Hill's muscle model

In biomechanics, Hill's muscle model refers to the 3-element model consisting of a contractile element (CE) in series with a lightly-damped elastic spring element (SE) and in parallel with lightly-damped elastic parallel element (PE). Within this model, the estimated force-velocity relation for the CE element is usually modeled by what is commonly called Hill's equation, which was based on careful experiments involving tetanized muscle contraction where various muscle loads and associated velocities were measured. They were derived by the famous physiologist Archibald Vivian Hill, who by 1938 when he introduced this model and equation had already won the Nobel Prize for Physiology. He continued to publish in this area through 1970. There are many forms of the basic "Hill-based" or "Hill-type" models, with hundreds of publications having used this model structure for experimental and simulation studies. Most major musculoskeletal simulation packages make use of this model.

AV Hill's force-velocity equation for tetanized muscle

This is a popular state equation applicable to skeletal muscle that has been stimulated to show Tetanic contraction. It relates tension to velocity with regard to the internal thermodynamics. The equation is

${\displaystyle \left(v+b\right)(F+a)=b(F_{0}+a),\qquad (1)}$ 

where

• ${\displaystyle F}$  is the tension (or load) in the muscle
• ${\displaystyle v}$  is the velocity of contraction
• ${\displaystyle F_{0}}$  is the maximum isometric tension (or load) generated in the muscle
• ${\displaystyle a}$  coefficient of shortening heat
• ${\displaystyle b=a\cdot v_{0}/F_{0}}$ 
• ${\displaystyle v_{0}}$  is the maximum velocity, when ${\displaystyle F=0}$ 

Although Hill's equation looks very much like the van der Waals equation, the former has units of energy dissipation, while the latter has units of energy. Hill's equation demonstrates that the relationship between F and v is hyperbolic. Therefore, the higher the load applied to the muscle, the lower the contraction velocity. Similarly, the higher the contraction velocity, the lower the tension in the muscle. This hyperbolic form has been found to fit the empirical constant only during isotonic contractions near resting length.^[1]

The muscle tension decreases as the shortening velocity increases. This feature has been attributed to two main causes. The major appears to be the loss in tension as the cross bridges in the contractile element and then reform in a shortened condition. The second cause appears to be the fluid viscosity in both the contractile element and the connective tissue. Whichever the cause of loss of tension, it is a viscous friction and can therefore be modeled as a fluid damper .^[2]

Three-element model

 

Muscle length vs Force. In Hill's muscle model the active and passive forces are respectively ${\displaystyle F_{CE}}$  and ${\displaystyle F_{PE}}$ .

 

Hill's elastic muscle model. F: Force; CE: Contractile Element; SE: Series Element; PE: Parallel Element.

The three-element Hill muscle model is a representation of the muscle mechanical response. The model is constituted by a contractile element (CE) and two non-linear spring elements, one in series (SE) and another in parallel (PE). The active force of the contractile element comes from the force generated by the actin and myosin cross-bridges at the sarcomere level. It is fully extensible when inactive but capable of shortening when activated. The connective tissues (fascia, epimysium, perimysium and endomysium) that surround the contractile element influences the muscle's force-length curve. The parallel element represents the passive force of these connective tissues and has a soft tissue mechanical behavior. The parallel element is responsible for the muscle passive behavior when it is stretched, even when the contractile element is not activated. The series element represents the tendon and the intrinsic elasticity of the myofilaments. It also has a soft tissue response and provides energy storing mechanism.^[2][3]

The net force-length characteristics of a muscle is a combination of the force-length characteristics of both active and passive elements. The forces in the contractile element, in the series element and in the parallel element, ${\displaystyle F^{CE}}$ , ${\displaystyle F^{SE}}$  and ${\displaystyle F^{PE}}$ , respectively, satisfy

${\displaystyle F=F^{PE}+F^{SE},\qquad F^{CE}=F^{SE},\qquad (2)}$ 

On the other hand, the muscle length ${\displaystyle L}$  and the lengths ${\displaystyle L^{CE}}$ , ${\displaystyle L^{SE}}$  and ${\displaystyle L^{PE}}$  of those elements satisfy

${\displaystyle L=L^{PE},\qquad L=L^{CE}+L^{SE},\qquad (3)}$ 

During isometric contractions the series elastic component is under tension and therefore is stretched a finite amount. Because the overall length of the muscle is kept constant, the stretching of the series element can only occur if there is an equal shortening of the contractile element itself.^[2]

The forces in the parallel, series and contractile elements are defined by:

$${\displaystyle F^{PE}(\lambda _{f})=F_{0}f^{PE}(\lambda _{f}),\qquad F^{SE}(\lambda ^{SE},\lambda ^{CE})=F_{0}f^{SE}(\lambda ^{SE},\lambda ^{CE}),\qquad F^{CE}(\lambda ^{CE},{\dot {\lambda }}^{CE},a)=F_{0}f_{L}^{CE}(\lambda ^{CE})f_{V}^{CE}({\dot {\lambda }}^{CE})a,\qquad (4)}$$

 

where ${\textstyle \lambda _{f},\lambda _{CE},\lambda _{SE}}$  are strain measures for the different elements defined by:

$${\displaystyle \lambda _{f}={\frac {L}{L_{0}}},\quad \lambda ^{CE}={\frac {L^{CE}}{L_{0}}},\quad \lambda ^{SE}={\frac {L}{L^{CE}}},\qquad (5)}$$

 

where ${\textstyle L}$  is the deformed muscle length and ${\textstyle L^{CE}}$  is the deformed muscle length due to motion of the contractile element, both from equation (3). ${\textstyle L_{0}}$  is the rest length of the muscle. ${\displaystyle \lambda _{f}}$  can be split as ${\textstyle \lambda _{f}=\lambda ^{SE}\lambda ^{CE}}$ . The force term, ${\displaystyle F_{0}}$ , is the peak isometric muscle force and the functions ${\textstyle f^{PE},f^{SE},f_{L}^{CE},f_{V}^{CE}}$  are given by:

$${\displaystyle {\begin{array}{lcr}f^{PE}(\lambda _{f})={\begin{cases}2cA(\lambda _{f}-1)e^{c(\lambda _{f}-1)^{2}},&\lambda _{f}>1\\{\text{0}},&{\text{otherwise}}\end{cases}},&(6)\\[4pt]f^{SE}(\lambda ^{SE},\lambda ^{CE})={\begin{cases}0.1(e^{100\lambda ^{CE}(\lambda ^{SE}-1)}-1),&\lambda ^{SE}\geq 1\\{\text{0}},&{\text{otherwise}}\end{cases}},&(7)\\[4pt]f_{L}^{CE}(\lambda ^{CE})={\begin{cases}-4(\lambda ^{CE}-1)^{2}+1,&0.5\leq \lambda ^{CE}\leq 1.5\\{\text{0}},&{\text{otherwise}}\end{cases}},&(8)\\[4pt]f_{V}^{CE}({\dot {\lambda }}^{CE})={\begin{cases}{\text{0}},&{\dot {\lambda }}^{CE}<-10s^{-1}\\-{\frac {1}{\arctan(5)}}\arctan(-0.5{\dot {\lambda }}^{CE})+1,&-10s^{-1}\leq {\dot {\lambda }}^{CE}\leq 2s^{-1}\\{\frac {\pi }{4\arctan(5)}}+1,&{\dot {\lambda }}^{CE}>2s^{-1}\end{cases}},&(9)\end{array}}}$$

 

where ${\displaystyle c,A}$  are empirical constants. The function ${\displaystyle a(t)}$  from equation (4) represents the muscle activation. It is defined based on the ordinary differential equation:

$${\displaystyle {\frac {da(t)}{dt}}={\frac {1}{\tau _{rise}}}(1-a(t)u(t)+{\frac {1}{\tau _{fall}}}(a_{min}-a(t))(1-u(t))),\qquad (10)}$$

 

where ${\displaystyle \tau _{rise},\tau _{fall}}$  are time constants related to rise and decay for muscle activation and ${\displaystyle a_{min}}$  is a minimum bound, all determined from experiments. ${\displaystyle u(t)}$  is the neural excitation that leads to muscle contraction.^[4][5]

Viscoelasticity

Muscles present viscoelasticity, therefore a viscous damper may be included in the model, when the dynamics of the second-order critically damped twitch is regarded. One common model for muscular viscosity is an exponential form damper, where

${\displaystyle F_{D}=k({\dot {L}}_{D})^{a},\qquad (11)}$ 

is added to the model's global equation, whose ${\displaystyle k}$  and ${\displaystyle a}$  are constants.^[2]

See also

• Muscle contraction

References

1. Hill, A.V. (October 1938). "The heat of shortening and dynamics constants of muscles". Proc. R. Soc. Lond. B. London: Royal Society. 126 (843): 136–195. doi:10.1098/rspb.1938.0050.
2. Fung, Y.-C. (1993). Biomechanics: Mechanical Properties of Living Tissues. New York: Springer-Verlag. p. 568. ISBN 0-387-97947-6.
3. Martins, J.A.C.; Pires, E.B; Salvado, R.; Dinis, P.B. (1998). "Numerical model of passive and active behavior of skeletal muscles". Computer Methods in Applied Mechanics and Engineering. Elsevier. 151 (3–4): 419–433. Bibcode:1998CMAME.151..419M. doi:10.1016/S0045-7825(97)00162-X.
4. Pandy, Marcus G.; Zajac, Felix E.; Sim, Eunsup; Levine, William S. (1990-01-01). "An optimal control model for maximum-height human jumping". Journal of Biomechanics. 23 (12): 1185–1198. doi:10.1016/0021-9290(90)90376-E. ISSN 0021-9290. PMID 2292598.
5. Martins, J. A. C.; Pato, M. P. M.; Pires, E. B. (2006-09-01). "A finite element model of skeletal muscles". Virtual and Physical Prototyping. 1 (3): 159–170. doi:10.1080/17452750601040626. ISSN 1745-2759. S2CID 137665181.