HLA-B57 (B57) is an HLA-Bserotype. B57 is a split antigen from the B17 broad antigen, the sister serotype B58.[1] The serotype identifies the more common HLA-B*58 gene products.[2] (For terminology help see: HLA-serotype tutorial.) Like B58, B57 is involved in drug-induced inflammatory skin disorders.
HLA-B*5701 is associated with drug-induced inflammatory disease of the skin. Individuals with B57 are more sensitive to the drug abacavir.[3] Abacavir is an antiretroviral drug used in treatment of HIV, however in sensitive individuals fever, skin rash, fatigue, gastrointestinal symptoms such as nausea, vomiting, diarrhea or abdominal pain and respiratory symptoms such as pharyngitis, dyspnea, or cough can develop. FDA has advised that people from at-risk ethnic groups, (see alle distribution table) be screened prior to drug-therapy.[4] [Note: phenotype frequencies are roughly double allele frequencies -tabled values- when allele frequency is less than 30%]
The mechanism by which abacavir causes this type 4 hypersensitivity reaction is by binding in the antigen-binding cleft of the HLA-B*57:01 protein, allowing new, "non-self" antigens to bind and be presented to T cells.[5]
Serotypeedit
B57 and B17 serotype recognition of some more common HLA B*57 alleles[6]
^Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem. 260 (22): 11924–33. doi:10.1016/S0021-9258(17)38967-6. PMID 2995352.
^Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC2848993. PMID 20356336.
alpha, β2mg, with, bound, peptidemajor, histocompatibility, complex, human, class, b57alleles, 5701, 5702, 5703, 5704structure, shared, datalocus, 6p21, serotype, split, antigen, from, broad, antigen, sister, serotype, serotype, identifies, more, common, gene,. HLA B alpha b2MG with bound peptidemajor histocompatibility complex human class I B57Alleles 5701 5702 5703 5704Structure See HLA B Shared dataLocus chr 6 6p21 31HLA B57 B57 is an HLA B serotype B57 is a split antigen from the B17 broad antigen the sister serotype B58 1 The serotype identifies the more common HLA B 58 gene products 2 For terminology help see HLA serotype tutorial Like B58 B57 is involved in drug induced inflammatory skin disorders Contents 1 Disease 2 Serotype 3 Allele distribution 4 ReferencesDisease editHLA B 5701 is associated with drug induced inflammatory disease of the skin Individuals with B57 are more sensitive to the drug abacavir 3 Abacavir is an antiretroviral drug used in treatment of HIV however in sensitive individuals fever skin rash fatigue gastrointestinal symptoms such as nausea vomiting diarrhea or abdominal pain and respiratory symptoms such as pharyngitis dyspnea or cough can develop FDA has advised that people from at risk ethnic groups see alle distribution table be screened prior to drug therapy 4 Note phenotype frequencies are roughly double allele frequencies tabled values when allele frequency is less than 30 The mechanism by which abacavir causes this type 4 hypersensitivity reaction is by binding in the antigen binding cleft of the HLA B 57 01 protein allowing new non self antigens to bind and be presented to T cells 5 Serotype editB57 and B17 serotype recognition of some more common HLA B 57 alleles 6 B 57 B57 B17 Sampleallele size N 5701 92 5 3670 5702 78 8 65 5703 85 6 412 5704 67 7 32Allele distribution editHLA B 5701 frequencies freqref Population 7 South Africa Natal Tamil 10 2 7 India Tamil Nadu Nadar 8 2 7 Spain E Andalusia Gipsy 7 1 7 Ireland South 5 8 7 India North Delhi 4 9 7 India New Delhi 3 8 7 Ireland Northern 3 8 7 Azores Central Islands 3 6 7 Cuban White 3 6 7 France South East 3 5 7 China Guangzhou Han 3 3 7 China North Han 3 3 7 Czech Republic 3 3 7 Russia Tuva 2 3 3 7 Cape Verde NW Islands 3 2 7 Azores Terceira Island 3 1 7 Portugal South 3 1 7 Thailand 3 3 1 7 Uganda Kampala 3 1 7 Portugal Centre 3 0 7 Tunisia 3 0 7 India Andhra Pradesh Golla 2 9 7 Belgium 2 0 7 China Inner Mongolia 2 0 7 Croatia 2 0 7 SP Javanese Indonesians 2 0 7 Singapore Riau Malay 2 0 7 India North Hindus 1 9 7 Bulgaria 1 8 7 Thailand 1 8 7 Finland 1 7 7 Macedonia pop 4 1 6 7 Madeira 1 6 7 Indig Australian Cape York Penin 1 5 7 Israel Arab Druse 1 5 7 Sudanese 1 5 7 Morocco Nador Metalsa Berber 1 4 7 Oman 1 3 7 Mexico Mestizos 1 2 7 Zambia Lusaka 1 1 7 Shijiazhuang Tianjian Han 1 0 7 Iran Baloch 1 0 7 USA Asian 1 0HLA B 5702 frequencies freqref Population 7 Zambia Lusaka 2 3 7 Senegal Niokholo Mandenka 1 6 7 Kenya 1 4 7 Mali Bandiagara 1 1 7 South African Natal Zulu 1 0B 5703 7 Zambia Lusaka 5 7 7 Cameroon Bakola Pygmy 5 0 7 Ivory Coast Akan Adiopodoume 4 6 7 Zimbabwe Harare Shona 4 4 7 South African Natal Zulu 4 0 7 Cameroon Bamileke 3 2 7 Cameroon Beti 3 2 7 Kenya Nandi 2 9 7 Israel Ashk amp Non Ashk Jews 2 8 7 Cameroon Yaounde 2 7 7 Tunisia Tunis 2 3 7 Saudi Arabia Guraiat and Hail 1 5References edit Ways JP Coppin HL Parham P 1985 The complete primary structure of HLA Bw58 J Biol Chem 260 22 11924 33 doi 10 1016 S0021 9258 17 38967 6 PMID 2995352 Marsh S G Albert E D Bodmer W F Bontrop R E Dupont B Erlich H A Fernandez Vina M Geraghty D E Holdsworth R Hurley C K Lau M Lee K W Mach B Maiers M Mayr W R Muller C R Parham P Petersdorf E W Sasazuki T Strominger J L Svejgaard A Terasaki P I Tiercy J M Trowsdale J 2010 Nomenclature for factors of the HLA system 2010 Tissue Antigens 75 4 291 455 doi 10 1111 j 1399 0039 2010 01466 x PMC 2848993 PMID 20356336 Chung WH Hung SI Chen YT August 2007 Human leukocyte antigens and drug hypersensitivity Curr Opin Allergy Clin Immunol 7 4 317 23 doi 10 1097 ACI 0b013e3282370c5f PMID 17620823 S2CID 31415054 https www fda gov cder drug InfoSheets HCP abacavirHCP htm FDA abacavir alert web access July 29 2008 Illing Patricia T Vivian Julian P Dudek Nadine L Kostenko Lyudmila Chen Zhenjun Bharadwaj Mandvi Miles John J Kjer Nielsen Lars Gras Stephanie Williamson Nicholas A Burrows Scott R 2012 06 28 Immune self reactivity triggered by drug modified HLA peptide repertoire Nature 486 7404 554 558 doi 10 1038 nature11147 ISSN 0028 0836 PMID 22722860 S2CID 4408811 derived from IMGT HLA a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh Middleton D Menchaca L Rood H Komerofsky R 2003 New allele frequency database http www allelefrequencies net Tissue Antigens 61 5 403 7 doi 10 1034 j 1399 0039 2003 00062 x PMID 12753660 a href Template Cite journal html title Template Cite journal cite journal a External link in code class cs1 code title code help Retrieved from https en wikipedia org w index php title HLA B57 amp oldid 1185908405, wikipedia, wiki, book, books, library,
