HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[9][10]
^ abcGRCh38: Ensembl release 89: ENSG00000162374 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028546 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.
^Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. S2CID 26037558.
^Lukong, Kiven E.; Chang, Kai-wei; Khandjian, Edouard W.; Richard, Stéphane (2008-08-01). "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416–425. doi:10.1016/j.tig.2008.05.004. ISSN 0168-9525. PMID 18597886.
^Nora Perrone-Bizzozero; Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.
^Federico Bolognani; Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436. S2CID 27076039.
^Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. United States. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174.
Further readingedit
Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB (1992). "The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues". Am. J. Pathol. 141 (4): 881–6. PMC1886624. PMID 1415481.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. S2CID 26037558.
Graus F, Ferrer I (1990). "Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis". Neurosci. Lett. 112 (1): 14–8. doi:10.1016/0304-3940(90)90314-Y. PMID 2166930. S2CID 24113954.
Sekido Y, Bader SA, Carbone DP, et al. (1994). "Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines". Cancer Res. 54 (18): 4988–92. PMID 8069866.
Torà M, Graus F, de Bolòs C, Real FX (1997). "Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas". Neurology. 48 (3): 735–41. doi:10.1212/wnl.48.3.735. PMID 9065557. S2CID 23410604.
Lazarova DL, Spengler BA, Biedler JL, Ross RA (1999). "HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts". Oncogene. 18 (17): 2703–10. doi:10.1038/sj.onc.1202621. PMID 10348344.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC85909. PMID 10848602.
Wang X, Tanaka Hall TM (2001). "Structural basis for recognition of AU-rich element RNA by the HuD protein". Nat. Struct. Biol. 8 (2): 141–5. doi:10.1038/84131. PMID 11175903. S2CID 12462183.
Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI (2002). "Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD". J. Biol. Chem. 277 (31): 27996–8002. doi:10.1074/jbc.M201982200. PMID 12034726.
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules". J. Cell Sci. 115 (Pt 19): 3817–27. doi:10.1242/jcs.00058. PMID 12235292.
Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. doi:10.1523/JNEUROSCI.22-20-08827.2002. PMC6757688. PMID 12388589.
Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ (2003). "Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD". J. Biol. Chem. 278 (8): 5710–7. doi:10.1074/jbc.M209383200. PMID 12468554.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Plonquet A, Garcia-Pons F, Fernandez E, et al. (2004). "Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human". J. Neuroimmunol. 142 (1–2): 93–100. doi:10.1016/S0165-5728(03)00269-8. PMID 14512168. S2CID 12038485.
Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID 15358174.
Rousseau A, Benyahia B, Dalmau J, et al. (2005). "T cell response to Hu-D peptides in patients with anti-Hu syndrome". J. Neurooncol. 71 (3): 231–6. doi:10.1007/s11060-004-1723-1. PMC2586925. PMID 15735910.
Noureddine MA, Qin XJ, Oliveira SA, et al. (2005). "Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease". Hum. Genet. 117 (1): 27–33. doi:10.1007/s00439-005-1259-2. PMID 15827745. S2CID 22359866.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
protein, otherwise, known, elav, like, protein, protein, that, humans, encoded, elavl4, gene, elavl4available, structurespdbortholog, search, pdbe, rcsblist, codes1fxl, 1g2eidentifiersaliaseselavl4, pnem, elav, like, neuron, specific, binding, protein, elav, l. HuD otherwise known as ELAV like protein 4 is a protein that in humans is encoded by the ELAVL4 gene 5 6 ELAVL4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1FXL 1G2EIdentifiersAliasesELAVL4 HUD PNEM HuD ELAV like neuron specific RNA binding protein 4 ELAV like RNA binding protein 4External IDsOMIM 168360 MGI 107427 HomoloGene 40729 GeneCards ELAVL4Gene location Human Chr Chromosome 1 human 1 Band1p33 p32 3Start50 024 029 bp 1 End50 203 772 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 C7 4 51 42 cMStart110 203 722 bp 2 End110 351 909 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellganglionic eminenceBrodmann area 23middle temporal gyrusponsBrodmann area 46parietal lobepostcentral gyrussuperior frontal gyrusspermTop expressed inhabenulaventral tegmental areamedial vestibular nucleussuperior cervical gangliontrigeminal ganglionganglionic eminenceneural tubepontine nucleimedial ganglionic eminencedorsal tegmental nucleusMore reference expression dataBioGPSMore reference expression dataOrthologsSpeciesHumanMouseEntrez199615572EnsemblENSG00000162374ENSMUSG00000028546UniProtP26378Q61701RefSeq mRNA NM 001144774NM 001144775NM 001144776NM 001144777NM 001294348NM 021952NM 001324208NM 001324209NM 001324212NM 001324213NM 001324214NM 001324215NM 001324216NM 001324217NM 001038698NM 001163397NM 001163399NM 010488NM 001347178NM 001357190RefSeq protein NP 001138246NP 001138247NP 001138248NP 001138249NP 001281277NP 001311137NP 001311138NP 001311141NP 001311142NP 001311143NP 001311144NP 001311145NP 001311146NP 068771NP 001033787NP 001156869NP 001156871NP 001334107NP 034618NP 001344119Location UCSC Chr 1 50 02 50 2 MbChr 4 110 2 110 35 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe HuD ELAVL4 protein is an RNA binding protein 7 HuD contains three RRM protein domains enabling RNA binding 8 HuD is expressed only in neurons and it binds to AU rich element containing mRNAs As a result of this interaction the half life of the transcript is increased HuD is important in neurons during brain development and plasticity 9 10 Interactions editHuD protein has been shown to interact with NXF1 11 References edit a b c GRCh38 Ensembl release 89 ENSG00000162374 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028546 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Muresu R Baldini A Gress T Posner JB Furneaux HM Siniscalco M Dec 1993 Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen HuD to human chromosome site 1p34 Cytogenet Cell Genet 65 3 177 8 doi 10 1159 000133626 PMID 8222755 Entrez Gene ELAVL4 ELAV embryonic lethal abnormal vision Drosophila like 4 Hu antigen D Szabo A Dalmau J Manley G et al 1991 HuD a paraneoplastic encephalomyelitis antigen contains RNA binding domains and is homologous to Elav and Sex lethal Cell 67 2 325 33 doi 10 1016 0092 8674 91 90184 Z PMID 1655278 S2CID 26037558 Lukong Kiven E Chang Kai wei Khandjian Edouard W Richard Stephane 2008 08 01 RNA binding proteins in human genetic disease Trends in Genetics 24 8 416 425 doi 10 1016 j tig 2008 05 004 ISSN 0168 9525 PMID 18597886 Nora Perrone Bizzozero Federico Bolognani 2002 Role of HuD and other RNA binding proteins in neural development and plasticity J Neurosci Res 68 2 121 126 doi 10 1002 jnr 10175 PMID 11948657 Federico Bolognani Nora Perrone Bizzozero 2008 RNA protein interactions and control of mRNA stability in neurons J Neurosci Res 86 3 481 489 doi 10 1002 jnr 21473 PMID 17853436 S2CID 27076039 Saito Kuniaki Fujiwara Toshinobu Katahira Jun Inoue Kunio Sakamoto Hiroshi Aug 2004 TAP NXF1 the primary mRNA export receptor specifically interacts with a neuronal RNA binding protein HuD Biochem Biophys Res Commun United States 321 2 291 7 doi 10 1016 j bbrc 2004 06 140 ISSN 0006 291X PMID 15358174 Further reading editDalmau J Furneaux HM Cordon Cardo C Posner JB 1992 The expression of the Hu paraneoplastic encephalomyelitis sensory neuronopathy antigen in human normal and tumor tissues Am J Pathol 141 4 881 6 PMC 1886624 PMID 1415481 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Szabo A Dalmau J Manley G et al 1991 HuD a paraneoplastic encephalomyelitis antigen contains RNA binding domains and is homologous to Elav and Sex lethal Cell 67 2 325 33 doi 10 1016 0092 8674 91 90184 Z PMID 1655278 S2CID 26037558 Graus F Ferrer I 1990 Analysis of a neuronal antigen Hu expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis Neurosci Lett 112 1 14 8 doi 10 1016 0304 3940 90 90314 Y PMID 2166930 S2CID 24113954 Sekido Y Bader SA Carbone DP et al 1994 Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines Cancer Res 54 18 4988 92 PMID 8069866 Tora M Graus F de Bolos C Real FX 1997 Cell surface expression of paraneoplastic encephalomyelitis sensory neuronopathy associated Hu antigens in small cell lung cancers and neuroblastomas Neurology 48 3 735 41 doi 10 1212 wnl 48 3 735 PMID 9065557 S2CID 23410604 Lazarova DL Spengler BA Biedler JL Ross RA 1999 HuD a neuronal specific RNA binding protein is a putative regulator of N myc pre mRNA processing stability in malignant human neuroblasts Oncogene 18 17 2703 10 doi 10 1038 sj onc 1202621 PMID 10348344 Park S Myszka DG Yu M et al 2000 HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU rich RNA Mol Cell Biol 20 13 4765 72 doi 10 1128 MCB 20 13 4765 4772 2000 PMC 85909 PMID 10848602 Wang X Tanaka Hall TM 2001 Structural basis for recognition of AU rich element RNA by the HuD protein Nat Struct Biol 8 2 141 5 doi 10 1038 84131 PMID 11175903 S2CID 12462183 Beckel Mitchener AC Miera A Keller R Perrone Bizzozero NI 2002 Poly A tail length dependent stabilization of GAP 43 mRNA by the RNA binding protein HuD J Biol Chem 277 31 27996 8002 doi 10 1074 jbc M201982200 PMID 12034726 Behrends U Jandl T Golbeck A et al 2002 Novel products of the HUD HUC NNP 1 and alpha internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library Int J Cancer 100 6 669 77 doi 10 1002 ijc 10550 PMID 12209604 Aronov S Aranda G Behar L Ginzburg I 2003 Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules J Cell Sci 115 Pt 19 3817 27 doi 10 1242 jcs 00058 PMID 12235292 Angenstein F Evans AM Settlage RE et al 2002 A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA mRNAs in neurons J Neurosci 22 20 8827 37 doi 10 1523 JNEUROSCI 22 20 08827 2002 PMC 6757688 PMID 12388589 Deschenes Furry J Belanger G Perrone Bizzozero N Jasmin BJ 2003 Post transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor treated PC12 cells by the RNA binding protein HuD J Biol Chem 278 8 5710 7 doi 10 1074 jbc M209383200 PMID 12468554 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Plonquet A Garcia Pons F Fernandez E et al 2004 Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human J Neuroimmunol 142 1 2 93 100 doi 10 1016 S0165 5728 03 00269 8 PMID 14512168 S2CID 12038485 Saito K Fujiwara T Katahira J et al 2004 TAP NXF1 the primary mRNA export receptor specifically interacts with a neuronal RNA binding protein HuD Biochem Biophys Res Commun 321 2 291 7 doi 10 1016 j bbrc 2004 06 140 PMID 15358174 Rousseau A Benyahia B Dalmau J et al 2005 T cell response to Hu D peptides in patients with anti Hu syndrome J Neurooncol 71 3 231 6 doi 10 1007 s11060 004 1723 1 PMC 2586925 PMID 15735910 Noureddine MA Qin XJ Oliveira SA et al 2005 Association between the neuron specific RNA binding protein ELAVL4 and Parkinson disease Hum Genet 117 1 27 33 doi 10 1007 s00439 005 1259 2 PMID 15827745 S2CID 22359866 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HuD protein amp oldid 1170992075, wikipedia, wiki, book, books, library,
