In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.[5]
Interactionsedit
Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.[6]
^Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
Further readingedit
Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature. 407 (6806): 916–20. Bibcode:2000Natur.407..916C. doi:10.1038/35038103. PMID 11057672. S2CID 205009928.
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". J. Immunol. 172 (4): 2225–31. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Pradhan A, Lambert QT, Reuther GW (2008). "Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18502–7. doi:10.1073/pnas.0702388104. PMC2141806. PMID 18003935.
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
interleukin, receptor, alpha, subunit, interleukin, receptor, alpha, subunit, interleukin, receptor, il27ra, human, gene, il27raidentifiersaliasesil27ra, crl1, 27ra, il27r, tccr, wsx1, zcytor1, interleukin, receptor, subunit, alphaexternal, idsomim, 605350, 13. Interleukin 27 receptor alpha is a subunit of the interleukin 27 receptor IL27RA is its human gene 5 IL27RAIdentifiersAliasesIL27RA CRL1 IL 27RA IL27R TCCR WSX1 zcytor1 Interleukin 27 receptor alpha subunit interleukin 27 receptor subunit alphaExternal IDsOMIM 605350 MGI 1355318 HomoloGene 3562 GeneCards IL27RAGene location Human Chr Chromosome 19 human 1 Band19p13 12Start14 031 762 bp 1 End14 053 218 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 C2Start84 756 923 bp 2 End84 769 218 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytelymph nodebloodappendixspleenbone marrow cellsupper lobe of left lungleft ventriclethymusright lungTop expressed inlymph nodebloodthymusspleenextraocular musclesubcutaneous adipose tissueventriclewhite adipose tissueright lung lobeatriumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransmembrane signaling receptor activity interleukin 27 receptor activity cytokine receptor activity cytokine bindingCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane receptor complexBiological processnegative regulation of type 2 immune response cell surface receptor signaling pathway positive regulation of interferon gamma production regulation of isotype switching to IgG isotypes positive regulation of T helper 1 type immune response immune response defense response to Gram positive bacterium interleukin 27 mediated signaling pathway interleukin 35 mediated signaling pathway negative regulation of cellular extravasation negative regulation of T helper 17 type immune response negative regulation of T cell extravasationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez946650931EnsemblENSG00000104998ENSG00000288185ENSMUSG00000005465UniProtQ6UWB1O70394RefSeq mRNA NM 004843NM 016671RefSeq protein NP 004834NP 057880Location UCSC Chr 19 14 03 14 05 MbChr 8 84 76 84 77 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editIn mice CD4 helper T cells differentiate into type 1 Th1 cells which are critical for cell mediated immunity predominantly under the influence of IL12 Also IL4 influences their differentiation into type 2 Th2 cells which are critical for most antibody responses Mice deficient in these cytokines their receptors or associated transcription factors have impaired but are not absent of Th1 or Th2 immune responses This gene encodes a protein which is similar to the mouse T cell cytokine receptor Tccr at the amino acid level and is predicted to be a glycosylated transmembrane protein 5 Interactions editInterleukin 27 receptor alpha subunit has been shown to interact with STAT1 6 References edit a b c ENSG00000288185 GRCh38 Ensembl release 89 ENSG00000104998 ENSG00000288185 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000005465 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene IL27RA interleukin 27 receptor alpha Takeda A Hamano S Yamanaka A Hanada T Ishibashi T Mak TW Yoshimura A Yoshida H May 2003 Cutting edge role of IL 27 WSX 1 signaling for induction of T bet through activation of STAT1 during initial Th1 commitment J Immunol 170 10 4886 90 doi 10 4049 jimmunol 170 10 4886 PMID 12734330 Further reading editSprecher CA Grant FJ Baumgartner JW Presnell SR Schrader SK Yamagiwa T Whitmore TE O Hara PJ Foster DF 1998 Cloning and characterization of a novel class I cytokine receptor Biochem Biophys Res Commun 246 1 82 90 doi 10 1006 bbrc 1998 8576 PMID 9600072 Chen Q Ghilardi N Wang H Baker T Xie MH Gurney A Grewal IS de Sauvage FJ 2000 Development of Th1 type immune responses requires the type I cytokine receptor TCCR Nature 407 6806 916 20 Bibcode 2000Natur 407 916C doi 10 1038 35038103 PMID 11057672 S2CID 205009928 Pflanz S Timans JC Cheung J Rosales R Kanzler H Gilbert J Hibbert L Churakova T Travis M Vaisberg E Blumenschein WM Mattson JD Wagner JL To W Zurawski S McClanahan TK Gorman DM Bazan JF de Waal Malefyt R Rennick D Kastelein RA 2002 IL 27 a heterodimeric cytokine composed of EBI3 and p28 protein induces proliferation of naive CD4 T cells Immunity 16 6 779 90 doi 10 1016 S1074 7613 02 00324 2 PMID 12121660 Takeda A Hamano S Yamanaka A Hanada T Ishibashi T Mak TW Yoshimura A Yoshida H 2003 Cutting edge role of IL 27 WSX 1 signaling for induction of T bet through activation of STAT1 during initial Th1 commitment J Immunol 170 10 4886 90 doi 10 4049 jimmunol 170 10 4886 PMID 12734330 Pflanz S Hibbert L Mattson J Rosales R Vaisberg E Bazan JF Phillips JH McClanahan TK de Waal Malefyt R Kastelein RA 2004 WSX 1 and glycoprotein 130 constitute a signal transducing receptor for IL 27 J Immunol 172 4 2225 31 doi 10 4049 jimmunol 172 4 2225 PMID 14764690 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Pradhan A Lambert QT Reuther GW 2008 Transformation of hematopoietic cells and activation of JAK2 V617F by IL 27R a component of a heterodimeric type I cytokine receptor Proc Natl Acad Sci U S A 104 47 18502 7 doi 10 1073 pnas 0702388104 PMC 2141806 PMID 18003935 nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en 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