Fritz Heinrich Jakob Lewy, a German-American neurologist, first identified and described inclusions in the brain cells of patients with Parkinson’s disease and published his findings in the Lewandowsky’s Handbook of Neurology in 1912.[3]I-cells also called inclusion cells are abnormal fibroblasts having a large number of dark inclusions in the cytoplasm of the cell (mainly in the central area). They are metabolically inactive structures of a cell and are not enclosed by a membrane.[4] The inclusions are of various fats, proteins, carbohydrates, pigments, excretory products, crystals,[5] and other insolubles. They are found in the cytoplasm of a cell in both prokaryotes and eukaryotes.[6] They are seen in Mucolipidosis II,[7] and Mucolipidosis III, also called inclusion-cell or I-cell disease where lysosomal enzyme transport and storage is affected.[8]
In this image there are multiple Schaumann bodies with crystalline inclusions.[1]Schaumann bodies are calcium and protein inclusions inside of Langhans giant cells as part of a granuloma.[2]Histological slide of the human herpes virus-6 showing infected cells, with inclusion bodies in both the nucleus and the cytoplasm.[9]Photomicrograph of a region of substantia nigra in a Parkinson's patient showing Lewy bodies (inclusions aggregated to form Lewy bodies).[10]
ReferencesEdit
^USA, Yale Rosen from (2011-08-04), The crystalline inclusions that may be found within the giant cells in sarcoidosis and other granulomatous disorders consist mainly of calcium oxalate and well as some calcium cargbonate. In this image there are multiple Schaumann bodies closely associated with crystalline inclusions. In many cases the crystals appear to serve as a nidus around which Schaumann bodies are formed. H&E stain., retrieved 2021-12-10
^Engelhardt, Eliasz (October 2017). "Lafora and Trétiakoff: the naming of the inclusion bodies discovered by Lewy". Arquivos de Neuro-Psiquiatria. 75 (10): 751–753. doi:10.1590/0004-282X20170116. ISSN 0004-282X. PMID 29166468.
^Lakna (2018-11-03). "What is the Difference Between Cell Organelles and Cell Inclusions". Pediaa.Com. Retrieved 2021-12-09.
^Leliaert, Frederik; Coppejans, Eric (March 2004). "Crystalline cell inclusions: a new diagnostic character in the Cladophorophyceae (Chlorophyta)". Phycologia. 43 (2): 189–203. doi:10.2216/i0031-8884-43-2-189.1. ISSN 0031-8884. S2CID 86155723.
^"inclusion body | biology | Britannica". www.britannica.com. Retrieved 2021-12-09.
^al.], consultants Daniel Albert ... [et (2012). Dorland's illustrated medical dictionary (32nd ed.). Philadelphia, PA: Saunders/Elsevier. pp. 319 and 928. ISBN978-1-4160-6257-8.
^"Mucolipidoses Fact Sheet | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved 2021-12-09.
^photographer, Unknown (October 1986), Deutsch: Lichtmikroskopische Aufnahme von infizierten T-Lymphozyten mit typischen sogenannten Einschlusskörperchen (HE-Färbung). Einschlüsse bei einer HHV6-Infektion (dunkelblaue Punkte)., retrieved 2021-12-10
^Rajan, Suraj (2012-05-12), English: Photomicrograph of a region of substantia nigra in a Parkinson's patient showing Lewy bodies and Lewy neurites. It shows a 60-times magnification of the alpha synuclein intraneuronal inclusions aggregated to form Lewy bodies. Stains used: mouse monoclonal alpha-synuclein antibody; counterstained with Mayer's haematoxylin., retrieved 2021-12-10
This cell biology article is a stub. You can help Wikipedia by expanding it.
cell, this, article, about, inclusion, cells, intestinal, cells, enteroendocrine, cell, cell, fritz, heinrich, jakob, lewy, german, american, neurologist, first, identified, described, inclusions, brain, cells, patients, with, parkinson, disease, published, fi. This article is about inclusion cells For the intestinal cells see Enteroendocrine cell I cell Fritz Heinrich Jakob Lewy a German American neurologist first identified and described inclusions in the brain cells of patients with Parkinson s disease and published his findings in the Lewandowsky s Handbook of Neurology in 1912 3 I cells also called inclusion cells are abnormal fibroblasts having a large number of dark inclusions in the cytoplasm of the cell mainly in the central area They are metabolically inactive structures of a cell and are not enclosed by a membrane 4 The inclusions are of various fats proteins carbohydrates pigments excretory products crystals 5 and other insolubles They are found in the cytoplasm of a cell in both prokaryotes and eukaryotes 6 They are seen in Mucolipidosis II 7 and Mucolipidosis III also called inclusion cell or I cell disease where lysosomal enzyme transport and storage is affected 8 In this image there are multiple Schaumann bodies with crystalline inclusions 1 Schaumann bodies are calcium and protein inclusions inside of Langhans giant cells as part of a granuloma 2 Histological slide of the human herpes virus 6 showing infected cells with inclusion bodies in both the nucleus and the cytoplasm 9 Photomicrograph of a region of substantia nigra in a Parkinson s patient showing Lewy bodies inclusions aggregated to form Lewy bodies 10 References Edit USA Yale Rosen from 2011 08 04 The crystalline inclusions that may be found within the giant cells in sarcoidosis and other granulomatous disorders consist mainly of calcium oxalate and well as some calcium cargbonate In this image there are multiple Schaumann bodies closely associated with crystalline inclusions In many cases the crystals appear to serve as a nidus around which Schaumann bodies are formed H amp E stain retrieved 2021 12 10 Schaumann body Wikipedia 2021 07 12 retrieved 2021 12 10 Engelhardt Eliasz October 2017 Lafora and Tretiakoff the naming of the inclusion bodies discovered by Lewy Arquivos de Neuro Psiquiatria 75 10 751 753 doi 10 1590 0004 282X20170116 ISSN 0004 282X PMID 29166468 Lakna 2018 11 03 What is the Difference Between Cell Organelles and Cell Inclusions Pediaa Com Retrieved 2021 12 09 Leliaert Frederik Coppejans Eric March 2004 Crystalline cell inclusions a new diagnostic character in the Cladophorophyceae Chlorophyta Phycologia 43 2 189 203 doi 10 2216 i0031 8884 43 2 189 1 ISSN 0031 8884 S2CID 86155723 inclusion body biology Britannica www britannica com Retrieved 2021 12 09 al consultants Daniel Albert et 2012 Dorland s illustrated medical dictionary 32nd ed Philadelphia PA Saunders Elsevier pp 319 and 928 ISBN 978 1 4160 6257 8 Mucolipidoses Fact Sheet National Institute of Neurological Disorders and Stroke www ninds nih gov Retrieved 2021 12 09 photographer Unknown October 1986 Deutsch Lichtmikroskopische Aufnahme von infizierten T Lymphozyten mit typischen sogenannten Einschlusskorperchen HE Farbung Einschlusse bei einer HHV6 Infektion dunkelblaue Punkte retrieved 2021 12 10 Rajan Suraj 2012 05 12 English Photomicrograph of a region of substantia nigra in a Parkinson s patient showing Lewy bodies and Lewy neurites It shows a 60 times magnification of the alpha synuclein intraneuronal inclusions aggregated to form Lewy bodies Stains used mouse monoclonal alpha synuclein antibody counterstained with Mayer s haematoxylin retrieved 2021 12 10 This cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title I cell amp oldid 1138976766, wikipedia, wiki, book, books, library,
