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Interleukin 10 receptor, alpha subunit

April 11, 2024

Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.

IL10RA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL10RA, CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, Interleukin 10 receptor, alpha subunit, interleukin 10 receptor subunit alpha
External IDsOMIM: 146933 MGI: 96538 HomoloGene: 1196 GeneCards: IL10RA
Orthologs
SpeciesHumanMouse
Entrez

3587

16154

Ensembl

ENSG00000110324

ENSMUSG00000032089

UniProt

Q13651

Q61727

RefSeq (mRNA)

NM_001558

NM_008348
NM_001324486

RefSeq (protein)

NP_001549

NP_001311415
NP_032374

Location (UCSC)Chr 11: 117.99 – 118 MbChr 9: 45.17 – 45.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IL10RA has also been designated CDw210a (cluster of differentiation w210a).

Function edit

See also: PI 3-kinase/AKT pathway

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.[5]

Interactions edit

Interleukin 10 receptor, alpha subunit has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110324 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032089 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha".
  6. ^ Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. Bibcode:1993PNAS...9011267H. doi:10.1073/pnas.90.23.11267. PMC 47963. PMID 8248239.
  7. ^ Josephson K, Logsdon NJ, Walter MR (July 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. doi:10.1016/s1074-7613(01)00169-8. PMID 11485736.
  8. ^ Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (May 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. doi:10.1074/jbc.270.21.12906. PMID 7759550.
  9. ^ Josephson K, McPherson DT, Walter MR (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D. 57 (Pt 12): 1908–11. doi:10.1107/s0907444901016249. PMID 11717514.
  10. ^ Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (May 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. doi:10.1046/j.1432-1327.1999.00363.x. PMID 10231374.
  11. ^ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. 277 (50): 48220–6. doi:10.1074/jbc.M205757200. PMID 12374810.
  12. ^ Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952.

Further reading edit

  • Donnelly RP, Dickensheets H, Finbloom DS (1999). "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes". J. Interferon Cytokine Res. 19 (6): 563–73. doi:10.1089/107999099313695. PMID 10433356. S2CID 35958614.
  • Carson WE, Lindemann MJ, Baiocchi R, Linett M, Tan JC, Chou CC, Narula S, Caligiuri MA (1995). "The functional characterization of interleukin-10 receptor expression on human natural killer cells". Blood. 85 (12): 3577–85. doi:10.1182/blood.V85.12.3577.bloodjournal85123577. PMID 7540068.
  • Ho AS, Wei SH, Mui AL, Miyajima A, Moore KW (1995). "Functional regions of the mouse interleukin-10 receptor cytoplasmic domain". Mol. Cell. Biol. 15 (9): 5043–53. doi:10.1128/mcb.15.9.5043. PMC 230751. PMID 7544437.
  • Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. doi:10.1074/jbc.270.21.12906. PMID 7759550.
  • Taniyama T, Takai S, Miyazaki E, Fukumura R, Sato J, Kobayashi Y, Hirakawa T, Moore KW, Yamada K (1995). "The human interleukin-10 receptor gene maps to chromosome 11q23.3". Hum. Genet. 95 (1): 99–101. doi:10.1007/BF00225083. PMID 7814035. S2CID 205672.
  • Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. doi:10.4049/jimmunol.152.4.1821. PMID 8120391.
  • Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. Bibcode:1993PNAS...9011267H. doi:10.1073/pnas.90.23.11267. PMC 47963. PMID 8248239.
  • Tan JC, Indelicato SR, Narula SK, Zavodny PJ, Chou CC (1993). "Characterization of interleukin-10 receptors on human and mouse cells". J. Biol. Chem. 268 (28): 21053–9. doi:10.1016/S0021-9258(19)36892-9. PMID 8407942.
  • Lai CF, Ripperger J, Morella KK, Jurlander J, Hawley TS, Carson WE, Kordula T, Caligiuri MA, Hawley RG, Fey GH, Baumann H (1996). "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements". J. Biol. Chem. 271 (24): 13968–75. doi:10.1074/jbc.271.24.13968. PMID 8662928.
  • Zdanov A, Schalk-Hihi C, Wlodawer A (1997). "Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor". Protein Sci. 5 (10): 1955–62. doi:10.1002/pro.5560051001. PMC 2143256. PMID 8897595.
  • Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220. PMID 9312047.
  • Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. doi:10.1046/j.1432-1327.1999.00363.x. PMID 10231374.
  • Müschen A, Mirmohammadsadegh A, Jarzebska-Deussen B, Abts HF, Ruzicka T, Michel G (1999). "Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes". Inflamm. Res. 48 (10): 539–43. doi:10.1007/s000110050500. PMID 10563471. S2CID 22779271.
  • Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G (2001). "Regulatory activity of autocrine IL-10 on dendritic cell functions". J. Immunol. 166 (7): 4312–8. doi:10.4049/jimmunol.166.7.4312. PMID 11254683.
  • Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. doi:10.1016/S1074-7613(01)00169-8. PMID 11485736.
  • Crepaldi L, Gasperini S, Lapinet JA, Calzetti F, Pinardi C, Liu Y, Zurawski S, de Waal Malefyt R, Moore KW, Cassatella MA (2001). "Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10". J. Immunol. 167 (4): 2312–22. doi:10.4049/jimmunol.167.4.2312. PMID 11490020.
  • Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW (2001). "IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase". J. Immunol. 167 (8): 4436–42. doi:10.4049/jimmunol.167.8.4436. PMID 11591769.
  • Josephson K, McPherson DT, Walter MR (2002). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D. 57 (Pt 12): 1908–11. doi:10.1107/S0907444901016249. PMID 11717514.
  • Wolk K, Kunz S, Asadullah K, Sabat R (2002). "Cutting edge: immune cells as sources and targets of the IL-10 family members?". J. Immunol. 168 (11): 5397–402. doi:10.4049/jimmunol.168.11.5397. PMID 12023331.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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April 11, 2024
interleukin, receptor, alpha, subunit, interleukin, receptor, subunit, alpha, subunit, interleukin, receptor, il10ra, human, gene, il10raavailable, structurespdbortholog, search, pdbe, rcsblist, codes1j7v, 1lqs, 1y6k, 1y6m, 1y6n, 5ixiidentifiersaliasesil10ra, . Interleukin 10 receptor subunit alpha is a subunit for the interleukin 10 receptor IL10RA is its human gene IL10RAAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1J7V 1LQS 1Y6K 1Y6M 1Y6N 5IXIIdentifiersAliasesIL10RA CD210 CD210a CDW210A HIL 10R IL 10R1 IL10R Interleukin 10 receptor alpha subunit interleukin 10 receptor subunit alphaExternal IDsOMIM 146933 MGI 96538 HomoloGene 1196 GeneCards IL10RAGene location Human Chr Chromosome 11 human 1 Band11q23 3Start117 986 370 bp 1 End118 003 037 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 A5 2 9 24 84 cMStart45 165 135 bp 2 End45 180 447 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodspleenbone marrow cellslymph nodeappendixgallbladderrectumright coronary arteryupper lobe of left lungTop expressed inspleenbloodankle jointthymussubcutaneous adipose tissuesuperior frontal gyruslipesophagusyolk sacwhite adipose tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding interleukin 10 binding signal transducer activity interleukin 10 receptor activity signaling receptor activity cytokine receptor activityCellular componentintegral component of membrane membrane plasma membrane cytoplasmBiological processresponse to lipopolysaccharide regulation of synapse organization cytokine mediated signaling pathway negative regulation of autophagy positive regulation of receptor signaling pathway via JAK STAT ubiquitin dependent endocytosisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez358716154EnsemblENSG00000110324ENSMUSG00000032089UniProtQ13651Q61727RefSeq mRNA NM 001558NM 008348NM 001324486RefSeq protein NP 001549NP 001311415NP 032374Location UCSC Chr 11 117 99 118 MbChr 9 45 17 45 18 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseIL10RA has also been designated CDw210a cluster of differentiation w210a Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editSee also PI 3 kinase AKT pathway The protein encoded by this gene is a receptor for interleukin 10 This protein is structurally related to interferon receptors It has been shown to mediate the immunosuppressive signal of interleukin 10 and thus inhibits the synthesis of proinflammatory cytokines This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate 2 PI 3 kinase AKT pathway Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases 5 Interactions editInterleukin 10 receptor alpha subunit has been shown to interact with Interleukin 10 6 7 8 9 10 and Janus kinase 1 11 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000110324 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032089 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene IL10RA interleukin 10 receptor alpha Ho AS Liu Y Khan TA Hsu DH Bazan JF Moore KW December 1993 A receptor for interleukin 10 is related to interferon receptors Proc Natl Acad Sci U S A 90 23 11267 71 Bibcode 1993PNAS 9011267H doi 10 1073 pnas 90 23 11267 PMC 47963 PMID 8248239 Josephson K Logsdon NJ Walter MR July 2001 Crystal structure of the IL 10 IL 10R1 complex reveals a shared receptor binding site Immunity 15 1 35 46 doi 10 1016 s1074 7613 01 00169 8 PMID 11485736 Tan JC Braun S Rong H DiGiacomo R Dolphin E Baldwin S Narula SK Zavodny PJ Chou CC May 1995 Characterization of recombinant extracellular domain of human interleukin 10 receptor J Biol Chem 270 21 12906 11 doi 10 1074 jbc 270 21 12906 PMID 7759550 Josephson K McPherson DT Walter MR December 2001 Purification crystallization and preliminary X ray diffraction of a complex between IL 10 and soluble IL 10R1 Acta Crystallogr D 57 Pt 12 1908 11 doi 10 1107 s0907444901016249 PMID 11717514 Hoover DM Schalk Hihi C Chou CC Menon S Wlodawer A Zdanov A May 1999 Purification of receptor complexes of interleukin 10 stoichiometry and the importance of deglycosylation in their crystallization Eur J Biochem 262 1 134 41 doi 10 1046 j 1432 1327 1999 00363 x PMID 10231374 Usacheva A Sandoval R Domanski P Kotenko SV Nelms K Goldsmith MA Colamonici OR December 2002 Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation J Biol Chem 277 50 48220 6 doi 10 1074 jbc M205757200 PMID 12374810 Usacheva A Kotenko S Witte MM Colamonici OR August 2002 Two distinct domains within the N terminal region of Janus kinase 1 interact with cytokine receptors J Immunol 169 3 1302 8 doi 10 4049 jimmunol 169 3 1302 PMID 12133952 Further reading editDonnelly RP Dickensheets H Finbloom DS 1999 The interleukin 10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes J Interferon Cytokine Res 19 6 563 73 doi 10 1089 107999099313695 PMID 10433356 S2CID 35958614 Carson WE Lindemann MJ Baiocchi R Linett M Tan JC Chou CC Narula S Caligiuri MA 1995 The functional characterization of interleukin 10 receptor expression on human natural killer cells Blood 85 12 3577 85 doi 10 1182 blood V85 12 3577 bloodjournal85123577 PMID 7540068 Ho AS Wei SH Mui AL Miyajima A Moore KW 1995 Functional regions of the mouse interleukin 10 receptor cytoplasmic domain Mol Cell Biol 15 9 5043 53 doi 10 1128 mcb 15 9 5043 PMC 230751 PMID 7544437 Tan JC Braun S Rong H DiGiacomo R Dolphin E Baldwin S Narula SK Zavodny PJ Chou CC 1995 Characterization of recombinant extracellular domain of human interleukin 10 receptor J Biol Chem 270 21 12906 11 doi 10 1074 jbc 270 21 12906 PMID 7759550 Taniyama T Takai S Miyazaki E Fukumura R Sato J Kobayashi Y Hirakawa T Moore KW Yamada K 1995 The human interleukin 10 receptor gene maps to chromosome 11q23 3 Hum Genet 95 1 99 101 doi 10 1007 BF00225083 PMID 7814035 S2CID 205672 Liu Y Wei SH Ho AS de Waal Malefyt R Moore KW 1994 Expression cloning and characterization of a human IL 10 receptor J Immunol 152 4 1821 9 doi 10 4049 jimmunol 152 4 1821 PMID 8120391 Ho AS Liu Y Khan TA Hsu DH Bazan JF Moore KW 1994 A receptor for interleukin 10 is related to interferon receptors Proc Natl Acad Sci U S A 90 23 11267 71 Bibcode 1993PNAS 9011267H doi 10 1073 pnas 90 23 11267 PMC 47963 PMID 8248239 Tan JC Indelicato SR Narula SK Zavodny PJ Chou CC 1993 Characterization of interleukin 10 receptors on human and mouse cells J Biol Chem 268 28 21053 9 doi 10 1016 S0021 9258 19 36892 9 PMID 8407942 Lai CF Ripperger J Morella KK Jurlander J Hawley TS Carson WE Kordula T Caligiuri MA Hawley RG Fey GH Baumann H 1996 Receptors for interleukin IL 10 and IL 6 type cytokines use similar signaling mechanisms for inducing transcription through IL 6 response elements J Biol Chem 271 24 13968 75 doi 10 1074 jbc 271 24 13968 PMID 8662928 Zdanov A Schalk Hihi C Wlodawer A 1997 Crystal structure of human interleukin 10 at 1 6 A resolution and a model of a complex with its soluble receptor Protein Sci 5 10 1955 62 doi 10 1002 pro 5560051001 PMC 2143256 PMID 8897595 Kotenko SV Krause CD Izotova LS Pollack BP Wu W Pestka S 1997 Identification and functional characterization of a second chain of the interleukin 10 receptor complex EMBO J 16 19 5894 903 doi 10 1093 emboj 16 19 5894 PMC 1170220 PMID 9312047 Hoover DM Schalk Hihi C Chou CC Menon S Wlodawer A Zdanov A 1999 Purification of receptor complexes of interleukin 10 stoichiometry and the importance of deglycosylation in their crystallization Eur J Biochem 262 1 134 41 doi 10 1046 j 1432 1327 1999 00363 x PMID 10231374 Muschen A Mirmohammadsadegh A Jarzebska Deussen B Abts HF Ruzicka T Michel G 1999 Differential IL 10 receptor gene expression in acute versus chronic atopic eczema Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes Inflamm Res 48 10 539 43 doi 10 1007 s000110050500 PMID 10563471 S2CID 22779271 Corinti S Albanesi C la Sala A Pastore S Girolomoni G 2001 Regulatory activity of autocrine IL 10 on dendritic cell functions J Immunol 166 7 4312 8 doi 10 4049 jimmunol 166 7 4312 PMID 11254683 Josephson K Logsdon NJ Walter MR 2001 Crystal structure of the IL 10 IL 10R1 complex reveals a shared receptor binding site Immunity 15 1 35 46 doi 10 1016 S1074 7613 01 00169 8 PMID 11485736 Crepaldi L Gasperini S Lapinet JA Calzetti F Pinardi C Liu Y Zurawski S de Waal Malefyt R Moore KW Cassatella MA 2001 Up regulation of IL 10R1 expression is required to render human neutrophils fully responsive to IL 10 J Immunol 167 4 2312 22 doi 10 4049 jimmunol 167 4 2312 PMID 11490020 Zhou JH Broussard SR Strle K Freund GG Johnson RW Dantzer R Kelley KW 2001 IL 10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate 2 and phosphatidylinositol 3 kinase J Immunol 167 8 4436 42 doi 10 4049 jimmunol 167 8 4436 PMID 11591769 Josephson K McPherson DT Walter MR 2002 Purification crystallization and preliminary X ray diffraction of a complex between IL 10 and soluble IL 10R1 Acta Crystallogr D 57 Pt 12 1908 11 doi 10 1107 S0907444901016249 PMID 11717514 Wolk K Kunz S Asadullah K Sabat R 2002 Cutting edge immune cells as sources and targets of the IL 10 family members J Immunol 168 11 5397 402 doi 10 4049 jimmunol 168 11 5397 PMID 12023331 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interleukin 10 receptor alpha subunit amp oldid 1216952553, wikipedia, wiki, book, books, library,

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