The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.[6] Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[5]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000171476 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000059325 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abChen, Fabian; Kook, Hyun; Milewski, Rita; Gitler, Aaron D.; Lu, Min Min; Li, Jun; Nazarian, Ronniel; Schnepp, Robert; Jen, Kuangyu; Biben, Christine; Runke, Greg; Mackay, Joel P.; Novotny, Jiri; Schwartz, Robert J.; Harvey, Richard P.; Mullins, Mary C.; Epstein, Jonathan A. (September 2002). "Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development". Cell. 110 (6): 713–723. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045. S2CID 12189105.
^Li, Deqiang; Takeda, Norifumi; Jain, Rajan; Manderfield, Lauren J.; Liu, Feiyan; Li, Li; Anderson, Stewart A.; Epstein, Jonathan A. (November 2015). "Hopx distinguishes hippocampal from lateral ventricle neural stem cells". Stem Cell Research. 15 (3): 522–529. doi:10.1016/j.scr.2015.09.015. PMC4704104. PMID 26451648.
^Berg, Daniel A.; Su, Yijing; Jimenez-Cyrus, Dennisse; Patel, Aneek; Huang, Nancy; Morizet, David; Lee, Stephanie; Shah, Reeti; Ringeling, Francisca Rojas; Jain, Rajan; Epstein, Jonathan A.; Wu, Qing-Feng; Canzar, Stefan; Ming, Guo-Li; Song, Hongjun; Bond, Allison M. (April 2019). "A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis". Cell. 177 (3): 654–668.e15. doi:10.1016/j.cell.2019.02.010. PMC6496946. PMID 30929900.
Further readingEdit
Kook H, Epstein JA (October 2003). "Hopping to the beat. Hop regulation of cardiac gene expression". Trends in Cardiovascular Medicine. 13 (7): 261–4. doi:10.1016/S1050-1738(03)00107-5. PMID 14522464.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Asanoma K, Matsuda T, Kondo H, Kato K, Kishino T, Niikawa N, Wake N, Kato H (January 2003). "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics. 81 (1): 15–25. doi:10.1016/S0888-7543(02)00011-3. PMID 12573257.
Chen Y, Petersen S, Pacyna-Gengelbach M, Pietas A, Petersen I (2003). "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer". Oncology. 64 (4): 450–8. doi:10.1159/000070306. PMID 12759545. S2CID 3205741.
Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA (September 2003). "Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop". The Journal of Clinical Investigation. 112 (6): 863–71. doi:10.1172/JCI19137. PMC193673. PMID 12975471.
Adu J, Leong FT, Smith NR, Leek JP, Markham AF, Robinson PA, Mighell AJ (December 2002). "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development". Mechanisms of Development. 119. 119 Suppl 1: S43-7. doi:10.1016/S0925-4773(03)00090-X. PMID 14516659. S2CID 11648378.
Lemaire F, Millon R, Muller D, Rabouel Y, Bracco L, Abecassis J, Wasylyk B (July 2004). "Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma". British Journal of Cancer. 91 (2): 258–61. doi:10.1038/sj.bjc.6601952. PMC2409811. PMID 15213722.
Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C (July 2004). "A novel homeobox gene overexpressed in thyroid carcinoma". Thyroid. 14 (7): 500–5. doi:10.1089/1050725041517020. PMID 15307938.
Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ (October 2004). "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma". Cancer Genetics and Cytogenetics. 154 (1): 27–35. doi:10.1016/j.cancergencyto.2004.01.026. PMID 15381369.
Asanoma K, Kato H, Inoue T, Matsuda T, Wake N (August 2004). "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The Journal of Reproductive Medicine. 49 (8): 617–26. PMID 15457851.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC1347501. PMID 16381901.
Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP (September 2006). "Analysis of the structure and function of the transcriptional coregulator HOP". Biochemistry. 45 (35): 10584–90. doi:10.1021/bi060641s. PMID 16939210.
Kee HJ, Kim JR, Nam KI, Park HY, Shin S, Kim JC, Shimono Y, Takahashi M, Jeong MH, Kim N, Kim KK, Kook H (March 2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". The Journal of Biological Chemistry. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.
Americo TA, Chiarini LB, Linden R (June 2007). "Signaling induced by hop/STI-1 depends on endocytosis". Biochemical and Biophysical Research Communications. 358 (2): 620–5. doi:10.1016/j.bbrc.2007.04.202. PMID 17498662.
hopx, homeodomain, only, protein, protein, that, humans, encoded, gene, important, regulator, cardiac, development, marker, hippocampal, neural, stem, cells, available, structurespdbortholog, search, pdbe, rcsblist, codes1uhs, 2hi3identifiersaliases, cameo, la. Homeodomain only protein is a protein that in humans is encoded by the HOPX gene 5 It is an important regulator of cardiac development 6 and a marker of hippocampal neural stem cells 7 8 HOPXAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1UHS 2HI3IdentifiersAliasesHOPX CAMEO HOD HOP LAGY NECC1 OB1 SMAP31 TOTO HOP homeoboxExternal IDsOMIM 607275 MGI 1916782 HomoloGene 15859 GeneCards HOPXGene location Human Chr Chromosome 4 human 1 Band4q12Start56 647 988 bp 1 End56 681 899 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 C3 3Start77 234 835 bp 2 End77 262 968 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus epididymishuman peniscavity of mouthskin of abdomenvulvaright lungupper lobe of left lunggumsbody of tongueamniotic fluidTop expressed inright lung lobeleft lungsuperior surface of tongueright ventricleleft lung lobeesophagusinterventricular septumcorneal stromahair folliclelipMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein binding DNA binding transcription factor activity RNA polymerase II specificCellular componentcytoplasm nucleusBiological processregulation of transcription by RNA polymerase II negative regulation of cell differentiation multicellular organism development regulation of transcription DNA templated transcription DNA templated trophectodermal cell differentiation chaperone mediated protein complex assembly cell differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8452574318EnsemblENSG00000171476ENSMUSG00000059325UniProtQ9BPY8Q8R1H0RefSeq mRNA NM 001145459NM 001145460NM 032495NM 139211NM 139212NM 001159900NM 001159901NM 175606RefSeq protein NP 001138931NP 001138932NP 115884NP 631957NP 631958NP 001153372NP 001153373NP 783199Location UCSC Chr 4 56 65 56 68 MbChr 5 77 23 77 26 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction EditThe protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding It was reported that choriocarcinoma cell lines and tissues failed to express this gene which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts Studies in mice suggested that this protein may interact with serum response factor SRF and modulate SRF dependent cardiac specific gene expression and cardiac development 6 Multiple alternatively spliced transcript variants encoding the same protein have been observed the full length natures of only some have been determined 5 References Edit a b c GRCh38 Ensembl release 89 ENSG00000171476 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000059325 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene HOP homeodomain only protein a b Chen Fabian Kook Hyun Milewski Rita Gitler Aaron D Lu Min Min Li Jun Nazarian Ronniel Schnepp Robert Jen Kuangyu Biben Christine Runke Greg Mackay Joel P Novotny Jiri Schwartz Robert J Harvey Richard P Mullins Mary C Epstein Jonathan A September 2002 Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development Cell 110 6 713 723 doi 10 1016 S0092 8674 02 00932 7 PMID 12297045 S2CID 12189105 Li Deqiang Takeda Norifumi Jain Rajan Manderfield Lauren J Liu Feiyan Li Li Anderson Stewart A Epstein Jonathan A November 2015 Hopx distinguishes hippocampal from lateral ventricle neural stem cells Stem Cell Research 15 3 522 529 doi 10 1016 j scr 2015 09 015 PMC 4704104 PMID 26451648 Berg Daniel A Su Yijing Jimenez Cyrus Dennisse Patel Aneek Huang Nancy Morizet David Lee Stephanie Shah Reeti Ringeling Francisca Rojas Jain Rajan Epstein Jonathan A Wu Qing Feng Canzar Stefan Ming Guo Li Song Hongjun Bond Allison M April 2019 A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis Cell 177 3 654 668 e15 doi 10 1016 j cell 2019 02 010 PMC 6496946 PMID 30929900 Further reading EditKook H Epstein JA October 2003 Hopping to the beat Hop regulation of cardiac gene expression Trends in Cardiovascular Medicine 13 7 261 4 doi 10 1016 S1050 1738 03 00107 5 PMID 14522464 Hartley JL Temple GF Brasch MA November 2000 DNA cloning using in vitro site specific recombination Genome Research 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Asanoma K Matsuda T Kondo H Kato K Kishino T Niikawa N Wake N Kato H January 2003 NECC1 a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif Genomics 81 1 15 25 doi 10 1016 S0888 7543 02 00011 3 PMID 12573257 Chen Y Petersen S Pacyna Gengelbach M Pietas A Petersen I 2003 Identification of a novel homeobox containing gene LAGY which is downregulated in lung cancer Oncology 64 4 450 8 doi 10 1159 000070306 PMID 12759545 S2CID 3205741 Kook H Lepore JJ Gitler AD Lu MM Wing Man Yung W Mackay J Zhou R Ferrari V Gruber P Epstein JA September 2003 Cardiac hypertrophy and histone deacetylase dependent transcriptional repression mediated by the atypical homeodomain protein Hop The Journal of Clinical Investigation 112 6 863 71 doi 10 1172 JCI19137 PMC 193673 PMID 12975471 Adu J Leong FT Smith NR Leek JP Markham AF Robinson PA Mighell AJ December 2002 Expression of mOb1 a novel atypical 73 amino acid K50 homeodomain protein during mouse development Mechanisms of Development 119 119 Suppl 1 S43 7 doi 10 1016 S0925 4773 03 00090 X PMID 14516659 S2CID 11648378 Lemaire F Millon R Muller D Rabouel Y Bracco L Abecassis J Wasylyk B July 2004 Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma British Journal of Cancer 91 2 258 61 doi 10 1038 sj bjc 6601952 PMC 2409811 PMID 15213722 Pauws E Sijmons GG Yaka C Ris Stalpers C July 2004 A novel homeobox gene overexpressed in thyroid carcinoma Thyroid 14 7 500 5 doi 10 1089 1050725041517020 PMID 15307938 Toruner GA Ulger C Alkan M Galante AT Rinaggio J Wilk R Tian B Soteropoulos P Hameed MR Schwalb MN Dermody JJ October 2004 Association between gene expression profile and tumor invasion in oral squamous cell carcinoma Cancer Genetics and Cytogenetics 154 1 27 35 doi 10 1016 j cancergencyto 2004 01 026 PMID 15381369 Asanoma K Kato H Inoue T Matsuda T Wake N August 2004 Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts The Journal of Reproductive Medicine 49 8 617 26 PMID 15457851 Wiemann S Arlt D Huber W Wellenreuther R Schleeger S Mehrle A Bechtel S Sauermann M Korf U Pepperkok R Sultmann H Poustka A October 2004 From ORFeome to biology a functional genomics pipeline Genome Research 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Mehrle A Rosenfelder H Schupp I del Val C Arlt D Hahne F Bechtel S Simpson J Hofmann O Hide W Glatting KH Huber W Pepperkok R Poustka A Wiemann S January 2006 The LIFEdb database in 2006 Nucleic Acids Research 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 Kook H Yung WW Simpson RJ Kee HJ Shin S Lowry JA Loughlin FE Yin Z Epstein JA Mackay JP September 2006 Analysis of the structure and function of the transcriptional coregulator HOP Biochemistry 45 35 10584 90 doi 10 1021 bi060641s PMID 16939210 Kee HJ Kim JR Nam KI Park HY Shin S Kim JC Shimono Y Takahashi M Jeong MH Kim N Kim KK Kook H March 2007 Enhancer of polycomb1 a novel homeodomain only protein binding partner induces skeletal muscle differentiation The Journal of Biological Chemistry 282 10 7700 9 doi 10 1074 jbc M611198200 PMID 17192267 Americo TA Chiarini LB Linden R June 2007 Signaling induced by hop STI 1 depends on endocytosis Biochemical and Biophysical Research Communications 358 2 620 5 doi 10 1016 j bbrc 2007 04 202 PMID 17498662 External links EditHOPX protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HOPX amp oldid 1141390734, wikipedia, wiki, book, books, library,
