HLA-B58 (B58) is an HLA-Bserotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57.[1] The serotype identifies the more common HLA-B*58 gene products.[2] (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.
HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome.[5][6] Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN).[7] The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.[8]
Referencesedit
^Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem. 260 (22): 11924–33. doi:10.1016/S0021-9258(17)38967-6. PMID 2995352.
^Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC2848993. PMID 20356336.
^Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W (2009). "Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population". Pharmacogenet Genomics. 19 (9): 704–9. doi:10.1097/FPC.0b013e328330a3b8. PMID 19696695. S2CID 24941838.
^Hung SI, Chung WH, Liou LB, et al. (March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proc. Natl. Acad. Sci. U.S.A. 102 (11): 4134–9. Bibcode:2005PNAS..102.4134H. doi:10.1073/pnas.0409500102. PMC554812. PMID 15743917.
^Lonjou C, Borot N, Sekula P, et al. (February 2008). "A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs". Pharmacogenet. Genomics. 18 (2): 99–107. doi:10.1097/FPC.0b013e3282f3ef9c. PMID 18192896. S2CID 35512622.
December 20, 2023
alpha, β2mg, with, bound, peptidemajor, histocompatibility, complex, human, class, b58alleles, 5801, 5802structure, shared, datalocus, 6p21, serotype, split, antigen, from, broad, antigen, sister, serotype, serotype, identifies, more, common, gene, products, t. HLA B alpha b2MG with bound peptidemajor histocompatibility complex human class I B58Alleles 5801 5802Structure See HLA B Shared dataLocus chr 6 6p21 31HLA B58 B58 is an HLA B serotype B58 is a split antigen from the B17 broad antigen the sister serotype B57 1 The serotype identifies the more common HLA B 58 gene products 2 For terminology help see HLA serotype tutorial B 5801 is associated with allopurinol induced inflammatory necrotic skin disease Contents 1 Serotype 2 Allele distribution 3 Disease 4 ReferencesSerotype editB58 and B17 serotype recognition of some more common HLA B 58 alleles 3 B 58 B58 B17 Sampleallele size N 5801 79 4 2096 5802 72 3 837Allele distribution editHLA B 5801 frequencies freqref Population 4 Cameroon Pygmy Baka 15 0 4 India Khandesh Pawra 15 0 4 Cameroon Sawa 11 5 4 Taiwan Hakka 10 9 4 Kenya Nandi 10 0 4 India West Bhils 9 0 4 China South Han 8 9 4 China Inner Mongolia 8 8 4 India North Delhi 8 8 4 Thailand Northeast 8 4 4 Guinea Bissau 7 8 4 Thailand 7 7 4 India Mumbai Marathas 7 4 4 India Andhra Pradesh Golla 7 2 4 Kenya Luo 7 0 4 Senegal Niokholo Mandenka 6 9 4 India New Delhi 6 8 4 Oman 6 8 4 Russia Tuva 2 6 7 4 South Korea 3 6 5 4 Italy Sardinia 3 6 4 4 Burkina Faso Fulani 6 1 4 Taiwan Siraya 5 9 4 India North Hindus 5 8 4 Burkina Faso Mossi 5 7 4 Cameroon Yaounde 5 4 4 Cameroon Bamileke 5 2 4 Singapore Riau Malay 5 0 4 Saudi Arabia Guraiat and Hail 4 6 4 France Corsica 4 5 4 Sudanese 4 5 4 Zimbabwe Harare Shona 4 4 4 Burkina Faso Rimaibe 4 3 4 Iran Baloch 4 0 4 South African Natal Zulu 4 0 4 Tunisia 4 0 4 Uganda Kampala 4 0 4 Cameroon Beti 3 7 4 Tunisia Ghannouch 3 7 4 Taiwan Pazeh 3 6 4 Tunisia Tunis 3 4 4 Italy North 1 3 3 4 Israel Ashkenazi and Non Ashkenazi Jews 3 2 4 India West Coast Parsis 3 0 4 China North Han 2 9 4 Ivory Coast Akan Adiopodoume 2 3 4 Mali Bandiagara 2 2 4 Mexico Zaptotec Oaxaca 2 2 4 South Africa Natal Tamil 2 0 4 China Yunnan Nu 1 9 4 Bulgaria 1 8 4 China Tibet Autonomous Region Tibetans 1 6 4 France South East 1 6 4 Israel Arab Druse 1 5 4 Czech Republic 1 4 4 Georgia Tbilisi Georgians 1 4 4 Jordan Amman 1 4 4 Morocco Nador Metalsa berber 1 4 4 Croatia 1 3 4 Romanian 1 3 4 Spain Eastern Andalusia 1 2 4 Australian Aborigine Cape York Peninsula 1 0B 5802 4 Cameroon Bamileke 14 3 4 Kenya Luo 12 5 4 Cameroon Yaounde 10 9 4 Cameroon Pygmy Baka 10 0 4 Cameroon Beti 9 8 4 Kenya Nandi 8 5 4 South African Natal Zulu 8 5 4 Cameroon Sawa 7 7 4 Zimbabwe Harare Shona 6 4 4 Cape Verde Northwestern Islands 5 6 4 Uganda Kampala 4 4 4 Central Africa Republic Mbenzele Pygmy 4 0 4 Zambia Lusaka 2 3 4 Iran Baloch 1 0 4 Tunisia 1 0Disease editHLA B 5801 is involved in allopurinol sensitive drug induced Stevens Johnson syndrome 5 6 Allopurinol is a frequent cause of severe cutaneous adverse reactions including drug hypersensitivity syndrome Stevens Johnson syndrome and toxic epidermal necrolysis SJS TEN 7 The association with allopurinol sensitivity in SJS TEN was extremely strong in Asia and somewhat less associated in Europeans 8 References edit Ways JP Coppin HL Parham P 1985 The complete primary structure of HLA Bw58 J Biol Chem 260 22 11924 33 doi 10 1016 S0021 9258 17 38967 6 PMID 2995352 Marsh S G Albert E D Bodmer W F Bontrop R E Dupont B Erlich H A Fernandez Vina M Geraghty D E Holdsworth R Hurley C K Lau M Lee K W Mach B Maiers M Mayr W R Muller C R Parham P Petersdorf E W Sasazuki T Strominger J L Svejgaard A Terasaki P I Tiercy J M Trowsdale J 2010 Nomenclature for factors of the HLA system 2010 Tissue Antigens 75 4 291 455 doi 10 1111 j 1399 0039 2010 01466 x PMC 2848993 PMID 20356336 derived from IMGT HLA a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by Middleton D Menchaca L Rood H Komerofsky R 2003 New allele frequency database http www allelefrequencies net Tissue Antigens 61 5 403 7 doi 10 1034 j 1399 0039 2003 00062 x PMID 12753660 a href Template Cite journal html title Template Cite journal cite journal a External link in code class cs1 code title code help Chung WH Hung SI Chen YT August 2007 Human leukocyte antigens and drug hypersensitivity Curr Opin Allergy Clin Immunol 7 4 317 23 doi 10 1097 ACI 0b013e3282370c5f PMID 17620823 S2CID 31415054 Tassaneeyakul W Jantararoungtong T Chen P Lin PY Tiamkao S Khunarkornsiri U Chucherd P Konyoung P Vannaprasaht S Choonhakarn C Pisuttimarn P Sangviroon A Tassaneeyakul W 2009 Strong association between HLA B 5801 and allopurinol induced Stevens Johnson syndrome and toxic epidermal necrolysis in a Thai population Pharmacogenet Genomics 19 9 704 9 doi 10 1097 FPC 0b013e328330a3b8 PMID 19696695 S2CID 24941838 Hung SI Chung WH Liou LB et al March 2005 HLA B 5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol Proc Natl Acad Sci U S A 102 11 4134 9 Bibcode 2005PNAS 102 4134H doi 10 1073 pnas 0409500102 PMC 554812 PMID 15743917 Lonjou C Borot N Sekula P et al February 2008 A European study of HLA B in Stevens Johnson syndrome and toxic epidermal necrolysis related to five high risk drugs Pharmacogenet Genomics 18 2 99 107 doi 10 1097 FPC 0b013e3282f3ef9c PMID 18192896 S2CID 35512622 Retrieved from https en wikipedia org w index php title HLA B58 amp oldid 1184080196, wikipedia, wiki, book, books, library,
