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Wikipedia

IRF1

January 01, 1970

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.[4][5]

IRF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIRF1, IRF-1, MAR, interferon regulatory factor 1
External IDsOMIM: 147575 MGI: 96590 HomoloGene: 1658 GeneCards: IRF1
Orthologs
SpeciesHumanMouse
Entrez

3659

16362

Ensembl

ENSG00000125347

ENSMUSG00000018899

UniProt

P10914

P15314

RefSeq (mRNA)

NM_002198

NM_001159393
NM_001159396
NM_008390

RefSeq (protein)

NP_002189
NP_001341853
NP_001341854

NP_001152865
NP_001152868
NP_032416

Location (UCSC)n/aChr 11: 53.66 – 53.67 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta,[6] IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain,[7] which is highly conserved among all IRF proteins.

Beyond its function as a transcription factor, IRF-1 has also been shown to trans-activate the tumour suppressor protein p53 through the recruitment of its co-factor p300.[8]

IRF-1 has been shown to play roles in the immune response, regulating apoptosis, DNA damage and tumor suppression.[9]

Regulation edit

It has been shown that the extreme C-terminus of IRF-1 regulates its ability to activate transcription, nanobodies targeting this domain (MF1) are able to increase IRF-1 activity.[10]

Interactions edit

IRF1 has been shown to interact with:

See also edit

References edit

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018899 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Maruyama M, Fujita T, Taniguchi T (Jun 1989). "Sequence of a cDNA coding for human IRF-1". Nucleic Acids Res. 17 (8): 3292. doi:10.1093/nar/17.8.3292. PMC 317732. PMID 2726461.
  5. ^ Itoh S, Harada H, Nakamura Y, White R, Taniguchi T (Nov 1991). "Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31". Genomics. 10 (4): 1097–9. doi:10.1016/0888-7543(91)90208-V. PMID 1680796.
  6. ^ Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y, Miyata T, Taniguchi T (September 1988). "Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements". Cell. 54 (6): 903–13. doi:10.1016/S0092-8674(88)91307-4. PMID 3409321. S2CID 35063951.
  7. ^ Escalante CR, Yie J, Thanos D, Aggarwal AK (January 1998). "Structure of IRF-1 with bound DNA reveals determinants of interferon regulation". Nature. 391 (6662): 103–6. Bibcode:1998Natur.391..103E. doi:10.1038/34224. PMID 9422515. S2CID 4394514.
  8. ^ Dornan D, Eckert M, Wallace M, Shimizu H, Ramsay E, Hupp TR, Ball KL (November 2004). "Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53". Mol. Cell. Biol. 24 (22): 10083–98. doi:10.1128/MCB.24.22.10083-10098.2004. PMC 525491. PMID 15509808.
  9. ^ "Entrez Gene: IRF1 interferon regulatory factor 1".
  10. ^ Möller A, Pion E, Narayan V, Ball KL (December 2010). "Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain". J. Biol. Chem. 285 (49): 38348–61. doi:10.1074/jbc.M110.149476. PMC 2992268. PMID 20817723.
  11. ^ Narayan V, Pion E, Landré V, Müller P, Ball KL (October 2010). "Docking dependent ubiquitination of the interferon regulatory factor-1 tumour suppressor protein by the ubiquitin ligase CHIP". J Biol Chem. 286 (1): 607–19. doi:10.1074/jbc.M110.153122. PMC 3013021. PMID 20947504.
  12. ^ Kular RK, Yehiely F, Kotlo KU, Cilensek ZM, Bedi R, Deiss LP (October 2009). "GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1". J. Interferon Cytokine Res. 29 (10): 645–55. doi:10.1089/jir.2008.0099. PMID 19642896.
  13. ^ Narayan V, Eckert M, Zylicz A, Zylicz M, Ball KL (September 2009). "Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery". J Biol Chem. 284 (38): 25889–99. doi:10.1074/jbc.M109.019505. PMC 2757990. PMID 19502235.
  14. ^ Schaper F, Kirchhoff S, Posern G, Köster M, Oumard A, Sharf R, Levi BZ, Hauser H (October 1998). "Functional domains of interferon regulatory factor I (IRF-1)". Biochem. J. 335 (1): 147–57. doi:10.1042/bj3350147. PMC 1219763. PMID 9742224.
  15. ^ Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (June 1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. doi:10.1074/jbc.270.22.13063. PMID 7768900.
  16. ^ Umegaki N, Tamai K, Nakano H, Moritsugu R, Yamazaki T, Hanada K, Katayama I, Kaneda Y (June 2007). "Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1". J. Invest. Dermatol. 127 (6): 1456–64. doi:10.1038/sj.jid.5700716. PMID 17255955.
  17. ^ Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K (October 2006). "Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15136–41. Bibcode:2006PNAS..10315136N. doi:10.1073/pnas.0607181103. PMC 1586247. PMID 17018642.
  18. ^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. doi:10.1128/MCB.19.3.1810. PMC 83974. PMID 10022868.
  19. ^ Chatterjee-Kishore M, van Den Akker F, Stark GR (July 2000). "Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1". J. Biol. Chem. 275 (27): 20406–11. doi:10.1074/jbc.M001861200. PMID 10764778.
  20. ^ Sgarbanti M, Borsetti A, Moscufo N, Bellocchi MC, Ridolfi B, Nappi F, Marsili G, Marziali G, Coccia EM, Ensoli B, Battistini A (May 2002). "Modulation of human immunodeficiency virus 1 replication by interferon regulatory factors". J. Exp. Med. 195 (10): 1359–70. doi:10.1084/jem.20010753. PMC 2193759. PMID 12021315.
  21. ^ Lee JH, Chun T, Park SY, Rho SB (September 2008). "Interferon regulatory factor-1 (IRF-1) regulates VEGF-induced angiogenesis in HUVECs". Biochim. Biophys. Acta. 1783 (9): 1654–62. doi:10.1016/j.bbamcr.2008.04.006. PMID 18472010.
  22. ^ Gupta, M.; Rath, PC (2014). "Interferon regulatory factor-1 (IRF-1) interacts with regulated in development and DNA damage response 2 (REDD2) in the cytoplasm of mouse bone marrow cells". Int J Biol Macromol. 65: 41–50. doi:10.1016/j.ijbiomac.2014.01.005. PMID 24412152.

Further reading edit

  • Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie. 80 (8–9): 641–50. doi:10.1016/S0300-9084(99)80017-0. PMID 9865486.
  • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie. 80 (8–9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487.
  • Yu-Lee L (2002). "Stimulation of interferon regulatory factor-1 by prolactin". Lupus. 10 (10): 691–9. doi:10.1191/096120301717164921. PMID 11721695. S2CID 13547888.
  • Pine R (2002). "IRF and tuberculosis". J. Interferon Cytokine Res. 22 (1): 15–25. doi:10.1089/107999002753452629. PMID 11846972.
  • Romeo G, Fiorucci G, Chiantore MV, Percario ZA, Vannucchi S, Affabris E (2002). "IRF-1 as a negative regulator of cell proliferation". J. Interferon Cytokine Res. 22 (1): 39–47. doi:10.1089/107999002753452647. PMID 11846974.
  • Cha Y, Sims SH, Romine MF, Kaufmann M, Deisseroth AB (1992). "Human interferon regulatory factor 1: intron-exon organization". DNA Cell Biol. 11 (8): 605–11. doi:10.1089/dna.1992.11.605. PMID 1382447.
  • Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell. 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID 2475256. S2CID 2033941.
  • Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y, Miyata T, Taniguchi T (1988). "Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements". Cell. 54 (6): 903–13. doi:10.1016/S0092-8674(88)91307-4. PMID 3409321. S2CID 35063951.
  • Harada H, Takahashi E, Itoh S, Harada K, Hori TA, Taniguchi T (1994). "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system". Mol. Cell. Biol. 14 (2): 1500–9. doi:10.1128/MCB.14.2.1500. PMC 358505. PMID 7507207.
  • Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. doi:10.1074/jbc.270.22.13063. PMID 7768900.
  • Willman CL, Sever CE, Pallavicini MG, Harada H, Tanaka N, Slovak ML, Yamamoto H, Harada K, Meeker TC, List AF (1993). "Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia". Science. 259 (5097): 968–71. Bibcode:1993Sci...259..968W. doi:10.1126/science.8438156. PMID 8438156. S2CID 40142541.
  • Drew PD, Franzoso G, Becker KG, Bours V, Carlson LM, Siebenlist U, Ozato K (1997). "NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression". J. Interferon Cytokine Res. 15 (12): 1037–45. doi:10.1089/jir.1995.15.1037. PMID 8746784.
  • Ronco LV, Karpova AY, Vidal M, Howley PM (1998). "Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity". Genes Dev. 12 (13): 2061–72. doi:10.1101/gad.12.13.2061. PMC 316980. PMID 9649509.
  • Nozawa H, Oda E, Ueda S, Tamura G, Maesawa C, Muto T, Taniguchi T, Tanaka N (1998). "Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer". Int. J. Cancer. 77 (4): 522–7. doi:10.1002/(SICI)1097-0215(19980812)77:4<522::AID-IJC8>3.0.CO;2-W. PMID 9679752. S2CID 25951704.
  • Schaper F, Kirchhoff S, Posern G, Köster M, Oumard A, Sharf R, Levi BZ, Hauser H (1998). "Functional domains of interferon regulatory factor I (IRF-1)". Biochem. J. 335 (1): 147–57. doi:10.1042/bj3350147. PMC 1219763. PMID 9742224.
  • Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (1999). "The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. doi:10.1128/MCB.19.3.1810. PMC 83974. PMID 10022868.

External links edit

 
Wikimedia Commons has media related to Interferon regulatory factor 1 (IRF-1).

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
irf1, interferon, regulatory, factor, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1if1identifiersaliases, interferon, regulatory, factor, 1external, idsomim, 147575, 96590, homologene, 1658, genecards, g. Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene 4 5 IRF1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1IF1IdentifiersAliasesIRF1 IRF 1 MAR interferon regulatory factor 1External IDsOMIM 147575 MGI 96590 HomoloGene 1658 GeneCards IRF1Gene location Mouse Chr Chromosome 11 mouse 1 Band11 B1 3 11 32 0 cMStart53 660 841 bp 1 End53 669 200 bp 1 RNA expression patternBgeeHumanMouse ortholog n aTop expressed injejunumduodenumcorneal stromalarge intestinespleencolonileumcrypt of lieberkuhn of small intestineright lungright ventricleBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding sequence specific DNA binding DNA binding transcription factor activity DNA binding transcription activator activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA binding protein binding DNA binding transcription factor activity RNA polymerase II specificCellular componentcytoplasm cytosol nucleoplasm nucleusBiological processapoptotic process regulation of CD8 positive alpha beta T cell proliferation CD8 positive alpha beta T cell differentiation regulation of innate immune response negative regulation of regulatory T cell differentiation regulation of transcription DNA templated cellular response to interferon beta interferon gamma mediated signaling pathway immune system process regulation of adaptive immune response blood coagulation regulation of MyD88 dependent toll like receptor signaling pathway transcription by RNA polymerase II transcription DNA templated regulation of cell cycle positive regulation of transcription DNA templated cellular response to mechanical stimulus defense response to virus type I interferon signaling pathway regulation of immune response regulation of gene expression innate immune response negative regulation of transcription DNA templated positive regulation of type I interferon production positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation positive regulation of interferon beta productionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez365916362EnsemblENSG00000125347ENSMUSG00000018899UniProtP10914P15314RefSeq mRNA NM 002198NM 001159393NM 001159396NM 008390RefSeq protein NP 002189NP 001341853NP 001341854NP 001152865NP 001152868NP 032416Location UCSC n aChr 11 53 66 53 67 MbPubMed search 2 3 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Regulation 3 Interactions 4 See also 5 References 6 Further reading 7 External linksFunction editInterferon regulatory factor 1 was the first member of the interferon regulatory transcription factor IRF family identified Initially described as a transcription factor able to activate expression of the cytokine Interferon beta 6 IRF 1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes IRF 1 regulates expression of target genes by binding to an interferon stimulated response element ISRE in their promoters The IRF 1 protein binds to the ISRE via an N terminal helix turn helix DNA binding domain 7 which is highly conserved among all IRF proteins Beyond its function as a transcription factor IRF 1 has also been shown to trans activate the tumour suppressor protein p53 through the recruitment of its co factor p300 8 IRF 1 has been shown to play roles in the immune response regulating apoptosis DNA damage and tumor suppression 9 Regulation editIt has been shown that the extreme C terminus of IRF 1 regulates its ability to activate transcription nanobodies targeting this domain MF1 are able to increase IRF 1 activity 10 Interactions editIRF1 has been shown to interact with CHIP 11 GAGE 12 HSP70 HSP90 13 IRF8 14 15 KPNA2 16 MYD88 17 PCAF 18 STAT1 19 TAT 20 VEGFR2 21 REDD2 22 See also editIRF2 Interferon regulatory factorsReferences edit a b c GRCm38 Ensembl release 89 ENSMUSG00000018899 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Maruyama M Fujita T Taniguchi T Jun 1989 Sequence of a cDNA coding for human IRF 1 Nucleic Acids Res 17 8 3292 doi 10 1093 nar 17 8 3292 PMC 317732 PMID 2726461 Itoh S Harada H Nakamura Y White R Taniguchi T Nov 1991 Assignment of the human interferon regulatory factor 1 IRF1 gene to chromosome 5q23 q31 Genomics 10 4 1097 9 doi 10 1016 0888 7543 91 90208 V PMID 1680796 Miyamoto M Fujita T Kimura Y Maruyama M Harada H Sudo Y Miyata T Taniguchi T September 1988 Regulated expression of a gene encoding a nuclear factor IRF 1 that specifically binds to IFN beta gene regulatory elements Cell 54 6 903 13 doi 10 1016 S0092 8674 88 91307 4 PMID 3409321 S2CID 35063951 Escalante CR Yie J Thanos D Aggarwal AK January 1998 Structure of IRF 1 with bound DNA reveals determinants of interferon regulation Nature 391 6662 103 6 Bibcode 1998Natur 391 103E doi 10 1038 34224 PMID 9422515 S2CID 4394514 Dornan D Eckert M Wallace M Shimizu H Ramsay E Hupp TR Ball KL November 2004 Interferon regulatory factor 1 binding to p300 stimulates DNA dependent acetylation of p53 Mol Cell Biol 24 22 10083 98 doi 10 1128 MCB 24 22 10083 10098 2004 PMC 525491 PMID 15509808 Entrez Gene IRF1 interferon regulatory factor 1 Moller A Pion E Narayan V Ball KL December 2010 Intracellular activation of interferon regulatory factor 1 by nanobodies to the multifunctional Mf1 domain J Biol Chem 285 49 38348 61 doi 10 1074 jbc M110 149476 PMC 2992268 PMID 20817723 Narayan V Pion E Landre V Muller P Ball KL October 2010 Docking dependent ubiquitination of the interferon regulatory factor 1 tumour suppressor protein by the ubiquitin ligase CHIP J Biol Chem 286 1 607 19 doi 10 1074 jbc M110 153122 PMC 3013021 PMID 20947504 Kular RK Yehiely F Kotlo KU Cilensek ZM Bedi R Deiss LP October 2009 GAGE an antiapoptotic protein binds and modulates the expression of nucleophosmin B23 and interferon regulatory factor 1 J Interferon Cytokine Res 29 10 645 55 doi 10 1089 jir 2008 0099 PMID 19642896 Narayan V Eckert M Zylicz A Zylicz M Ball KL September 2009 Cooperative regulation of the interferon regulatory factor 1 tumor suppressor protein by core components of the molecular chaperone machinery J Biol Chem 284 38 25889 99 doi 10 1074 jbc M109 019505 PMC 2757990 PMID 19502235 Schaper F Kirchhoff S Posern G Koster M Oumard A Sharf R Levi BZ Hauser H October 1998 Functional domains of interferon regulatory factor I IRF 1 Biochem J 335 1 147 57 doi 10 1042 bj3350147 PMC 1219763 PMID 9742224 Sharf R Azriel A Lejbkowicz F Winograd SS Ehrlich R Levi BZ June 1995 Functional domain analysis of interferon consensus sequence binding protein ICSBP and its association with interferon regulatory factors J Biol Chem 270 22 13063 9 doi 10 1074 jbc 270 22 13063 PMID 7768900 Umegaki N Tamai K Nakano H Moritsugu R Yamazaki T Hanada K Katayama I Kaneda Y June 2007 Differential regulation of karyopherin alpha 2 expression by TGF beta1 and IFN gamma in normal human epidermal keratinocytes evident contribution of KPNA2 for nuclear translocation of IRF 1 J Invest Dermatol 127 6 1456 64 doi 10 1038 sj jid 5700716 PMID 17255955 Negishi H Fujita Y Yanai H Sakaguchi S Ouyang X Shinohara M Takayanagi H Ohba Y Taniguchi T Honda K October 2006 Evidence for licensing of IFN gamma induced IFN regulatory factor 1 transcription factor by MyD88 in Toll like receptor dependent gene induction program Proc Natl Acad Sci U S A 103 41 15136 41 Bibcode 2006PNAS 10315136N doi 10 1073 pnas 0607181103 PMC 1586247 PMID 17018642 Masumi A Wang IM Lefebvre B Yang XJ Nakatani Y Ozato K March 1999 The histone acetylase PCAF is a phorbol ester inducible coactivator of the IRF family that confers enhanced interferon responsiveness Mol Cell Biol 19 3 1810 20 doi 10 1128 MCB 19 3 1810 PMC 83974 PMID 10022868 Chatterjee Kishore M van Den Akker F Stark GR July 2000 Adenovirus E1A down regulates LMP2 transcription by interfering with the binding of stat1 to IRF1 J Biol Chem 275 27 20406 11 doi 10 1074 jbc M001861200 PMID 10764778 Sgarbanti M Borsetti A Moscufo N Bellocchi MC Ridolfi B Nappi F Marsili G Marziali G Coccia EM Ensoli B Battistini A May 2002 Modulation of human immunodeficiency virus 1 replication by interferon regulatory factors J Exp Med 195 10 1359 70 doi 10 1084 jem 20010753 PMC 2193759 PMID 12021315 Lee JH Chun T Park SY Rho SB September 2008 Interferon regulatory factor 1 IRF 1 regulates VEGF induced angiogenesis in HUVECs Biochim Biophys Acta 1783 9 1654 62 doi 10 1016 j bbamcr 2008 04 006 PMID 18472010 Gupta M Rath PC 2014 Interferon regulatory factor 1 IRF 1 interacts with regulated in development and DNA damage response 2 REDD2 in the cytoplasm of mouse bone marrow cells Int J Biol Macromol 65 41 50 doi 10 1016 j ijbiomac 2014 01 005 PMID 24412152 Further reading editHarada H Taniguchi T Tanaka N 1999 The role of interferon regulatory factors in the interferon system and cell growth control Biochimie 80 8 9 641 50 doi 10 1016 S0300 9084 99 80017 0 PMID 9865486 Pitha PM Au WC Lowther W Juang YT Schafer SL Burysek L Hiscott J Moore PA 1999 Role of the interferon regulatory factors IRFs in virus mediated signaling and regulation of cell growth Biochimie 80 8 9 651 8 doi 10 1016 S0300 9084 99 80018 2 PMID 9865487 Yu Lee L 2002 Stimulation of interferon regulatory factor 1 by prolactin Lupus 10 10 691 9 doi 10 1191 096120301717164921 PMID 11721695 S2CID 13547888 Pine R 2002 IRF and tuberculosis J Interferon Cytokine Res 22 1 15 25 doi 10 1089 107999002753452629 PMID 11846972 Romeo G Fiorucci G Chiantore MV Percario ZA Vannucchi S Affabris E 2002 IRF 1 as a negative regulator of cell proliferation J Interferon Cytokine Res 22 1 39 47 doi 10 1089 107999002753452647 PMID 11846974 Cha Y Sims SH Romine MF Kaufmann M Deisseroth AB 1992 Human interferon regulatory factor 1 intron exon organization DNA Cell Biol 11 8 605 11 doi 10 1089 dna 1992 11 605 PMID 1382447 Harada H Fujita T Miyamoto M Kimura Y Maruyama M Furia A Miyata T Taniguchi T 1989 Structurally similar but functionally distinct factors IRF 1 and IRF 2 bind to the same regulatory elements of IFN and IFN inducible genes Cell 58 4 729 39 doi 10 1016 0092 8674 89 90107 4 PMID 2475256 S2CID 2033941 Miyamoto M Fujita T Kimura Y Maruyama M Harada H Sudo Y Miyata T Taniguchi T 1988 Regulated expression of a gene encoding a nuclear factor IRF 1 that specifically binds to IFN beta gene regulatory elements Cell 54 6 903 13 doi 10 1016 S0092 8674 88 91307 4 PMID 3409321 S2CID 35063951 Harada H Takahashi E Itoh S Harada K Hori TA Taniguchi T 1994 Structure and regulation of the human interferon regulatory factor 1 IRF 1 and IRF 2 genes implications for a gene network in the interferon system Mol Cell Biol 14 2 1500 9 doi 10 1128 MCB 14 2 1500 PMC 358505 PMID 7507207 Sharf R Azriel A Lejbkowicz F Winograd SS Ehrlich R Levi BZ 1995 Functional domain analysis of interferon consensus sequence binding protein ICSBP and its association with interferon regulatory factors J Biol Chem 270 22 13063 9 doi 10 1074 jbc 270 22 13063 PMID 7768900 Willman CL Sever CE Pallavicini MG Harada H Tanaka N Slovak ML Yamamoto H Harada K Meeker TC List AF 1993 Deletion of IRF 1 mapping to chromosome 5q31 1 in human leukemia and preleukemic myelodysplasia Science 259 5097 968 71 Bibcode 1993Sci 259 968W doi 10 1126 science 8438156 PMID 8438156 S2CID 40142541 Drew PD Franzoso G Becker KG Bours V Carlson LM Siebenlist U Ozato K 1997 NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression J Interferon Cytokine Res 15 12 1037 45 doi 10 1089 jir 1995 15 1037 PMID 8746784 Ronco LV Karpova AY Vidal M Howley PM 1998 Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor 3 and inhibits its transcriptional activity Genes Dev 12 13 2061 72 doi 10 1101 gad 12 13 2061 PMC 316980 PMID 9649509 Nozawa H Oda E Ueda S Tamura G Maesawa C Muto T Taniguchi T Tanaka N 1998 Functionally inactivating point mutation in the tumor suppressor IRF 1 gene identified in human gastric cancer Int J Cancer 77 4 522 7 doi 10 1002 SICI 1097 0215 19980812 77 4 lt 522 AID IJC8 gt 3 0 CO 2 W PMID 9679752 S2CID 25951704 Schaper F Kirchhoff S Posern G Koster M Oumard A Sharf R Levi BZ Hauser H 1998 Functional domains of interferon regulatory factor I IRF 1 Biochem J 335 1 147 57 doi 10 1042 bj3350147 PMC 1219763 PMID 9742224 Masumi A Wang IM Lefebvre B Yang XJ Nakatani Y Ozato K 1999 The histone acetylase PCAF is a phorbol ester inducible coactivator of the IRF family that confers enhanced interferon responsiveness Mol Cell Biol 19 3 1810 20 doi 10 1128 MCB 19 3 1810 PMC 83974 PMID 10022868 External links edit nbsp Wikimedia Commons has media related to Interferon regulatory factor 1 IRF 1 IRF1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH FactorBook IRF1 This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title IRF1 amp oldid 1190647751, wikipedia, wiki, book, books, library,

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