HNRNPA2B1 gene contains 12 exons, including a B1 protein specific 36-nucleotide mini-exon. The entire length of intron/exon organization of HNRNPA2B1 is identical to that of the HNRNPA1 gene which indicates a common origin by gene duplication.[6]
Functionedit
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.[7] HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33.
The HNRNPA2 and HNRNPB1 proteins are involved in packaging nascent mRNA, in alternative splicing, and in cytoplasmic RNA trafficking, translation, and stabilization. HNRNPA2 and HNRNPB1 also appear to function in telomere maintenance, cell proliferation and differentiation, and glucose transport.[8][9]
Function of HNRNPA2B1 gene can be effectively examined by siRNA knockdown based on an independent validation.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000122566 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004980 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Biamonti G, Ruggiu M, Saccone S, Della Valle G, Riva S (August 1994). "Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1". Nucleic Acids Res. 22 (11): 1996–2002. doi:10.1093/nar/22.11.1996. PMC308112. PMID 8029005.
^Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, Győrffy B (1 January 2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy: Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMC5056990. PMID 27673562.
^Pancetti F, Bosser R, Krehan A, Pyerin W, Itarte E, Bachs O (June 1999). "Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2". Biochem. Biophys. Res. Commun. 260 (1): 17–22. doi:10.1006/bbrc.1999.0849. PMID 10381337.
^Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP (2013). "Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS". Nature. 495 (7442): 467–73. Bibcode:2013Natur.495..467K. doi:10.1038/nature11922. PMC3756911. PMID 23455423.
^Xuan Yang, Wang Jingshu, Ban Liying, Lu Jian-Jun, Yi Canhui, Li Zhenglin, Yu Wendan, Li Mei, Xu Tingting, Yang Wenjing, Tang Zhipeng, Tang Ranran, Xiao Xiangsheng, Meng Songshu, Chen Yiming, Liu Quentin, Huang Wenlin, Guo Wei, Cui Xiaonan, Deng Wuguo, (2016), hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers, Molecular Oncology, 10, doi: 10.1016/j.molonc.2015.11.010. Available from: http://onlinelibrary.wiley.com/doi/10.1016/j.molonc.2015.11.010/abstract;jsessionid=F7FAA0EE2ECB0751450320F2792BFD9E.f03t01
Further readingedit
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Bauw G, Rasmussen HH, van den Bulcke M, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (1990). "Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes". Electrophoresis. 11 (7): 528–36. doi:10.1002/elps.1150110703. PMID 1699755. S2CID 24768114.
Wilk HE, Schaefer KP, Agris PF, Boak AM, Kovacs SA (1991). "U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA". Mol. Cell. Biochem. 106 (1): 55–66. doi:10.1007/BF00231189. PMID 1833625. S2CID 22696966.
Burd CG, Swanson MS, Görlach M, Dreyfuss G (1989). "Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9788–92. Bibcode:1989PNAS...86.9788B. doi:10.1073/pnas.86.24.9788. PMC298587. PMID 2557628.
Kumar A, Williams KR, Szer W (1986). "Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins". J. Biol. Chem. 261 (24): 11266–73. doi:10.1016/S0021-9258(18)67378-8. PMID 3733753.
Faura M, Renau-Piqueras J, Bachs O, Bosser R (1995). "Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues". Biochem. Biophys. Res. Commun. 217 (2): 554–60. doi:10.1006/bbrc.1995.2811. PMID 7503735.
Kozu T, Henrich B, Schäfer KP (1995). "Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1". Genomics. 25 (2): 365–71. doi:10.1016/0888-7543(95)80035-K. PMID 7789969.
Van Laer L, Van Camp G, Green ED, Huizing EH, Willems PJ (1997). "Physical mapping of the HOXA1 gene and the hnRPA2B1 gene in a YAC contig from human chromosome 7p14-p15". Hum. Genet. 99 (6): 831–3. doi:10.1007/s004390050457. PMID 9187682. S2CID 42177403.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
Montuenga LM, Zhou J, Avis I, Vos M, Martinez A, Cuttitta F, Treston AM, Sunday M, Mulshine JL (1998). "Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development". Am. J. Respir. Cell Mol. Biol. 19 (4): 554–62. doi:10.1165/ajrcmb.19.4.3185. hdl:10171/20162. PMID 9761751.
Pancetti F, Bosser R, Krehan A, Pyerin W, Itarte E, Bachs O (1999). "Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2". Biochem. Biophys. Res. Commun. 260 (1): 17–22. doi:10.1006/bbrc.1999.0849. PMID 10381337.
Hamilton BJ, Nichols RC, Tsukamoto H, Boado RJ, Pardridge WM, Rigby WF (1999). "hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo". Biochem. Biophys. Res. Commun. 261 (3): 646–51. doi:10.1006/bbrc.1999.1040. PMID 10441480.
Nichols RC, Wang XW, Tang J, Hamilton BJ, High FA, Herschman HR, Rigby WF (2000). "The RGG domain in hnRNP A2 affects subcellular localization". Exp. Cell Res. 256 (2): 522–32. doi:10.1006/excr.2000.4827. PMID 10772824.
Matsui M, Horiguchi H, Kamma H, Fujiwara M, Ohtsubo R, Ogata T (2000). "Testis- and developmental stage-specific expression of hnRNP A2/B1 splicing isoforms, B0a/b". Biochim. Biophys. Acta. 1493 (1–2): 33–40. doi:10.1016/s0167-4781(00)00154-8. PMID 10978504.
Zhou J, Allred DC, Avis I, Martínez A, Vos MD, Smith L, Treston AM, Mulshine JL (2001). "Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer". Breast Cancer Res. Treat. 66 (3): 217–24. doi:10.1023/A:1010631915831. PMID 11510693. S2CID 27708432.
Pioli PA, Rigby WF (2001). "The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression". J. Biol. Chem. 276 (43): 40346–52. doi:10.1074/jbc.M105391200. PMID 11517223.
Kim SH, Dierssen M, Ferreres JC, Fountoulakis M, Lubec G (2001). "Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains". Protein Expression in Down Syndrome Brain. pp. 273–80. doi:10.1007/978-3-7091-6262-0_22. ISBN978-3-211-83704-7. PMID 11771750. {{cite book}}: |journal= ignored (help)
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC1370266. PMID 11991638.
Li S, Zhang P, Freibaum BD, et al. (2016). "Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy". Human Molecular Genetics. 25 (5): 936–950. doi:10.1093/hmg/ddv627. PMC4754048. PMID 26744327.
Herman S, Fischer A, Presumey J, Hoffmann M, Koenders MI, Escriou V, Apparailly F, Steiner G (2015). "Inhibition of Inflammation and Bone Erosion by RNA Interference–Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis". Arthritis & Rheumatology. 67 (9): 2536–2546. doi:10.1002/art.39223. PMID 26017221.
Kentaro I, Shinji K, Shoko U, Akihito M, Nozomi O, Tatsuki S, Senko T, Tomoe K, Yoichi T, Kengo M, Takao Y, Shingo D, Isamu S, Fumio S (2015). "Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors". Bioorganic & Medicinal Chemistry. 23 (18): 6118–6124. doi:10.1016/j.bmc.2015.08.001. PMID 26314924.
Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A (2016). "A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1". Genes & Development. 30 (9): 1070–1085. doi:10.1101/gad.277392.116. PMC4863738. PMID 27151978.
QU XH, LIU JL, ZHONG XW, LI X, ZHANG QG (2015). "Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancer". Oncology Letters. 10 (3): 1677–1685. doi:10.3892/ol.2015.3457. PMC4533760. PMID 26622731.
Alarcón CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie SF (2015). "HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events". Cell. 162 (6): 1299–1308. doi:10.1016/j.cell.2015.08.011. PMC4673968. PMID 26321680.
April 13, 2024
hnrnpa2b1, heterogeneous, nuclear, ribonucleoproteins, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1x4bidentifiersaliases, hnrnpa2, hnrnpb1, hnrpa2, hnrpa2b1, hnrpb1, ibmpfd2, rnpa2, snrpb1, heterogeneou. Heterogeneous nuclear ribonucleoproteins A2 B1 is a protein that in humans is encoded by the HNRNPA2B1 gene 5 HNRNPA2B1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1X4BIdentifiersAliasesHNRNPA2B1 HNRNPA2 HNRNPB1 HNRPA2 HNRPA2B1 HNRPB1 IBMPFD2 RNPA2 SNRPB1 heterogeneous nuclear ribonucleoprotein A2 B1External IDsOMIM 600124 MGI 104819 HomoloGene 22992 GeneCards HNRNPA2B1Gene location Human Chr Chromosome 7 human 1 Band7p15 2Start26 171 151 bp 1 End26 201 529 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 B3Start51 460 932 bp 2 End51 469 894 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ininternal globus pallidusganglionic eminenceendometriumpyloruscardiarenal medullagerminal epitheliumthymuscecumcerebellar hemisphereTop expressed inprimitive streakabdominal wallmaxillary prominenceganglionic eminencesacculesomitesuperior cervical gangliondermisyolk sacmedial ganglionic eminenceMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionN6 methyladenosine containing RNA binding pre mRNA intronic binding miRNA binding single stranded telomeric DNA binding mRNA 3 UTR binding protein binding nucleic acid binding RNA binding G rich strand telomeric DNA binding identical protein binding mRNA bindingCellular componentcytoplasm catalytic step 2 spliceosome membrane extracellular region spliceosomal complex nucleus nucleoplasm telomere Cajal body nuclear matrix extracellular exosome ribonucleoprotein complexBiological processmRNA splicing via spliceosome mRNA transport miRNA transport RNA transport mRNA processing negative regulation of transcription by RNA polymerase II negative regulation of mRNA splicing via spliceosome primary miRNA processing RNA splicing G quadruplex DNA unwinding positive regulation of telomere maintenance via telomere lengthening positive regulation of telomerase RNA reverse transcriptase activity mRNA export from nucleus RNA metabolic process interleukin 12 mediated signaling pathway transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez318153379EnsemblENSG00000122566ENSMUSG00000004980UniProtP22626O88569RefSeq mRNA NM 002137NM 031243NM 016806NM 182650RefSeq protein NP 002128NP 112533NP 058086NP 872591NP 001361674Location UCSC Chr 7 26 17 26 2 MbChr 6 51 46 51 47 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Structure 2 Function 3 Interactions 4 Role in diseases 5 References 6 Further readingStructure editHNRNPA2B1 gene contains 12 exons including a B1 protein specific 36 nucleotide mini exon The entire length of intron exon organization of HNRNPA2B1 is identical to that of the HNRNPA1 gene which indicates a common origin by gene duplication 6 Function editThis gene belongs to the A B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins hnRNPs The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA hnRNA These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties The protein encoded by this gene has two repeats of quasi RRM domains that bind to RNAs This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms 7 HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis systemic lupus erythematosus and mixed connective tissue disease When referred to as an autoantigen hnRNPA2B1 is also known as RA33 The HNRNPA2 and HNRNPB1 proteins are involved in packaging nascent mRNA in alternative splicing and in cytoplasmic RNA trafficking translation and stabilization HNRNPA2 and HNRNPB1 also appear to function in telomere maintenance cell proliferation and differentiation and glucose transport 8 9 Function of HNRNPA2B1 gene can be effectively examined by siRNA knockdown based on an independent validation 10 Interactions editHNRPA2B1 has been shown to interact with casein kinase 2 alpha 1 11 Role in diseases editThe mutation p D290V 302V in hnRNPA2B1 is implicated in dementia myopathy Paget s disease of bone and ALS 12 Mutations in hnRNPA2B1 and hnRNPA1 cause of amyotrophic lateral sclerosis and multisystem proteinopathy 13 hnRNPA2 B1 is found to activate cyclooxygenase 2 and promote tumor growth in human lung cancers 14 References edit a b c GRCh38 Ensembl release 89 ENSG00000122566 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004980 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Biamonti G Ruggiu M Saccone S Della Valle G Riva S August 1994 Two homologous genes originated by duplication encode the human hnRNP proteins A2 and A1 Nucleic Acids Res 22 11 1996 2002 doi 10 1093 nar 22 11 1996 PMC 308112 PMID 8029005 Error 403 Entrez Gene HNRPA2B1 heterogeneous nuclear ribonucleoprotein A2 B1 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2 B1 Homo sapiens human Gene NCBI Error 403 Munkacsy G Sztupinszki Z Herman P Ban B Penzvalto Z Szarvas N Gyorffy B 1 January 2016 Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18 5 Failure Rate across 429 Independent Experiments Molecular Therapy Nucleic Acids 5 9 e366 doi 10 1038 mtna 2016 66 ISSN 2162 2531 PMC 5056990 PMID 27673562 Pancetti F Bosser R Krehan A Pyerin W Itarte E Bachs O June 1999 Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2 Biochem Biophys Res Commun 260 1 17 22 doi 10 1006 bbrc 1999 0849 PMID 10381337 Kim HJ Kim NC Wang YD Scarborough EA Moore J Diaz Z MacLea KS Freibaum B Li S Molliex A Kanagaraj AP Carter R Boylan KB Wojtas AM Rademakers R Pinkus JL Greenberg SA Trojanowski JQ Traynor BJ Smith BN Topp S Gkazi AS Miller J Shaw CE Kottlors M Kirschner J Pestronk A Li YR Ford AF Gitler AD Benatar M King OD Kimonis VE Ross ED Weihl CC Shorter J Taylor JP 2013 Mutations in prion like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS Nature 495 7442 467 73 Bibcode 2013Natur 495 467K doi 10 1038 nature11922 PMC 3756911 PMID 23455423 Kim HJ Kim NC Wang YD Scarborough EA Moore J Diaz Z et al Mutations in prion like domains in hnRNPA2B1 and hnRNPA1 causemultisystem proteinopathy and ALS Nature 2013 495 467 73 Available from https www researchgate net publication 235770144 Mutations in prion like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS Retrieved 28 Mar 2017 Xuan Yang Wang Jingshu Ban Liying Lu Jian Jun Yi Canhui Li Zhenglin Yu Wendan Li Mei Xu Tingting Yang Wenjing Tang Zhipeng Tang Ranran Xiao Xiangsheng Meng Songshu Chen Yiming Liu Quentin Huang Wenlin Guo Wei Cui Xiaonan Deng Wuguo 2016 hnRNPA2 B1 activates cyclooxygenase 2 and promotes tumor growth in human lung cancers Molecular Oncology 10 doi 10 1016 j molonc 2015 11 010 Available from http onlinelibrary wiley com doi 10 1016 j molonc 2015 11 010 abstract jsessionid F7FAA0EE2ECB0751450320F2792BFD9E f03t01Further reading editDawson SJ White LA 1992 Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin J Infect 24 3 317 20 doi 10 1016 S0163 4453 05 80037 4 PMID 1602151 Bauw G Rasmussen HH van den Bulcke M van Damme J Puype M Gesser B Celis JE Vandekerckhove J 1990 Two dimensional gel electrophoresis protein electroblotting and microsequencing a direct link between proteins and genes Electrophoresis 11 7 528 36 doi 10 1002 elps 1150110703 PMID 1699755 S2CID 24768114 Wilk HE Schaefer KP Agris PF Boak AM Kovacs SA 1991 U1 SnRNP association with HnRNP involves an initial non specific splice site independent interaction of U1 SnRNP protein with HnRNA Mol Cell Biochem 106 1 55 66 doi 10 1007 BF00231189 PMID 1833625 S2CID 22696966 Burd CG Swanson MS Gorlach M Dreyfuss G 1989 Primary structures of the heterogeneous nuclear ribonucleoprotein A2 B1 and C2 proteins a diversity of RNA binding proteins is generated by small peptide inserts Proc Natl Acad Sci U S A 86 24 9788 92 Bibcode 1989PNAS 86 9788B doi 10 1073 pnas 86 24 9788 PMC 298587 PMID 2557628 Kumar A Williams KR Szer W 1986 Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single stranded DNA binding proteins J Biol Chem 261 24 11266 73 doi 10 1016 S0021 9258 18 67378 8 PMID 3733753 Faura M Renau Piqueras J Bachs O Bosser R 1995 Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues Biochem Biophys Res Commun 217 2 554 60 doi 10 1006 bbrc 1995 2811 PMID 7503735 Kozu T Henrich B Schafer KP 1995 Structure and expression of the gene HNRPA2B1 encoding the human hnRNP protein A2 B1 Genomics 25 2 365 71 doi 10 1016 0888 7543 95 80035 K PMID 7789969 Van Laer L Van Camp G Green ED Huizing EH Willems PJ 1997 Physical mapping of the HOXA1 gene and the hnRPA2B1 gene in a YAC contig from human chromosome 7p14 p15 Hum Genet 99 6 831 3 doi 10 1007 s004390050457 PMID 9187682 S2CID 42177403 Neubauer G King A Rappsilber J Calvio C Watson M Ajuh P Sleeman J Lamond A Mann M 1998 Mass spectrometry and EST database searching allows characterization of the multi protein spliceosome complex Nat Genet 20 1 46 50 doi 10 1038 1700 PMID 9731529 S2CID 585778 Montuenga LM Zhou J Avis I Vos M Martinez A Cuttitta F Treston AM Sunday M Mulshine JL 1998 Expression of heterogeneous nuclear ribonucleoprotein A2 B1 changes with critical stages of mammalian lung development Am J Respir Cell Mol Biol 19 4 554 62 doi 10 1165 ajrcmb 19 4 3185 hdl 10171 20162 PMID 9761751 Pancetti F Bosser R Krehan A Pyerin W Itarte E Bachs O 1999 Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2 Biochem Biophys Res Commun 260 1 17 22 doi 10 1006 bbrc 1999 0849 PMID 10381337 Hamilton BJ Nichols RC Tsukamoto H Boado RJ Pardridge WM Rigby WF 1999 hnRNP A2 and hnRNP L bind the 3 UTR of glucose transporter 1 mRNA and exist as a complex in vivo Biochem Biophys Res Commun 261 3 646 51 doi 10 1006 bbrc 1999 1040 PMID 10441480 Nichols RC Wang XW Tang J Hamilton BJ High FA Herschman HR Rigby WF 2000 The RGG domain in hnRNP A2 affects subcellular localization Exp Cell Res 256 2 522 32 doi 10 1006 excr 2000 4827 PMID 10772824 Matsui M Horiguchi H Kamma H Fujiwara M Ohtsubo R Ogata T 2000 Testis and developmental stage specific expression of hnRNP A2 B1 splicing isoforms B0a b Biochim Biophys Acta 1493 1 2 33 40 doi 10 1016 s0167 4781 00 00154 8 PMID 10978504 Zhou J Allred DC Avis I Martinez A Vos MD Smith L Treston AM Mulshine JL 2001 Differential expression of the early lung cancer detection marker heterogeneous nuclear ribonucleoprotein A2 B1 hnRNP A2 B1 in normal breast and neoplastic breast cancer Breast Cancer Res Treat 66 3 217 24 doi 10 1023 A 1010631915831 PMID 11510693 S2CID 27708432 Pioli PA Rigby WF 2001 The von Hippel Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression J Biol Chem 276 43 40346 52 doi 10 1074 jbc M105391200 PMID 11517223 Kim SH Dierssen M Ferreres JC Fountoulakis M Lubec G 2001 Increased protein levels of heterogeneous nuclear ribonucleoprotein A2 B1 in fetal Down syndrome brains Protein Expression in Down Syndrome Brain pp 273 80 doi 10 1007 978 3 7091 6262 0 22 ISBN 978 3 211 83704 7 PMID 11771750 a href Template Cite book html title Template Cite book cite book a journal ignored help Andersen JS Lyon CE Fox AH Leung AK Lam YW Steen H Mann M Lamond AI 2002 Directed proteomic analysis of the human nucleolus Curr Biol 12 1 1 11 Bibcode 2002CBio 12 1A doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Jurica MS Licklider LJ Gygi SR Grigorieff N Moore MJ 2002 Purification and characterization of native spliceosomes suitable for three dimensional structural analysis RNA 8 4 426 39 doi 10 1017 S1355838202021088 PMC 1370266 PMID 11991638 Li S Zhang P Freibaum BD et al 2016 Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy Human Molecular Genetics 25 5 936 950 doi 10 1093 hmg ddv627 PMC 4754048 PMID 26744327 Herman S Fischer A Presumey J Hoffmann M Koenders MI Escriou V Apparailly F Steiner G 2015 Inhibition of Inflammation and Bone Erosion by RNA Interference Mediated Silencing of Heterogeneous Nuclear RNP A2 B1 in Two Experimental Models of Rheumatoid Arthritis Arthritis amp Rheumatology 67 9 2536 2546 doi 10 1002 art 39223 PMID 26017221 Kentaro I Shinji K Shoko U Akihito M Nozomi O Tatsuki S Senko T Tomoe K Yoichi T Kengo M Takao Y Shingo D Isamu S Fumio S 2015 Ridaifen G tamoxifen analog is a potent anticancer drug working through a combinatorial association with multiple cellular factors Bioorganic amp Medicinal Chemistry 23 18 6118 6124 doi 10 1016 j bmc 2015 08 001 PMID 26314924 Geissler R Simkin A Floss D Patel R Fogarty EA Scheller J Grimson A 2016 A widespread sequence specific mRNA decay pathway mediated by hnRNPs A1 and A2 B1 Genes amp Development 30 9 1070 1085 doi 10 1101 gad 277392 116 PMC 4863738 PMID 27151978 QU XH LIU JL ZHONG XW LI X ZHANG QG 2015 Insights into the roles of hnRNP A2 B1 and AXL in non small cell lung cancer Oncology Letters 10 3 1677 1685 doi 10 3892 ol 2015 3457 PMC 4533760 PMID 26622731 Alarcon CR Goodarzi H Lee H Liu X Tavazoie S Tavazoie SF 2015 HNRNPA2B1 is a mediator of m6A dependent nuclear RNA processing events Cell 162 6 1299 1308 doi 10 1016 j cell 2015 08 011 PMC 4673968 PMID 26321680 Retrieved from https en wikipedia org w index php title HNRNPA2B1 amp oldid 1216721996, wikipedia, wiki, book, books, library,
