Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene.[5] IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes.
As the name implies, these genes are induced by interferon and form part of its signaling pathway. In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In humans, IFITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.[6]
IFITM proteins have been identified as antiviral restriction factors that block the early stages of viral replication.[7] They inhibit influenza A virus replication,[8] and infection with a wide range of other enveloped viruses[9]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000185201 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000060591 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Interferon induced transmembrane protein 2". Retrieved 2016-02-21.
^Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (December 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev. Cell. 9 (6): 745–56. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
^Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL (January 2013). "IFITM proteins restrict viral membrane hemifusion". PLOS Pathog. 9 (1): e1003124. doi:10.1371/journal.ppat.1003124. PMC3554583. PMID 23358889.
^Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL (October 2011). "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. doi:10.1371/journal.ppat.1002337. PMC3203188. PMID 22046135.
^Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ (December 2009). "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus". Cell. 139 (7): 1243–54. doi:10.1016/j.cell.2009.12.017. PMC2824905. PMID 20064371.
Further readingedit
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
interferon, induced, transmembrane, protein, protein, that, humans, encoded, ifitm2, gene, ifitm1, member, ifitm, family, interferon, induced, transmembrane, protein, which, encoded, ifitm, genes, ifitm2identifiersaliasesifitm2, dspa2c, interferon, induced, tr. Interferon induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene 5 IFITM1 is a member of the IFITM family Interferon induced transmembrane protein which is encoded by IFITM genes IFITM2IdentifiersAliasesIFITM2 1 8D DSPA2c interferon induced transmembrane protein 2External IDsOMIM 605578 MGI 1933382 HomoloGene 74574 GeneCards IFITM2Gene location Human Chr Chromosome 11 human 1 Band11p15 5Start303 655 bp 1 End309 397 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 F5Start140 534 750 bp 2 End140 535 900 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbloodright lungpericardiumperiodontal fiberspleenupper lobe of left lungleft uterine tubeolfactory bulbcanal of the cervixright coronary arteryTop expressed inadrenal glanduteruslungurinary bladderlipwhite adipose tissuezone of skinheartstomachneural tubeMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez1058180876EnsemblENSG00000185201ENSMUSG00000060591UniProtQ01629Q99J93RefSeq mRNA NM 006435NM 030694RefSeq protein NP 006426NP 109619Location UCSC Chr 11 0 3 0 31 MbChr 7 140 53 140 54 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse As the name implies these genes are induced by interferon and form part of its signaling pathway In the absence of interferon stimulation IFITM proteins can express broadly in tissues and cell lines In humans IFITM1 IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts 6 Antiviral function editFurther information IFITM1 Antiviral function of IFITM proteins IFITM proteins have been identified as antiviral restriction factors that block the early stages of viral replication 7 They inhibit influenza A virus replication 8 and infection with a wide range of other enveloped viruses 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000185201 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000060591 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Interferon induced transmembrane protein 2 Retrieved 2016 02 21 Tanaka SS Yamaguchi YL Tsoi B Lickert H Tam PP December 2005 IFITM Mil fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion Dev Cell 9 6 745 56 doi 10 1016 j devcel 2005 10 010 PMID 16326387 Li K Markosyan RM Zheng YM Golfetto O Bungart B Li M Ding S He Y Liang C Lee JC Gratton E Cohen FS Liu SL January 2013 IFITM proteins restrict viral membrane hemifusion PLOS Pathog 9 1 e1003124 doi 10 1371 journal ppat 1003124 PMC 3554583 PMID 23358889 Feeley EM Sims JS John SP Chin CR Pertel T Chen LM Gaiha GD Ryan BJ Donis RO Elledge SJ Brass AL October 2011 IFITM3 inhibits influenza A virus infection by preventing cytosolic entry PLOS Pathog 7 10 e1002337 doi 10 1371 journal ppat 1002337 PMC 3203188 PMID 22046135 Brass AL Huang IC Benita Y John SP Krishnan MN Feeley EM Ryan BJ Weyer JL van der Weyden L Fikrig E Adams DJ Xavier RJ Farzan M Elledge SJ December 2009 The IFITM proteins mediate cellular resistance to influenza A H1N1 virus West Nile virus and dengue virus Cell 139 7 1243 54 doi 10 1016 j cell 2009 12 017 PMC 2824905 PMID 20064371 Further reading edit nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interferon induced transmembrane protein 2 amp oldid 1188033100, wikipedia, wiki, book, books, library,
