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Wikipedia

ITIH3

August 24, 2023

Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene.[5][6][7]

ITIH3
Identifiers
AliasesITIH3, H3P, ITI-HC3, SHAP, inter-alpha-trypsin inhibitor heavy chain 3
External IDsOMIM: 146650 MGI: 96620 HomoloGene: 1669 GeneCards: ITIH3
Orthologs
SpeciesHumanMouse
Entrez

3699

16426

Ensembl

ENSG00000162267

ENSMUSG00000006522

UniProt

Q06033

Q61704

RefSeq (mRNA)

NM_002217

NM_008407

RefSeq (protein)

NP_002208

NP_032433

Location (UCSC)Chr 3: 52.79 – 52.81 MbChr 14: 30.63 – 30.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162267 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006522 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP (Apr 1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur J Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.
  6. ^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. S2CID 84807160.
  7. ^ "Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3".

Further reading

  • Salier JP, Simon D, Rouet P, et al. (1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
  • Enghild JJ, Salvesen G, Hefta SA, et al. (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. doi:10.1016/S0021-9258(17)35235-3. PMID 1898736.
  • Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322.
  • Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. doi:10.1016/S0021-9258(18)71575-5. PMID 2476436.
  • Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta. 1219 (2): 551–4. doi:10.1016/0167-4781(94)90087-6. PMID 7522574.
  • Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. doi:10.1111/j.1432-1033.1993.tb17717.x. PMID 7681778.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". Biochem. J. 328 (1): 185–91. doi:10.1042/bj3280185. PMC 1218904. PMID 9359851.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.
  • Thuveson M, Fries E (1999). "Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin". J. Biol. Chem. 274 (10): 6741–6. doi:10.1074/jbc.274.10.6741. PMID 10037773.
  • Bourguignon J, Borghi H, Sesboüé R, et al. (1999). "Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue". J. Histochem. Cytochem. 47 (12): 1625–32. doi:10.1177/002215549904701214. PMID 10567446.
  • Thuveson M, Fries E (2000). "The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor". J. Biol. Chem. 275 (40): 30996–1000. doi:10.1074/jbc.M002399200. PMID 10893227.
  • Kato M, Seki N, Sugano S, et al. (2002). "Identification of sonic hedgehog-responsive genes using cDNA microarray". Biochem. Biophys. Res. Commun. 289 (2): 472–8. doi:10.1006/bbrc.2001.5976. PMID 11716497.
  • Paris S, Sesboüé R, Delpech B, et al. (2002). "Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains". Int. J. Cancer. 97 (5): 615–20. doi:10.1002/ijc.10120. PMID 11807786. S2CID 41750371.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


 

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

August 24, 2023
itih3, inter, alpha, trypsin, inhibitor, heavy, chain, protein, that, humans, encoded, gene, identifiersaliases, shap, inter, alpha, trypsin, inhibitor, heavy, chain, 3external, idsomim, 146650, 96620, homologene, 1669, genecards, gene, location, human, chromo. Inter alpha trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene 5 6 7 ITIH3IdentifiersAliasesITIH3 H3P ITI HC3 SHAP inter alpha trypsin inhibitor heavy chain 3External IDsOMIM 146650 MGI 96620 HomoloGene 1669 GeneCards ITIH3Gene location Human Chr Chromosome 3 human 1 Band3p21 1Start52 794 768 bp 1 End52 809 009 bp 1 Gene location Mouse Chr Chromosome 14 mouse 2 Band14 14 BStart30 630 529 bp 2 End30 645 717 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liverright coronary arterypopliteal arteryleft coronary arterysaphenous veintibial nervesural nervespleenspermright lungTop expressed inventromedial nucleusleft lobe of liverdorsomedial hypothalamic nucleusparaventricular nucleus of hypothalamuslateral hypothalamusarcuate nucleusdorsal tegmental nucleusmammillary bodyventral tegmental areamedial vestibular nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionpeptidase inhibitor activity endopeptidase inhibitor activity serine type endopeptidase inhibitor activity protein bindingCellular componentextracellular exosome platelet dense granule lumen extracellular regionBiological processnegative regulation of peptidase activity hyaluronan metabolic process negative regulation of endopeptidase activity platelet degranulationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez369916426EnsemblENSG00000162267ENSMUSG00000006522UniProtQ06033Q61704RefSeq mRNA NM 002217NM 008407RefSeq protein NP 002208NP 032433Location UCSC Chr 3 52 79 52 81 MbChr 14 30 63 30 65 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseSee also EditInter alpha trypsin inhibitor ITIH1 ITIH2 ITIH4References Edit a b c GRCh38 Ensembl release 89 ENSG00000162267 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000006522 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Diarra Mehrpour M Bourguignon J Sesboue R Mattei MG Passage E Salier JP Martin JP Apr 1989 Human plasma inter alpha trypsin inhibitor is encoded by four genes on three chromosomes Eur J Biochem 179 1 147 54 doi 10 1111 j 1432 1033 1989 tb14532 x PMID 2465147 Jean L Risler JL Nagase T Coulouarn C Nomura N Salier JP May 1999 The nuclear protein PH5P of the inter alpha inhibitor superfamily a missing link between poly ADP ribose polymerase and the inter alpha inhibitor family and a novel actor of DNA repair FEBS Lett 446 1 6 8 doi 10 1016 S0014 5793 99 00173 8 PMID 10100603 S2CID 84807160 Entrez Gene ITIH3 inter alpha globulin inhibitor H3 Further reading EditSalier JP Simon D Rouet P et al 1992 Homologous chromosomal locations of the four genes for inter alpha inhibitor and pre alpha inhibitor family in human and mouse assignment of the ancestral gene for the lipocalin superfamily Genomics 14 1 83 8 doi 10 1016 S0888 7543 05 80287 3 PMID 1385302 Enghild JJ Salvesen G Hefta SA et al 1991 Chondroitin 4 sulfate covalently cross links the chains of the human blood protein pre alpha inhibitor J Biol Chem 266 2 747 51 doi 10 1016 S0021 9258 17 35235 3 PMID 1898736 Salier JP Diarra Mehrpour M Sesboue R et al 1988 Isolation and characterization of cDNAs encoding the heavy chain of human inter alpha trypsin inhibitor I alpha TI unambiguous evidence for multipolypeptide chain structure of I alpha TI Proc Natl Acad Sci U S A 84 23 8272 6 doi 10 1073 pnas 84 23 8272 PMC 299524 PMID 2446322 Enghild JJ Thogersen IB Pizzo SV Salvesen G 1989 Analysis of inter alpha trypsin inhibitor and a novel trypsin inhibitor pre alpha trypsin inhibitor from human plasma Polypeptide chain stoichiometry and assembly by glycan J Biol Chem 264 27 15975 81 doi 10 1016 S0021 9258 18 71575 5 PMID 2476436 Diarra Mehrpour M Bourguignon J Sarafan N et al 1994 Tandem orientation of the inter alpha trypsin inhibitor heavy chain H1 and H3 genes Biochim Biophys Acta 1219 2 551 4 doi 10 1016 0167 4781 94 90087 6 PMID 7522574 Bourguignon J Diarra Mehrpour M Thiberville L et al 1993 Human pre alpha trypsin inhibitor precursor heavy chain cDNA and deduced amino acid sequence Eur J Biochem 212 3 771 6 doi 10 1111 j 1432 1033 1993 tb17717 x PMID 7681778 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Blom AM Thuveson M Fries E 1998 Intracellular coupling of bikunin and the heavy chain of rat pre alpha inhibitor in COS 1 cells Biochem J 328 1 185 91 doi 10 1042 bj3280185 PMC 1218904 PMID 9359851 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Diarra Mehrpour M Sarafan N Bourguignon J et al 1998 Human inter alpha trypsin inhibitor heavy chain H3 gene Genomic organization promoter analysis and gene linkage J Biol Chem 273 41 26809 19 doi 10 1074 jbc 273 41 26809 PMID 9756925 Thuveson M Fries E 1999 Intracellular proteolytic processing of the heavy chain of rat pre alpha inhibitor The COOH terminal propeptide is required for coupling to bikunin J Biol Chem 274 10 6741 6 doi 10 1074 jbc 274 10 6741 PMID 10037773 Bourguignon J Borghi H Sesboue R et al 1999 Immunohistochemical distribution of inter alpha trypsin inhibitor chains in normal and malignant human lung tissue J Histochem Cytochem 47 12 1625 32 doi 10 1177 002215549904701214 PMID 10567446 Thuveson M Fries E 2000 The low pH in trans Golgi triggers autocatalytic cleavage of pre alpha inhibitor heavy chain precursor J Biol Chem 275 40 30996 1000 doi 10 1074 jbc M002399200 PMID 10893227 Kato M Seki N Sugano S et al 2002 Identification of sonic hedgehog responsive genes using cDNA microarray Biochem Biophys Res Commun 289 2 472 8 doi 10 1006 bbrc 2001 5976 PMID 11716497 Paris S Sesboue R Delpech B et al 2002 Inhibition of tumor growth and metastatic spreading by overexpression of inter alpha trypsin inhibitor family chains Int J Cancer 97 5 615 20 doi 10 1002 ijc 10120 PMID 11807786 S2CID 41750371 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ITIH3 amp oldid 1171091556, wikipedia, wiki, book, books, library,

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