Technetium (99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used by nuclear medicine physicians for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections[2] and inflammatory bowel disease.[3] Exametazime (the part without technetium) is sometimes referred to as hexamethylpropylene amine oxime or HMPAO, although correct chemical names are:[4]
^Moretti JL, Defer G, Cinotti L, Cesaro P, Degos JD, Vigneron N, et al. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European Journal of Nuclear Medicine. 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169. S2CID 11934803.
^Weldon MJ, Joseph AE, French A, Saverymuttu SH, Maxwell JD (October 1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut. 37 (4): 557–64. doi:10.1136/gut.37.4.557. PMC1382910. PMID 7489945.
^Ui K, Yamaguchi T (December 1991). "[Therapy and diagnosis of emergency shock patients]". Nihon Naika Gakkai Zasshi. The Journal of the Japanese Society of Internal Medicine. 80 (12): 1892–6. doi:10.2169/naika.80.1892. PMID 1804909.
technetium, 99mtc, exametazime, radiopharmaceutical, sold, under, trade, name, ceretec, used, nuclear, medicine, physicians, detection, altered, regional, cerebral, perfusion, stroke, other, cerebrovascular, diseases, also, used, labelling, leukocytes, localis. Technetium 99mTc exametazime is a radiopharmaceutical sold under the trade name Ceretec and is used by nuclear medicine physicians for the detection of altered regional cerebral perfusion in stroke 1 and other cerebrovascular diseases It can also be used for the labelling of leukocytes to localise intra abdominal infections 2 and inflammatory bowel disease 3 Exametazime the part without technetium is sometimes referred to as hexamethylpropylene amine oxime or HMPAO although correct chemical names are 4 NE N 3R 3 3 2R 3E 3 hydroxyiminobutan 2 yl amino 2 2 dimethylpropyl amino butan 2 ylidene hydroxylamine or 3 3 2 2 dimethyl 1 3 propanediyl diimino bis 2 butanone dioxime Technetium 99mTc exametazimeClinical dataTrade namesCeretecLicense dataUS FDA CeretecRoutes ofadministrationIntravenousATC codeV09AA01 WHO V09HA02 WHO labelled leucocytes Legal statusLegal statusUS onlyIdentifiersIUPAC name 3RS 3 RS 3 3 2 2 Dimethyltrimethylene diimino di 2 butanone dioximato 3 N N N N oxotechnetium 99mTc CAS Number99944 78 2 NPubChem CID9552069UNII3B744AG22NChemical and physical dataFormulaC 13H 25N 4O 3TcMolar mass383 g mol 13D model JSmol Interactive imageInteractive imageChiralityracemicSMILES CC1 C CN2 Tc 3 N4C1 N O H O N 3 C C C H 4C C C C H 2C OCC1 C CN2 Tc 3 N4C1 N O H O N 3 C C C H 4C C C C H 2C O N Y what is this verify Chemistry edit nbsp One of the two enantiomers of exametazimeThe drug consists of exametazime as a chelating agent for the radioisotope technetium 99m Both enantiomeric forms of exametazime are used the drug is racemic 5 The third stereoisomer of this structure the meso form is not included References edit Moretti JL Defer G Cinotti L Cesaro P Degos JD Vigneron N et al 1990 Luxury perfusion with 99mTc HMPAO and 123I IMP SPECT imaging during the subacute phase of stroke European Journal of Nuclear Medicine 16 1 17 22 doi 10 1007 BF01566007 PMID 2307169 S2CID 11934803 Weldon MJ Joseph AE French A Saverymuttu SH Maxwell JD October 1995 Comparison of 99m technetium hexamethylpropylene amine oxime labelled leucocyte with 111 indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra abdominal abscess Gut 37 4 557 64 doi 10 1136 gut 37 4 557 PMC 1382910 PMID 7489945 Ui K Yamaguchi T December 1991 Therapy and diagnosis of emergency shock patients Nihon Naika Gakkai Zasshi The Journal of the Japanese Society of Internal Medicine 80 12 1892 6 doi 10 2169 naika 80 1892 PMID 1804909 Exametazime PubChem National Institutes of Health Monography in the European Pharmacopoeia PDF External links editEuropean Association of Nuclear Medicine Ceretec GE Healthcare Ceretec Exametazime ligand CID 9552071 from PubChem nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Technetium 99mTc exametazime amp oldid 1135492136, wikipedia, wiki, book, books, library,
