EJ (Jul 2002). "Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes". Molecular Biology and Evolution. 19 (7): 1053–65. doi:10.1093/oxfordjournals.molbev.a004164. PMID 12082125.
  14. ^ Douady CJ, Catzeflis F, Raman J, Springer MS, Stanhope MJ (Jul 2003). "The Sahara as a vicariant agent, and the role of Miocene climatic events, in the diversification of the mammalian order Macroscelidea (elephant shrews)". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8325–30. Bibcode:2003PNAS..100.8325D. doi:10.1073/pnas.0832467100. PMC 166228. PMID 12821774.
  15. ^ Poux C, Douzery EJ (May 2004). "Primate phylogeny, evolutionary rate variations, and divergence times: a contribution from the nuclear gene IRBP". American Journal of Physical Anthropology. 124 (1): 01–16. doi:10.1002/ajpa.10322. PMID 15085543.
  16. ^ Jansa SA, Weksler M (Apr 2004). "Phylogeny of muroid rodents: relationships within and among major lineages as determined by IRBP gene sequences". Molecular Phylogenetics and Evolution. 31 (1): 256–76. doi:10.1016/j.ympev.2003.07.002. PMID 15019624.
  17. ^ Horvath JE, Weisrock DW, Embry SL, Fiorentino I, Balhoff JP, Kappeler P, Wray GA, Willard HF, Yoder AD (Mar 2008). "Development and application of a phylogenomic toolkit: resolving the evolutionary history of Madagascar's lemurs". Genome Research. 18 (3): 489–99. doi:10.1101/gr.7265208. PMC 2259113. PMID 18245770.
  18. ^ Genoways HH, Hamilton MJ, Bell DM, Chambers RR, Bradley RD (2008). "Hybrid zones, genetic isolation, and systematics of pocket gophers (genus Geomys) in Nebraska". J. Mammal. 89 (4): 826–836. doi:10.1644/07-mamm-a-408.1.
  19. ^ Tomozawa M, Suzuki H (Mar 2008). "A trend of central versus peripheral structuring in mitochondrial and nuclear gene sequences of the Japanese wood mouse, Apodemus speciosus". Zoological Science. 25 (3): 273–85. doi:10.2108/zsj.25.273. PMID 18393564. S2CID 38824060.
  20. ^ Oliveira R, Castro D, Godinho R, Luikart G, Alves PC (June 2009). "Species identification using a small nuclear gene: application to sympatric wild carnivores from South-western Europe". Conserv. Genet. 11 (3): 1023–1032. doi:10.1007/s10592-009-9947-4. S2CID 21422211.
  21. ^ Schneider H, Sampaio I, Harada ML, Barroso CM, Schneider MP, Czelusniak J, Goodman M (Jun 1996). "Molecular phylogeny of the New World monkeys (Platyrrhini, primates) based on two unlinked nuclear genes: IRBP intron 1 and epsilon-globin sequences". American Journal of Physical Anthropology. 100 (2): 153–79. doi:10.1002/(SICI)1096-8644(199606)100:2<153::AID-AJPA1>3.0.CO;2-Z. PMID 8771309.

Further reading edit

  • Fong SL, Fong WB, Morris TA, Kedzie KM, Bridges CD (Mar 1990). "Characterization and comparative structural features of the gene for human interstitial retinol-binding protein". The Journal of Biological Chemistry. 265 (7): 3648–53. doi:10.1016/S0021-9258(19)39642-5. PMID 2303470.
  • Albini A, Toffenetti J, Zhu Z, Chader GJ, Noonan DM (Sep 1990). "Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene". Nucleic Acids Research. 18 (17): 5181–7. doi:10.1093/nar/18.17.5181. PMC 332140. PMID 2402443.
  • Liou GI, Ma DP, Yang YW, Geng L, Zhu C, Baehr W (May 1989). "Human interstitial retinoid-binding protein. Gene structure and primary structure". The Journal of Biological Chemistry. 264 (14): 8200–6. doi:10.1016/S0021-9258(18)83169-6. PMID 2542268.
  • Si JS, Borst DE, Redmond TM, Nickerson JM (Aug 1989). "Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences". Gene. 80 (1): 99–108. doi:10.1016/0378-1119(89)90254-0. PMID 2792773. S2CID 34897302.
  • Nakamura Y, Lathrop M, Bragg T, Leppert M, O'Connell P, Jones C, Lalouel JM, White R (Nov 1988). "An extended genetic linkage map of markers for human chromosome 10". Genomics. 3 (4): 389–92. doi:10.1016/0888-7543(88)90133-4. PMID 2907505.
  • Fong SL, Bridges CD (Oct 1988). "Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA". The Journal of Biological Chemistry. 263 (30): 15330–4. doi:10.1016/S0021-9258(19)37592-1. PMID 3170584.
  • Liou GI, Fong SL, Gosden J, van Tuinen P, Ledbetter DH, Christie S, Rout D, Bhattacharya S, Cook RG, Li Y (Jul 1987). "Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization". Somatic Cell and Molecular Genetics. 13 (4): 315–23. doi:10.1007/BF01534925. PMID 3455009. S2CID 20206120.
  • Fong SL, Cook RG, Alvarez RA, Liou GI, Landers RA, Bridges CD (Sep 1986). "N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species". FEBS Letters. 205 (2): 309–12. doi:10.1016/0014-5793(86)80918-8. PMID 3743780. S2CID 45787370.
  • Redmond TM, Wiggert B, Robey FA, Chader GJ (Nov 1986). "Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing". The Biochemical Journal. 240 (1): 19–26. doi:10.1042/bj2400019. PMC 1147370. PMID 3827838.
  • Chen Y, Houghton LA, Brenna JT, Noy N (Aug 1996). "Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal". The Journal of Biological Chemistry. 271 (34): 20507–15. doi:10.1074/jbc.271.34.20507. PMID 8702792.
  • Shaw NS, Noy N (Feb 2001). "Interphotoreceptor retinoid-binding protein contains three retinoid binding sites". Experimental Eye Research. 72 (2): 183–90. doi:10.1006/exer.2000.0945. PMID 11161734.
  • Foltz DR, Nye JS (Aug 2001). "Hyperphosphorylation and association with RBP of the intracellular domain of Notch1". Biochemical and Biophysical Research Communications. 286 (3): 484–92. doi:10.1006/bbrc.2001.5421. PMID 11511084.
  • Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ (Jun 2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate". Blood. 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799.

External links edit

  • GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
  • "Overview of the coding DNA and protein sequence alignments of the RBP3 marker". OrthoMaM – a biological database of orthologous mammalian markers. The rbp3 evolutionary marker can be found, together with the corresponding gene phylogeny[permanent dead link]

April 11, 2024
rbp3, retinol, binding, protein, interstitial, also, known, interphotoreceptor, retinoid, binding, protein, irbp, protein, that, humans, encoded, gene, orthologs, have, been, identified, most, eutherians, except, tenrecs, armadillos, horizontal, gene, transfer. Retinol binding protein 3 interstitial RBP3 also known as interphotoreceptor retinoid binding protein IRBP is a protein that in humans is encoded by the RBP3 gene 5 RBP3 orthologs 6 have been identified in most eutherians except tenrecs and armadillos A horizontal gene transfer from bacteria has been proposed to explain the evolution of the eye in chordates 7 RBP3IdentifiersAliasesRBP3 D10S64 D10S65 D10S66 IRBP RBPI RP66 retinol binding protein 3External IDsOMIM 180290 MGI 97878 HomoloGene 9261 GeneCards RBP3Gene location Human Chr Chromosome 10 human 1 Band10q11 22Start47 348 363 bp 1 End47 357 881 bp 1 Gene location Mouse Chr Chromosome 14 mouse 2 Band14 B 14 20 8 cMStart33 675 960 bp 2 End33 686 173 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inretinal pigment epitheliumhippocampal formationhippocampus propermesencephalonfrontal lobeprefrontal cortexsubstantia nigraspinal cordBrodmann area 9duodenumTop expressed inretinal pigment epitheliumpineal glandouter nuclear layerright ventricleiriscorneaextraocular muscletemporal muscleconjunctival fornixneckMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionserine type peptidase activity retinoid binding retinal binding retinol bindingCellular componentextracellular vesicle extracellular region interphotoreceptor matrix extracellular space cone matrix sheathBiological processproteolysis retinoid metabolic process lipid metabolism visual perception transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez594919661EnsemblENSG00000265203ENSMUSG00000041534UniProtP10745P49194RefSeq mRNA NM 002900NM 015745RefSeq protein NP 002891NP 056560Location UCSC Chr 10 47 35 47 36 MbChr 14 33 68 33 69 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Gene 3 Structure 4 Application 5 References 6 Further reading 7 External linksFunction editThe inter photoreceptor retinoid binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium RPE and the photoreceptor cells It is thought to transport retinoids between the RPE and the photoreceptors a critical role in the visual process 8 9 Gene editThe human IRBP gene is approximately 9 5 kbp in length and consists of four exons separated by three introns The introns are 1 6 1 9 kbp long The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4 3 kilobase mRNA that is translated and processed into a glycosylated protein of 135 000 Da Structure editThe amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33 38 identity suggesting a series of gene duplication events In the gene the boundaries of these domains are not defined by exon intron junctions as might have been expected The first three homology domains and part of the fourth are all encoded by the first large exon which is 3 180 base pairs long The remainder of the fourth domain is encoded in the last three exons which are 191 143 and approximately 740 base pairs long respectively 5 Application editThe rbp3 gene is commonly used in animals as a nuclear DNA phylogenetic marker 6 The exon 1 has first been used in a pioneer study to provide evidence for monophyly of Chiroptera 10 Then it has been used to infer the phylogeny of placental mammal orders 11 12 and of the major clades of Rodentia 13 Macroscelidea 14 and Primates 15 RBP3 is also useful at lower taxonomic levels e g in muroid rodents 16 and Malagasy primates 17 at the phylogeography level in Geomys and Apodemus rodents 18 19 and even for carnivora species identification purposes 20 Note that the RBP3 intron 1 has also been used to investigate the platyrrhine primates phylogenetics 21 References edit a b c GRCh38 Ensembl release 89 ENSG00000265203 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000041534 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene RBP3 retinol binding protein 3 interstitial a b OrthoMaM phylogenetic marker RBP3 gene exon 1 permanent dead link Kalluraya CA Weitzel AJ Tsu BV Daugherty MD 2023 04 18 Bacterial origin of a key innovation in the evolution of the vertebrate eye Proceedings of the National Academy of Sciences 120 16 e2214815120 Bibcode 2023PNAS 12014815K doi 10 1073 pnas 2214815120 ISSN 0027 8424 PMC 10120077 PMID 37036996 Pennisi E 10 Apr 2023 An ancient gene stolen from bacteria set the stage for human sight Science doi 10 1126 science adi2029 Retrieved 11 Apr 2023 Kusakabe TG Takimoto N Jin M Tsuda M Oct 2009 Evolution and the origin of the visual retinoid cycle in vertebrates Philosophical Transactions B 364 1531 2897 2910 doi 10 1098 rstb 2009 0043 PMC 2781855 PMID 19720652 Stanhope MJ Czelusniak J Si JS Nickerson J Goodman M Jun 1992 A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein with convincing evidence for bat monophyly Molecular Phylogenetics and Evolution 1 2 148 60 doi 10 1016 1055 7903 92 90026 D PMID 1342928 Stanhope MJ Smith MR Waddell VG Porter CA Shivji MS Goodman M Aug 1996 Mammalian evolution and the interphotoreceptor retinoid binding protein IRBP gene convincing evidence for several superordinal clades Journal of Molecular Evolution 43 2 83 92 Bibcode 1996JMolE 43 83S doi 10 1007 BF02337352 PMID 8660440 S2CID 25865281 Madsen O Scally M Douady CJ Kao DJ DeBry RW Adkins R Amrine HM Stanhope MJ de Jong WW Springer MS Feb 2001 Parallel adaptive radiations in two major clades of placental mammals Nature 409 6820 610 4 doi 10 1038 35054544 PMID 11214318 S2CID 4398233 Huchon D Madsen O Sibbald MJ Ament K Stanhope MJ Catzeflis F de Jong WW Douzery EJ Jul 2002 Rodent phylogeny and a timescale for the evolution of Glires evidence from an extensive taxon sampling using three nuclear genes Molecular Biology and Evolution 19 7 1053 65 doi 10 1093 oxfordjournals molbev a004164 PMID 12082125 Douady CJ Catzeflis F Raman J Springer MS Stanhope MJ Jul 2003 The Sahara as a vicariant agent and the role of Miocene climatic events in the diversification of the mammalian order Macroscelidea elephant shrews Proceedings of the National Academy of Sciences of the United States of America 100 14 8325 30 Bibcode 2003PNAS 100 8325D doi 10 1073 pnas 0832467100 PMC 166228 PMID 12821774 Poux C Douzery EJ May 2004 Primate phylogeny evolutionary rate variations and divergence times a contribution from the nuclear gene IRBP American Journal of Physical Anthropology 124 1 01 16 doi 10 1002 ajpa 10322 PMID 15085543 Jansa SA Weksler M Apr 2004 Phylogeny of muroid rodents relationships within and among major lineages as determined by IRBP gene sequences Molecular Phylogenetics and Evolution 31 1 256 76 doi 10 1016 j ympev 2003 07 002 PMID 15019624 Horvath JE Weisrock DW Embry SL Fiorentino I Balhoff JP Kappeler P Wray GA Willard HF Yoder AD Mar 2008 Development and application of a phylogenomic toolkit resolving the evolutionary history of Madagascar s lemurs Genome Research 18 3 489 99 doi 10 1101 gr 7265208 PMC 2259113 PMID 18245770 Genoways HH Hamilton MJ Bell DM Chambers RR Bradley RD 2008 Hybrid zones genetic isolation and systematics of pocket gophers genus Geomys in Nebraska J Mammal 89 4 826 836 doi 10 1644 07 mamm a 408 1 Tomozawa M Suzuki H Mar 2008 A trend of central versus peripheral structuring in mitochondrial and nuclear gene sequences of the Japanese wood mouse Apodemus speciosus Zoological Science 25 3 273 85 doi 10 2108 zsj 25 273 PMID 18393564 S2CID 38824060 Oliveira R Castro D Godinho R Luikart G Alves PC June 2009 Species identification using a small nuclear gene application to sympatric wild carnivores from South western Europe Conserv Genet 11 3 1023 1032 doi 10 1007 s10592 009 9947 4 S2CID 21422211 Schneider H Sampaio I Harada ML Barroso CM Schneider MP Czelusniak J Goodman M Jun 1996 Molecular phylogeny of the New World monkeys Platyrrhini primates based on two unlinked nuclear genes IRBP intron 1 and epsilon globin sequences American Journal of Physical Anthropology 100 2 153 79 doi 10 1002 SICI 1096 8644 199606 100 2 lt 153 AID AJPA1 gt 3 0 CO 2 Z PMID 8771309 Further reading editFong SL Fong WB Morris TA Kedzie KM Bridges CD Mar 1990 Characterization and comparative structural features of the gene for human interstitial retinol binding protein The Journal of Biological Chemistry 265 7 3648 53 doi 10 1016 S0021 9258 19 39642 5 PMID 2303470 Albini A Toffenetti J Zhu Z Chader GJ Noonan DM Sep 1990 Hypomethylation of the interphotoreceptor retinoid binding protein IRBP promotor and first exon is linked to expression of the gene Nucleic Acids Research 18 17 5181 7 doi 10 1093 nar 18 17 5181 PMC 332140 PMID 2402443 Liou GI Ma DP Yang YW Geng L Zhu C Baehr W May 1989 Human interstitial retinoid binding protein Gene structure and primary structure The Journal of Biological Chemistry 264 14 8200 6 doi 10 1016 S0021 9258 18 83169 6 PMID 2542268 Si JS Borst DE Redmond TM Nickerson JM Aug 1989 Cloning of cDNAs encoding human interphotoreceptor retinoid binding protein IRBP and comparison with bovine IRBP sequences Gene 80 1 99 108 doi 10 1016 0378 1119 89 90254 0 PMID 2792773 S2CID 34897302 Nakamura Y Lathrop M Bragg T Leppert M O Connell P Jones C Lalouel JM White R Nov 1988 An extended genetic linkage map of markers for human chromosome 10 Genomics 3 4 389 92 doi 10 1016 0888 7543 88 90133 4 PMID 2907505 Fong SL Bridges CD Oct 1988 Internal quadruplication in the structure of human interstitial retinol binding protein deduced from its cloned cDNA The Journal of Biological Chemistry 263 30 15330 4 doi 10 1016 S0021 9258 19 37592 1 PMID 3170584 Liou GI Fong SL Gosden J van Tuinen P Ledbetter DH Christie S Rout D Bhattacharya S Cook RG Li Y Jul 1987 Human interstitial retinol binding protein IRBP cloning partial sequence and chromosomal localization Somatic Cell and Molecular Genetics 13 4 315 23 doi 10 1007 BF01534925 PMID 3455009 S2CID 20206120 Fong SL Cook RG Alvarez RA Liou GI Landers RA Bridges CD Sep 1986 N terminal sequence homologies in interstitial retinol binding proteins from 10 vertebrate species FEBS Letters 205 2 309 12 doi 10 1016 0014 5793 86 80918 8 PMID 3743780 S2CID 45787370 Redmond TM Wiggert B Robey FA Chader GJ Nov 1986 Interspecies conservation of structure of interphotoreceptor retinoid binding protein Similarities and differences as adjudged by peptide mapping and N terminal sequencing The Biochemical Journal 240 1 19 26 doi 10 1042 bj2400019 PMC 1147370 PMID 3827838 Chen Y Houghton LA Brenna JT Noy N Aug 1996 Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid binding protein with 11 cis retinal The Journal of Biological Chemistry 271 34 20507 15 doi 10 1074 jbc 271 34 20507 PMID 8702792 Shaw NS Noy N Feb 2001 Interphotoreceptor retinoid binding protein contains three retinoid binding sites Experimental Eye Research 72 2 183 90 doi 10 1006 exer 2000 0945 PMID 11161734 Foltz DR Nye JS Aug 2001 Hyperphosphorylation and association with RBP of the intracellular domain of Notch1 Biochemical and Biophysical Research Communications 286 3 484 92 doi 10 1006 bbrc 2001 5421 PMID 11511084 Howard OM Dong HF Su SB Caspi RR Chen X Plotz P Oppenheim JJ Jun 2005 Autoantigens signal through chemokine receptors uveitis antigens induce CXCR3 and CXCR5 expressing lymphocytes and immature dendritic cells to migrate Blood 105 11 4207 14 doi 10 1182 blood 2004 07 2697 PMC 1895027 PMID 15713799 External links editGeneReviews NCBI NIH UW entry on Retinitis Pigmentosa Overview Overview of the coding DNA and protein sequence alignments of the RBP3 marker OrthoMaM a biological database of orthologous mammalian markers The rbp3 evolutionary marker can be found together with the corresponding gene phylogeny permanent dead link Retrieved from https en wikipedia org w index php title RBP3 amp oldid 1218326839, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.