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Wikipedia

IRS2

January 01, 1970

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.[5]

IRS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIRS2, IRS-2, insulin receptor substrate 2
External IDsOMIM: 600797 MGI: 109334 HomoloGene: 2778 GeneCards: IRS2
Orthologs
SpeciesHumanMouse
Entrez

8660

384783

Ensembl

ENSG00000185950

ENSMUSG00000038894

UniProt

Q9Y4H2

P81122

RefSeq (mRNA)

NM_003749

NM_001081212

RefSeq (protein)

NP_003740

NP_001074681

Location (UCSC)Chr 13: 109.75 – 109.79 MbChr 8: 11.03 – 11.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
For chemical compound with molecular formula IrS2, see Iridium disulfide.

Function edit

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.[6]

Mice lacking IRS2 have a diabetic phenotype[7] as well as a 40% reduction in brain mass.[8]

Interactions edit

IRS2 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185950 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038894 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T (Oct 1997). "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain". J Biol Chem. 272 (40): 25267–74. doi:10.1074/jbc.272.40.25267. PMID 9312143.
  6. ^ "Entrez Gene: IRS2 insulin receptor substrate 2".
  7. ^ Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF (October 2004). "Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes". J. Clin. Invest. 114 (7): 908–16. doi:10.1172/JCI22217. PMC 518668. PMID 15467829.
  8. ^ Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF (August 2003). "Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation". J. Neurosci. 23 (18): 7084–92. doi:10.1523/JNEUROSCI.23-18-07084.2003. PMC 6740672. PMID 12904469.
  9. ^ Sozzani P, Hasan L, Séguélas MH, Caput D, Ferrara P, Pipy B, Cambon C (March 1998). "IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production". Biochem. Biophys. Res. Commun. 244 (3): 665–70. doi:10.1006/bbrc.1998.8314. PMID 9535722.
  10. ^ Rui L, Yuan M, Frantz D, Shoelson S, White MF (November 2002). "SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2". J. Biol. Chem. 277 (44): 42394–8. doi:10.1074/jbc.C200444200. PMID 12228220.
  11. ^ Argetsinger LS, Norstedt G, Billestrup N, White MF, Carter-Su C (November 1996). "Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling". J. Biol. Chem. 271 (46): 29415–21. doi:10.1074/jbc.271.46.29415. PMID 8910607.
  12. ^ Verdier F, Chrétien S, Billat C, Gisselbrecht S, Lacombe C, Mayeux P (October 1997). "Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation". J. Biol. Chem. 272 (42): 26173–8. doi:10.1074/jbc.272.42.26173. PMID 9334184.
  13. ^ Kim B, Cheng HL, Margolis B, Feldman EL (December 1998). "Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling". J. Biol. Chem. 273 (51): 34543–50. doi:10.1074/jbc.273.51.34543. PMID 9852124.
  14. ^ Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL (May 2002). "An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events". Diabetologia. 45 (5): 657–67. doi:10.1007/s00125-002-0798-5. PMID 12107746.

Further reading edit

  • White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action". Mol. Cell. Biochem. 182 (1–2): 3–11. doi:10.1023/A:1006806722619. PMID 9609109. S2CID 32623861.
  • Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
  • Sesti G, Federici M, Hribal ML, et al. (2001). "Defects of the insulin receptor substrate (IRS) system in human metabolic disorders". FASEB J. 15 (12): 2099–111. doi:10.1096/fj.01-0009rev. PMID 11641236. S2CID 6429338.
  • Gibson SL, Ma Z, Shaw LM (2007). "Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis". Cell Cycle. 6 (6): 631–7. doi:10.4161/cc.6.6.3987. PMID 17361103.
  • Dearth RK, Cui X, Kim HJ, et al. (2007). "Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2". Cell Cycle. 6 (6): 705–13. doi:10.4161/cc.6.6.4035. PMID 17374994.
  • Johnston JA, Wang LM, Hanson EP, et al. (1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases". J. Biol. Chem. 270 (48): 28527–30. doi:10.1074/jbc.270.48.28527. PMID 7499365.
  • Patti ME, Sun XJ, Bruening JC, et al. (1995). "4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice". J. Biol. Chem. 270 (42): 24670–3. doi:10.1074/jbc.270.42.24670. PMID 7559579.
  • Sun XJ, Wang LM, Zhang Y, et al. (1995). "Role of IRS-2 in insulin and cytokine signalling". Nature. 377 (6545): 173–7. Bibcode:1995Natur.377..173S. doi:10.1038/377173a0. PMID 7675087. S2CID 4336107.
  • Ridderstråle M, Degerman E, Tornqvist H (1995). "Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes". J. Biol. Chem. 270 (8): 3471–4. doi:10.1074/jbc.270.8.3471. PMID 7876077.
  • Platanias LC, Uddin S, Yetter A, et al. (1996). "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2". J. Biol. Chem. 271 (1): 278–82. doi:10.1074/jbc.271.1.278. PMID 8550573.
  • Beitner-Johnson D, Blakesley VA, Shen-Orr Z, et al. (1996). "The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling". J. Biol. Chem. 271 (16): 9287–90. doi:10.1074/jbc.271.16.9287. PMID 8621590.
  • Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E (1996). "Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786". J. Biol. Chem. 271 (11): 5980–3. doi:10.1074/jbc.271.11.5980. PMID 8626379.
  • He W, Craparo A, Zhu Y, et al. (1996). "Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2". J. Biol. Chem. 271 (20): 11641–5. doi:10.1074/jbc.271.20.11641. PMID 8662806.
  • Zhang WR, Li PM, Oswald MA, Goldstein BJ (1996). "Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR". Mol. Endocrinol. 10 (5): 575–84. doi:10.1210/mend.10.5.8732688. PMID 8732688. S2CID 42128485.
  • Argetsinger LS, Norstedt G, Billestrup N, et al. (1997). "Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling". J. Biol. Chem. 271 (46): 29415–21. doi:10.1074/jbc.271.46.29415. PMID 8910607.
  • Thiselton DL, Hampson RM, Nayudu M, et al. (1997). "Mapping the RP2 locus for X-linked retinitis pigmentosa on proximal Xp: a genetically defined 5-cM critical region and exclusion of candidate genes by physical mapping". Genome Res. 6 (11): 1093–102. doi:10.1101/gr.6.11.1093. PMID 8938433.
  • Izuhara K, Harada N (1997). "Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells". Biochem. Biophys. Res. Commun. 229 (2): 624–9. doi:10.1006/bbrc.1996.1854. PMID 8954948.
  • Vanhaesebroeck B, Welham MJ, Kotani K, et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
  • Sawka-Verhelle D, Baron V, Mothe I, et al. (1997). "Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor". J. Biol. Chem. 272 (26): 16414–20. doi:10.1074/jbc.272.26.16414. PMID 9195949.
  • Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR (1997). "Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart". J. Biol. Chem. 272 (38): 23696–702. doi:10.1074/jbc.272.38.23696. PMID 9295312.

January 01, 1970
irs2, insulin, receptor, substrate, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3fqw, 3fqxidentifiersaliases, insulin, receptor, substrate, 2external, idsomim, 600797, 109334, homologene, 2778, genecards. Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene 5 IRS2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3FQW 3FQXIdentifiersAliasesIRS2 IRS 2 insulin receptor substrate 2External IDsOMIM 600797 MGI 109334 HomoloGene 2778 GeneCards IRS2Gene location Human Chr Chromosome 13 human 1 Band13q34Start109 752 695 bp 1 End109 786 583 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 A1 1 8 5 35 cMStart11 034 681 bp 2 End11 058 458 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inRegion I of hippocampus properpostcentral gyrusorbitofrontal cortexBrodmann area 46entorhinal cortexmiddle temporal gyrusinferior olivary nucleusinternal globus pallidusBrodmann area 23lower lobe of lungTop expressed inmolarsuperior frontal gyrusentorhinal cortexcerebellar cortexyolk sacretinal pigment epitheliummedial dorsal nucleusislet of LangerhansRegion I of hippocampus propermedulla oblongataMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioninsulin receptor binding 14 3 3 protein binding phosphatidylinositol 3 kinase binding protein binding protein kinase binding phosphatidylinositol 4 5 bisphosphate 3 kinase activity 1 phosphatidylinositol 3 kinase activity signal transducer activity protein phosphatase binding protein domain specific bindingCellular componentcytoplasm cytosol plasma membrane protein containing complexBiological processpositive regulation of fatty acid beta oxidation positive regulation of glucose import positive regulation of glycogen biosynthetic process cellular response to peptide positive regulation of cell migration positive regulation of glucose metabolic process response to glucose MAPK cascade mammary gland development regulation of lipid metabolic process negative regulation of long chain fatty acid import across plasma membrane brain development positive regulation of mesenchymal cell proliferation positive regulation of B cell proliferation positive regulation of cell population proliferation lipid homeostasis glucose metabolic process cellular response to insulin stimulus negative regulation of B cell apoptotic process cell population proliferation phosphatidylinositol mediated signaling cellular response to glucose stimulus signal transduction positive regulation of insulin secretion negative regulation of kinase activity phosphatidylinositol 3 phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process insulin receptor signaling pathway axon guidance interleukin 7 mediated signaling pathway positive regulation of protein kinase B signaling positive regulation of phosphatidylinositol 3 kinase signaling positive regulation of Ras protein signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8660384783EnsemblENSG00000185950ENSMUSG00000038894UniProtQ9Y4H2P81122RefSeq mRNA NM 003749NM 001081212RefSeq protein NP 003740NP 001074681Location UCSC Chr 13 109 75 109 79 MbChr 8 11 03 11 06 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse For chemical compound with molecular formula IrS2 see Iridium disulfide Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene encodes the insulin receptor substrate 2 a cytoplasmic signaling molecule that mediates effects of insulin insulin like growth factor 1 and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation as well as by an interleukin 4 receptor associated kinase in response to IL4 treatment 6 Mice lacking IRS2 have a diabetic phenotype 7 as well as a 40 reduction in brain mass 8 Interactions editIRS2 has been shown to interact with PLCG1 9 SOCS1 10 and PIK3R1 11 12 13 14 References edit a b c GRCh38 Ensembl release 89 ENSG00000185950 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038894 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ogihara T Isobe T Ichimura T Taoka M Funaki M Sakoda H Onishi Y Inukai K Anai M Fukushima Y Kikuchi M Yazaki Y Oka Y Asano T Oct 1997 14 3 3 protein binds to insulin receptor substrate 1 one of the binding sites of which is in the phosphotyrosine binding domain J Biol Chem 272 40 25267 74 doi 10 1074 jbc 272 40 25267 PMID 9312143 Entrez Gene IRS2 insulin receptor substrate 2 Lin X Taguchi A Park S Kushner JA Li F Li Y White MF October 2004 Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes J Clin Invest 114 7 908 16 doi 10 1172 JCI22217 PMC 518668 PMID 15467829 Schubert M Brazil DP Burks DJ Kushner JA Ye J Flint CL Farhang Fallah J Dikkes P Warot XM Rio C Corfas G White MF August 2003 Insulin receptor substrate 2 deficiency impairs brain growth and promotes tau phosphorylation J Neurosci 23 18 7084 92 doi 10 1523 JNEUROSCI 23 18 07084 2003 PMC 6740672 PMID 12904469 Sozzani P Hasan L Seguelas MH Caput D Ferrara P Pipy B Cambon C March 1998 IL 13 induces tyrosine phosphorylation of phospholipase C gamma 1 following IRS 2 association in human monocytes relationship with the inhibitory effect of IL 13 on ROI production Biochem Biophys Res Commun 244 3 665 70 doi 10 1006 bbrc 1998 8314 PMID 9535722 Rui L Yuan M Frantz D Shoelson S White MF November 2002 SOCS 1 and SOCS 3 block insulin signaling by ubiquitin mediated degradation of IRS1 and IRS2 J Biol Chem 277 44 42394 8 doi 10 1074 jbc C200444200 PMID 12228220 Argetsinger LS Norstedt G Billestrup N White MF Carter Su C November 1996 Growth hormone interferon gamma and leukemia inhibitory factor utilize insulin receptor substrate 2 in intracellular signaling J Biol Chem 271 46 29415 21 doi 10 1074 jbc 271 46 29415 PMID 8910607 Verdier F Chretien S Billat C Gisselbrecht S Lacombe C Mayeux P October 1997 Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate 2 An alternate pathway for erythropoietin induced phosphatidylinositol 3 kinase activation J Biol Chem 272 42 26173 8 doi 10 1074 jbc 272 42 26173 PMID 9334184 Kim B Cheng HL Margolis B Feldman EL December 1998 Insulin receptor substrate 2 and Shc play different roles in insulin like growth factor I signaling J Biol Chem 273 51 34543 50 doi 10 1074 jbc 273 51 34543 PMID 9852124 Hamer I Foti M Emkey R Cordier Bussat M Philippe J De Meyts P Maeder C Kahn CR Carpentier JL May 2002 An arginine to cysteine 252 mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events Diabetologia 45 5 657 67 doi 10 1007 s00125 002 0798 5 PMID 12107746 Further reading editWhite MF 1999 The IRS signalling system a network of docking proteins that mediate insulin action Mol Cell Biochem 182 1 2 3 11 doi 10 1023 A 1006806722619 PMID 9609109 S2CID 32623861 Jiang H Harris MB Rothman P 2000 IL 4 IL 13 signaling beyond JAK STAT J Allergy Clin Immunol 105 6 Pt 1 1063 70 doi 10 1067 mai 2000 107604 PMID 10856136 Sesti G Federici M Hribal ML et al 2001 Defects of the insulin receptor substrate IRS system in human metabolic disorders FASEB J 15 12 2099 111 doi 10 1096 fj 01 0009rev PMID 11641236 S2CID 6429338 Gibson SL Ma Z Shaw LM 2007 Divergent roles for IRS 1 and IRS 2 in breast cancer metastasis Cell Cycle 6 6 631 7 doi 10 4161 cc 6 6 3987 PMID 17361103 Dearth RK Cui X Kim HJ et al 2007 Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate IRS 1 and IRS 2 Cell Cycle 6 6 705 13 doi 10 4161 cc 6 6 4035 PMID 17374994 Johnston JA Wang LM Hanson EP et al 1996 Interleukins 2 4 7 and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells Potential role of JAK kinases J Biol Chem 270 48 28527 30 doi 10 1074 jbc 270 48 28527 PMID 7499365 Patti ME Sun XJ Bruening JC et al 1995 4PS insulin receptor substrate IRS 2 is the alternative substrate of the insulin receptor in IRS 1 deficient mice J Biol Chem 270 42 24670 3 doi 10 1074 jbc 270 42 24670 PMID 7559579 Sun XJ Wang LM Zhang Y et al 1995 Role of IRS 2 in insulin and cytokine signalling Nature 377 6545 173 7 Bibcode 1995Natur 377 173S doi 10 1038 377173a0 PMID 7675087 S2CID 4336107 Ridderstrale M Degerman E Tornqvist H 1995 Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate 1 and its association with phosphatidylinositol 3 kinase in primary adipocytes J Biol Chem 270 8 3471 4 doi 10 1074 jbc 270 8 3471 PMID 7876077 Platanias LC Uddin S Yetter A et al 1996 The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2 J Biol Chem 271 1 278 82 doi 10 1074 jbc 271 1 278 PMID 8550573 Beitner Johnson D Blakesley VA Shen Orr Z et al 1996 The proto oncogene product c Crk associates with insulin receptor substrate 1 and 4PS Modulation by insulin growth factor I IGF and enhanced IGF I signaling J Biol Chem 271 16 9287 90 doi 10 1074 jbc 271 16 9287 PMID 8621590 Sawka Verhelle D Tartare Deckert S White MF Van Obberghen E 1996 Insulin receptor substrate 2 binds to the insulin receptor through its phosphotyrosine binding domain and through a newly identified domain comprising amino acids 591 786 J Biol Chem 271 11 5980 3 doi 10 1074 jbc 271 11 5980 PMID 8626379 He W Craparo A Zhu Y et al 1996 Interaction of insulin receptor substrate 2 IRS 2 with the insulin and insulin like growth factor I receptors Evidence for two distinct phosphotyrosine dependent interaction domains within IRS 2 J Biol Chem 271 20 11641 5 doi 10 1074 jbc 271 20 11641 PMID 8662806 Zhang WR Li PM Oswald MA Goldstein BJ 1996 Modulation of insulin signal transduction by eutopic overexpression of the receptor type protein tyrosine phosphatase LAR Mol Endocrinol 10 5 575 84 doi 10 1210 mend 10 5 8732688 PMID 8732688 S2CID 42128485 Argetsinger LS Norstedt G Billestrup N et al 1997 Growth hormone interferon gamma and leukemia inhibitory factor utilize insulin receptor substrate 2 in intracellular signaling J Biol Chem 271 46 29415 21 doi 10 1074 jbc 271 46 29415 PMID 8910607 Thiselton DL Hampson RM Nayudu M et al 1997 Mapping the RP2 locus for X linked retinitis pigmentosa on proximal Xp a genetically defined 5 cM critical region and exclusion of candidate genes by physical mapping Genome Res 6 11 1093 102 doi 10 1101 gr 6 11 1093 PMID 8938433 Izuhara K Harada N 1997 Interleukin 4 activates two distinct pathways of phosphatidylinositol 3 kinase in the same cells Biochem Biophys Res Commun 229 2 624 9 doi 10 1006 bbrc 1996 1854 PMID 8954948 Vanhaesebroeck B Welham MJ Kotani K et al 1997 P110delta a novel phosphoinositide 3 kinase in leukocytes Proc Natl Acad Sci U S A 94 9 4330 5 Bibcode 1997PNAS 94 4330V doi 10 1073 pnas 94 9 4330 PMC 20722 PMID 9113989 Sawka Verhelle D Baron V Mothe I et al 1997 Tyr624 and Tyr628 in insulin receptor substrate 2 mediate its association with the insulin receptor J Biol Chem 272 26 16414 20 doi 10 1074 jbc 272 26 16414 PMID 9195949 Algenstaedt P Antonetti DA Yaffe MB Kahn CR 1997 Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2 ATPases in muscle and heart J Biol Chem 272 38 23696 702 doi 10 1074 jbc 272 38 23696 PMID 9295312 Retrieved from https en wikipedia org w index php title IRS2 amp oldid 1187239496, wikipedia, wiki, book, books, library,

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