Hyperkeratinization (American English or hyperkeratinisation in British) is a disorder of the cells lining the inside of a hair follicle. It is the normal function of these cells to detach or slough off (desquamate) from the skin lining at normal intervals. The dead cells are then forced out of the follicle (primarily by the growing hair). However, in hyperkeratinization, this process is interrupted and a number of these dead skin cells do not leave the follicle because of an excess of keratin, a natural protein found in the skin. This excess of keratin, which is influenced by genetics, results in an increased adherence/bonding of dead skin cells together. This cohesion of cells will block or "cap" the hair follicle (leading to keratosis pilaris) or clog the sebaceous/oil duct (leading to acne). Pathogens may also play a role in causing, perpetuating, or simply taking advantage of this phenomenon, such as virulent sub-strains of Cutibacterium acnes and irregular migration of Staphylococcus epidermidis from the outer surface of the skin into the follicle, where commensal strains of C. acnes exclusively habitate. It itches mildly at times, and strongly at others. Very often it cannot be felt at all.[1][2]
^Lomholt, H. B.; Kilian, M (2010). "Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne". PLOS ONE. 5 (8): e12277. Bibcode:2010PLoSO...512277L. doi:10.1371/journal.pone.0012277. PMC2924382. PMID 20808860.
^Bek-Thomsen, M; Lomholt, H. B.; Kilian, M (2008). "Acne is not associated with yet-uncultured bacteria". Journal of Clinical Microbiology. 46 (10): 3355–60. doi:10.1128/JCM.00799-08. PMC2566126. PMID 18716234.
Further readingedit
Van Scott, Eugene J.; Yu, Ruey J. (1984). "Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids". Journal of the American Academy of Dermatology. 11 (5). Elsevier BV: 867–879. doi:10.1016/s0190-9622(84)80466-1. ISSN 0190-9622.
Thiboutot, D. M. (2000-01-01). "The role of follicular hyperkeratinization in acne". Journal of Dermatological Treatment. 11 (2): 5–8. doi:10.1080/095466300750163645. ISSN 0954-6634.
External linksedit
April 11, 2024
hyperkeratinization, american, english, hyperkeratinisation, british, disorder, cells, lining, inside, hair, follicle, normal, function, these, cells, detach, slough, desquamate, from, skin, lining, normal, intervals, dead, cells, then, forced, follicle, prima. Hyperkeratinization American English or hyperkeratinisation in British is a disorder of the cells lining the inside of a hair follicle It is the normal function of these cells to detach or slough off desquamate from the skin lining at normal intervals The dead cells are then forced out of the follicle primarily by the growing hair However in hyperkeratinization this process is interrupted and a number of these dead skin cells do not leave the follicle because of an excess of keratin a natural protein found in the skin This excess of keratin which is influenced by genetics results in an increased adherence bonding of dead skin cells together This cohesion of cells will block or cap the hair follicle leading to keratosis pilaris or clog the sebaceous oil duct leading to acne Pathogens may also play a role in causing perpetuating or simply taking advantage of this phenomenon such as virulent sub strains of Cutibacterium acnes and irregular migration of Staphylococcus epidermidis from the outer surface of the skin into the follicle where commensal strains of C acnes exclusively habitate It itches mildly at times and strongly at others Very often it cannot be felt at all 1 2 HyperkeratinizationOther namesHyperkeratinisationSpecialtyDermatology Contents 1 See also 2 References 3 Further reading 4 External linksSee also editHyperkeratosisReferences edit Lomholt H B Kilian M 2010 Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne PLOS ONE 5 8 e12277 Bibcode 2010PLoSO 512277L doi 10 1371 journal pone 0012277 PMC 2924382 PMID 20808860 Bek Thomsen M Lomholt H B Kilian M 2008 Acne is not associated with yet uncultured bacteria Journal of Clinical Microbiology 46 10 3355 60 doi 10 1128 JCM 00799 08 PMC 2566126 PMID 18716234 Further reading editVan Scott Eugene J Yu Ruey J 1984 Hyperkeratinization corneocyte cohesion and alpha hydroxy acids Journal of the American Academy of Dermatology 11 5 Elsevier BV 867 879 doi 10 1016 s0190 9622 84 80466 1 ISSN 0190 9622 Thiboutot D M 2000 01 01 The role of follicular hyperkeratinization in acne Journal of Dermatological Treatment 11 2 5 8 doi 10 1080 095466300750163645 ISSN 0954 6634 External links edit Retrieved from https en wikipedia org w index php title Hyperkeratinization amp oldid 1218141829, wikipedia, wiki, book, books, library,
