This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[7]
Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMC395231. PMID 7913891.
Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
Bingle CD, Gowan S (1996). "Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter". Biochem. J. 319 ( Pt 3) (Pt 3): 669–74. doi:10.1042/bj3190669. PMC1217841. PMID 8920965.
Sauvageau G, Thorsteinsdottir U, Hough MR, et al. (1997). "Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation". Immunity. 6 (1): 13–22. doi:10.1016/S1074-7613(00)80238-1. PMID 9052833.
Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
Viganò MA, Di Rocco G, Zappavigna V, Mavilio F (1998). "Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context". Mol. Cell. Biol. 18 (11): 6201–12. doi:10.1128/MCB.18.11.6201. PMC109207. PMID 9774637.
Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Nakamura N, Yoshimi T, Miura T (2002). "Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3". Cell Growth Differ. 13 (4): 195–203. PMID 11971819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Pineault N, Abramovich C, Ohta H, Humphries RK (2004). "Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1". Mol. Cell. Biol. 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMC350554. PMID 14966272.
Roche J, Zeng C, Barón A, et al. (2004). "Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics". Leukemia. 18 (6): 1059–63. doi:10.1038/sj.leu.2403366. PMID 15085154. S2CID 9417756.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Speleman F, Cauwelier B, Dastugue N, et al. (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias". Leukemia. 19 (3): 358–66. doi:10.1038/sj.leu.2403657. PMID 15674412.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
hoxb3, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, hox2, hox2g, homeobox, b3external, idsomim, 142966, 96184, homologene, 1617, genecards, gene, location, human, chromosome, human, band17q21, 32start48, end48, gene, location, m. Homeobox protein Hox B3 is a protein that in humans is encoded by the HOXB3 gene 5 6 7 HOXB3IdentifiersAliasesHOXB3 HOX2 HOX2G Hox 2 7 homeobox B3External IDsOMIM 142966 MGI 96184 HomoloGene 1617 GeneCards HOXB3Gene location Human Chr Chromosome 17 human 1 Band17q21 32Start48 548 870 bp 1 End48 604 912 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 D 11 59 84 cMStart96 214 152 bp 2 End96 238 756 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubecorpus epididymiscaput epididymisseminal vesiculagastric mucosatransverse colonendometriumrectumrenal medullaleft uterine tubeTop expressed invas deferensmedullary collecting ductinferior ganglion of vagus nervehair follicleabdominal wallPaneth cellleft lung lobeseminal vesiculadermisinferior ganglion of glossopharyngeal nerveMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity DNA binding sequence specific DNA binding DNA binding transcription activator activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specificCellular componentnucleusBiological processembryonic skeletal system morphogenesis multicellular organism development glossopharyngeal nerve morphogenesis definitive hemopoiesis thyroid gland development cartilage development face development regulation of transcription DNA templated negative regulation of transcription by RNA polymerase II regulation of neurogenesis rhombomere development angiogenesis hematopoietic progenitor cell differentiation transcription DNA templated anterior posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez321315410EnsemblENSG00000120093ENSMUSG00000048763UniProtP14651P09026RefSeq mRNA NM 002146NM 001330322NM 001330323NM 001384747NM 001384749NM 001384750NM 001079869NM 010458RefSeq protein NP 001317251NP 001317252NP 002137NP 001073338NP 034588Location UCSC Chr 17 48 55 48 6 MbChr 11 96 21 96 24 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA binding domain It is included in a cluster of homeobox B genes located on chromosome 17 The encoded protein functions as a sequence specific transcription factor that is involved in development Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia AML 7 Contents 1 See also 2 References 3 Further reading 4 External linksSee also EditHomeoboxReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000120093 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000048763 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine McAlpine PJ Shows TB Aug 1990 Nomenclature for human homeobox genes Genomics 7 3 460 doi 10 1016 0888 7543 90 90186 X PMID 1973146 Scott MP Dec 1992 Vertebrate homeobox gene nomenclature Cell 71 4 551 3 doi 10 1016 0092 8674 92 90588 4 PMID 1358459 S2CID 13370372 a b Entrez Gene HOXB3 homeobox B3 Further reading EditGiampaolo A Acampora D Zappavigna V et al 1989 Differential expression of human HOX 2 genes along the anterior posterior axis in embryonic central nervous system Differentiation 40 3 191 7 doi 10 1111 j 1432 0436 1989 tb00598 x PMID 2570724 Acampora D D Esposito M Faiella A et al 1990 The human HOX gene family Nucleic Acids Res 17 24 10385 402 doi 10 1093 nar 17 24 10385 PMC 335308 PMID 2574852 Boncinelli E Acampora D Pannese M et al 1990 Organization of human class I homeobox genes Genome 31 2 745 56 doi 10 1139 g89 133 PMID 2576652 Guazzi S Lonigro R Pintonello L et al 1994 The thyroid transcription factor 1 gene is a candidate target for regulation by Hox proteins EMBO J 13 14 3339 47 doi 10 1002 j 1460 2075 1994 tb06636 x PMC 395231 PMID 7913891 Apiou F Flagiello D Cillo C et al 1996 Fine mapping of human HOX gene clusters Cytogenet Cell Genet 73 1 2 114 5 doi 10 1159 000134320 PMID 8646877 Bingle CD Gowan S 1996 Oct 1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter Biochem J 319 Pt 3 Pt 3 669 74 doi 10 1042 bj3190669 PMC 1217841 PMID 8920965 Sauvageau G Thorsteinsdottir U Hough MR et al 1997 Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation Immunity 6 1 13 22 doi 10 1016 S1074 7613 00 80238 1 PMID 9052833 Guazzi S Pintonello ML Vigano A Boncinelli E 1998 Regulatory interactions between the human HOXB1 HOXB2 and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells J Biol Chem 273 18 11092 9 doi 10 1074 jbc 273 18 11092 PMID 9556594 Vigano MA Di Rocco G Zappavigna V Mavilio F 1998 Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA Binding Context Mol Cell Biol 18 11 6201 12 doi 10 1128 MCB 18 11 6201 PMC 109207 PMID 9774637 Kosaki K Kosaki R Suzuki T et al 2002 Complete mutation analysis panel of the 39 human HOX genes Teratology 65 2 50 62 doi 10 1002 tera 10009 PMID 11857506 Nakamura N Yoshimi T Miura T 2002 Increased gene expression of lung marker proteins in the homeobox B3 overexpressed fetal lung cell line M3E3 C3 Cell Growth Differ 13 4 195 203 PMID 11971819 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Pineault N Abramovich C Ohta H Humphries RK 2004 Differential and Common Leukemogenic Potentials of Multiple NUP98 Hox Fusion Proteins Alone or with Meis1 Mol Cell Biol 24 5 1907 17 doi 10 1128 MCB 24 5 1907 1917 2004 PMC 350554 PMID 14966272 Roche J Zeng C Baron A et al 2004 Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics Leukemia 18 6 1059 63 doi 10 1038 sj leu 2403366 PMID 15085154 S2CID 9417756 Brandenberger R Wei H Zhang S et al 2005 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat Biotechnol 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Speleman F Cauwelier B Dastugue N et al 2005 A new recurrent inversion inv 7 p15q34 leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T cell acute lymphoblastic leukemias Leukemia 19 3 358 66 doi 10 1038 sj leu 2403657 PMID 15674412 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 External links EditHOXB3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HOXB3 amp oldid 1103561985, wikipedia, wiki, book, books, library,
