The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.[7]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000216490 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031838 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. doi:10.1016/S0021-9258(18)37889-X. PMID 3136170.
^Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. Bibcode:2000PNAS...97..745A. doi:10.1073/pnas.97.2.745. PMC15401. PMID 10639150.
^ ab"Entrez Gene: IFI30 interferon, gamma-inducible protein 30".
Further readingEdit
Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet. 20 (1): 1. PMID 16170.
Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association. 52 (1): 9. PMID 1069150.
Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. doi:10.1074/jbc.M003459200. PMID 10852914.
Phan UT, Maric M, Dick TP, Cresswell P (2001). "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics. 53 (4): 342–6. doi:10.1007/s002510100323. PMID 11491538. S2CID 848449.
Haque MA, Li P, Jackson SK, et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMC2193747. PMID 12021307.
Phan UT, Lackman RL, Cresswell P (2002). "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. Bibcode:2002PNAS...9912298P. doi:10.1073/pnas.182430499. PMC129439. PMID 12198183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
ifi30, gamma, interferon, inducible, lysosomal, thiol, reductase, enzyme, that, humans, encoded, gene, identifiersaliases, gilt, ip30, lysosomal, thiol, reductase, lysosomal, thiol, reductaseexternal, idsomim, 604664, 2137648, homologene, 38171, genecards, gen. Gamma interferon inducible lysosomal thiol reductase is an enzyme that in humans is encoded by the IFI30 gene 5 6 7 IFI30IdentifiersAliasesIFI30 GILT IFI 30 IP30 IP 30 lysosomal thiol reductase IFI30 lysosomal thiol reductaseExternal IDsOMIM 604664 MGI 2137648 HomoloGene 38171 GeneCards IFI30Gene location Human Chr Chromosome 19 human 1 Band19p13 11Start18 173 162 bp 1 End18 178 117 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 B3 3Start71 215 419 bp 2 End71 219 307 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodappendixspleenupper lobe of left lungright lunglymph nodeduodenumplacentagallbladderTop expressed inspleenduodenumcolonyolk sacjejunumstomachileumthymuszone of skinlipMore reference expression dataBioGPSn aGene ontologyMolecular functionoxidoreductase activity protein binding oxidoreductase activity acting on a sulfur group of donorsCellular componentextracellular region cell junction lysosomal lumen intracellular membrane bounded organelle lysosome cytosolBiological processinterferon gamma mediated signaling pathway immune system process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class ISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1043765972EnsemblENSG00000216490ENSMUSG00000031838UniProtP13284Q9ESY9RefSeq mRNA NM 006332NM 023065RefSeq protein NP 006323NP 075552Location UCSC Chr 19 18 17 18 18 MbChr 8 71 22 71 22 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds The enzyme is expressed constitutively in antigen presenting cells and induced by gamma interferon in other cell types This enzyme has an important role in MHC class II restricted antigen processing 7 References Edit a b c GRCh38 Ensembl release 89 ENSG00000216490 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031838 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Luster AD Weinshank RL Feinman R Ravetch JV Sep 1988 Molecular and biochemical characterization of a novel gamma interferon inducible protein J Biol Chem 263 24 12036 43 doi 10 1016 S0021 9258 18 37889 X PMID 3136170 Arunachalam B Phan UT Geuze HJ Cresswell P Mar 2000 Enzymatic reduction of disulfide bonds in lysosomes Characterization of a Gamma interferon inducible lysosomal thiol reductase GILT Proc Natl Acad Sci U S A 97 2 745 50 Bibcode 2000PNAS 97 745A doi 10 1073 pnas 97 2 745 PMC 15401 PMID 10639150 a b Entrez Gene IFI30 interferon gamma inducible protein 30 Further reading EditCsanyi E 1977 Endre Kotai 1914 1976 Magyar traumatologia orthopaedia es helyreallito sebeszet 20 1 1 PMID 16170 Sabin NM 1977 Letters to the editors The Journal of the Wisconsin Dental Association 52 1 9 PMID 1069150 Phan UT Arunachalam B Cresswell P 2000 Gamma interferon inducible lysosomal thiol reductase GILT Maturation activity and mechanism of action J Biol Chem 275 34 25907 14 doi 10 1074 jbc M003459200 PMID 10852914 Phan UT Maric M Dick TP Cresswell P 2001 Multiple species express thiol oxidoreductases related to GILT Immunogenetics 53 4 342 6 doi 10 1007 s002510100323 PMID 11491538 S2CID 848449 Haque MA Li P Jackson SK et al 2002 Absence of g Interferon inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes J Exp Med 195 10 1267 77 doi 10 1084 jem 20011853 PMC 2193747 PMID 12021307 Phan UT Lackman RL Cresswell P 2002 Role of the C terminal propeptide in the activity and maturation of g interferon inducible lysosomal thiol reductase GILT Proc Natl Acad Sci U S A 99 19 12298 303 Bibcode 2002PNAS 9912298P doi 10 1073 pnas 182430499 PMC 129439 PMID 12198183 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IFI30 amp oldid 1113101114, wikipedia, wiki, book, books, library,
