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Response element

January 01, 1970

Response elements are short sequences of DNA within a gene promoter or enhancer region that are able to bind specific transcription factors and regulate transcription of genes.

Under conditions of stress, a transcription activator protein binds to the response element and stimulates transcription. If the same response element sequence is located in the control regions of different genes, then these genes will be activated by the same stimuli, thus producing a coordinated response.

Hormone response element edit

A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene, that is able to bind to a specific hormone receptor complex and therefore regulate transcription.[1] The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signalled by the steroid hormone.

A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.[2]

HRE are used in transgenic animal cells as inducers of gene expression.

Examples of HREs include estrogen response elements and androgen response elements.

Examples edit

Examples of response elements include:

References edit

  1. ^ a b Kimball JW (25 April 2011). "Steroid Hormone Receptors and their Response Elements". Kimball's Biology Pages.
  2. ^ Krieger M, Scott MP, Matsudaira PT, Lodish HF, Darnell JE, Lawrence Z, Kaiser C, Berk A (2003). Molecular Cell Biology (Fifth ed.). San Francisco: W.H. Freeman. p. 973 pages. ISBN 0-7167-4366-3.
  3. ^ Penvose, A; Keenan, JL; Bray, D; Ramlall, V; Siggers, T (7 June 2019). "Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity". Nature Communications. 10 (1): 2514. Bibcode:2019NatCo..10.2514P. doi:10.1038/s41467-019-10264-3. PMC 6555819. PMID 31175293.

External links edit


 

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January 01, 1970
response, element, short, sequences, within, gene, promoter, enhancer, region, that, able, bind, specific, transcription, factors, regulate, transcription, genes, under, conditions, stress, transcription, activator, protein, binds, response, element, stimulate. Response elements are short sequences of DNA within a gene promoter or enhancer region that are able to bind specific transcription factors and regulate transcription of genes Under conditions of stress a transcription activator protein binds to the response element and stimulates transcription If the same response element sequence is located in the control regions of different genes then these genes will be activated by the same stimuli thus producing a coordinated response Contents 1 Hormone response element 2 Examples 3 References 4 External linksHormone response element editA hormone response element HRE is a short sequence of DNA within the promoter of a gene that is able to bind to a specific hormone receptor complex and therefore regulate transcription 1 The sequence is most commonly a pair of inverted repeats separated by three nucleotides which also indicates that the receptor binds as a dimer Specifically HRE responds to steroid hormones as the activated steroid receptor is the transcription factor binding HRE This regulates the transcription of genes signalled by the steroid hormone A gene may have many different response elements allowing complex control to be exerted over the level and rate of transcription 2 HRE are used in transgenic animal cells as inducers of gene expression Examples of HREs include estrogen response elements and androgen response elements Examples editExamples of response elements include Nuclear receptor response elements two 6 meric repeats for dimeric binding Type 2 NR response elements direct repeat RGKTCA motifs canonically AGGTCA 3 Vitamin D response element VDRE Retinoic acid response elements RAREs ROR response element Thyroid hormone response element Growth hormone response element GHRE Peroxisome proliferator hormone response elements PPREs Type 1 NR response elements typical of hormone response elements inverted repeat 1 estrogen response elements EREs androgen response elements AREs glucocorticoid response elements GREs cAMP response element CRE B recognition element AhR dioxin or xenobiotic responsive element Hypoxia responsive elements Serum response element SRE Metal responsive element MRE DNA damage response element DRE IFN stimulated response elements ISREs Calcium response element CaRE1 Antioxidant response element ARE p53 response element Sterol regulatory element Polycomb Response Elements PREs Rev response element RRE Wnt response element WRE core CTTTGReferences edit a b Kimball JW 25 April 2011 Steroid Hormone Receptors and their Response Elements Kimball s Biology Pages Krieger M Scott MP Matsudaira PT Lodish HF Darnell JE Lawrence Z Kaiser C Berk A 2003 Molecular Cell Biology Fifth ed San Francisco W H Freeman p 973 pages ISBN 0 7167 4366 3 Penvose A Keenan JL Bray D Ramlall V Siggers T 7 June 2019 Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity Nature Communications 10 1 2514 Bibcode 2019NatCo 10 2514P doi 10 1038 s41467 019 10264 3 PMC 6555819 PMID 31175293 External links editresponse element at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Response element amp oldid 1167090382 Hormone response element, wikipedia, wiki, book, books, library,

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