Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3gene.[5] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin [6][7][8]
HP1BP3 deficiency in mice results in severe dwarfism and impaired bone mass, caused by altered endocrine IGF-1 signaling.[22] The gene is highly expressed in the brain and a number of behavioral phenotypes have been described for the mice. Lack of HP1BP3 led to impaired maternal behavior and reduced anxiety, leading to a dramatic reduction in litter survival.[23] This may be related to the connection between HP1BP3 and postpartum depression in humans.[24] Finally, HP1BP3 has been implicated in Alzheimer's disease.[1].[25]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000127483 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028759 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: heterochromatin protein 1, binding protein 3". Retrieved 2011-08-30.
^Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J (February 2015). "HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth". Nucleic Acids Research. 43 (4): 2074–90. doi:10.1093/nar/gkv089. PMC4344522. PMID 25662603.
^Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK (September 2014). "Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression". Molecular & Cellular Proteomics. 13 (9): 2183–97. doi:10.1074/mcp.M113.034975. PMC4159643. PMID 24830416.
^Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC2825445. PMID 20042602.
^"Body weight data for Hp1bp3". Wellcome Trust Sanger Institute.
^"DEXA data for Hp1bp3". Wellcome Trust Sanger Institute.
^"Clinical chemistry data for Hp1bp3". Wellcome Trust Sanger Institute.
^"Heart weight data for Hp1bp3". Wellcome Trust Sanger Institute.
^"Citrobacter infection data for Hp1bp3". Wellcome Trust Sanger Institute.
^ abcGerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
^Mouse Resources Portal, Wellcome Trust Sanger Institute.
^Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC3572410. PMID 21677750.
^Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
^van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC3218837. PMID 21722353.
^Garfinkel BP, Arad S, Le PT, Bustin M, Rosen CJ, Gabet Y, Orly J (December 2015). "Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway". Endocrinology. 156 (12): 4558–70. doi:10.1210/en.2015-1668. PMC5393342. PMID 26402843.
^Guintivano J, Arad M, Gould TD, Payne JL, Kaminsky ZA (May 2014). "Antenatal prediction of postpartum depression with blood DNA methylation biomarkers". Molecular Psychiatry. 19 (5): 560–7. doi:10.1038/mp.2013.62. PMC7039252. PMID 23689534.
^Neuner SM, Garfinkel BP, Wilmott LA, Ignatowska-Jankowska BM, Citri A, Orly J, Lu L, Overall RW, Mulligan MK, Kempermann G, Williams RW, O'Connell KM, Kaczorowski CC (June 2016). "Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging". Neurobiology of Aging. 46: 58–67. doi:10.1016/j.neurobiolaging.2016.06.008. PMC5018442. PMID 27460150.
Further readingEdit
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC2896464. PMID 20379614.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (April 2009). "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex". Molecular Cell. 34 (2): 145–54. doi:10.1016/j.molcel.2009.03.013. PMC2727917. PMID 19394292.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW (April 2009). "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia". European Archives of Psychiatry and Clinical Neuroscience. 259 (3): 151–63. doi:10.1007/s00406-008-0847-2. PMID 19165527. S2CID 33815571.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC2825445. PMID 20042602.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW (2009). "In vitro nuclear interactome of the HIV-1 Tat protein". Retrovirology. 6: 47. doi:10.1186/1742-4690-6-47. PMC2702331. PMID 19454010.
August 27, 2023
hp1bp3, heterochromatin, protein, binding, protein, protein, that, humans, encoded, gene, been, identified, novel, subtype, linker, histone, involved, structure, heterochromatin, available, structurespdbortholog, search, pdbe, rcsblist, codes2rqpidentifiersali. Heterochromatin protein 1 binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene 5 It has been identified as a novel subtype of the linker histone H1 involved in the structure of heterochromatin 6 7 8 HP1BP3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2RQPIdentifiersAliasesHP1BP3 HP1 BP74 HP1BP74 heterochromatin protein 1 binding protein 3External IDsOMIM 616072 MGI 109369 HomoloGene 7774 GeneCards HP1BP3Gene location Human Chr Chromosome 1 human 1 Band1p36 12Start20 742 679 bp 1 End20 787 323 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 D3Start137 943 607 bp 2 End137 971 994 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inBrodmann area 23tibiacancellous boneparietal pleuravisceral pleuraAchilles tendonparotid glandseminal vesiculagerminal epitheliumganglionic eminenceTop expressed inrenal corpusclemedullary collecting ductcondyleascending aortaaortic valveganglionic eminencethymusolfactory bulbmaxillary prominencefossaMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding nucleosome binding protein binding chromatin bindingCellular componentnucleosome nucleus chromosome nuclear speckBiological processregulation of nucleus size nucleosome assembly heterochromatin organization regulation of transcription DNA templated regulation of cell population proliferation cellular response to hypoxiaSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5080915441EnsemblENSG00000127483ENSMUSG00000028759UniProtQ5SSJ5Q3TEA8RefSeq mRNA NM 016287NM 001372052NM 001122896NM 001122897NM 001285478NM 001285479NM 001285480NM 001285481NM 010470NM 001356431NM 001356432RefSeq protein NP 057371NP 001358981NP 001363716NP 001363717NP 001363718NP 001363719NP 001363720NP 001363721NP 001363722NP 001363723NP 001363724NP 001363725NP 001363726NP 001116368NP 001116369NP 001272407NP 001272408NP 001272409NP 001272410NP 034600NP 001343360NP 001343361Location UCSC Chr 1 20 74 20 79 MbChr 4 137 94 137 97 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseModel organisms EditHp1bp3 knockout mouse phenotype Characteristic PhenotypeHomozygote viability AbnormalRecessive lethal study NormalFertility NormalBody weight Abnormal 9 Anxiety NormalNeurological assessment NormalGrip strength NormalHot plate NormalDysmorphology NormalIndirect calorimetry NormalGlucose tolerance test NormalAuditory brainstem response NormalDEXA Abnormal 10 Radiography NormalBody temperature NormalEye morphology NormalClinical chemistry Abnormal 11 Haematology NormalPeripheral blood lymphocytes AbnormalMicronucleus test NormalHeart weight Abnormal 12 Eye Histopathology NormalCitrobacter infection Normal 13 All tests and analysis from 14 15 Model organisms have been used in the study of HP1BP3 function A conditional knockout mouse line called Hp1bp3tm1a EUCOMM Wtsi 16 17 was generated as part of the International Knockout Mouse Consortium program a high throughput mutagenesis project to generate and distribute animal models of disease to interested scientists at the Wellcome Trust Sanger Institute 18 19 20 Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion 14 21 Twenty three tests were carried out and six significant phenotypes were reported Fewer homozygous mutant embryos were identified during gestation than predicted by Mendelian ratio Homozygous mutant female adults had decreased body weight heart weight and bone mineral density and increased blood urea levels and T cell number 14 HP1BP3 deficiency in mice results in severe dwarfism and impaired bone mass caused by altered endocrine IGF 1 signaling 22 The gene is highly expressed in the brain and a number of behavioral phenotypes have been described for the mice Lack of HP1BP3 led to impaired maternal behavior and reduced anxiety leading to a dramatic reduction in litter survival 23 This may be related to the connection between HP1BP3 and postpartum depression in humans 24 Finally HP1BP3 has been implicated in Alzheimer s disease 1 25 References Edit a b c GRCh38 Ensembl release 89 ENSG00000127483 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028759 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene heterochromatin protein 1 binding protein 3 Retrieved 2011 08 30 Garfinkel BP Melamed Book N Anuka E Bustin M Orly J February 2015 HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth Nucleic Acids Research 43 4 2074 90 doi 10 1093 nar gkv089 PMC 4344522 PMID 25662603 Dutta B Ren Y Hao P Sim KH Cheow E Adav S Tam JP Sze SK September 2014 Profiling of the Chromatin associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression Molecular amp Cellular Proteomics 13 9 2183 97 doi 10 1074 mcp M113 034975 PMC 4159643 PMID 24830416 Hayashihara K Uchiyama S Shimamoto S Kobayashi S Tomschik M Wakamatsu H No D Sugahara H Hori N Noda M Ohkubo T Zlatanova J Matsunaga S Fukui K February 2010 The middle region of an HP1 binding protein HP1 BP74 associates with linker DNA at the entry exit site of nucleosomal DNA The Journal of Biological Chemistry 285 9 6498 507 doi 10 1074 jbc M109 092833 PMC 2825445 PMID 20042602 Body weight data for Hp1bp3 Wellcome Trust Sanger Institute DEXA data for Hp1bp3 Wellcome Trust Sanger Institute Clinical chemistry data for Hp1bp3 Wellcome Trust Sanger Institute Heart weight data for Hp1bp3 Wellcome Trust Sanger Institute Citrobacter infection data for Hp1bp3 Wellcome Trust Sanger Institute a b c Gerdin AK 2010 The Sanger Mouse Genetics Programme High throughput characterisation of knockout mice Acta Ophthalmologica 88 S248 doi 10 1111 j 1755 3768 2010 4142 x S2CID 85911512 Mouse Resources Portal Wellcome Trust Sanger Institute International Knockout Mouse Consortium Mouse Genome Informatics Skarnes WC Rosen B West AP Koutsourakis M Bushell W Iyer V Mujica AO Thomas M Harrow J Cox T Jackson D Severin J Biggs P Fu J Nefedov M de Jong PJ Stewart AF Bradley A June 2011 A conditional knockout resource for the genome wide study of mouse gene function Nature 474 7351 337 42 doi 10 1038 nature10163 PMC 3572410 PMID 21677750 Dolgin E June 2011 Mouse library set to be knockout Nature 474 7351 262 3 doi 10 1038 474262a PMID 21677718 Collins FS Rossant J Wurst W January 2007 A mouse for all reasons Cell 128 1 9 13 doi 10 1016 j cell 2006 12 018 PMID 17218247 S2CID 18872015 van der Weyden L White JK Adams DJ Logan DW 2011 The mouse genetics toolkit revealing function and mechanism Genome Biology 12 6 224 doi 10 1186 gb 2011 12 6 224 PMC 3218837 PMID 21722353 Garfinkel BP Arad S Le PT Bustin M Rosen CJ Gabet Y Orly J December 2015 Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 HP1BP3 Is Associated With Alterations in the Endocrine IGF 1 Pathway Endocrinology 156 12 4558 70 doi 10 1210 en 2015 1668 PMC 5393342 PMID 26402843 Garfinkel BP Arad S Neuner S Netser S Wagner S Kaczorowski CC Rosen CJ Gal M Soreq H Orly J July 2016 HP1BP3 expression determines maternal behavior and offspring survival Genes Brain and Behavior 15 7 678 88 doi 10 1111 gbb 12312 PMID 27470444 S2CID 3980338 Guintivano J Arad M Gould TD Payne JL Kaminsky ZA May 2014 Antenatal prediction of postpartum depression with blood DNA methylation biomarkers Molecular Psychiatry 19 5 560 7 doi 10 1038 mp 2013 62 PMC 7039252 PMID 23689534 Neuner SM Garfinkel BP Wilmott LA Ignatowska Jankowska BM Citri A Orly J Lu L Overall RW Mulligan MK Kempermann G Williams RW O Connell KM Kaczorowski CC June 2016 Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging Neurobiology of Aging 46 58 67 doi 10 1016 j neurobiolaging 2016 06 008 PMC 5018442 PMID 27460150 Further reading EditRose JE Behm FM Drgon T Johnson C Uhl GR 2010 Personalized smoking cessation interactions between nicotine dose dependence and quit success genotype score Molecular Medicine 16 7 8 247 53 doi 10 2119 molmed 2009 00159 PMC 2896464 PMID 20379614 Ouyang J Shi Y Valin A Xuan Y Gill G April 2009 Direct binding of CoREST1 to SUMO 2 3 contributes to gene specific repression by the LSD1 CoREST1 HDAC complex Molecular Cell 34 2 145 54 doi 10 1016 j molcel 2009 03 013 PMC 2727917 PMID 19394292 Martins de Souza D Gattaz WF Schmitt A Rewerts C Maccarrone G Dias Neto E Turck CW April 2009 Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia European Archives of Psychiatry and Clinical Neuroscience 259 3 151 63 doi 10 1007 s00406 008 0847 2 PMID 19165527 S2CID 33815571 Flachsbart F Franke A Kleindorp R Caliebe A Blanche H Schreiber S Nebel A December 2010 Investigation of genetic susceptibility factors for human longevity a targeted nonsynonymous SNP study Mutation Research 694 1 2 13 9 doi 10 1016 j mrfmmm 2010 08 006 PMID 20800603 Hayashihara K Uchiyama S Shimamoto S Kobayashi S Tomschik M Wakamatsu H No D Sugahara H Hori N Noda M Ohkubo T Zlatanova J Matsunaga S Fukui K February 2010 The middle region of an HP1 binding protein HP1 BP74 associates with linker DNA at the entry exit site of nucleosomal DNA The Journal of Biological Chemistry 285 9 6498 507 doi 10 1074 jbc M109 092833 PMC 2825445 PMID 20042602 Gautier VW Gu L O Donoghue N Pennington S Sheehy N Hall WW 2009 In vitro nuclear interactome of the HIV 1 Tat protein Retrovirology 6 47 doi 10 1186 1742 4690 6 47 PMC 2702331 PMID 19454010 Retrieved from https en wikipedia org w index php title HP1BP3 amp oldid 1170068627, wikipedia, wiki, book, books, library,
