IL20RA is an alpha-chain with a long intracellular domain. IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26.[5]
Signalingedit
Receptors made up of IL20RA signal through a JAK-STAT signaling pathway.[5] In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellulardomains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. STAT then binds to docking sites created by JAK phosphorylation and becomes phosphorylated by JAK. STATs then dimerize and move to the nucleus to act as transcription factors. The specific genes expressed are dependent on the specific JAK, STAT, as well as by SOCS proteins, which can inhibit the JAK-STAT signal, regulating it.where the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated.[1] IL20RA has multiple docking sites for STAT3.[5][9]
Link to Immune System and Diseaseedit
Research indicates that IL20RA is found in some immune cells. For example, IL20RA is sometimes found in lung macrophages. Research indicates that IL20RA presence may be related to disease. In people with rheumatoid arthiritis, IL20RA is present in blood monocytes.[8]
IL20RA has also been linked with psoriasis, and atherosclerosis, all diseases associated with inflammation. The specific role of IL20RA in these diseases is unknown.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000016402 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020007 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcdeWegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101. PMID 20864382.
^Wirtz, Mary K.; Keller, Kate E. (2016). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 1–8. doi:10.1155/2016/4083735. ISSN 0962-9351. PMC4745377. PMID 26903709.
^ abcRutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (December 2014). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1741. PMID 25421700. S2CID 29114703.
^ abKragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224. PMC6167463. PMID 30319661.
^Blumberg, Hal; Conklin, Darrell; Xu, WenFeng; Grossmann, Angelika; Brender, Ty; Carollo, Susan; Eagan, Maribeth; Foster, Don; Haldeman, Betty A; Hammond, Angie; Haugen, Harald; Jelinek, Laura; Kelly, James D; Madden, Karen; Maurer, Mark F (2001-01-12). "Interleukin 20: Discovery, Receptor Identification, and Role in Epidermal Function". Cell. 104 (1): 9–19. doi:10.1016/S0092-8674(01)00187-8. ISSN 0092-8674. PMID 11163236.
Further readingedit
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Xie MH, Aggarwal S, Ho WH, et al. (2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R". J. Biol. Chem. 275 (40): 31335–31339. doi:10.1074/jbc.M005304200. PMID 10875937.
Blumberg H, Conklin D, Xu WF, et al. (2001). "Interleukin 20: discovery, receptor identification, and role in epidermal function". Cell. 104 (1): 9–19. doi:10.1016/S0092-8674(01)00187-8. PMID 11163236. S2CID 7460710.
Dumoutier L, Leemans C, Lejeune D, et al. (2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". J. Immunol. 167 (7): 3545–9. doi:10.4049/jimmunol.167.7.3545. PMID 11564763.
Wang M, Tan Z, Zhang R, et al. (2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2". J. Biol. Chem. 277 (9): 7341–7347. doi:10.1074/jbc.M106043200. PMID 11706020.
Parrish-Novak J, Xu W, Brender T, et al. (2003). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions". J. Biol. Chem. 277 (49): 47517–47523. doi:10.1074/jbc.M205114200. PMID 12351624.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. doi:10.1038/nature02055. PMID 14574404.
Pletnev S, Magracheva E, Kozlov S, et al. (2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20". Biochemistry. 42 (43): 12617–12624. doi:10.1021/bi0354583. PMID 14580208.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Sheikh F, Baurin VV, Lewis-Antes A, et al. (2004). "Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2". J. Immunol. 172 (4): 2006–10. doi:10.4049/jimmunol.172.4.2006. PMID 14764663.
Hör S, Pirzer H, Dumoutier L, et al. (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J. Biol. Chem. 279 (32): 33343–33351. doi:10.1074/jbc.M405000200. PMID 15178681.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
interleukin, receptor, alpha, subunit, subunit, interleukin, receptor, interleukin, receptor, interleukin, receptor, interleukin, receptor, alpha, subunit, also, referred, il20r1, il20ra, il20ra, receptor, involved, both, inflammatory, anti, inflammatory, resp. Interleukin 20 receptor alpha subunit is a subunit of the interleukin 20 receptor the interleukin 26 receptor and the interleukin 24 receptor 5 The interleukin 20 receptor alpha subunit is also referred to as IL20R1 6 or IL20RA 7 The IL20RA receptor is involved in both pro inflammatory and anti inflammatory responses signaling through the JAK STAT pathway 5 IL20RAAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4DOHIdentifiersAliasesIL20RA CRF2 8 IL 20R alpha IL 20R1 IL 20RA Interleukin 20 receptor alpha subunit interleukin 20 receptor subunit alphaExternal IDsOMIM 605620 MGI 3605069 HomoloGene 8685 GeneCards IL20RAGene location Human Chr Chromosome 6 human 1 Band6q23 3Start136 999 971 bp 1 End137 045 180 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 A3Start19 588 318 bp 2 End19 635 801 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomenright uterine tubebronchial epithelial cellendometriumpalpebral conjunctivaminor salivary glandbody of pancreasvaginaislet of Langerhansparotid glandTop expressed inspermatidlipsuperior frontal gyrusskin of abdomenadrenal glandskin of backcarotid bodyesophagusolfactory bulbepidermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncytokine receptor activity interleukin 20 binding protein bindingCellular componentintegral component of membrane membrane plasma membraneBiological processregulation of bone resorption positive regulation of intrinsic apoptotic signaling pathway cytokine mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez53832237313EnsemblENSG00000016402ENSMUSG00000020007UniProtQ9UHF4Q6PHB0RefSeq mRNA NM 001278722NM 001278723NM 001278724NM 014432NM 172786RefSeq protein NP 001265651NP 001265652NP 001265653NP 055247NP 766374Location UCSC Chr 6 137 137 05 MbChr 10 19 59 19 64 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseIL20RA is found in the skin lungs ovaries testes and placenta with low gene expression in the intestine and liver 7 IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis osteoclasts found in bones and epithelial cells of the intestine and trachea IL20RA is also found in some immune cells 8 Contents 1 Structure and function 2 Signaling 3 Link to Immune System and Disease 4 References 5 Further readingStructure and function editIL20RA is an alpha chain with a long intracellular domain IL20RA along with the IL 20 receptor beta subunit form the heterodimeric interleukin 20 receptor which binds the cytokines IL 19 IL 20 and IL 24 IL20RA also forms a complex with the IL 10 receptor beta subunit which binds the cytokine IL 26 5 Signaling editReceptors made up of IL20RA signal through a JAK STAT signaling pathway 5 In this pathway after a cytokine binds IL20RA and the beta subunit JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA STAT then binds to docking sites created by JAK phosphorylation and becomes phosphorylated by JAK STATs then dimerize and move to the nucleus to act as transcription factors The specific genes expressed are dependent on the specific JAK STAT as well as by SOCS proteins which can inhibit the JAK STAT signal regulating it where the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated 1 IL20RA has multiple docking sites for STAT3 5 9 Link to Immune System and Disease editResearch indicates that IL20RA is found in some immune cells For example IL20RA is sometimes found in lung macrophages Research indicates that IL20RA presence may be related to disease In people with rheumatoid arthiritis IL20RA is present in blood monocytes 8 IL20RA has also been linked with psoriasis and atherosclerosis all diseases associated with inflammation The specific role of IL20RA in these diseases is unknown 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000016402 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020007 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c d e Wegenka Ursula Maria 2010 10 01 IL 20 Biological functions mediated through two types of receptor complexes Cytokine amp Growth Factor Reviews IL 10 Family of Cytokines 21 5 353 363 doi 10 1016 j cytogfr 2010 08 001 ISSN 1359 6101 PMID 20864382 Wirtz Mary K Keller Kate E 2016 The Role of the IL 20 Subfamily in Glaucoma Mediators of Inflammation 2016 1 8 doi 10 1155 2016 4083735 ISSN 0962 9351 PMC 4745377 PMID 26903709 a b c Rutz Sascha Wang Xiaoting Ouyang Wenjun December 2014 The IL 20 subfamily of cytokines from host defence to tissue homeostasis Nature Reviews Immunology 14 12 783 795 doi 10 1038 nri3766 ISSN 1474 1741 PMID 25421700 S2CID 29114703 a b Kragstrup Tue W Andersen Thomas Heftdal Line D Hvid Malene Gerwien Jens Sivakumar Pallavur Taylor Peter C Senolt Ladislav Deleuran Bent 2018 09 25 The IL 20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis Frontiers in Immunology 9 2226 doi 10 3389 fimmu 2018 02226 ISSN 1664 3224 PMC 6167463 PMID 30319661 Blumberg Hal Conklin Darrell Xu WenFeng Grossmann Angelika Brender Ty Carollo Susan Eagan Maribeth Foster Don Haldeman Betty A Hammond Angie Haugen Harald Jelinek Laura Kelly James D Madden Karen Maurer Mark F 2001 01 12 Interleukin 20 Discovery Receptor Identification and Role in Epidermal Function Cell 104 1 9 19 doi 10 1016 S0092 8674 01 00187 8 ISSN 0092 8674 PMID 11163236 Further reading editBonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Xie MH Aggarwal S Ho WH et al 2000 Interleukin IL 22 a novel human cytokine that signals through the interferon receptor related proteins CRF2 4 and IL 22R J Biol Chem 275 40 31335 31339 doi 10 1074 jbc M005304200 PMID 10875937 Blumberg H Conklin D Xu WF et al 2001 Interleukin 20 discovery receptor identification and role in epidermal function Cell 104 1 9 19 doi 10 1016 S0092 8674 01 00187 8 PMID 11163236 S2CID 7460710 Dumoutier L Leemans C Lejeune D et al 2001 Cutting edge STAT activation by IL 19 IL 20 and mda 7 through IL 20 receptor complexes of two types J Immunol 167 7 3545 9 doi 10 4049 jimmunol 167 7 3545 PMID 11564763 Wang M Tan Z Zhang R et al 2002 Interleukin 24 MDA 7 MOB 5 signals through two heterodimeric receptors IL 22R1 IL 20R2 and IL 20R1 IL 20R2 J Biol Chem 277 9 7341 7347 doi 10 1074 jbc M106043200 PMID 11706020 Parrish Novak J Xu W Brender T et al 2003 Interleukins 19 20 and 24 signal through two distinct receptor complexes Differences in receptor ligand interactions mediate unique biological functions J Biol Chem 277 49 47517 47523 doi 10 1074 jbc M205114200 PMID 12351624 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Clark HF Gurney AL Abaya E et al 2003 The secreted protein discovery initiative SPDI a large scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment Genome Res 13 10 2265 2270 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 811 doi 10 1038 nature02055 PMID 14574404 Pletnev S Magracheva E Kozlov S et al 2003 Characterization of the recombinant extracellular domains of human interleukin 20 receptors and their complexes with interleukin 19 and interleukin 20 Biochemistry 42 43 12617 12624 doi 10 1021 bi0354583 PMID 14580208 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 45 doi 10 1038 ng1285 PMID 14702039 Sheikh F Baurin VV Lewis Antes A et al 2004 Cutting edge IL 26 signals through a novel receptor complex composed of IL 20 receptor 1 and IL 10 receptor 2 J Immunol 172 4 2006 10 doi 10 4049 jimmunol 172 4 2006 PMID 14764663 Hor S Pirzer H Dumoutier L et al 2004 The T cell lymphokine interleukin 26 targets epithelial cells through the interleukin 20 receptor 1 and interleukin 10 receptor 2 chains J Biol Chem 279 32 33343 33351 doi 10 1074 jbc M405000200 PMID 15178681 Zhang Z Henzel WJ 2005 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Sci 13 10 2819 2824 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interleukin 20 receptor alpha subunit amp oldid 1173112103, wikipedia, wiki, book, books, library,
