The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFNAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000243646 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022969 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lutfalla G, McInnis MG, Antonarakis SE, Uzé G (1995). "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor". J. Mol. Evol. 41 (3): 338–44. doi:10.1007/BF01215180. PMID 7563119. S2CID 38574595.
Lutfalla G, Gardiner K, Uzé G (1993). "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR". Genomics. 16 (2): 366–73. doi:10.1006/geno.1993.1199. PMID 8314576.
Gibbs VC, Pennica D (1997). "CRF2-4: isolation of cDNA clones encoding the human and mouse proteins". Gene. 186 (1): 97–101. doi:10.1016/S0378-1119(96)00690-7. PMID 9047351.
Kotenko SV, Krause CD, Izotova LS, et al. (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC1170220. PMID 9312047.
Spencer SD, Di Marco F, Hooley J, et al. (1998). "The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor". J. Exp. Med. 187 (4): 571–8. doi:10.1084/jem.187.4.571. PMC2212143. PMID 9463407.
Reboul J, Gardiner K, Monneron D, et al. (1999). "Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster". Genome Res. 9 (3): 242–50. doi:10.1101/gr.9.3.242. PMC310731. PMID 10077530.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Xie MH, Aggarwal S, Ho WH, et al. (2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R". J. Biol. Chem. 275 (40): 31335–9. doi:10.1074/jbc.M005304200. PMID 10875937.
Dumoutier L, Van Roost E, Colau D, Renauld JC (2000). "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10144–9. Bibcode:2000PNAS...9710144D. doi:10.1073/pnas.170291697. PMC27764. PMID 10954742.
Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. Bibcode:2001PNAS...98.7570L. doi:10.1073/pnas.121165198. PMC34709. PMID 11416224.
Hollborn M, Kohen L, Wiedemann P, Enzmann V (2001). "The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors". Graefes Arch. Clin. Exp. Ophthalmol. 239 (4): 294–301. doi:10.1007/s004170100263. PMID 11450494. S2CID 676836.
Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. doi:10.1016/S1074-7613(01)00169-8. PMID 11485736.
Sheppard P, Kindsvogel W, Xu W, et al. (2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119. S2CID 35764259.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Kotenko SV, Gallagher G, Baurin VV, et al. (2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex". Nat. Immunol. 4 (1): 69–77. doi:10.1038/ni875. PMID 12483210. S2CID 2734534.
Hör S, Pirzer H, Dumoutier L, et al. (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J. Biol. Chem. 279 (32): 33343–51. doi:10.1074/jbc.M405000200. PMID 15178681.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Pletnev S, Magracheva E, Wlodawer A, Zdanov A (2006). "A model of the ternary complex of interleukin-10 with its soluble receptors". BMC Struct. Biol. 5: 10. doi:10.1186/1472-6807-5-10. PMC1192808. PMID 15985167.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
interleukin, receptor, beta, subunit, subunit, interleukin, receptor, il10rb, human, gene, il10rbavailable, structurespdbortholog, search, pdbe, rcsblist, codes3lqmidentifiersaliasesil10rb, cdw210b, crf2, crfb4, d21s58, d21s66, 10r2, interleukin, receptor, sub. Interleukin 10 receptor beta subunit is a subunit for the interleukin 10 receptor IL10RB is its human gene 5 IL10RBAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes3LQMIdentifiersAliasesIL10RB CDW210B CRF2 4 CRFB4 D21S58 D21S66 IL 10R2 Interleukin 10 receptor beta subunit interleukin 10 receptor subunit betaExternal IDsOMIM 123889 MGI 109380 HomoloGene 523 GeneCards IL10RBGene location Human Chr Chromosome 21 human 1 Band21q22 11Start33 266 367 bp 1 End33 310 187 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 C3 3 16 52 87 cMStart91 203 052 bp 2 End91 222 722 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inplacentamonocytebloodrectumspleenduodenumappendixgallbladderstromal cell of endometriumlymph nodeTop expressed inadrenal glandinterventricular septumright ventricleright lung lobejejunumleft colonsciatic nervespleensubcutaneous adipose tissuesubmandibular glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding interleukin 10 receptor activity signaling receptor activity cytokine receptor activityCellular componentintegral component of membrane interleukin 28 receptor complex membrane plasma membraneBiological processinflammatory response defense response to virus immune response signal transduction cytokine mediated signaling pathway positive regulation of receptor signaling pathway via JAK STATSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez358816155EnsemblENSG00000243646ENSMUSG00000022969UniProtQ08334Q61190RefSeq mRNA NM 000628NM 008349RefSeq protein NP 000619n aLocation UCSC Chr 21 33 27 33 31 MbChr 16 91 2 91 22 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse IL10RB has also been designated CDw210b cluster of differentiation w210b The protein encoded by this gene belongs to the cytokine receptor family It is an accessory chain essential for the active interleukin 10 receptor complex Coexpression of this and IL10RA proteins has been shown to be required for IL10 induced signal transduction This gene and three other interferon receptor genes IFNAR2 IFNAR1 and IFNGR2 form a class II cytokine receptor gene cluster located in a small region on chromosome 21 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000243646 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022969 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene IL10RB interleukin 10 receptor beta Further reading editLutfalla G McInnis MG Antonarakis SE Uze G 1995 Structure of the human CRFB4 gene comparison with its IFNAR neighbor J Mol Evol 41 3 338 44 doi 10 1007 BF01215180 PMID 7563119 S2CID 38574595 Lutfalla G Gardiner K Uze G 1993 A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR Genomics 16 2 366 73 doi 10 1006 geno 1993 1199 PMID 8314576 Gibbs VC Pennica D 1997 CRF2 4 isolation of cDNA clones encoding the human and mouse proteins Gene 186 1 97 101 doi 10 1016 S0378 1119 96 00690 7 PMID 9047351 Kotenko SV Krause CD Izotova LS et al 1997 Identification and functional characterization of a second chain of the interleukin 10 receptor complex EMBO J 16 19 5894 903 doi 10 1093 emboj 16 19 5894 PMC 1170220 PMID 9312047 Spencer SD Di Marco F Hooley J et al 1998 The orphan receptor CRF2 4 is an essential subunit of the interleukin 10 receptor J Exp Med 187 4 571 8 doi 10 1084 jem 187 4 571 PMC 2212143 PMID 9463407 Reboul J Gardiner K Monneron D et al 1999 Comparative genomic analysis of the interferon interleukin 10 receptor gene cluster Genome Res 9 3 242 50 doi 10 1101 gr 9 3 242 PMC 310731 PMID 10077530 Hattori M Fujiyama A Taylor TD et al 2000 The DNA sequence of human chromosome 21 Nature 405 6784 311 9 Bibcode 2000Natur 405 311H doi 10 1038 35012518 PMID 10830953 Xie MH Aggarwal S Ho WH et al 2000 Interleukin IL 22 a novel human cytokine that signals through the interferon receptor related proteins CRF2 4 and IL 22R J Biol Chem 275 40 31335 9 doi 10 1074 jbc M005304200 PMID 10875937 Dumoutier L Van Roost E Colau D Renauld JC 2000 Human interleukin 10 related T cell derived inducible factor molecular cloning and functional characterization as an hepatocyte stimulating factor Proc Natl Acad Sci U S A 97 18 10144 9 Bibcode 2000PNAS 9710144D doi 10 1073 pnas 170291697 PMC 27764 PMID 10954742 Lewis K Li C Perrin MH et al 2001 Identification of urocortin III an additional member of the corticotropin releasing factor CRF family with high affinity for the CRF2 receptor Proc Natl Acad Sci U S A 98 13 7570 5 Bibcode 2001PNAS 98 7570L doi 10 1073 pnas 121165198 PMC 34709 PMID 11416224 Hollborn M Kohen L Wiedemann P Enzmann V 2001 The influence of pro inflammatory cytokines on human retinal pigment epithelium cell receptors Graefes Arch Clin Exp Ophthalmol 239 4 294 301 doi 10 1007 s004170100263 PMID 11450494 S2CID 676836 Josephson K Logsdon NJ Walter MR 2001 Crystal structure of the IL 10 IL 10R1 complex reveals a shared receptor binding site Immunity 15 1 35 46 doi 10 1016 S1074 7613 01 00169 8 PMID 11485736 Sheppard P Kindsvogel W Xu W et al 2003 IL 28 IL 29 and their class II cytokine receptor IL 28R Nat Immunol 4 1 63 8 doi 10 1038 ni873 PMID 12469119 S2CID 35764259 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kotenko SV Gallagher G Baurin VV et al 2003 IFN lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Nat Immunol 4 1 69 77 doi 10 1038 ni875 PMID 12483210 S2CID 2734534 Hor S Pirzer H Dumoutier L et al 2004 The T cell lymphokine interleukin 26 targets epithelial cells through the interleukin 20 receptor 1 and interleukin 10 receptor 2 chains J Biol Chem 279 32 33343 51 doi 10 1074 jbc M405000200 PMID 15178681 Zhang Z Henzel WJ 2005 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Sci 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Pletnev S Magracheva E Wlodawer A Zdanov A 2006 A model of the ternary complex of interleukin 10 with its soluble receptors BMC Struct Biol 5 10 doi 10 1186 1472 6807 5 10 PMC 1192808 PMID 15985167 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interleukin 10 receptor beta subunit amp oldid 1188033286, wikipedia, wiki, book, books, library,
