IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000134070 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000060477 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcMuzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
^ abWesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
^Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.
Further readingedit
Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews. 9 (3–4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.
Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal. 339 ( Pt 2) (2): 227–31. doi:10.1042/0264-6021:3390227. PMC1220149. PMID 10191251.
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.
McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. PMID 11744690.
Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.
irak2, interleukin, receptor, associated, kinase, like, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3mopidentifiersaliases, irak, interleukin, receptor, associated, kinase, 2external, idsomim, 603304, 242. Interleukin 1 receptor associated kinase like 2 is an enzyme that in humans is encoded by the IRAK2 gene 5 6 IRAK2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3MOPIdentifiersAliasesIRAK2 IRAK 2 interleukin 1 receptor associated kinase 2External IDsOMIM 603304 MGI 2429603 HomoloGene 1207 GeneCards IRAK2Gene location Human Chr Chromosome 3 human 1 Band3p25 3Start10 164 919 bp 1 End10 243 745 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 E3 6 52 82 cMStart113 615 428 bp 2 End113 671 987 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic epithelial cellsecondary oocytepancreatic ductal cellpalpebral conjunctivagastrocnemius muscletibialis anterior muscleamniotic fluidendothelial cellislet of Langerhansright lobe of liverTop expressed injejunumurinary bladderwhite adipose tissuespleenleft lungcolonproximal tubuleduodenumileumliverMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding protein kinase activity protein homodimerization activity protein serine threonine kinase activity protein binding protein heterodimerization activity ATP bindingCellular componentcytoplasm cytosol plasma membrane endosome membrane nucleusBiological processresponse to interleukin 1 negative regulation of DNA binding transcription factor activity toll like receptor signaling pathway protein phosphorylation JNK cascade positive regulation of NF kappaB transcription factor activity toll like receptor 9 signaling pathway negative regulation of NF kappaB transcription factor activity nucleotide binding oligomerization domain containing signaling pathway lipopolysaccharide mediated signaling pathway signal transduction regulation of cytokine mediated signaling pathway I kappaB kinase NF kappaB signaling inflammatory response MyD88 dependent toll like receptor signaling pathway intracellular signal transduction interleukin 1 mediated signaling pathway cytokine mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez3656108960EnsemblENSG00000134070ENSMUSG00000060477UniProtO43187Q8CFA1RefSeq mRNA NM 001570NM 001113553NM 172161RefSeq protein NP 001561NP 001107025NP 751893Location UCSC Chr 3 10 16 10 24 MbChr 6 113 62 113 67 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editIRAK2 encodes the interleukin 1 receptor associated kinase 2 one of two putative serine threonine kinases that become associated with the interleukin 1 receptor IL1R upon stimulation IRAK2 is reported to participate in the IL1 induced upregulation of NF kappaB 6 Interactions editIRAK2 has been shown to interact with TRAF6 5 7 and Myd88 5 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000134070 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000060477 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c Muzio M Ni J Feng P Dixit VM Nov 1997 IRAK Pelle family member IRAK 2 and MyD88 as proximal mediators of IL 1 signaling Science 278 5343 1612 5 Bibcode 1997Sci 278 1612M doi 10 1126 science 278 5343 1612 PMID 9374458 a b Entrez Gene IRAK2 interleukin 1 receptor associated kinase 2 a b Wesche H Gao X Li X Kirschning CJ Stark GR Cao Z Jul 1999 IRAK M is a novel member of the Pelle interleukin 1 receptor associated kinase IRAK family The Journal of Biological Chemistry 274 27 19403 10 doi 10 1074 jbc 274 27 19403 PMID 10383454 Fitzgerald KA Palsson McDermott EM Bowie AG Jefferies CA Mansell AS Brady G Brint E Dunne A Gray P Harte MT McMurray D Smith DE Sims JE Bird TA O Neill LA Sep 2001 Mal MyD88 adapter like is required for Toll like receptor 4 signal transduction Nature 413 6851 78 83 Bibcode 2001Natur 413 78F doi 10 1038 35092578 PMID 11544529 S2CID 4333764 Further reading editAuron PE 1999 The interleukin 1 receptor ligand interactions and signal transduction Cytokine amp Growth Factor Reviews 9 3 4 221 37 doi 10 1016 S1359 6101 98 00018 5 PMID 9918122 Maschera B Ray K Burns K Volpe F Apr 1999 Overexpression of an enzymically inactive interleukin 1 receptor associated kinase activates nuclear factor kappaB The Biochemical Journal 339 Pt 2 2 227 31 doi 10 1042 0264 6021 3390227 PMC 1220149 PMID 10191251 Wesche H Gao X Li X Kirschning CJ Stark GR Cao Z Jul 1999 IRAK M is a novel member of the Pelle interleukin 1 receptor associated kinase IRAK family The Journal of Biological Chemistry 274 27 19403 10 doi 10 1074 jbc 274 27 19403 PMID 10383454 Fitzgerald KA Palsson McDermott EM Bowie AG Jefferies CA Mansell AS Brady G Brint E Dunne A Gray P Harte MT McMurray D Smith DE Sims JE Bird TA O Neill LA Sep 2001 Mal MyD88 adapter like is required for Toll like receptor 4 signal transduction Nature 413 6851 78 83 Bibcode 2001Natur 413 78F doi 10 1038 35092578 PMID 11544529 S2CID 4333764 McDermott EP O Neill LA Mar 2002 Ras participates in the activation of p38 MAPK by interleukin 1 by associating with IRAK IRAK2 TRAF6 and TAK 1 The Journal of Biological Chemistry 277 10 7808 15 doi 10 1074 jbc M108133200 PMID 11744690 Shin BK Wang H Yim AM Le Naour F Brichory F Jang JH Zhao R Puravs E Tra J Michael CW Misek DE Hanash SM Feb 2003 Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function The Journal of Biological Chemistry 278 9 7607 16 doi 10 1074 jbc M210455200 PMID 12493773 Bin LH Xu LG Shu HB Jul 2003 TIRP a novel Toll interleukin 1 receptor TIR domain containing adapter protein involved in TIR signaling The Journal of Biological Chemistry 278 27 24526 32 doi 10 1074 jbc M303451200 PMID 12721283 Kuzmin I Geil L Gibson L Cavinato T Loukinov D Lobanenkov V Lerman MI Feb 2005 Transcriptional regulator CTCF controls human interleukin 1 receptor associated kinase 2 promoter Journal of Molecular Biology 346 2 411 22 doi 10 1016 j jmb 2004 11 066 PMID 15670593 Keating SE Maloney GM Moran EM Bowie AG Nov 2007 IRAK 2 participates in multiple toll like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination The Journal of Biological Chemistry 282 46 33435 43 doi 10 1074 jbc M705266200 PMID 17878161 Portal nbsp Biology This EC 2 7 enzyme related article is a stub You can help Wikipedia by expanding it vte nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IRAK2 amp oldid 1079111426, wikipedia, wiki, book, books, library,
