Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPABgene.[5] Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B,[6] it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.[7][8]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]
^Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Letters. 290 (1–2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314. S2CID 11348906.
^Akindahunsi AA, Bandiera A, Manzini G (February 2005). "Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences". Computational Biology and Chemistry. 29 (1): 13–23. doi:10.1016/j.compbiolchem.2004.11.002. PMID 15680582.
^Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW (April 2005). "Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis". Developmental Cell. 8 (4): 505–15. doi:10.1016/j.devcel.2005.01.012. PMID 15809033.
^Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, et al. (June 2003). "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome". The Journal of Biological Chemistry. 278 (26): 23906–14. doi:10.1074/jbc.M300746200. PMID 12692135.
Further readingedit
Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Letters. 290 (1–2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314. S2CID 11348906.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, et al. (October 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
Lau PP, Zhu HJ, Nakamuta M, Chan L (January 1997). "Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing". The Journal of Biological Chemistry. 272 (3): 1452–5. doi:10.1074/jbc.272.3.1452. PMID 8999813.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hay DC, Kemp GD, Dargemont C, Hay RT (May 2001). "Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription". Molecular and Cellular Biology. 21 (10): 3482–90. doi:10.1128/MCB.21.10.3482-3490.2001. PMC100270. PMID 11313474.
Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochemical and Biophysical Research Communications. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Percipalle P, Jonsson A, Nashchekin D, Karlsson C, Bergman T, Guialis A, et al. (April 2002). "Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins". Nucleic Acids Research. 30 (8): 1725–34. doi:10.1093/nar/30.8.1725. PMC113215. PMID 11937625.
Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, et al. (October 2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". The Journal of Neuroscience. 22 (20): 8827–37. doi:10.1523/jneurosci.22-20-08827.2002. PMC6757688. PMID 12388589.
Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, et al. (June 2003). "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome". The Journal of Biological Chemistry. 278 (26): 23906–14. doi:10.1074/jbc.M300746200. PMID 12692135.
Zhang S, Schlott B, Görlach M, Grosse F (2004). "DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner". Nucleic Acids Research. 32 (1): 1–10. doi:10.1093/nar/gkg933. PMC373260. PMID 14704337.
Gao C, Guo H, Wei J, Mi Z, Wai P, Kuo PC (March 2004). "S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages". The Journal of Biological Chemistry. 279 (12): 11236–43. doi:10.1074/jbc.M313385200. PMID 14722087.
Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.
hnrnpab, heterogeneous, nuclear, ribonucleoprotein, also, known, protein, which, humans, encoded, gene, although, this, gene, named, reference, first, cloning, binding, protein, with, similarity, hnrnp, hnrnp, member, hnrnp, subfamily, hnrnps, groups, together. Heterogeneous nuclear ribonucleoprotein A B also known as HNRNPAB is a protein which in humans is encoded by the HNRNPAB gene 5 Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B 6 it is not a member of the HNRNP A B subfamily of HNRNPs but groups together closely with HNRNPD AUF1 and HNRNPDL 7 8 HNRNPABAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes3S7RIdentifiersAliasesHNRNPAB ABBP1 HNRPAB heterogeneous nuclear ribonucleoprotein A BExternal IDsOMIM 602688 MGI 1330294 HomoloGene 74950 GeneCards HNRNPABGene location Human Chr Chromosome 5 human 1 Band5q35 3Start178 204 533 bp 1 End178 211 163 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B1 3Start51 490 927 bp 2 End51 497 674 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inembryoganglionic eminencehuman penisrectumvulvagumsthymusnippleepithelium of esophaguscecumTop expressed inprimitive streakabdominal wallmedial ganglionic eminencecondylehair folliclevas deferensrenal corpusclefossaconjunctival fornixmedullary collecting ductMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity nucleic acid binding sequence specific DNA binding protein binding mRNA binding RNA binding sequence specific double stranded DNA bindingCellular componentcytoplasm RNA polymerase II transcription regulator complex nucleus nucleoplasm ribonucleoprotein complexBiological processpositive regulation of transcription DNA templated epithelial to mesenchymal transitionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez318215384EnsemblENSG00000197451ENSMUSG00000020358UniProtQ99729Q99020RefSeq mRNA NM 031266NM 004499NM 001048061NM 010448RefSeq protein NP 004490NP 112556NP 001041526NP 034578Location UCSC Chr 5 178 2 178 21 MbChr 11 51 49 51 5 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins hnRNPs The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA hnRNA complexes They are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm The hnRNP proteins have distinct nucleic acid binding properties The protein encoded by this gene which binds to one of the components of the multiprotein editosome complex has two repeats of quasi RRM RNA recognition motif domains that bind to RNAs Two alternatively spliced transcript variants encoding different isoforms have been described for this gene 5 Interactions editHNRNPAB has been shown to interact with TP63 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000197451 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020358 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b HNRNPAB heterogeneous nuclear ribonucleoprotein A B Homo sapiens human Khan FA Jaiswal AK Szer W September 1991 Cloning and sequence analysis of a human type A B hnRNP protein FEBS Letters 290 1 2 159 61 doi 10 1016 0014 5793 91 81249 8 PMID 1717314 S2CID 11348906 Akindahunsi AA Bandiera A Manzini G February 2005 Vertebrate 2xRBD hnRNP proteins a comparative analysis of genome mRNA and protein sequences Computational Biology and Chemistry 29 1 13 23 doi 10 1016 j compbiolchem 2004 11 002 PMID 15680582 Czaplinski K Kocher T Schelder M Segref A Wilm M Mattaj IW April 2005 Identification of 40LoVe a Xenopus hnRNP D family protein involved in localizing a TGF beta related mRNA during oogenesis Developmental Cell 8 4 505 15 doi 10 1016 j devcel 2005 01 012 PMID 15809033 Fomenkov A Huang YP Topaloglu O Brechman A Osada M Fomenkova T et al June 2003 P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay Wells syndrome The Journal of Biological Chemistry 278 26 23906 14 doi 10 1074 jbc M300746200 PMID 12692135 Further reading editKhan FA Jaiswal AK Szer W September 1991 Cloning and sequence analysis of a human type A B hnRNP protein FEBS Letters 290 1 2 159 61 doi 10 1016 0014 5793 91 81249 8 PMID 1717314 S2CID 11348906 Maruyama K Sugano S January 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Gress TM Muller Pillasch F Geng M Zimmerhackl F Zehetner G Friess H et al October 1996 A pancreatic cancer specific expression profile Oncogene 13 8 1819 30 PMID 8895530 Lau PP Zhu HJ Nakamuta M Chan L January 1997 Cloning of an Apobec 1 binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing The Journal of Biological Chemistry 272 3 1452 5 doi 10 1074 jbc 272 3 1452 PMID 8999813 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S October 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Hay DC Kemp GD Dargemont C Hay RT May 2001 Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF kappaB dependent transcription Molecular and Cellular Biology 21 10 3482 90 doi 10 1128 MCB 21 10 3482 3490 2001 PMC 100270 PMID 11313474 Lau PP Chang BH Chan L April 2001 Two hybrid cloning identifies an RNA binding protein GRY RBP as a component of apobec 1 editosome Biochemical and Biophysical Research Communications 282 4 977 83 doi 10 1006 bbrc 2001 4679 PMID 11352648 Andersen JS Lyon CE Fox AH Leung AK Lam YW Steen H et al January 2002 Directed proteomic analysis of the human nucleolus Current Biology 12 1 1 11 Bibcode 2002CBio 12 1A doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Percipalle P Jonsson A Nashchekin D Karlsson C Bergman T Guialis A et al April 2002 Nuclear actin is associated with a specific subset of hnRNP A B type proteins Nucleic Acids Research 30 8 1725 34 doi 10 1093 nar 30 8 1725 PMC 113215 PMID 11937625 Angenstein F Evans AM Settlage RE Moran ST Ling SC Klintsova AY et al October 2002 A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA mRNAs in neurons The Journal of Neuroscience 22 20 8827 37 doi 10 1523 jneurosci 22 20 08827 2002 PMC 6757688 PMID 12388589 Fomenkov A Huang YP Topaloglu O Brechman A Osada M Fomenkova T et al June 2003 P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay Wells syndrome The Journal of Biological Chemistry 278 26 23906 14 doi 10 1074 jbc M300746200 PMID 12692135 Zhang S Schlott B Gorlach M Grosse F 2004 DNA dependent protein kinase DNA PK phosphorylates nuclear DNA helicase II RNA helicase A and hnRNP proteins in an RNA dependent manner Nucleic Acids Research 32 1 1 10 doi 10 1093 nar gkg933 PMC 373260 PMID 14704337 Gao C Guo H Wei J Mi Z Wai P Kuo PC March 2004 S nitrosylation of heterogeneous nuclear ribonucleoprotein A B regulates osteopontin transcription in endotoxin stimulated murine macrophages The Journal of Biological Chemistry 279 12 11236 43 doi 10 1074 jbc M313385200 PMID 14722087 Ong SE Mittler G Mann M November 2004 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC Nature Methods 1 2 119 26 doi 10 1038 nmeth715 PMID 15782174 S2CID 6654604 Beausoleil SA Villen J Gerber SA Rush J Gygi SP October 2006 A probability based approach for high throughput protein phosphorylation analysis and site localization Nature Biotechnology 24 10 1285 92 doi 10 1038 nbt1240 PMID 16964243 S2CID 14294292 Ewing RM Chu P Elisma F Li H Taylor P Climie S et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Molecular Systems Biology 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HNRNPAB amp oldid 1216722118, wikipedia, wiki, book, books, library,
