The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]
References
^ abcGRCh38: Ensembl release 89: ENSG00000130589 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027580 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC16267. PMID 10737800.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi:10.1073/pnas.182426699. PMC129355. PMID 12189208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC514446. PMID 15302935.
Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
pric285, peroxisomal, proliferator, activated, receptor, interacting, complex, also, known, human, gene, helz2identifiersaliaseshelz2, pdip, helicase, with, zinc, finger, 2external, idsomim, 611265, 2385169, homologene, 14118, genecards, helz2gene, location, h. Peroxisomal proliferator activated receptor A interacting complex 285 also known as PRIC285 is a human gene 5 HELZ2IdentifiersAliasesHELZ2 PDIP 1 PRIC285 helicase with zinc finger 2External IDsOMIM 611265 MGI 2385169 HomoloGene 14118 GeneCards HELZ2Gene location Human Chr Chromosome 20 human 1 Band20q13 33Start63 558 086 bp 1 End63 574 239 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 H4Start180 869 408 bp 2 End180 883 820 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbone marrow cellsbloodsural nerveappendixmonocytestromal cell of endometriumspleenupper lobe of left lunggallbladderbody of stomachTop expressed inlymph nodespleensubmandibular glandleft lobe of liverbloodPaneth cellsubcutaneous adipose tissueintestinal villusjejunumileumMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding nucleotide binding protein binding ATP binding hydrolase activity helicase activity nuclear receptor coactivator activity metal ion binding RNA binding ribonuclease activityCellular componentmembrane nucleus nucleoplasm cytoplasmBiological processregulation of transcription DNA templated transcription DNA templated positive regulation of transcription by RNA polymerase II regulation of lipid metabolic process nuclear transcribed mRNA catabolic process nonsense mediated decay RNA phosphodiester bond hydrolysisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez85441229003EnsemblENSG00000130589ENSMUSG00000027580UniProtQ9BYK8E9QAM5RefSeq mRNA NM 001037335NM 033405NM 183162RefSeq protein NP 001032412NP 208384NP 898985Location UCSC Chr 20 63 56 63 57 MbChr 2 180 87 180 88 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a nuclear transcriptional co activator for peroxisome proliferator activated receptor alpha The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex This gene is a member of the DNA2 NAM7 helicase gene family Alternatively spliced transcript variants encoding different isoforms have been found for this gene 5 References Edit a b c GRCh38 Ensembl release 89 ENSG00000130589 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027580 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene PRIC285 peroxisomal proliferator activated receptor A interacting complex 285 Further reading EditNakajima D Okazaki N Yamakawa H et al 2003 Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Res 9 3 99 106 doi 10 1093 dnares 9 3 99 PMID 12168954 Dias Neto E Correa RG Verjovski Almeida S et al 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags Proc Natl Acad Sci U S A 97 7 3491 6 Bibcode 2000PNAS 97 3491D doi 10 1073 pnas 97 7 3491 PMC 16267 PMID 10737800 Nagase T Kikuno R Hattori A et al 2001 Prediction of the coding sequences of unidentified human genes XIX The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 7 6 347 55 doi 10 1093 dnares 7 6 347 PMID 11214970 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Surapureddi S Yu S Bu H et al 2002 Identification of a transcriptionally active peroxisome proliferator activated receptor alpha interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator Proc Natl Acad Sci U S A 99 18 11836 41 Bibcode 2002PNAS 9911836S doi 10 1073 pnas 182426699 PMC 129355 PMID 12189208 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Beausoleil SA Jedrychowski M Schwartz D et al 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Tomaru T Satoh T Yoshino S et al 2006 Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid binding domain of peroxisome proliferator activated receptor gamma Endocrinology 147 1 377 88 doi 10 1210 en 2005 0450 PMID 16239304 This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PRIC285 amp oldid 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