Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[2][3][4] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment of insomnia.[5] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[6]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). from the original on 2023-08-03. Retrieved 2023-08-16.
^Tanaka E, Terada M, Misawa S, Wakasugi C (June 1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B: Biomedical Sciences and Applications. 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
^. non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-04-05.
^Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical Toxicology. 23 (1): 54–61. doi:10.1093/jat/23.1.54. PMID 10022210.
^Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T (February 2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and Clinical Neurosciences. 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461. S2CID 20863635.
^Sakai Y (October 1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems". Japanese Journal of Pharmacology. 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.
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haloxazolam, marketed, japan, under, brand, name, somelin, drug, which, benzodiazepine, derivative, similar, hypnotic, properties, benzodiazepine, drugs, triazolam, temazepam, flunitrazepam, such, indicated, treatment, insomnia, study, cats, comparing, estazol. Haloxazolam marketed in Japan under the brand name Somelin is a drug which is a benzodiazepine derivative 2 3 4 It has similar hypnotic properties as the benzodiazepine drugs triazolam temazepam and flunitrazepam and as such is indicated for the treatment of insomnia 5 A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons whereas estazolam affects both alpha and gamma motor neurons 6 HaloxazolamClinical dataTrade namesSomelin JP AHFS Drugs comInternational Drug NamesRoutes ofadministrationOralATC codenoneLegal statusLegal statusBR Class B1 Psychoactive drugs 1 CA Schedule IV DE Anlage III Special prescription form required US Schedule IVPharmacokinetic dataMetabolismHepaticExcretionRenalIdentifiersIUPAC name 10 bromo 11b 2 fluorophenyl 2 3 5 7 tetrahydro 1 3 oxazolo 3 2 d 1 4 benzodiazepin 6 oneCAS Number59128 97 1 NPubChem CID3563DrugBankDB01476 YChemSpider3442 YUNIIM448L2V8XPKEGGD01758 NChEMBLChEMBL2104461 NChemical and physical dataFormulaC 17H 14Br F N 2O 2Molar mass377 213 g mol 13D model JSmol Interactive imageSMILES Fc1ccccc1C42OCCN2CC O Nc3c4cc Br cc3InChI InChI 1S C17H14BrFN2O2 c18 11 5 6 15 13 9 11 17 12 3 1 2 4 14 12 19 21 7 8 23 17 10 16 22 20 15 h1 6 9H 7 8 10H2 H 20 22 YKey XDKCGKQHVBOOHC UHFFFAOYSA N Y N Y what is this See also editBenzodiazepineReferences edit Anvisa 2023 03 31 RDC Nº 784 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 784 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 2023 04 04 Archived from the original on 2023 08 03 Retrieved 2023 08 16 Tanaka E Terada M Misawa S Wakasugi C June 1996 Simultaneous determination of twelve benzodiazepines in human serum using a new reversed phase chromatographic column on a 2 microns porous microspherical silica gel Journal of Chromatography B Biomedical Sciences and Applications 682 1 173 8 doi 10 1016 0378 4347 96 00121 1 PMID 8832439 Benzodiazepine Names non benzodiazepines org uk Archived from the original on 2008 12 08 Retrieved 2009 04 05 Guan F Seno H Ishii A Watanabe K Kumazawa T Hattori H Suzuki O 1999 Solid phase microextraction and GC ECD of benzophenones for detection of benzodiazepines in urine Journal of Analytical Toxicology 23 1 54 61 doi 10 1093 jat 23 1 54 PMID 10022210 Tan X Uchida S Matsuura M Nishihara K Kojima T February 2003 Long intermediate and short acting benzodiazepine effects on human sleep EEG spectra Psychiatry and Clinical Neurosciences 57 1 97 104 doi 10 1046 j 1440 1819 2003 01085 x PMID 12519461 S2CID 20863635 Sakai Y October 1983 Comparative study on the effects of haloxazolam and estazolam new sleep inducing drugs on the alpha and gamma motor systems Japanese Journal of Pharmacology 33 5 1017 25 doi 10 1254 jjp 33 1017 PMID 6139494 nbsp This sedative related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Haloxazolam amp oldid 1170617374, wikipedia, wiki, book, books, library,
